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Your search keyword '"Yao, Wei-Feng"' showing total 168 results
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168 results on '"Yao, Wei-Feng"'

5. Precise planning based on 3D-printed dry-laboratory models can reduce perioperative complications of laparoscopic surgery for complex hepatobiliary diseases: a preoperative cohort study

Author

Yao, Wei-Feng, primary, Huang, Xiao-Kun, additional, Fu, Tian-Wei, additional, Jin, Lei, additional, Du, Cheng-Fei, additional, Gao, Zhen-Yu, additional, Wang, Kai-Di, additional, Dai, Mu-Gen, additional, Liu, Si-Yu, additional, Liu, Jun-Wei, additional, Zhang, Cheng-Wu, additional, Liang, Lei, additional, and Huang, Dong-Sheng, additional

Published
2024
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14. Alternative processing technology for the preparation of carbonized Zingiberis Rhizoma by stir-frying with sand

Author

Shen Mei-Yu, Wang Jia-Li, Shi Hai-Pei, Yan Hui, Chen Pei-Dong, Yao Wei-Feng, Bao Bei-Hua, and Zhang Li

Subjects
stir-frying processing technology, fingerprint, gingerols, shogaols, Therapeutics. Pharmacology, RM1-950
Abstract

Context Carbonized ginger, a type of charry herb, has been used as a hemostatic medicine since ancient times. However, there are some serious problems such as inhomogeneous heating and emitting smoke during processing with traditional stir-frying method. Objective To investigate the feasibility to obtain carbonized ginger by stir-frying with sand instead of stir-frying method. Materials and methods Dried-ginger (100 g) was processed by stir-frying for 30 min at 270 ± 10 °C, or by stir-frying with sand (1:10, w/w) for 8 min at 240 ± 5 °C. The HPLC fingerprint was established for two samples. The adsorption capacity and major components including tannins, gingerols, shogaols and gingerone were quantitated by UV and HPLC, respectively. The hemostatic effect by prothrombin time (PT) and activated partial thromboplastin time (APTT) was evaluated in vitro. Results The similarity of the two samples for HPLC fingerprints was >0.93. The sand-fried samples showed significantly higher adsorption capacity compared with the stir-fried samples (4.915 vs. 4.593 mg/g; p 0.05). The PT and APTT values were similar between the stir-fried and sand-fried test groups and significantly lower compared to controls (p

Published
2020
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18. Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure.

Author

Wang, Dong-Dong, Dong, Meng-Meng, Xie, Ya-Ming, Xu, Fei-Qi, Fu, Tian-Wei, Wu, Yu-Chen, Zhang, Zhe, Lu, Yi, Liang, Lei, Yao, Wei-Feng, Shen, Guo-Liang, Liu, Jun-Wei, Zhang, Cheng-Wu, Xu, Qiu-Ran, and Xiao, Zun-Qiang

Subjects
LIVER failure, CHEMOEMBOLIZATION, LACTATES, LOGISTIC regression analysis, LACTATION, RECEIVER operating characteristic curves
Abstract

Background: Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR level and hyperbilirubinemia on or after postoperative day 5. This study aims to propose a new indicator for the early clinical prediction of PHLF. Methods: The peri-operative arterial lactate concentration level ratios were derived from time points within the 3 days before surgery and within POD1, the patients were divided into two groups: high lactate ratio group (≥ 1) and low lactate ratio group (< 1). We compared the differences in morbidity rates between the two groups. Utilized logistic regression analysis to identify the risk factors associated with PHLF development and ROC curves to compare the predictive value of lactate ratio and other liver function indicators for PHLF. Results: A total of 203 patients were enrolled in the study. Overall morbidity and severe morbidity occurred in 64.5 and 12.8 per cent of patients respectively. 39 patients (19.2%) met the criteria for PHLF, including 15 patients (7.4%) with clinically relevant Post-hepatectomy liver failure (CR-PHLF). With a significantly higher incidence of PHLF observed in the lactate ratio ≥ 1 group compared to the lactate ratio < 1 group (n = 34, 26.8% vs. n = 5, 6.6%, P < 0.001). Multivariable logistic regression analysis revealed that a lactate ratio ≥ 1 was an independent predictor for PHLF (OR: 3.239, 95% CI 1.097–9.565, P = 0.033). Additionally, lactate ratio demonstrated good predictive efficacy for PHLF (AUC = 0.792). Conclusions: Early assessment of peri-operative arterial lactate concentration level ratios may provide experience in early intervention of complications in patients with hepatocellular carcinoma, which can reduce the likelihood of PHLF occurrence and improve patient prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study.

Author

Xu, Fei‐Qi, Xu, Qing‐Yun, Zhu, Zhang‐Ji, Jin, Lei, Ye, Tai‐Wei, Du, Cheng‐Fei, Gao, Zhen‐Yu, Huang, Xiao‐Kun, Zhang, Zhe, Jin, Li‐Ming, and Yao, Wei‐Feng

Subjects
LIVER cancer, GENOME-wide association studies, FAT, ADIPOSE tissues, GENETIC epidemiology, FATTY liver
Abstract

Several observational studies have reported an association between obesity and primary liver cancer (PLC), while the causality behind this association and the comparison of the risk effects of different obesity indicators on PLC remain unclear. In this study, we performed two‐sample Mendelian randomization (MR) analyses to assess the associations of genetically determined liver fat, visceral adipose tissue (VAT), and body mass index (BMI) with the risk of PLC. The summary statistics of exposures were obtained from two genome‐wide association studies (GWASs) based on the UK Biobank (UKB) imaging cohort and the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. GWAS summary statistics for PLC were obtained from FinnGen consortium R7 release data, including 304 PLC cases and 218 488 controls. Inverse‐variance weighted (IVW) was used as the primary analysis, and a series of sensitivity analyses were performed to further verify the robustness of these findings. IVW analysis highlighted a significant association of genetically determined liver fat (OR per SD increase: 7.14; 95% CI: 5.10‐9.99; P = 2.35E‐30) and VAT (OR per SD increase: 5.70; 95% CI: 1.32‐24.72; P =.020) with PLC but not of BMI with PLC. The findings were further confirmed by a series of MR methods. No evidence of horizontal pleiotropy between these associations existed. Our study suggested that genetically determined liver fat and VAT rather than BMI were associated with an increased risk of PLC, which suggested that visceral fat distribution is more predictive of the clinical risk of PLC than common in vitro measures. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Precise planning based on 3D-printed dry-laboratory models can reduce perioperative complications of laparoscopic surgery for complex hepatobiliary diseases: A preoperative cohort study

Author

Yao, Wei-Feng, primary, Huang, Xiao-Kun, additional, Fu, Tian-Wei, additional, Jin, Lei, additional, Du, Cheng-Fei, additional, Gao, Zhen-Yu, additional, Wang, Kai-Di, additional, Dai, Mu-Gen, additional, Liu, Si-Yu, additional, Liu, Jun-Wei, additional, Zhang, Cheng-Wu, additional, Liang, Lei, additional, and Huang, Dong-Sheng, additional

Published
2023
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21. Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study

Author

Xu, Fei‐Qi, primary, Xu, Qing‐Yun, additional, Zhu, Zhang‐Ji, additional, Jin, Lei, additional, Ye, Tai‐Wei, additional, Du, Cheng‐Fei, additional, Gao, Zhen‐Yu, additional, Huang, Xiao‐Kun, additional, Zhang, Zhe, additional, Jin, Li‐Ming, additional, and Yao, Wei‐Feng, additional

Published
2023
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25. Survival benefit of adjuvant transcatheter arterial chemoembolization for patients with hepatocellular carcinoma after anatomical hepatectomy

Author

Ye, Tai-Wei, primary, Wang, Dong-Dong, additional, Lu, Wen-Feng, additional, Xie, Ya-Ming, additional, Xu, Fei-Qi, additional, Fu, Tian-Wei, additional, Zhang, Kang-Jun, additional, Liu, Si-Yu, additional, Xie, Gui-Lin, additional, Cheng, Jian, additional, Jiang, Kai, additional, Xiao, Zun-Qiang, additional, Yao, Wei-Feng, additional, Shen, Guo-Liang, additional, Liu, Jun-Wei, additional, Huang, Dong-Sheng, additional, Zhang, Cheng-Wu, additional, and Liang, Lei, additional

Published
2023
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28. Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy

Author

Zhang, Kang-Jun, Ye, Tai-Wei, Lu, Wen-Feng, Xu, Fei-Qi, Xie, Ya-Ming, Wang, Dong-Dong, Xiao, Zun-Qiang, Liu, Si-Yu, Yao, Wei-Feng, Cheng, Jian, Shen, Guo-Liang, Liu, Jun-Wei, Zhang, Cheng-Wu, Huang, Dong-Sheng, and Liang, Lei

Subjects
Cancer Research, Oncology
Abstract

Background & aimsThe long-term prognosis of patients with metabolic syndrome (MS) and hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after radical hepatectomy remains unclear. The purpose of this study was to elucidate the effect of MS on long-term survival for patients with HBV-related HCC after hepatectomy.MethodsPatients with HBV-HCC after hepatectomy were included. Patients were stratified into MS-HBV-HCC and HBV-HCC groups. Clinical features and surgical outcomes were compared between the two groups, and COX regression analysis was used to determine independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).Result389 patients (MS-HBV-HCC group: n=50, HBV-HCC group: n=339) were enrolled for further analysis. Baseline characteristics showed that patients with MS-HBV-HCC were associated with a high rate of elderly patients, ASA score, and co-morbid illness, but a lower rate of anatomy hepatectomy. There were no significant differences in perioperative complications. After excluding patients who relapsed or died within 90 days after surgery, multivariate Cox regression analysis showed MS was an independent risk factor of OS (HR 1.68, 95% CI 1.05-2.70, P = 0.032) and RFS (HR 1.78, 95% CI 1.24-2.57, P = 0.002).ConclusionMS is an independent risk factor for poor OS and RFS in HBV-infected HCC patients after radical hepatectomy. This suggests that we need to strengthen postoperative follow-up of the relevant population and encourage patients to develop a healthy lifestyle.

Published
2022

29. Short- and long-term outcomes of laparoscopic versus open liver resection for large hepatocellular carcinoma: a propensity score study

Author

Zhang, Kang-Jun, primary, Liang, Lei, additional, Diao, Yong-Kang, additional, Xie, Ya-Ming, additional, Wang, Dong-Dong, additional, Xu, Fei-Qi, additional, Ye, Tai-Wei, additional, Lu, Wen-Feng, additional, Cheng, Jian, additional, Shen, Guo-Liang, additional, Yao, Wei-Feng, additional, Lu, Yi, additional, Xiao, Zun-Qiang, additional, Zhang, Jun-Gang, additional, Zhang, Cheng-Wu, additional, Huang, Dong-Sheng, additional, and Liu, Jun-Wei, additional

Published
2022
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30. Atherosclerosis and Helminths Infection

Author

Shen, Shi-Wei, primary, Lu, Yun, additional, Li, Feng, additional, Shen, Zhen-Hai, additional, Xu, Ming, additional, Yao, Wei-Feng, additional, Qi, Hua-Jin, additional, Zhou, Ling, additional, Feng, Yin-Bo, additional, Wang, Ling, additional, Yun, Jing-Ting, additional, and Tong, Da-Xin, additional

Published
2017
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31. Association of preoperative albumin–bilirubin with surgical textbook outcomes following laparoscopic hepatectomy for hepatocellular carcinoma

Author

Xu, Fei-Qi, primary, Ye, Tai-Wei, additional, Wang, Dong-Dong, additional, Xie, Ya-Ming, additional, Zhang, Kang-Jun, additional, Cheng, Jian, additional, Xiao, Zun-Qiang, additional, Liu, Si-Yu, additional, Jiang, Kai, additional, Yao, Wei-Feng, additional, Shen, Guo-Liang, additional, Liu, Jun-Wei, additional, Zhang, Cheng-Wu, additional, Huang, Dong-Sheng, additional, and Liang, Lei, additional

Published
2022
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37. A gradient-based discriminant analysis method for process quality control of carbonized TCM via Fourier transform near infrared spectroscopy: A case study on carbonized Typhae Pollen

Author

Zhang Li, Jin Xin, Zhang Yi, Gao Ming-Liang, Wang Hang-Hang, Bao Bei-Hua, Cheng Fang-Fang, Yao Wei-Feng, Liu Ling-Run, Wang Tian-Shu, Chen Pei-Dong, and Zhou Ya-Nan

Subjects
Process quality, Quality Control, Spectroscopy, Near-Infrared, Fourier Analysis, Chemistry, business.industry, Near-infrared spectroscopy, Discriminant Analysis, Pattern recognition, Linear discriminant analysis, Convolutional neural network, Atomic and Molecular Physics, and Optics, Analytical Chemistry, symbols.namesake, Fourier transform, Gradient based algorithm, symbols, Pollen, Clinical efficacy, Artificial intelligence, Internal validation, Medicine, Chinese Traditional, business, Instrumentation, Spectroscopy
Abstract

Carbonized traditional Chinese medicine (TCM) is a kind of distinctive traditional drug which has been widely used in various bleeding syndromes for over two thousand years, and most of them are still in clinical use. Although they share similar processing method: stir-frying, there are no specific quality standards and few quality control researches carried out on carbonized TCM up until now. Carbonized Typhae Pollen (CTP) is a typical carbonized TCM with efficacy of eliminating blood stasis and stanching bleeding. In this study, a novel process quality control model coupled with near infrared spectroscopy was established, called Gradient-based Discriminant Analysis method (GDA). Compared with conventional modeling methods (Convolutional Neural Network, Linear Discriminant Analysis, Standard Normal Variate-LDA), GDA model applied in fiber optic probe acquisition mode exhibited highest test accuracy (0.961), satisfactory correct identification (internal validation, 100%; external validation, 97.1%) and excellent model stability. This method provided a perfect guideline for process quality control of Carbonized TCM as well as ensured their clinical efficacy.

Published
2021

39. MiR-200a inhibits cell proliferation and EMT by down-regulating the ASPH expression levels and affecting ERK and PI3K/Akt pathways in human hepatoma cells

Author

Yao, Wei-Feng, Liu, Jun-Wei, and Huang, Dong-Sheng

Subjects
Original Article
Abstract

The primary objective of this study was to investigate the role of miR-200a in cell proliferation and epithelial-mesenchymal transition (EMT) through regulating targeting aspartate-β-hydroxylase (ASPH), which may further affect the activation of ERK/PI3K/Akt pathway. Liver cancer and adjacent tissues were collected from 72 cases of liver cancer patients with surgery in our hospital. In this study, the mRNA expression level of miR-200a was significantly decreased by real-time PCR (RT-PCR) detection. ASPH expressions, however, had an opposite tendency compared to that of miR-200a. We found a significantly negative correlation between miR-200a expressions and ASPH expressions. The survival rate of liver cancer patients with the low expressed ASPH was significantly higher than those with the high expressed ASPH. RT-PCR and Western blot results showed that low expressed miR-200a and highexpressed ASPH were found in liver cancer cell lines. Further research discovered that miR-200a transfection could significantly decrease the relative luciferase activity when it was integrated with ASPH 3'-untranslated region (3'-UTR) in HepG2 cells. Cell Counting Kit (CCK-8) detection showed that treatment with miR-200a mimics reduced cell viability, while the over-expressed ASPH increased cell viability by regulating the c-mycmrna (c-Myc) and Cyclin-D1 expressions. The EMT-related genes including E-Cadherin, N-Cadherin and Vimentin expressions were significantly increased, whereas the over-expressed ASPH exerted the opposite effects. In addition, extracellular signal regulated kinase (ERK), phosphoinositide-3-kinase (PI3K) and serine threonine kinase (AKT) were suppressed by miR-200a mimics. In conclusion, miR-200a inhibits cell proliferation and EMT in human hepatoma cells by targeting ASPH and affecting ERK and PI3K/Akt signaling pathways.

Published
2018

45. Atherosclerosis and Helminths Infection

Author

Shen, Shi-Wei, Lu, Yun, Li, Feng, Shen, Zhen-Hai, Xu, Ming, Yao, Wei-Feng, Qi, Hua-Jin, Zhou, Ling, Feng, Yin-Bo, Wang, Ling, and Tong, Jing-Ting Yun and Da-Xin

Published
2017

47. The toxicity and efficacy evaluation of different fractions of Kansui fry-baked with vinegar on Walker-256 tumor-bearing malignant ascites effusion rats and normal rats

Author

Lou, Jian-Wei, primary, Cao, Liang-Liang, additional, Zhang, Qiao, additional, Jiang, Dong-jing, additional, Yao, Wei-Feng, additional, Bao, Bei-Hua, additional, Cao, Yu-Dan, additional, Tang, Yu-Ping, additional, Zhang, Li, additional, Wang, Kun, additional, and Dai, Guan-Cheng, additional

Published
2018
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50. Chemical Constituents from Euphorbia kansui

Author

Zhang, Qiao, primary, Zhou, Qin-Rong, additional, Lou, Jian-Wei, additional, Chen, Pei-Dong, additional, Yao, Wei-Feng, additional, Tao, Wei-Wei, additional, Tang, Yu-Ping, additional, Dai, Guan-Cheng, additional, Wang, Kun, additional, and Zhang, Li, additional

Published
2017
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