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Your search keyword '"de Vries, L.S."' showing total 20 results
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20 results on '"de Vries, L.S."'

1. Association between seizures and neurodevelopmental outcome at two- and five years in asphyxiated newborns with therapeutic hypothermia

Author

Langeslag, J.F., primary, Onland, W., additional, Groenendaal, F., additional, de Vries, L.S., additional, van Kaam, A.H., additional, de Haan, T.R., additional, van den Akker, Chris H.P., additional, de Boode, Willem P., additional, Cools, Filip, additional, ter Horst, Henk J., additional, Dijkman, Koen P., additional, Groenendaal, Floris, additional, de Haan, Timo R., additional, Simons, Sinno H.P., additional, Steggerda, Sylke J., additional, Mulder-Tollenaer, Suzanne, additional, and Zecic, Alexandra, additional

Published
2024
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2. Rapid exome sequencing as a first-tier test in neonates with suspected genetic disorder: results of a prospective multicenter clinical utility study in the Netherlands

Author

Olde Keizer, R.A.C.M., Marouane, A., Kerstjens-Frederikse, W.S., Deden, A.C., Lichtenbelt, K.D., Jonckers, T., Vervoorn, M., Vreeburg, M., Henneman, L., de Vries, L.S., Sinke, R.J., Pfundt, R., Stevens, S.J.C., Andriessen, P., van Lingen, R.A., Nelen, M., Scheffer, H., Stemkens, D., Oosterwijk, C., van Amstel, H.K.P., de Boode, W.P., van Zelst-Stams, W.A.G., Frederix, G.W.J., Vissers, L.E.L.M., RS: GROW - R4 - Reproductive and Perinatal Medicine, Genetica & Celbiologie, MUMC+: DA KG Polikliniek (9), and MUMC+: DA KG Lab Specialisten (9)

Subjects
Diagnostic workflow, All institutes and research themes of the Radboud University Medical Center, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Rapid exome sequencing, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6], Neonates, Clinical utility, Economic evaluation, COSTS
Abstract

Contains fulltext : 293809.pdf (Publisher’s version ) (Open Access) The introduction of rapid exome sequencing (rES) for critically ill neonates admitted to the neonatal intensive care unit has made it possible to impact clinical decision-making. Unbiased prospective studies to quantify the impact of rES over routine genetic testing are, however, scarce. We performed a clinical utility study to compare rES to conventional genetic diagnostic workup for critically ill neonates with suspected genetic disorders. In a multicenter prospective parallel cohort study involving five Dutch NICUs, we performed rES in parallel to routine genetic testing for 60 neonates with a suspected genetic disorder and monitored diagnostic yield and the time to diagnosis. To assess the economic impact of rES, healthcare resource use was collected for all neonates. rES detected more conclusive genetic diagnoses than routine genetic testing (20% vs. 10%, respectively), in a significantly shorter time to diagnosis (15 days (95% CI 10-20) vs. 59 days (95% CI 23-98, p

Published
2023

7. Variability in the diagnostic and management practices of post-hemorrhagic ventricular dilatation in very preterm infants across Canadian centers and comparison with European practices.

Author

Afifi, J., Leijser, L.M., de Vries, L.S., Shah, P.S., Mitra, S., Brouwer, M.J., Walling, S., and McNeely, P.D.

Subjects
PREMATURE infants, INTRAVENTRICULAR hemorrhage, LUMBAR puncture, THERAPEUTICS
Abstract

OBJECTIVES: To investigate the variability in diagnostic and therapeutic approaches to posthemorrhagic ventricular dilatation (PHVD) among Canadian neonatal centers, and secondary exploration of differences in approaches between Canadian and European practices. METHODS: We conducted a survey among Canadian tertiary neonatal centers on their local practices for managing very preterm infants with PHVD. The survey covered questions on the diagnostic criteria, timing and type of interventions and resources utilization (transfer to neurosurgical sites and neurodevelopmental follow-up). In a secondary exploration, Canadian responses were compared with responses to the same survey from European centers. RESULTS: 23/30 Canadian centers (77%) completed the survey. There was no consensus among Canadian centers on the criteria used for diagnosing PHVD or to initiate intervention. The therapeutic interventions also vary, both for temporizing procedures or permanent shunting. Compared to European practices, the Canadian approach relied less on the sole use of ultrasound criteria for diagnosing PHVD (43 vs 94%, p < 0.0001) or timing intervention (26 vs 63%, p = 0.007). Majority of European centers intervened early in the development of PHVD based on ultrasound parameters, whereas Canadian centers intervened based on clinical hydrocephalus, with fewer centers performing serial lumbar punctures prior to neurosurgical procedures (40 vs 81%, p = 0.003). CONCLUSION: Considerable variability exists in diagnosis and management of PHVD in preterm infants among Canadian tertiary centers and between Canadian and European practices. Given the potential implications of the inter-center practice variability on the short- and long-term outcomes of preterm infants with PHVD, efforts towards evidence-based Canada-wide practice standardization are underway. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Supplementary Material for: The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

Author

Reubsaet, P., Brouwer, A.J., Van Haastert, I.C., Brouwer, M.J., Koopman, C., Groenendaal, F., and De Vries, L.S.

Abstract

Background: Very preterm infants often show germinal matrix-intraventricular hemorrhage (GMH-IVH) on cranial ultrasound (cUS). Aim: To determine the impact of low-grade GMH-IVH on early neurodevelopmental outcome in very preterm infants. Methods: A retrospective case-control study in very preterm infants with and without low-grade GMH-IVH on cUS. Additional magnetic resonance imaging (MRI) was available in all infants with a gestational age (GA) 28 weeks. Infants were seen at 2 years' corrected age to assess neurodevelopment. Results: In total, 136 infants (GA 24-32 weeks) with low-grade GMH-IVH on cUS were matched with 255 controls. Outcome data was available for 342 (87%) infants. Adverse outcome (i.e., cerebral palsy [CP], neurodevelopmental delay) was present in 11 (9%) cases and 20 (9%) controls. No statistically significant differences in outcome were found between cases and controls. Additional MRI was performed in 165/391 infants (42%) and showed additional lesions in 73 (44%) infants that could explain subsequent development of CP in 2 out of 5 infants and epilepsy in 1 of 2 infants. Conclusion: Very preterm infants with low-grade GMH-IVH on cUS have a similar early neurodevelopmental outcome compared with controls. Additional MRI showed mostly subtle abnormalities that were missed with cUS, but these could not explain subsequent development of CP and developmental delay in all infants.

Published
2017
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