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The 82Sr/82Rb generator is used to produce a radiopharmaceutical rubidium-82 chloride in saline solution for PET imaging. In this work, we studied the effect of the amount of stable strontium and calcium delivered to the sorbent (on the basis of hydrated tin dioxide) on the maximum volume of radiopharmaceutical solution that can be obtained from the generator. Sr and Ca may be delivered to the sorbent from the initial solution of strontium-82 chloride or from the eluent (0.9% NaCl) during medical application of the generator. It is shown that this volume depends on the value CSr + 0.11CCa, where CSr and CCa are molar concentrations of the elements in 1 g of the sorbent. The obtained results make it possible to increase significantly the productivity and reliability of the used generators. [ABSTRACT FROM AUTHOR]

Various methods have been developed for the extraction of a promising medical radionuclide 117mSn from proton-irradiated TiSb intermetallic compound, a target material suitable for irradiation with an intense beam of accelerated protons. To separate radiotin from Ti, Sb, and radionuclides of other elements, methods of ion-exchange chromatography and liquid extraction were used, in particular, the anion-exchange separation of tin and titanium in the form of a peroxide complex in HCl solution, extraction of tin with benzene from iodide solutions, and chromatographic purification on silica gel from citrate solutions. As a result, 117mSn of high purity, which meets the requirements for nuclear medicine, was obtained. [ABSTRACT FROM AUTHOR]

The ability of inorganic hydroxide sorbents Termoxid-5 (T-5) and Termoxid-39 (T-39) heat-treated at temperatures from 100 to 950°C to take up radionuclides of the 225Ac subfamily was examined in a wide range of solution acidities and salt compositions. T-5 and T-39 are principally suitable for the development of both direct and inverse 225Ac/213Bi generators with the activity of hundreds of millicuries of 225Ac. [ABSTRACT FROM AUTHOR]