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453 results on '"Young, Robert H."'

4. Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries

Author

Nelson, Alexander T., Harris, Anne K., Watson, Dave, Kamihara, Junne, Chen, Kenneth S., Stall, Jennifer N., Devins, Kyle M., Young, Robert H., Olson, Damon R., Mallinger, Paige H.R., Mitchell, Sarah G., Hoffman, Lindsey M., Halliday, Gail, Suleymanova, Amina M., Glade Bender, Julia L., Messinger, Yoav H., Herzog, Cynthia E., Field, Amanda L., Frazier, A. Lindsay, Stewart, Douglas R., Dehner, Louis P., Hill, D. Ashley, Billmire, Deborah F., Schneider, Dominik T., and Schultz, Kris Ann P.

Published
2024
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8. Cystic Granulosa Cell Tumors of the Ovary: An Analysis of 80 Cases of an Often Diagnostically Challenging Entity

Author

Boyraz, Baris, Watkins, Jaclyn C., Soubeyran, Isabelle, Bonhomme, Benjamin, Croce, Sabrina, Oliva, Esther, and Young, Robert H.

Subjects
Women -- Health aspects, Endocrine manifestations of general diseases -- Diagnosis -- Care and treatment, Diagnosis, Differential -- Methods, Ovarian tumors -- Diagnosis -- Care and treatment, Health
Abstract

* Context.--Granulosa cell tumors (GCTs) of both adult (AGCT) and juvenile (JGCT) types can rarely be completely or dominantly cystic, creating diagnostic difficulty because the cyst lining epithelium is often denuded. Objective.--To describe clinical, gross, microscopic, immunohistochemical, and molecular features of cystic GCTs with an emphasis on their differential diagnosis. Design.--We report 80 cystic GCTs (24 AGCTs and 56 JGCTs) in patients from ages 3 to 83 years (average ages, 35 years for AGCT and 22 years for jGcT). Results.--Nineteen of 43 patients with known clinical information (3 AGCT and 16 JGCT) had androgenic manifestations. All tumors were greater than 8 cm (average, 17 cm) with minimal to absent gross solid component. Denudation of cells lining the cysts was prominent. Invagination of the epithelium into the cyst walls was a key diagnostic feature, was present as cords, trabeculae, solid nests, and small and large follicles, and was identified in most tumors (17 AGCTs and 45 JGCTs). Cytologic atypia was essentially absent in AGCTs, whereas 14 JGCTs showed moderate to severe atypia of bizarre type. A theca cell component was present in all tumors and was extensive in 54. A FOXL2 hotspot mutation was identified in 1 of 4 AGCTs tested. Conclusions.--Despite extensive denudation, the finding of typical architectural patterns and cytologic features as well as, in some cases, androgenic manifestations helps differentiate cystic GCTs from follicle cysts, the most common and challenging differential diagnosis, as well as other cystic neoplasms that may enter the differential diagnosis. FOXL2 sequencing may show a false-negative result in cystic AGCT because of the limited number of cells present within the tumor sample., It has been known for many years that granulosa cell tumors (GCTs) of both juvenile (JGCT) and adult (AGCT) types may sometimes be completely or predominantly cystic. Interest in this [...]

Published
2022
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16. Genomic profile analysis of leiomyomas with bizarre nuclei and fumarate hydratase deficient leiomyomas: Strengths, weaknesses, and limitations of array‐CGH interpretation

Author

Fontanges, Quitterie, primary, Dubos, Paul, additional, Lesluyes, Tom, additional, Laizet, Yec'han, additional, Velasco, Valérie, additional, Meléndez, Bárbara, additional, D'Haene, Nicky, additional, Oliva, Esther, additional, Young, Robert H., additional, Mayeur, Laetitia, additional, Rebier, Flora, additional, Alamé, Mélissa, additional, Larmonier, Claire, additional, Devouassoux‐Shisheboran, Mojgan, additional, Arnould, Laurent, additional, Soubeyran, Isabelle, additional, Chakiba, Camille, additional, Floquet, Anne, additional, Babin, Guillaume, additional, Guyon, Frédéric, additional, Mery, Eliane, additional, Le Guellec, Sophie, additional, Noël, Jean‐Christophe, additional, Croce, Sabrina, additional, and Chibon, Frédéric, additional

Published
2024
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20. High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities

Author

Zou, Youran, Turashvili, Gulisa, Soslow, Robert A., Park, Kay J., Croce, Sabrina, McCluggage, W. Glenn, Stewart, Colin J.R., Oda, Yoshinao, Oliva, Esther, Young, Robert H., Da Cruz Paula, Arnaud, Dessources, Kimberly, Ashley, Charles W., Hensley, Martee L., Yip, Stephen, Weigelt, Britta, Benayed, Ryma, Antonescu, Cristina R., Lee, Cheng-Han, and Chiang, Sarah

Published
2020
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23. Martin C. Mihm Jr: Remembrances of a great physician, charismatic person, and good friend.

Author

Young, Robert H.

Subjects
*TELEPHONE numbers, *ANATOMICAL pathology, *FOOTBALL, *RESTAURANTS, *PROFESSIONAL sports
Abstract

This document is a remembrance of Dr. Martin C. Mihm Jr., a physician and friend, written by Robert H. Young. Young describes Dr. Mihm as a remarkable individual with vast knowledge in skin pathology and clinical medicine. He shares personal anecdotes about their interactions and highlights Dr. Mihm's love for good food, opera, and generosity. The author emphasizes Dr. Mihm's contributions to the field of medicine and his impact on those who knew him. [Extracted from the article]

Published
2024
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28. Contributors

Author

Al-Ahmadie, Hikmat A., primary, Amin, Mahul B., additional, Amin, Shahrier, additional, Ayala, Alberto G., additional, Bonsib, Stephen M., additional, Bostwick, David G., additional, Cheng, Liang, additional, Divatia, Mukul, additional, Compérat, Eva, additional, Emerson, Robert E., additional, González-Peramato, Pilar, additional, Kim, Kyu-Rae, additional, Lack, Ernest E., additional, Lopez-Beltran, Antonio, additional, Ma, Jun, additional, MacLennan, Gregory T., additional, Montironi, Rodolfo, additional, Nistal, Manuel, additional, Paal, Edina, additional, Paniagua, Ricardo, additional, Renshaw, Andrew A., additional, Reuter, Victor E., additional, Ro, Jae Y., additional, Ulbright, Thomas M., additional, and Young, Robert H., additional

Published
2020
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32. ZC3H7B-BCOR high-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity

Author

Lewis, Natasha, Soslow, Robert A, Delair, Deborah F, Park, Kay J, Murali, Rajmohan, Hollmann, Travis J, Davidson, Ben, Micci, Francesca, Panagopoulos, Ioannis, Hoang, Lien N, Arias-Stella, Javier A, III, Oliva, Esther, Young, Robert H, Hensley, Martee L, Leitao, Mario M, Jr, Hameed, Meera, Benayed, Ryma, Ladanyi, Marc, Frosina, Denise, Jungbluth, Achim A, Antonescu, Cristina R, and Chiang, Sarah

Published
2018
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36. Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD

Author

Young, Robert H.

Subjects
Ovarian tumors -- Identification and classification -- Diagnosis -- Development and progression, Health
Abstract

* Context.--This year being the 60th anniversary of the publication of the excellent book Endocrine Pathology of the Ovary by John McLean Morris, MD, and Robert E. Scully, Md, the writer reflects on that work and in particular the remarkable contributions of its second author to our knowledge in this area.Objective.--To review ovarian sex cord-stromal tumors.Data Sources.--Literature and personal experience.Conclusions.--The essay begins with remarks on the oftentimes straightforward stromal tumors of the ovary because the commonest of them, the fibroma, dominates from the viewpoint of case numbers. Then, the sclerosing stromal tumor and the peculiar so-called luteinized thecomas of the type associated with sclerosing peritonitis are discussed in greater detail and their wide spectrum is illustrated. Brief mention is made of 2 rare neoplasms: the ovarian myxoma and signet-ring stromal tumor. Discussion then turns to the more recently recognized intriguing tumor tentatively designated microcystic stromal tumor and the commonest malignant tumor in this entire family, the so-called adult granulosa cell tumor, which despite its name may occasionally be seen in young individuals. The second variant of granulosa cell tumor--that which usually, but not always, occurs in the young--the so-called juvenile granulosa cell tumor, is then discussed. In the section of Sertoli-Leydig cell tumors, particular attention is focused on unusual tumors with heterologous elements and the remarkable so-called retiform tumors, which have a predilection for the young, often have distinctive gross features, and exhibit slitlike spaces and papillae. The essay concludes with consideration of the sex cord tumor with annular tubules.(Arch Pathol Lab Med. 2018;142:1459-1484; doi: 10.5858/arpa.2018-0291-RA), I am delighted to contribute an essay to this symposium based on a meeting that was a most pleasant experience, and furthermore it is always enjoyable to write on a [...]

Published
2018
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37. DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry

Author

Schultz, Kris Ann P., Harris, Anne K., Finch, Michael, Dehner, Louis P., Brown, Jubilee B., Gershenson, David M., Young, Robert H., Field, Amanda, Yu, Weiying, Turner, Joyce, Cost, Nicholas G., Schneider, Dominik T., Stewart, Douglas R., Frazier, A. Lindsay, Messinger, Yoav, and Hill, D. Ashley

Published
2017
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