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Your search keyword '"Yi, William"' showing total 21 results
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21 results on '"Yi, William"'

12. BF170 hydrochloride enhances the emergence of hematopoietic stem and progenitor cells.

Author

Wen Ye Liu, Yu Yan Ding, Zheng Shen, Cong Xu, Yi, William, Ding Wang, Yi Zhou, Zon, Leonard I., and Jing-Xia Liu

Subjects
HEMATOPOIETIC stem cells, BLOOD flow, PROGENITOR cells, CELLULAR signal transduction, BRACHYDANIO
Abstract

Generation of hematopoietic stemand progenitor cells (HSPCs) ex vivo and in vivo, especially the generation of safe therapeutic HSPCs, still remains inefficient. In this study, we have identified compound BF170 hydrochloride as a previously unreported pro-hematopoiesis molecule, using the differentiation assays of primary zebrafish blastomere cell culture and mouse embryoid bodies (EBs), and we demonstrate that BF170 hydrochloride promoted definitive hematopoiesis in vivo. During zebrafish definitive hematopoiesis, BF170 hydrochloride increases blood flow, expands hemogenic endothelium (HE) cells and promotes HSPC emergence. Mechanistically, the primary cilia-Ca2+-Notch/NO signaling pathway, which is downstream of the blood flow, mediated the effects of BF170 hydrochloride on HSPC induction in vivo. Our findings, for the first time, reveal that BF170 hydrochloride is a compound that enhances HSPC induction and may be applied to the ex vivo expansion of HSPCs. [ABSTRACT FROM AUTHOR]

Published
2024
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13. BF170 hydrochloride enhances the emergence of hematopoietic stem and progenitor cells.

Author

WenYe Liu, YuYan Ding, Zheng Shen, Cong Xu, Yi, William, Ding Wang, Yi Zhou, Zon, Leonard I., and Jing-Xia Liu

Subjects
HEMATOPOIETIC stem cells, CELL culture, BLOOD flow, PROGENITOR cells, HEMATOPOIESIS
Abstract

Generation of hematopoietic stemand progenitor cells (HSPCs) ex vivo and in vivo, especially the generation of safe therapeutic HSPCs, still remains inefficient. In this study, we have identified compound BF170 hydrochloride as a previously unreported pro-hematopoiesis molecule, using the differentiation assays of primary zebrafish blastomere cell culture and mouse embryoid bodies (EBs), and we demonstrate that BF170 hydrochloride promoted definitive hematopoiesis in vivo. During zebrafish definitive hematopoiesis, BF170 hydrochloride increases blood flow, expands hemogenic endothelium (HE) cells and promotes HSPC emergence. Mechanistically, the primary cilia-Ca2+-Notch/NO signaling pathway, which is downstream of the blood flow, mediated the effects of BF170 hydrochloride on HSPC induction in vivo. Our findings, for the first time, reveal that BF170 hydrochloride is a compound that enhances HSPC induction and may be applied to the ex vivo expansion of HSPCs. [ABSTRACT FROM AUTHOR]

Published
2024
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21. A Systematic Review of Immersive Virtual Reality for Non-Technical Skills Training in Surgery

Author

Yi, William S., Rouhi, Armaun D., Duffy, Caoimhe C., Ghanem, Yazid K., Williams, Noel N., and Dumon, Kristoffel R.

Abstract

•Non-technical skill uses of immersive virtual reality in surgical education encompass applications that inform clinical decision making and anatomy/preoperative planning.•The mean Medical Education Research Quality Instrument (MERSQI) score of studies utilizing immersive virtual reality applications for surgical education was 10.3 ± 2.3 (max 18).•A wide variety of head mounted display technologies were utilized in immersive virtual reality studies, with the Oculus Rift being the most common.•Most immersive virtual reality studies utilized non-commercial software.

Published
2023
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