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7 results on '"Zhang, Zhongzi"'

2. A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma.

Author

Yu, Bin, Geng, Chengkui, Wu, Zhongxiong, Zhang, Zhongzi, Zhang, Aili, Yang, Ze, Huang, Jiazheng, Xiong, Ying, Yang, Huiqin, and Chen, Zhuoyuan

Subjects
TUMOR microenvironment, OSTEOSARCOMA, CELL cycle regulation, PROGRAMMED cell death 1 receptors, DISEASE risk factors, PROGNOSTIC models
Abstract

Osteosarcoma is generally considered a cold tumor and is characterized by epigenetic alterations. Although tumor cells are surrounded by many immune cells such as macrophages, T cells may be suppressed, be inactivated, or not be presented due to various mechanisms, which usually results in poor prognosis and insensitivity to immunotherapy. Immunotherapy is considered a promising anti-cancer therapy in osteosarcoma but requires more research, but osteosarcoma does not currently respond well to this therapy. The cancer immunity cycle (CIC) is essential for anti-tumor immunity, and is epigenetically regulated. Therefore, it is possible to modulate the immune microenvironment of osteosarcoma by targeting epigenetic factors. In this study, we explored the correlation between epigenetic modulation and CIC in osteosarcoma through bioinformatic methods. Based on the RNA data from TARGET and GSE21257 cohorts, we identified epigenetic related subtypes by NMF clustering and constructed a clinical prognostic model by the LASSO algorithm. ESTIMATE, Cibersort, and xCell algorithms were applied to analyze the tumor microenvironment. Based on eight epigenetic biomarkers (SFMBT2, SP140, CBX5, HMGN2, SMARCA4, PSIP1, ACTR6, and CHD2), two subtypes were identified, and they are mainly distinguished by immune response and cell cycle regulation. After excluding ACTR6 by LASSO regression, the prognostic model was established and it exhibited good predictive efficacy. The risk score showed a strong correlation with the tumor microenvironment, drug sensitivity and many immune checkpoints. In summary, our study sheds a new light on the CIC-related epigenetic modulation mechanism of osteosarcoma and helps search for potential drugs for osteosarcoma treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Biomechanical analysis and clinical effects of bridge combined fixation system for femoral fractures

Author

Daxing Wang, Qi Pu, Ying Xiong, Zhang Zhongzi, Fu Jia, Shao Gu, Hong Deng, Bailian Liu, and Qunhui Li

Subjects
Adult, Male, medicine.medical_treatment, Bone Screws, Finite Element Analysis, Walking, Bone healing, Fracture Fixation, Internal, Young Adult, Fixation (surgical), Flexural strength, Bone plate, Humans, Medicine, Displacement (orthopedic surgery), Femur, Bridge (dentistry), Aged, Orthodontics, business.industry, Mechanical Engineering, General Medicine, Middle Aged, Biomechanical Phenomena, Bending stiffness, Female, Stress, Mechanical, Implant, business, Bone Plates, Femoral Fractures
Abstract

This work aimed to compare the stress distribution and mechanical properties of our bridge combined fixation system and commonly used metal locking plate screw system by finite element analysis and by using the Zwick/Z100 testing machine. In addition, we also investigated the clinical outcome of our bridge combined fixation system for femoral fractures in 59 patients from June 2005 to January 2013. As a result, the stress distribution in the bone plate and screws of metal locking plate screw system during walking and climbing stairs was significantly lower than that of metal locking plate screw system. No significant difference in the displacement was observed between two systems. The equivalent bending stiffness of bridge combined fixation system was significantly lower than that of metal locking plate screw system. There were no significant differences in the bending strength, yield load, and maximum force between two systems. All the cases were followed up for 12–24 months (average 18 months). The X-ray showed bone callus was formed in most patients after 3 months, and the fracture line was faint and disappeared at 6–9 months postoperatively. No serious complications, such as implant breakage and wound infection, occurred postoperatively. According to self-developed standard for bone healing, clinical outcomes were rated as excellent or good in 55 out of 59 patients (success rate: 93.2%). Therefore, our findings suggest that our bridge combined fixation system may be a promising approach for treatment of long-bone fractures.

Published
2014

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