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Ganglion cysts are the most common soft-tissue tumors observed in the finger. Some tumors could be easily confused clinically with ganglion cysts due to their localization, mobility, shape, and being soft in nature. In this article, two cases of schwannoma and superficial acral myxoma that were clinically and radiologically confused with ganglion cysts are presented. Suspecting this tumor type in the preoperative diagnosis is essential to avoid unnecessary surgical approaches. Masses in close proximity to the nerve or nerve sheath are very important as they require preservation of the nerve during surgery. For these masses, surgeons should be prepared as these cases can have many intraoperative surprises in store.

Abstract Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal efficacy. Here we thus explore mechanisms underlying sensitivity and resistance to PARPi using two intrinsically PARPi sensitive (T22) and resistant (T127) syngeneic murine breast cancer models in female mice. We demonstrate that tumor associated macrophages (TAM) potentially contribute to the differential sensitivity to PARPi. By single-cell RNA-sequencing, we identify a TAM_C3 cluster, expressing genes implicated in anti-inflammatory activity, that is enriched in PARPi resistant T127 tumors and markedly decreased by PARPi in T22 tumors. Rps19/C5aR1 signaling is selectively elevated in TAM_C3. C5aR1 inhibition or transferring C5aR1hi cells increases and decreases PARPi sensitivity, respectively. High C5aR1 levels in human breast cancers are associated with poor responses to immune checkpoint blockade. Thus, targeting C5aR1 may selectively deplete pro-tumoral macrophages and engender sensitivity to PARPi and potentially other therapies.

The aim of this study is to examine friendship perceptions of Syrian and Turkish children attending the Project of Support to Sport Education Project that aims to gather Syrian and Turkish children through sport and to encourage communication and understanding the tolerate the differences they may have. The research group consists 108 children aged between 5 and 17. The data were obtained through metaphor and pictures. The data were analyzed by content analysis and chi-square test. As a result it was seen that Turkish children had more negative attitudes than Syrian children did [x[superscript 2] (sd = 1, n = 96) = 4.27, p <0.05]. In addition, it was seen that the theme "spending time" included description of what children were doing with their Turkish/Syrian friends. The theme "description of feelings" included children's feelings about their Turkish/Syrian friends. No significant difference was found between the themes [x[superscript 2] (sd = 1, n = 88) = 2.09, p> 0.05].

ÖZ: Araştırmada meslek yüksekokulu öğrencilerinin kişilik tipleri ile bireysel girişimcilik yönelimi ilişkisi üzerinde girişimcilik eğitiminin etkisi saptanmaya çalışılmıştır. Araştırmanın özgünlüğü, analizlerin girişimcilik eğitim öncesi ve sonrası şeklinde gerçekleştirilmiş ve meslek yüksekokulu öğrencilerine uygulanmış olmasıdır. Bu araştırma sayesinde girişimcilik eğitiminin etkisi hakkında bilginin elde edilmesi ile alana katkı sağlanacağı düşünülmektedir. Araştırmada girişimcilik dersi alan 194 öğrenciden hem yarıyıl başında hem de yarıyıl sonunda olmak üzere “tek grup ilk test ve son test tekniği” ile veri toplanmıştır. Kişilik tiplerini ölçmek için Rammstedt ve John (2007) tarafından geliştirilen beş faktör kişilik tipleri ölçeği ve bireysel girişimcilik yönelimini ölçmek için ise Bolton ve Lane (2012) tarafından geliştirilen ölçek kullanılmıştır. Araştırmada frekans, korelasyon ve regresyon analiz yöntemlerinden yararlanılmıştır. Analizler sonucunda beş faktör kişilik tipleri ile bireysel girişimcilik yönelimi arasında -bazı alt boyutlar hariç olmak üzere- anlamlı bir ilişki olduğu görülmüştür. Ek olarak ön test ve son test sonuçları karşılaştırıldığında girişimcilik eğitiminin kişilik tipleri ile bireysel girişimcilik yönelimi ilişkisini -bazı alt boyutlar hariç olmak üzere- etkilemediği görülmüştür. Araştırma sonucunda meslek yüksekokullarında okutulan girişimcilik ders içeriklerinin, öğrencilerin girişimcilik yeteneklerini geliştirmeye ve yönelimlerini arttırmaya yönelik hazırlanmasına ve uygulamalı metotlara daha fazla ağırlık verilmesine gereklilik olduğu sonucuna ulaşılmıştır. ABSTRACT: In the research, it was tried to determine the effect of entrepreneurship education on the relationship between personality types and individual entrepreneurial orientation of vocational school students. The originality of the research is that the analyzes were carried out before and after entrepreneurship education and applied to vocational school students. It is thought that this research will contribute to the field by obtaining information about the effect of entrepreneurship education. In the research, data were collected from 194 students who took entrepreneurship courses, both at the beginning of the semester and at the end of the semester, using the “single group pre-test and post-test technique”. The five-factor personality types scale developed by Rammstedt and John (2007) was used to measure personality types, and the scale developed by Bolton and Lane (2012) was used to measure individual entrepreneurial orientation. Frequency, correlation and regression analysis methods were used in the research. As a result of the analyses, it was seen that there was a significant relationship between five factor personality types and individual entrepreneurial orientation, except for some sub-dimensions. In addition, when the pre-test and post-test results were compared, it was seen that entrepreneurship training did not affect the relationship between personality types and individual entrepreneurial orientation, except for some sub-dimensions. As a result of the research, it was concluded that entrepreneurship course contents should be prepared to develop students’ entrepreneurial skills and increase their orientation, and that more emphasis should be given to applied methods.

Objective: De Quervain's disease is a stenosing tenosynovitis of the first dorsal compartment. Treatment options include conservative measures, injections, and surgery. The main purpose of this study is to eliminate uncertainty in the choice of treatment and to recommend the appropriate treatment to the patient based on Michigan hand questionnaire. Material and Methods: The age, sex, and treatment modality of the patients were recorded retrospectively. Patients' Michigan outcomes were assessed, and patients were divided into three groups: Patients who benefited from conservative treatments (Group 1), from injections (Group 2), and from surgery (Group 3). Statistical analysis of the data was performed. Results: The mean age of the 56 patients (54 women, 2 men) was 35.1±11.4 years. There was a difference between all groups in total hand function and pain scores (p < 0.05). Patients in group 1 were significantly different from the other groups (p < 0.05), and there was no significant difference between group 2 and group 3 (p > 0.05). Conclusion: Various methods have been described for De Quervain's tenosynovitis’s treatment. Choosing the right therapeutic steps for the right patients is important. It is possible to select treatment options by assessing overall hand function and activities of daily living with the Michigan Hand Outcome Questionnaire

In this paper, comparison of somatotype characteristics and anthropometric proportional relations of elite wrestlers at the level of styles and weights and, contribution to improvement and orientation of sport is aimed. 57 elite wrestlers took place in the European Championship Preparatory Camp of Turkish National Adults Wrestling Team (31 greco-roman style with 7 light weight, 14 medium weight and 10 heavy weight--with av. height: 168.9 cm. and av. weight: 81.1 kg.; 26 free style with 8 light weight, 12 are medium weight and 6 heavy weight--with av. height: 173.0 cm. and av. weight: 87.9 kg), analyzed in this study. As a result of anthropometric measurements, there are no meaningful differences between free style and greco-roman elite wrestlers both in style and weigh. Wrestlers, as evaluated in somatotype, free and greco-roman styles are characterized as endomorphic mesomorphy, lightweight wrestlers are measured as balanced mesomorphy, medium-weight wrestlers are found endomorphic mesomorphy and heavy-weight wrestlers are characterized as endomorphic mesomorphy. Meaningful difference have found between weights. In spite of there is no differentiate effect of styles for wrestlers, partake in the similar training, nutrition and competition programs from childhood, weight, leaning on differentiates of somatotypes in the frame of the components like height, weight, length of bust and arm etc., emanates differences.

Introduction: This study aimed to evaluate the effects of adherence to the Mediterranean Diet (MD) on eating attitudes and emotional appetite in young females aged 18-24. Methodology: A cross-sectional study (n=306) was conducted on young females. A questionnaire including demographic characteristics, Eating Attitudes Test-26 (EAT-26), Emotional Eating Questionnaire (EMAQ), and International Physical Activity Questionnaire (IPAQ) was applied. Daily food consumption was obtained from the 24-hour- food records and used to calculate the Mediterranean Diet Quality Index (MAI). The researchers measured the body weight (kg) and height (cm). Results: Half of the participants (50.7%) have low adherence to the MD, moderate in 25.2%, and high in 24.2%. There is no statistical difference in MAI scores between EAT-26 groups (p>0.05). The dieting status was higher (28.2%) in the disordered eating tendencies group compared to the group without disordered eating tendencies (11.1%) (χ2 =12.490, p

Aim of this study is to investigate effects of stem cells derived from the peripheral nerve and adipose tissues following the nerve crush injury in control and obese rats. For this aim, 41 Wistar Albino female rats were separated into eight equal groups; non-obese control (NOC) obese control (OC), non-obese injury (NOH), obese injury (OH), non-obese adipose (NOY), obese adipose (OY), non-obese nerve (NOPS), obese nerve (OPS). At the end of 8 weeks, all experimental animals without control groups were subjected to nerve crush procedure and sciatic nerve or fat stem cell homogenates were injected on the treatment group rats, and then, recovery process has been observed and histopathological, stereological, electrophysiological analyses and bioinformatic evaluation were made on removed sciatic nerves. Stereological results showed that adipose homogenate gave more successful results than peripheral nerve homogenates in the NOY group in comparison to the NOPS group in terms of myelinated axon number. Peripheral nerve homogenate has shown more successful results in the OPS group in comparison to the OY group. The number of unmyelinated axons was increased following treatment with adipose tissue homogenate in NOY and OY groups. In terms of myelin sheath thickness; we detected that treatments by peripheral nerve and especially adipose tissue homogenates lead to increase in the thickness of the axons of the peripheral nerves belong to the control and obese injury groups. All results showed that mesenchymal stem cell treatment by fresh tissue homogenates is successful in peripheral nerve regeneration and fat tissue is a considerable source of the stem cells for clinical applications.

Aim: Adding platelet-rich plasm (PRP) or mesenchymal stem cells are the most accepted methods to increase fat graft’s permanence. However, there is no consensus on timing and whether the effect of stem cells or PRP is observed more in the recipient area or in the donor area. It is aimed to present the application method and localization of PRP to be combined with fat graft to increase the survival. Material and Methods: in vitro part: Fat grafts were kept in a medium containing PRP. Cell output from the fat graft to the Petri dishes was examined every day. The time to recruit the maximum number of stem cells to the medium was determined (day 10). in vivo part: Eight group of rats were received PRP in different concentrations either to recipient or donor areas of fat grafts. After ten days, fat grafts were transferred to the recipient area. Ninety days after the transfer, histopathological examination and immunohistochemical staining were performed. Results: The group which had received the full-dose PRP to the recipient area showed the highest cellular integrity and vascularity (p< 0.05). Vascularity was superior in the half-dose PRP group compared to the control group (p< 0.05); cellular integrity did not increase. Donor site groups did not show increase in cellular integrity. Conclusion: Although PRP starts to increase fat graft permanence by increasing vascularity, it acts by preserving the cellular integrity of the fat cells as the concentrations increase. The PRP injection to the recipient area 10 days before fat grafting may provide higher survival rates.

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