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Abstract Background Platform-based fast delivery is developing rapidly in many cities across the world, especially in the food sector. Yet knowledge about the characteristics and the activity patterns of delivery couriers is scarce, especially in terms of their mobility behavior. Methodology Based on two questionnaire surveys conducted in 2020 and 2021 with 300 and 500 couriers respectively, this article analyses the profiles, motivations and mobility patterns of couriers working in Paris (France), with a focus on the impacts of the pandemic. Results First, the analysis of the profiles and motivations of couriers reveals that platform-based delivery is largely a temporary activity performed by young males of foreign origin, and undertaken as a student job or an entry to the labor market. Second, data on mobility patterns confirm that platform-based delivery is a dangerous activity with a high risk of road accidents. Moreover, many couriers break the law in order to increase their income by using motorized two-wheelers that are not legally permitted in France. We also show the use of shared bikes, which seems to be a great support tool for couriers who are starting work in this sector or have a problem with their own bikes. Third, the pandemic prompted many students to become platform-based delivery couriers in order to compensate for the lack of student jobs. It also worsened the working conditions of the majority of platform-based couriers. These findings raise new urban policy challenges and also new avenues for research in terms of topics and methods.

Acute Myeloid Leukemia (AML) is a complex disease with rapid progression and poor/unsatisfactory outcomes. In the past few years, the focus has been on developing newer therapies for AML; however, relapse remains a significant problem. Natural Killer cells have strong anti-tumor potential against AML. This NK-mediated cytotoxicity is often restricted by cellular defects caused by disease-associated mechanisms, which can lead to disease progression. A stark feature of AML is the low/no expression of the cognate HLA ligands for the activating KIR receptors, due to which these tumor cells evade NK-mediated lysis. Recently, different Natural Killer cell therapies have been implicated in treating AML, such as the adoptive NK cell transfer, Chimeric antigen receptormodified NK (CAR-NK) cell therapy, antibodies, cytokine, and drug treatment. However, the data available is scarce, and the outcomes vary between different transplant settings and different types of leukemia. Moreover, remission achieved by some of these therapies is only for a short time. In this mini-review, we will discuss the role of NK cell defects in AML progression, particularly the expression of different cell surface markers, the available NK cell therapies, and the results from various preclinical and clinical trials. [ABSTRACT FROM AUTHOR]

Acute Myeloid Leukemia (AML) is a complex disease with rapid progression and poor/unsatisfactory outcomes. In the past few years, the focus has been on developing newer therapies for AML; however, relapse remains a significant problem. Natural Killer cells have strong anti-tumor potential against AML. This NK-mediated cytotoxicity is often restricted by cellular defects caused by disease-associated mechanisms, which can lead to disease progression. A stark feature of AML is the low/no expression of the cognate HLA ligands for the activating KIR receptors, due to which these tumor cells evade NK-mediated lysis. Recently, different Natural Killer cell therapies have been implicated in treating AML, such as the adoptive NK cell transfer, Chimeric antigen receptor-modified NK (CAR-NK) cell therapy, antibodies, cytokine, and drug treatment. However, the data available is scarce, and the outcomes vary between different transplant settings and different types of leukemia. Moreover, remission achieved by some of these therapies is only for a short time. In this mini-review, we will discuss the role of NK cell defects in AML progression, particularly the expression of different cell surface markers, the available NK cell therapies, and the results from various preclinical and clinical trials.

Cycling has cut across public health and policy forums in the last decade given trends in urban governance for liveability and uptake of cycling during the COVID‐19 pandemic. This review discusses work that helps understand where, how, and why time spent cycling can contribute to health and well‐being. The review discusses how cycling geographies offers an alternative to biomedical approaches that measure the risks versus the medical benefits of riding a bike. The paper is structured around three key themes that characterise contemporary cycling geographies (a) cycling and neoliberalism; (b) cycling citizenship; and (c) everyday cycling. The paper argues, these studies have not gone far enough in understanding the relationship between well‐being and cycling. To help address this gap the review offers a 'mobile territories of well‐being' framework. To conclude, consideration is given to the policy implications of a cycling geographies research agenda engaging with a mobile territories of well‐being framework. [ABSTRACT FROM AUTHOR]

Background: Platform-based fast delivery is developing rapidly in many cities across the world, especially in the food sector. Yet knowledge about the characteristics and the activity patterns of delivery couriers is scarce, especially in terms of their mobility behavior. Methodology: Based on two questionnaire surveys conducted in 2020 and 2021 with 300 and 500 couriers respectively, this article analyses the profiles, motivations and mobility patterns of couriers working in Paris (France), with a focus on the impacts of the pandemic. Results: First, the analysis of the profiles and motivations of couriers reveals that platform-based delivery is largely a temporary activity performed by young males of foreign origin, and undertaken as a student job or an entry to the labor market. Second, data on mobility patterns confirm that platform-based delivery is a dangerous activity with a high risk of road accidents. Moreover, many couriers break the law in order to increase their income by using motorized two-wheelers that are not legally permitted in France. We also show the use of shared bikes, which seems to be a great support tool for couriers who are starting work in this sector or have a problem with their own bikes. Third, the pandemic prompted many students to become platform-based delivery couriers in order to compensate for the lack of student jobs. It also worsened the working conditions of the majority of platform-based couriers. These findings raise new urban policy challenges and also new avenues for research in terms of topics and methods. [ABSTRACT FROM AUTHOR]