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Your search keyword '"Yung, W. K."' showing total 193 results
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193 results on '"Yung, W. K."'

1. The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Author

Liu, Ilon, Jiang, Li, Samuelsson, Erik R., Marco Salas, Sergio, Beck, Alexander, Hack, Olivia A., Jeong, Daeun, Shaw, McKenzie L., Englinger, Bernhard, LaBelle, Jenna, Mire, Hafsa M., Madlener, Sibylle, Mayr, Lisa, Quezada, Michael A., Trissal, Maria, Panditharatna, Eshini, Ernst, Kati J., Vogelzang, Jayne, Gatesman, Taylor A., Halbert, Matthew E., Palova, Hana, Pokorna, Petra, Sterba, Jaroslav, Slaby, Ondrej, Geyeregger, Rene, Diaz, Aaron, Findlay, Izac J., Dun, Matthew D., Resnick, Adam, Suvà, Mario L., Jones, David T. W., Agnihotri, Sameer, Svedlund, Jessica, Koschmann, Carl, Haberler, Christine, Czech, Thomas, Slavc, Irene, Cotter, Jennifer A., Ligon, Keith L., Alexandrescu, Sanda, Yung, W. K. Alfred, Arrillaga-Romany, Isabel, Gojo, Johannes, Monje, Michelle, Nilsson, Mats, and Filbin, Mariella G.

Published
2022
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2. Table S1 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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3. Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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4. Supplemental Figures Legends from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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5. Data from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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6. Supplementary Appendix from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary

Published
2024
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7. A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma

Author

van den Bent, Martin, Azaro, Analia, De Vos, Filip, Sepulveda, Juan, Yung, W. K. Alfred, Wen, Patrick Y., Lassman, Andrew B., Joerger, Markus, Tabatabai, Ghazaleh, Rodon, Jordi, Tiedt, Ralph, Zhao, Sylvia, Kirsilae, Tiina, Cheng, Yi, Vicente, Sergio, Balbin, O. Alejandro, Zhang, Hefei, and Wick, Wolfgang

Published
2020
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10. CTNI-78. EVALUATION OF POST-PROGRESSION TREATMENTS AFTER VAL-083 IN RECURRENT AND NEWLY DIAGNOSED GBM MGMT-UNMETHYLATED PATIENTS

Author

Kamiya-Matsuoka, Carlos, primary, Weathers, Shiao-Pei, additional, Yung, W K Alfred, additional, Loghin, Monica, additional, Majd, Nazanin, additional, Brown, Dennis, additional, Langlands, John, additional, Schwartz, Richard, additional, Knight, Stephanie, additional, Puduvalli, Vinay, additional, de Groot, John, additional, and O'Brien, Barbara, additional

Published
2023
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11. CTIM-20. SYSTEMIC IMMUNE CORRELATES ASSOCIATED WITH LONG-TERM SURVIVAL AFTER THERAPEUTIC ADENOVIRUS (DNX2401) PLUS INTERFERON GAMMA FOR RECURRENT GLIOBLASTOMA EFFECT TRIAL (TARGET): A RANDOMIZED PHASE 1 TRIAL

Author

Ene, Chibawanye, primary, Singh, Sanjay, additional, Phillips, Lynette, additional, Venkataraman, Raja, additional, Puduvalli, Vinay, additional, Singh, Deep, additional, Tram, Nam, additional, Long, James, additional, Brady, Martin, additional, Raghavan, Raghu, additional, Tufaro, Frank, additional, Ewald, Brett, additional, Anand, P J, additional, Bradley Elder, J, additional, Fink, Karen, additional, Alfred Yung, W K, additional, Penas-Prado, Marta, additional, Navin, Nick, additional, Larman, Benjamin, additional, Gomez-Manzano, Candelaria, additional, Fueyo-Margareto, Juan, additional, Peterkin, Joanna, additional, and Lang, Frederick, additional

Published
2023
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12. CTNI-42. PHASE I CLINICAL TRIAL OF PEPOSERTIB PLUS RADIATION IN NEWLY DIAGNOSED MGMT-UNMETHYLATED GLIOBLASTOMA

Author

Majd, Nazanin, primary, Yeboa, D Nana, additional, Weathers, Shiao-Pei, additional, Yuan, Ying, additional, Robichaux, Christine, additional, Anssari, Haider Al, additional, Gachimova, Evguenia, additional, Loghin, Monica, additional, Kamiya-Matsuoka, Carlos, additional, O'Brien, Barbara, additional, Aaroe, Ashley, additional, Patel, Chirag, additional, Yung, W K Alfred, additional, Wintermark, Max, additional, Gule, Maria, additional, Ferguson, Sherise, additional, Puduvalli, Vinay, additional, and de Groot, John, additional

Published
2023
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13. CTIM-23. SAFETY RUN-IN RESULTS OF A PHASE I/II STUDY TO EVALUATE ATEZOLIZUMAB IN COMBINATION WITH CABOZANTINIB IN PATIENTS WITH RECURRENT GLIOBLASTOMA

Author

Weathers, Shiao-Pei, primary, Kamiya-Matsuoka, Carlos, additional, Majd, Nazanin, additional, Ashu, Alda, additional, Thompson, Chantell, additional, Gachimova, Evguenia, additional, Aaroe, Ashley, additional, Patel, Chirag, additional, Loghin, Monica, additional, O'Brien, Barbara, additional, Alfred Yung, W K, additional, Puduvalli, Vinay, additional, and de Groot, John, additional

Published
2023
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14. CTNI-85. GBM AGILE PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GBM: RESULTS OF FIRST EXPERIMENTAL ARM, REGORAFENIB

Author

Wen, Patrick, primary, Alexander, Brian, additional, Berry, Donald, additional, Buxton, Meredith, additional, Cavenee, Webster, additional, Colman, Howard, additional, de Groot, John, additional, Ellingson, Benjamin, additional, Gordon, Gary, additional, Hyddmark, Emma, additional, Khasraw, Mustafa, additional, Lim, Michael, additional, Mellinghoff, Ingo, additional, Mikkelsen, Tom, additional, Perry, James, additional, Powell, Ashley, additional, Sulman, Erik, additional, Tanner, Kirk, additional, Weller, Michael, additional, Yung, W K Alfred, additional, Blondin, Nicolas, additional, Brenner, Andrew, additional, Butt, Omar, additional, de la Fuente, Macarena, additional, Drappatz, Jan, additional, Iwamoto, Fabio, additional, Kim, Lyndon, additional, Lee, Eudocia, additional, Mantica, Megan, additional, Nabors, Burt, additional, Newton, Herbert, additional, Schiff, David, additional, Walbert, Tobias, additional, Weathers, Shiao-Pei, additional, Cloughesy, Timothy, additional, and Lassman, Andrew, additional

Published
2023
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15. EPCO-37. DISSECTING GBM EVOLUTION FOLLOWING STANDARD-OF-CARE BY LARGE-SCALE LONGITUDINAL SINGLE NUCLEUS RNA-SEQUENCING

Author

Nomura, Masashi, primary, Spitzer, Avishay, additional, Johnson, Kevin, additional, Garofano, Luciano, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Alfred Yung, W K, additional, Lasorella, Anna, additional, Iavarone, Antonio, additional, Verhaak, Roel, additional, Suva, Mario, additional, and Tirosh, Itay, additional

Published
2023
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16. EPCO-09. CHARACTERIZING THE GBM CELLULAR LANDSCAPE BY LARGE-SCALE SINGLE-NUCLEUS RNA-SEQUENCING

Author

Spitzer, Avishay, primary, Nomura, Masashi, additional, Garofano, Luciano, additional, Johnson, Kevin, additional, Nehar-Belaid, Djamel, additional, Oh, Young Taek, additional, Anderson, Kevin J, additional, Najac, Ryan D, additional, Bussema, Lillian, additional, Varn, Frederick, additional, D’Angelo, Fulvio, additional, Chowdhury, Tamrin, additional, Migliozzi, Simona, additional, Park, Jong Bae, additional, Ermini, Luca, additional, Golebiewska, Anna, additional, Niclou, Simone, additional, Das, Sunit, additional, Paek, Sun Ha, additional, Moon, Hyo-Eun, additional, Mathon, Bertrand, additional, Stefano, Anna-Luisa Di, additional, Bielle, Franck, additional, Laurenge, Alice, additional, Sanson, Marc, additional, Tanaka, Shota, additional, Saito, Nobuhito, additional, Keir, Steve, additional, Ashley, David, additional, Huse, Jason, additional, Yung, W K Alfred, additional, Lasorella, Anna, additional, Verhaak, Roel, additional, Iavarone, Antonio, additional, Tirosh, Itay, additional, and Suva, Mario, additional

Published
2023
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17. Longitudinal molecular trajectories of diffuse glioma in adults

Author

Barthel, Floris P., Johnson, Kevin C., Varn, Frederick S., Moskalik, Anzhela D., Tanner, Georgette, Kocakavuk, Emre, Anderson, Kevin J., Abiola, Olajide, Aldape, Kenneth, Alfaro, Kristin D., Alpar, Donat, Amin, Samirkumar B., Ashley, David M., Bandopadhayay, Pratiti, Barnholtz-Sloan, Jill S., Beroukhim, Rameen, Bock, Christoph, Brastianos, Priscilla K., Brat, Daniel J., Brodbelt, Andrew R., Bruns, Alexander F., Bulsara, Ketan R., Chakrabarty, Aruna, Chakravarti, Arnab, Chuang, Jeffrey H., Claus, Elizabeth B., Cochran, Elizabeth J., Connelly, Jennifer, Costello, Joseph F., Finocchiaro, Gaetano, Fletcher, Michael N., French, Pim J., Gan, Hui K., Gilbert, Mark R., Gould, Peter V., Grimmer, Matthew R., Iavarone, Antonio, Ismail, Azzam, Jenkinson, Michael D., Khasraw, Mustafa, Kim, Hoon, Kouwenhoven, Mathilde C. M., LaViolette, Peter S., Li, Meihong, Lichter, Peter, Ligon, Keith L., Lowman, Allison K., Malta, Tathiane M., Mazor, Tali, McDonald, Kerrie L., Molinaro, Annette M., Nam, Do-Hyun, Nayyar, Naema, Ng, Ho Keung, Ngan, Chew Yee, Niclou, Simone P., Niers, Johanna M., Noushmehr, Houtan, Noorbakhsh, Javad, Ormond, D. Ryan, Park, Chul-Kee, Poisson, Laila M., Rabadan, Raul, Radlwimmer, Bernhard, Rao, Ganesh, Reifenberger, Guido, Sa, Jason K., Schuster, Michael, Shaw, Brian L., Short, Susan C., Smitt, Peter A. Sillevis, Sloan, Andrew E., Smits, Marion, Suzuki, Hiromichi, Tabatabai, Ghazaleh, Van Meir, Erwin G., Watts, Colin, Weller, Michael, Wesseling, Pieter, Westerman, Bart A., Widhalm, Georg, Woehrer, Adelheid, Yung, W. K. Alfred, Zadeh, Gelareh, Huse, Jason T., De Groot, John F., Stead, Lucy F., and Verhaak, Roel G. W.

Published
2019
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18. NRG oncology RTOG 9006: a phase III randomized trial of hyperfractionated radiotherapy (RT) and BCNU versus standard RT and BCNU for malignant glioma patients

Author

Ali, Arif N., Zhang, Peixin, Yung, W. K. Alfred, Chen, Yuhchyau, Movsas, Benjamin, Urtasun, Raul C., Jones, Christopher U., Choi, Kwang N., Michalski, Jeff M., Fischbach, A. Jennifer, Markoe, Arnold M., Schultz, Christopher J., Penas-Prado, Marta, Garg, Madhur K., Hartford, Alan C., Kim, Harold E., Won, Minhee, and Curran, Jr, Walter J.

Published
2018
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19. Data from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Vivanco, Igor, primary, Robins, H. Ian, primary, Rohle, Daniel, primary, Campos, Carl, primary, Grommes, Christian, primary, Nghiemphu, Phioanh Leia, primary, Kubek, Sara, primary, Oldrini, Barbara, primary, Chheda, Milan G., primary, Yannuzzi, Nicolas, primary, Tao, Hui, primary, Zhu, Shaojun, primary, Iwanami, Akio, primary, Kuga, Daisuke, primary, Dang, Julie, primary, Pedraza, Alicia, primary, Brennan, Cameron W., primary, Heguy, Adriana, primary, Liau, Linda M., primary, Lieberman, Frank, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Reardon, David A., primary, Drappatz, Jan, primary, Wen, Patrick Y., primary, Lamborn, Kathleen R., primary, Chang, Susan M., primary, Prados, Michael D., primary, Fine, Howard A., primary, Horvath, Steve, primary, Wu, Nian, primary, Lassman, Andrew B., primary, DeAngelis, Lisa M., primary, Yong, William H., primary, Kuhn, John G., primary, Mischel, Paul S., primary, Mehta, Minesh P., primary, Cloughesy, Timothy F., primary, and Mellinghoff, Ingo K., primary

Published
2023
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20. Interview with Dr. Mellinghoff from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Vivanco, Igor, primary, Robins, H. Ian, primary, Rohle, Daniel, primary, Campos, Carl, primary, Grommes, Christian, primary, Nghiemphu, Phioanh Leia, primary, Kubek, Sara, primary, Oldrini, Barbara, primary, Chheda, Milan G., primary, Yannuzzi, Nicolas, primary, Tao, Hui, primary, Zhu, Shaojun, primary, Iwanami, Akio, primary, Kuga, Daisuke, primary, Dang, Julie, primary, Pedraza, Alicia, primary, Brennan, Cameron W., primary, Heguy, Adriana, primary, Liau, Linda M., primary, Lieberman, Frank, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Reardon, David A., primary, Drappatz, Jan, primary, Wen, Patrick Y., primary, Lamborn, Kathleen R., primary, Chang, Susan M., primary, Prados, Michael D., primary, Fine, Howard A., primary, Horvath, Steve, primary, Wu, Nian, primary, Lassman, Andrew B., primary, DeAngelis, Lisa M., primary, Yong, William H., primary, Kuhn, John G., primary, Mischel, Paul S., primary, Mehta, Minesh P., primary, Cloughesy, Timothy F., primary, and Mellinghoff, Ingo K., primary

Published
2023
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21. Supplementary Tables 1-8 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Vivanco, Igor, primary, Robins, H. Ian, primary, Rohle, Daniel, primary, Campos, Carl, primary, Grommes, Christian, primary, Nghiemphu, Phioanh Leia, primary, Kubek, Sara, primary, Oldrini, Barbara, primary, Chheda, Milan G., primary, Yannuzzi, Nicolas, primary, Tao, Hui, primary, Zhu, Shaojun, primary, Iwanami, Akio, primary, Kuga, Daisuke, primary, Dang, Julie, primary, Pedraza, Alicia, primary, Brennan, Cameron W., primary, Heguy, Adriana, primary, Liau, Linda M., primary, Lieberman, Frank, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Reardon, David A., primary, Drappatz, Jan, primary, Wen, Patrick Y., primary, Lamborn, Kathleen R., primary, Chang, Susan M., primary, Prados, Michael D., primary, Fine, Howard A., primary, Horvath, Steve, primary, Wu, Nian, primary, Lassman, Andrew B., primary, DeAngelis, Lisa M., primary, Yong, William H., primary, Kuhn, John G., primary, Mischel, Paul S., primary, Mehta, Minesh P., primary, Cloughesy, Timothy F., primary, and Mellinghoff, Ingo K., primary

Published
2023
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22. Supplementary Figure and Table Legends, Methods from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Vivanco, Igor, primary, Robins, H. Ian, primary, Rohle, Daniel, primary, Campos, Carl, primary, Grommes, Christian, primary, Nghiemphu, Phioanh Leia, primary, Kubek, Sara, primary, Oldrini, Barbara, primary, Chheda, Milan G., primary, Yannuzzi, Nicolas, primary, Tao, Hui, primary, Zhu, Shaojun, primary, Iwanami, Akio, primary, Kuga, Daisuke, primary, Dang, Julie, primary, Pedraza, Alicia, primary, Brennan, Cameron W., primary, Heguy, Adriana, primary, Liau, Linda M., primary, Lieberman, Frank, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Reardon, David A., primary, Drappatz, Jan, primary, Wen, Patrick Y., primary, Lamborn, Kathleen R., primary, Chang, Susan M., primary, Prados, Michael D., primary, Fine, Howard A., primary, Horvath, Steve, primary, Wu, Nian, primary, Lassman, Andrew B., primary, DeAngelis, Lisa M., primary, Yong, William H., primary, Kuhn, John G., primary, Mischel, Paul S., primary, Mehta, Minesh P., primary, Cloughesy, Timothy F., primary, and Mellinghoff, Ingo K., primary

Published
2023
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23. Supplementary Figures 1-10 from Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Author

Vivanco, Igor, primary, Robins, H. Ian, primary, Rohle, Daniel, primary, Campos, Carl, primary, Grommes, Christian, primary, Nghiemphu, Phioanh Leia, primary, Kubek, Sara, primary, Oldrini, Barbara, primary, Chheda, Milan G., primary, Yannuzzi, Nicolas, primary, Tao, Hui, primary, Zhu, Shaojun, primary, Iwanami, Akio, primary, Kuga, Daisuke, primary, Dang, Julie, primary, Pedraza, Alicia, primary, Brennan, Cameron W., primary, Heguy, Adriana, primary, Liau, Linda M., primary, Lieberman, Frank, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Reardon, David A., primary, Drappatz, Jan, primary, Wen, Patrick Y., primary, Lamborn, Kathleen R., primary, Chang, Susan M., primary, Prados, Michael D., primary, Fine, Howard A., primary, Horvath, Steve, primary, Wu, Nian, primary, Lassman, Andrew B., primary, DeAngelis, Lisa M., primary, Yong, William H., primary, Kuhn, John G., primary, Mischel, Paul S., primary, Mehta, Minesh P., primary, Cloughesy, Timothy F., primary, and Mellinghoff, Ingo K., primary

Published
2023
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24. Supplementary Table 2 from Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

Author

Lee, Eudocia Q., primary, Puduvalli, Vinay K., primary, Reid, Joel M., primary, Kuhn, John G., primary, Lamborn, Kathleen R., primary, Cloughesy, Timothy F., primary, Chang, Susan M., primary, Drappatz, Jan, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Robins, H. Ian, primary, Lieberman, Frank S., primary, Lassman, Andrew B., primary, McGovern, Renee M., primary, Xu, Jihong, primary, Desideri, Serena, primary, Ye, Xiabu, primary, Ames, Matthew M., primary, Espinoza-Delgado, Igor, primary, Prados, Michael D., primary, and Wen, Patrick Y., primary

Published
2023
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25. Supplementary Table 1 from Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

Author

Lee, Eudocia Q., primary, Puduvalli, Vinay K., primary, Reid, Joel M., primary, Kuhn, John G., primary, Lamborn, Kathleen R., primary, Cloughesy, Timothy F., primary, Chang, Susan M., primary, Drappatz, Jan, primary, Yung, W. K. Alfred, primary, Gilbert, Mark R., primary, Robins, H. Ian, primary, Lieberman, Frank S., primary, Lassman, Andrew B., primary, McGovern, Renee M., primary, Xu, Jihong, primary, Desideri, Serena, primary, Ye, Xiabu, primary, Ames, Matthew M., primary, Espinoza-Delgado, Igor, primary, Prados, Michael D., primary, and Wen, Patrick Y., primary

Published
2023
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31. EPCO-21. THE SPATIAL ORGANIZATION OF H3-K27M MUTANT DIFFUSE MIDLINE GLIOMA

Author

Liu, Ilon, primary, Li, Jiang, additional, Samuelsson, Erik, additional, Salas, Sergio Marco, additional, Beck, Alexander, additional, Hack, Olivia, additional, Jeong, Daeun, additional, Shaw, McKenzie, additional, Englinger, Bernhard, additional, Labelle, Jenna, additional, Mire, Hafsa, additional, Madlener, Sibylle, additional, Mayr, Lisa, additional, Quezada, Michael, additional, Trissal, Maria, additional, Panditharatna, Eshini, additional, Ernst, Kati, additional, Gatesman, Taylor, additional, Halbert, Matthew, additional, Palova, Hana, additional, Pokorna, Petra, additional, Sterba, Jaroslav, additional, Slaby, Ondrej, additional, Geyeregger, Rene, additional, Diaz, Aaron, additional, Resnick, Adam C, additional, Suva, Mario, additional, Jones, David, additional, Agnihotri, Sameer, additional, Ostlin, Jessica, additional, Koschmann, Carl, additional, Haberler, Christine, additional, Czech, Thomas, additional, Slavc, Irene, additional, Cotter, Jennifer, additional, Ligon, Keith, additional, Alexandrescu, Sanda, additional, Yung, W K Alfred, additional, Arrillaga-Romany, Isabel, additional, Gojo, Johannes, additional, Monje, Michelle, additional, Nilsson, Mats, additional, and Filbin, Mariella, additional

Published
2022
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32. CTNI-38. UPDATE ON GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA

Author

Buxton, Meredith, primary, Alexander, Brian, additional, Berry, Donald, additional, Cavenee, Webster, additional, Colman, Howard, additional, de Groot, John, additional, Ellingson, Benjamin, additional, Gordon, Gary, additional, Khasraw, Mustafa, additional, Lassman, Andrew, additional, Lee, Eudocia, additional, Li, Wenbin, additional, Lim, Michael, additional, Mellinghoff, Ingo, additional, Mikkelsen, Tom, additional, Nelli, Apoorva, additional, Perry, James, additional, Sulman, Erik, additional, Tanner, Kirk, additional, Weller, Michael, additional, Wen, Patrick Y, additional, Alfred Yung, W K, additional, and Cloughesy, Timothy, additional

Published
2022
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34. A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients

Author

Raizer, J. J., Giglio, P., Hu, J., Groves, M., Merrell, R., Conrad, C., Phuphanich, S., Puduvalli, V. K., Loghin, M., Paleologos, N., Yuan, Y., Liu, D., Rademaker, A., Yung, W. K., Vaillant, B., Rudnick, J., Chamberlain, M., Vick, N., Grimm, S., Tremont-Lukats, I. W., De Groot, J., Aldape, K., Gilbert, M. R., and Brain Tumor Trials Collaborative

Published
2016
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35. P11.65.B GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple treatment regimens in newly diagnosed and recurrent glioblastoma

Author

Weller, M, primary, Ellingson, B, additional, Alexander, B, additional, Wen, P, additional, Sulman, E, additional, Colman, H, additional, Berry, D, additional, Tanner, K, additional, Khasraw, M, additional, Lim, M, additional, Perry, J, additional, Lassman, A, additional, Cloughesy, T, additional, Yung, W K A, additional, Lee, E Q, additional, Mellinghoff, I, additional, Gordon, G, additional, de Groot, J, additional, Mikkelsen, T, additional, Cavenee, W, additional, Nelli, A, additional, Buxton, M, additional, and Li, W, additional

Published
2022
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37. Baseline tumor genomic and gut microbiota association with clinical outcomes in newly diagnosed glioblastoma (GBM) treated with atezolizumab in combination with temozolomide (TMZ) and radiation.

Author

Weathers, Shiao-Pei S., primary, Zhu, Haifeng, additional, Knafl, Mark, additional, Damania, Ashish, additional, Kamiya-Matsuoka, Carlos, additional, Harrison, Rebecca A., additional, Lyons, Larry, additional, Yun, Cindy, additional, Darbonne, Walter C., additional, Loghin, Monica, additional, Penas-Prado, Marta, additional, Majd, Nazanin, additional, Yung, W. K. Alfred, additional, O'Brien, Barbara Jane, additional, Wistuba, Ignacio Ivan, additional, Futreal, Andrew, additional, Wargo, Jennifer Ann, additional, Ajami, Nadim J., additional, Woodman, Scott Eric, additional, and de Groot, John Frederick, additional

Published
2022
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39. Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors

Author

Ellingson, Benjamin M, primary, Gerstner, Elizabeth R, additional, Lassman, Andrew B, additional, Chung, Caroline, additional, Colman, Howard, additional, Cole, Patricia E, additional, Leung, David, additional, Allen, Joshua E, additional, Ahluwalia, Manmeet S, additional, Boxerman, Jerrold, additional, Brown, Matthew, additional, Goldin, Jonathan, additional, Nduom, Edjah, additional, Hassan, Islam, additional, Gilbert, Mark R, additional, Mellinghoff, Ingo K, additional, Weller, Michael, additional, Chang, Susan, additional, Arons, David, additional, Meehan, Clair, additional, Selig, Wendy, additional, Tanner, Kirk, additional, Alfred Yung, W K, additional, van den Bent, Martin, additional, Wen, Patrick Y, additional, and Cloughesy, Timothy F, additional

Published
2022
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41. CTIM-04. BIOMARKER IMMUNE CORRELATES IN NEWLY DIAGNOSED GLIOBLASTOMA (GBM) TREATED WITH ATEZOLIZUMAB IN COMBINATION WITH TEMOZOLOMIDE (TMZ) AND RADIATION

Author

Weathers, Shiao-Pei, primary, Knafl, Mark, additional, Parra, Edwin, additional, Hernandez, Sharia, additional, Solis, Luisa, additional, Espiridion, Beatriz Sanchez, additional, Wistuba, Ignacio, additional, Futreal, Andrew, additional, Maru, Dipen, additional, Kamiya-Matsuoka, Carlos, additional, Harrison, Rebecca, additional, Joseph, Victory, additional, Yun, Cindy, additional, Darbonne, Walter, additional, Loghin, Monica, additional, Penas-Prado, Marta, additional, Majd, Nazanin, additional, Yung, W K Alfred, additional, O'Brien, Barbara, additional, Scott, Woodman, additional, and DeGroot, John, additional

Published
2021
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42. CTNI-26. PHASE 2 STUDY OF DIANHYDROGALACTITOL (VAL-083) IN PATIENTS WITH MGMT-UNMETHYLATED, BEVACIZUMAB-NAÏVE GLIOBLASTOMA IN THE RECURRENT AND ADJUVANT SETTING

Author

O'Brien, Barbara, primary, Penas-Prado, Marta, additional, Kamiya-Matsuoka, Carlos, additional, Weathers, Shiao-Pei, additional, Yung, W K Alfred, additional, Loghin, Monica, additional, Harrison, Rebecca, additional, Majd, Nazanin, additional, Knight, Stephanie, additional, Bacha, Jeffrey, additional, Brown, Dennis, additional, Johnson, Gregory, additional, Langlands, John, additional, Schwartz, Richard, additional, Kanekal, Sarath, additional, Steino, Anne, additional, Lopez, Lorena, additional, and DeGroot, John, additional

Published
2021
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43. EPCO-06. AGE- AND REGION-SPECIFIC MULTI-OMIC CHARACTERIZATION OF H3-K27M MUTANT DIFFUSE MIDLINE GLIOMA

Author

Liu, Ilon, primary, Li, Jiang, additional, Jeong, Daeun, additional, Hack, Olivia A, additional, Shaw, McKenzie, additional, Englinger, Bernhard, additional, Avihai, Byron, additional, Ernst, Kati, additional, Resnick, Adam, additional, Diaz, Aaron, additional, Jones, David, additional, Koschmann, Carl, additional, Kleinman, Claudia, additional, Jabado, Nada, additional, Cotter, Jennifer, additional, Ligon, Keith, additional, Alexandrescu, Sanda, additional, Yung, W K Alfred, additional, Czech, Thomas, additional, Arrillaga-Romany, Isabel, additional, Gojo, Johannes, additional, Slavc, Irene, additional, Monje, Michelle, additional, and Filbin, Mariella G, additional

Published
2021
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46. Report of National Brain Tumor Society roundtable workshop on innovating brain tumor clinical trials: building on lessons learned from COVID-19 experience

Author

Lee, Eudocia Q, primary, Selig, Wendy, additional, Meehan, Clair, additional, Bacha, Jeffrey, additional, Barone, Amy, additional, Bloomquist, Erik, additional, Chang, Susan M, additional, de Groot, John F, additional, Galanis, Evanthia, additional, Hassan, Islam, additional, Kalidas, Chitkala, additional, Khasraw, Mustafa, additional, Kvedar, Joseph C, additional, Lassman, Andrew B, additional, Puduvalli, Vinay, additional, Sahebjam, Solmaz, additional, Schwamm, Lee H, additional, Tamir, Sharon, additional, Welch, Mary, additional, Yung, W K Alfred, additional, Zadeh, Gelareh, additional, Arons, David, additional, and Wen, Patrick Y, additional

Published
2021
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47. Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas

Author

Boxerman, Jerrold L, Quarles, Chad C, Hu, Leland S, Erickson, Bradley J, Gerstner, Elizabeth R, Smits, Marion, Kaufmann, Timothy J, Barboriak, Daniel P, Huang, Raymond H, Wick, Wolfgang, Weller, Michael, Galanis, Evanthia, Kalpathy-Cramer, Jayashree, Shankar, Lalitha, Jacobs, Paula, Chung, Caroline, van den Bent, Martin J, Chang, Susan, Al Yung, W K, Cloughesy, Timothy F, Wen, Patrick Y, Gilbert, Mark R, Rosen, Bruce R, Ellingson, Benjamin M, Schmainda, Kathleen M, Boxerman, Jerrold L, Quarles, Chad C, Hu, Leland S, Erickson, Bradley J, Gerstner, Elizabeth R, Smits, Marion, Kaufmann, Timothy J, Barboriak, Daniel P, Huang, Raymond H, Wick, Wolfgang, Weller, Michael, Galanis, Evanthia, Kalpathy-Cramer, Jayashree, Shankar, Lalitha, Jacobs, Paula, Chung, Caroline, van den Bent, Martin J, Chang, Susan, Al Yung, W K, Cloughesy, Timothy F, Wen, Patrick Y, Gilbert, Mark R, Rosen, Bruce R, Ellingson, Benjamin M, and Schmainda, Kathleen M

Abstract

Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multicenter trials. Recently, the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition issued an updated consensus DSC-MRI protocol compatible with the standardized brain tumor imaging protocol (BTIP) for high-grade gliomas that is increasingly used in the clinical setting and is the default MRI protocol for the National Clinical Trials Network. After reviewing the basis for controversy over DSC-MRI protocols, this paper provides evidence-based best practices for clinical DSC-MRI as determined by the Committee, including pulse sequence (gradient echo vs spin echo), BTIP-compliant contrast agent dosing (preload and bolus), flip angle (FA), echo time (TE), and post-processing leakage correction. In summary, full-dose preload, full-dose bolus dosing using intermediate (60°) FA and field strength-dependent TE (40-50 ms at 1.5 T, 20-35 ms at 3 T) provides overall best accuracy and precision for cerebral blood volume estimates. When single-dose contrast agent usage is desired, no-preload, full-dose bolus dosing using low FA (30°) and field strength-dependent TE provides excellent performance, with reduced contrast agent usage and elimination of potential systematic errors introduced by variations in preload dose and incubation time.

Published
2020

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