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The present study is focused on investigating the mechanical properties of hybrid polymer composites. The reinforcement materials are animal bone (ox) particulate and E-glass fiber. The matrix material is epoxy resin. The following combinations are considered for investigation: (a) bone particulate weight percent (20%, 30%, and 40%), (b) E-glass fiber weight percent (20%, 30%, and 40%), and (c) bone particulate (10%, 20%, and 30%) and E-glass fiber (30%, 20%, and 10%) with epoxy resin 60% by weight percent. The test specimens are prepared as per the required ASTM standard for tensile, compressive, and flexural tests. The test results show that maximum tensile and compressive strength observed in 40% of E-glass fiber with 60% of epoxy matrix, correspondingly, is 254.964 MPa and 37.52 MPa. The maximum flexural strength observed in E-glass fiber reinforced composites is 250.43 MPa.