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Background and objectives: Multiple reforms aimed at improving the Chinese population's health have been introduced in recent years, including several designed to improve access to innovative drugs. We sought to review current factors affecting access to innovative drugs in China and to anticipate future trends. Methods: Targeted reviews of published literature and statistics on the Chinese healthcare system, medical insurance and reimbursement processes were conducted, as well as interviews with five Chinese experts involved in the reimbursement of innovative drugs. Results: Drug reimbursement in China is becoming increasingly centralized due to the removal of provincial pathways, the establishment of the National Healthcare Security Administration and the implementation of the National Reimbursement Drug List (NRDL), which is now the main route for drug reimbursement in China. There is also an increasing number of other channels via which patients may access innovative treatments, including various types of commercial insurance and special access. Health technology assessment (HTA) and health economic evidence are becoming pivotal elements of the NRDL decision-making process. Alongside the optimization of HTA decision making, innovative risk-sharing agreements are anticipated to be increasingly leveraged in the future to optimize access to highly specialized technologies and encourage innovation while safeguarding limited healthcare funds. Conclusions: Drug public reimbursement in China continues to align more closely with approaches widely used in Europe in terms of HTA, health economics and pricing. Centralization of decision-making processes for public reimbursement of innovative drugs allows consistency in assessment and access, which optimizes the improvement of the Chinese population's health. [ABSTRACT FROM AUTHOR]

Background/Aims: Intravenous bisphosphonate therapy is the first-line treatment in moderate-to-severe osteogenesis imperfecta (OI), but there are varied treatment protocols with little data on long-term efficacy. This study evaluates the clinical outcomes when transitioning from active bisphosphonate treatment to maintenance therapy. Methods: A retrospective review was conducted on 17 patients before treatment, following active treatment (zoledronate 0.05 mg/kg 6-monthly or pamidronate 6-9 mg/kg/year) and after establishment on maintenance treatment for more than 2 years (zoledronate 0.025 mg/kg 6-monthly or pamidronate <4 mg/kg/year). Results: There was a significant reduction in mean fracture rate from 1.5 ± 1.1 fractures/year at baseline to 0.7 ± 0.7 fractures/year on active treatment. Z-scores for lumbar spine bone mineral density, bone mineral content, volumetric bone mineral density and bone mineral content for lean tissue mass increased during active treatment. These improvements were maintained during the period of maintenance treatment. Vertebral height improved in fractured thoracic vertebrae from pre-treatment to active therapy and improved further during maintenance treatment. Metacarpal cortical thickness and relative cortical area also increased over the treatment periods. Conclusion: Maintenance intravenous bisphosphonate therapy preserved the beneficial effects of active treatment at the doses stated above. Further studies are required to determine the optimal bisphosphonate treatment regimen in the management of children with OI. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

A case study is presented of a 41-year-old Indonesian female presented with progressive growth of a left orbital mass. Examination showed blindness in left eye; magnetic resonance imaging brain and orbits showed retro-bulbar mass in the left orbit; further she was treated of solitary fibrous orbital tumour.

Objective: The present study examined (a) the presence of early maladaptive schemas and coping responses in children who have experienced maltreatment, (b) the relationship between early maladaptive schemas and coping responses, and (c) how qualitative findings compare to previous theoretical structures in quantitative studies., Method: There were 100 participants ( M age = 10.72 years, SD = 3.35; 64 girls, 30 boys, six transgender/nonbinary), with 70% identifying as White. Data were collected in collaboration with a community child advocacy center through forensic interviews in cases of reported child abuse. Early maladaptive schemas were assessed using an adapted version of the Dusseldorf Illustrated Schema Questionnaire for Children. Coping responses were assessed using the COPE Inventory. Information about individual and abuse factors was gathered from case reports. Child advocacy center staff completed the measures based on information obtained during forensic interviews., Results: All assessed early maladaptive schemas were endorsed in this sample; children reported an ability to adapt through the use of socially supported and self-sufficient coping responses. Hierarchical cluster analysis examining word similarity within coded texts demonstrated that subjugation and self-sacrifice were most strongly related., Conclusion: This mixed-method study integrating children's voices contributes a new perspective on early maladaptive schemas and coping responses that can provide education to multidisciplinary teams involved in forensic interviews. However, limits to generalizability must be considered given that the sample was derived from one region in the U.S. Midwest. (PsycInfo Database Record (c) 2024 APA, all rights reserved).