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4 results on '"Zingaretti, M. C."'

1. The Adipose Organ Is a Unitary Structure in Mice and Humans

Author

Giordano, A., primary, Cinti, F., additional, Canese, R., additional, Carpinelli, G., additional, Colleluori, G., additional, Di Vincenzo, A., additional, Palombelli, G., additional, Severi, I., additional, Moretti, M., additional, Redaelli, C., additional, Partridge, J., additional, Zingaretti, M. C., additional, Agostini, A., additional, Sternardi, F., additional, Giovagnoni, A., additional, Castorina, S., additional, and Cinti, S., additional

Published
2022
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2. The Adipose Organ Is a Unitary Structure in Mice and Humans

Author

Giordano, A., Cinti, Francesca, Canese, R., Carpinelli, G., Colleluori, G., Di Vincenzo, A., Palombelli, G., Severi, I., Moretti, M., Redaelli, Chiara, Partridge, J., Zingaretti, M. C., Agostini, A., Sternardi, F., Giovagnoni, A., Castorina, S., Cinti, Saverio, Cinti F. (ORCID:0000-0001-5170-7055), Redaelli C., Cinti S., Giordano, A., Cinti, Francesca, Canese, R., Carpinelli, G., Colleluori, G., Di Vincenzo, A., Palombelli, G., Severi, I., Moretti, M., Redaelli, Chiara, Partridge, J., Zingaretti, M. C., Agostini, A., Sternardi, F., Giovagnoni, A., Castorina, S., Cinti, Saverio, Cinti F. (ORCID:0000-0001-5170-7055), Redaelli C., and Cinti S.

Abstract

Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, the adipose organ undergoes remarkable morpho-functional alterations. The comprehension of the adipose organ function and organization is of paramount importance to understand its pathology and formulate future therapeutic strategies. In the present study, we performed anatomical dissections, magnetic resonance imaging, computed axial tomography and histological and immunohistochemical assessments of humans and mouse adipose tissues. We demonstrate that most of the two types of adipose tissues (white, WAT and brown, BAT) form a large unitary structure fulfilling all the requirements necessary to be considered as a true organ in both species. A detailed analysis of the gross anatomy of mouse adipose organs in different pathophysiological conditions (normal, cold, pregnancy, obesity) shows that the organ consists of a unitary structure composed of different tissues: WAT, BAT, and glands (pregnancy). Data from autoptic dissection of 8 cadavers, 2 females and 6 males (Age: 37.5 ± 9.7, BMI: 23 ± 2.7 kg/m2) and from detailed digital dissection of 4 digitalized cadavers, 2 females and 2 males (Age: 39 ± 14.2 years, BMI: 22.8 ± 4.3 kg/m2) confirmed the mixed (WAT and BAT) composition and the unitary structure of the adipose organ also in humans. Considering the remarkable endocrine roles of WAT and BAT, the definition of the endocrine adipose organ would be even more appropriate in mice and humans.

Published
2022

3. Human White Adipocytes Convert Into 'Rainbow' Adipocytes In Vitro

Author

Maurizi G., Poloni A., Mattiucci D., Santi S., Maurizi A., Izzi V., Giuliani A., Mancini S., Zingaretti M. C., Perugini J., Severi I., Falconi M., Vivarelli M., Rippo M. R., Corvera S., Giordano A., Leoni P., Cinti S., Maurizi, G., Poloni, A., Mattiucci, D., Santi, S., Maurizi, A., Izzi, V., Giuliani, A., Mancini, S., Zingaretti, M. C., Perugini, J., Severi, I., Falconi, M., Vivarelli, M., Rippo, M. R., Corvera, S., Giordano, A., Leoni, P., and Cinti, S.

Subjects
Genetic Markers, Time Factors, Adipocytes, White, Cell Plasticity, Time-Lapse Imaging, Humans, Cell Lineage, Obesity, Cell Shape, Cells, Cultured, Aged, Oligonucleotide Array Sequence Analysis, Aged, 80 and over, Microscopy, Confocal, Microscopy, Video, Adipogenesis, Gene Expression Profiling, Gene Expression Regulation, Developmental, Mesenchymal Stem Cells, Lipid Droplets, Middle Aged, Cellular Reprogramming, Lipid Metabolism, Microscopy, Electron, Adipocytes, Brown, Phenotype
Abstract

White adipocytes are plastic cells able to reversibly transdifferentiate into brown adipocytes and into epithelial glandular cells under physiologic stimuli in vivo. These plastic properties could be used in future for regenerative medicine, but are incompletely explored in their details. Here, we focused on plastic properties of human mature adipocytes (MA) combining gene expression profile through microarray analysis with morphologic data obtained by electron and time lapse microscopy. Primary MA showed the classic morphology and gene expression profile of functional mature adipocytes. Notably, despite their committed status, MA expressed high levels of reprogramming genes. MA from ceiling cultures underwent transdifferentiation toward fibroblast-like cells with a well-differentiated morphology and maintaining stem cell gene signatures. The main morphologic aspect of the transdifferentiation process was the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion further supported the liposecretion process. Of note, electron microscope findings suggesting liposecretion phenomena were found also in explants of human fat and rarely in vivo in fat biopsies from obese patients. In conclusion, both MA and post-liposecretion adipocytes show a well-differentiated phenotype with stem cell properties in line with the extraordinary plasticity of adipocytes in vivo. J. Cell. Physiol. 232: 2887–2899, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

4. Omental adipose tissue fibrosis and insulin resistance in severe obesity

Author

Guglielmi, V, primary, Cardellini, M, additional, Cinti, F, additional, Corgosinho, F, additional, Cardolini, I, additional, D'Adamo, M, additional, Zingaretti, M C, additional, Bellia, A, additional, Lauro, D, additional, Gentileschi, P, additional, Federici, M, additional, Cinti, S, additional, and Sbraccia, P, additional

Published
2015
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