1. Feasibility of Endoscopic Screening for Upper Gastrointestinal Malignancy in a Comprehensive Health Checkup
- Author
-
Nobuya Mimori, Sayaka Sato, Yohei Horikawa, Yuta Tahata, Hiroya Mizutamari, Saki Fushimi, and Yuhei Kato
- Subjects
medicine.medical_specialty ,030204 cardiovascular system & hematology ,Malignancy ,Gastroenterology ,Endoscopy, Gastrointestinal ,Upper Gastrointestinal Tract ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Stomach Neoplasms ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Upper gastrointestinal ,endoscopy ,Stromal tumor ,Adverse effect ,Gastrointestinal Neoplasms ,Retrospective Studies ,Gastrointestinal endoscopy ,screening and diagnosis ,medicine.diagnostic_test ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Endoscopy ,Feasibility Studies ,Original Article ,030211 gastroenterology & hepatology ,Endoscopic screening ,upper gastrointestinal malignancies ,business - Abstract
Objective In an effort to reduce mortality from gastric cancer, endoscopic screening was introduced in 2016 as a nationwide screening program in Japan. Recent developments in high-definition endoscopic imaging and diagnostic strategies have enabled the simultaneous detection of other upper gastrointestinal (U-GI) malignancies. Therefore, we conducted a study to evaluate the feasibility of endoscopic screening for U-GI malignancy in a comprehensive health checkup. Methods We retrospectively reviewed the data of 13,120 participants who had received a comprehensive health checkup in a single institution between April 2012 and March 2018. Participants were divided into two groups [gastrointestinal endoscopy (GIE) group (n=9,142) and gastrointestinal X-ray (X-ray) group (n=3,978)] and compared with regards to the screening results, adverse events, and detection rate of U-GI malignancies (gastric cancer or other) using a propensity-score matched analysis. Results The gastric cancer detection rate was significantly higher in the GIE group [34/9,142 (0.48%)] than in the X-ray group [3/3,978 (0.08%)] (p=0.003). Other U-GI malignancies were found only in the GIE group and comprised two hypopharyngeal cancers, five esophageal cancers, two duodenal cancers, and one duodenal gastrointestinal stromal tumor. Adverse events occurred in 6/9,142 (0.07%) participants in the GIE group and 18/3,978 (0.45%) participants in the X-ray group (p
- Published
- 2021