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23,613 results on '"Yang W."'

1. Nucleon pair parton distribution functions

Author

Yang, W. and Li, C.

Subjects
Nuclear Theory, High Energy Physics - Phenomenology
Abstract

Parton distribution functions (PDFs) are important quantities in describing nucleon structures. They are universal and process-independent. As a matter of fact, nucleon PDFs are inevitably affected by nuclear matter during nuclear scattering process. In order to study the nuclear PDFs (nPDFs), in this paper, we introduce the nucleon pair PDFs (dPDFs) to describe parton distributions in the nucleon pair which is confined to a nucleus. We first of all construct the nuclear state in terms of nucleonic Fock states and calculate the operator definition of nPDFs. Neglecting the higher order corrections or nucleon correlations, we find that nPDFs can be written as a sum of two terms which respectively correspond to PDFs and dPDFs. Nucleon pair PDFs which stem from nucleon-nucleon correlation are proportional to common nucleon PDFs but suppressed by a factor. It is naturally to obtain the slope of the EMC effect $dR_{EMC}/dx$ as long as the factor is independent of momentum fraction $x$. We further calculate the Paschos-Wolfenstein ratio to study the nuclear matter effect on the extraction of weak mixing angle or $\sin^2\theta_W$ by using dPDFs.

Published
2024

2. Hyperfine structure of the methanol molecule as traced by Class I methanol masers

Author

Agafonova, I. I., Bayandina, O. S., Gong, Y., Henkel, C., Kim, Kee-Tae, Kozlov, M. G., Lankhaar, B., Levshakov, S. A., Menten, K. M., Ubachs, W., Val'tts, I. E., and Yang, W.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present results on simultaneous observations of Class~I methanol masers at 25, 36, and 44 GHz towards 22 Galactic targets carried out with the Effelsberg 100-m telescope. The study investigates relations between the hyperfine (HF) structure of the torsion-rotation transitions in CH3OH and maser activity. By analyzing the radial velocity shifts between different maser lines together with the patterns of the HF structure based on laboratory measurements and quantum-chemical calculations, we find that in any source only one specific HF transition forms the maser emission and that this transition changes from source to source. The physical conditions leading to this selective behavior are still unclear. Using accurate laboratory rest frequencies for the 25 GHz transitions, we have refined the centre frequencies for the HF multiplets at 36, 44, and 95 GHz: f_36 = (36169.2488 +/- 0.0002_stat +/- 0.0004_sys) MHz. f_44 = (44069.4176 +/- 0.0002_stat +/- 0.0004_sys) MHz, and f_95 = (95169.4414 +/- 0.0003_stat +/- 0.0004_sys) MHz. Comparison with previous observations of 44 GHz masers performed 6-10 years ago with a Korean 21-m KVN telescope towards the same targets confirms the kinematic stability of Class~I maser line profiles during this time interval and reveals a systematic radial velocity shift of 0.013 +/- 0.005 km/s between the two telescopes., Comment: 24 pages, 8 figures, 9 tables; accepted for publication in MNRAS

Published
2024

3. Genetic aberrations in Chinese pancreatic cancer patients and their association with anatomic location and disease outcomes

Author

Junliang Lu, Ruoying Yu, Rui Liu, Xiaolong Liang, Jian Sun, Hui Zhang, Huanwen Wu, Zhiwen Zhang, Yang W. Shao, Junchao Guo, and Zhiyong Liang

Subjects
body and tail of pancreas, disease‐free survival, DNA Damage Repair pathway, head and neck of pancreas, KRAS subtype, overall survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Objectives Pancreatic cancer (PC) is one of the most lethal malignancies with an increasing death rate over the years. We performed targeted sequencing and survival analyses on 90 Chinese pancreatic cancer patients, hoping to identify genomic biomarkers associated with clinical outcomes and therapeutic options. Method Genomic DNA was extracted from formalin‐fixed paraffin‐embedded (FFPE) tissue specimens of 90 pancreatic cancer patients and sequenced. The associations with clinicopathological factors were analyzed. Result High prevalence of driver mutations in KRAS, TP53, CDKN2A, SMAD4, and ARID1A genes were found. Most mutated genes in PC belonged to cell cycle and DNA damage repair pathways. Tumors that arise from the pancreas’ body and tail (BT tumors) displayed a higher ratio of mutated KRAS and TP53 than those that arise from the pancreas’ head and neck (HN tumors), who showed less diverse KRAS subtypes. Patients with a KRAS p.G12R mutated tumor tended to have a prolonged disease‐free survival (DFS) and overall survival (OS) than other KRAS subtypes. Those with an altered ARID1A gene and more than two mutated driver genes tended to have a shorter DFS and OS. Conclusion HN and BT tumors of the pancreas displayed different mutational profiles, which had prognostic significances and indicated different potential therapeutic options.

Published
2021
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4. One-step synthesis of Cu-doped Pb$_{10}$(PO$_{4}$)$_{6}$Cl$_{2}$ apatite: A wide-gap semiconductor

Author

Yang, W. Z., Pang, Z. H., and Ren, Z.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

The recent claim of potential room-temperature superconductivity in Pb$_{10-x}$Cu$_{x}$(PO$_{4}$)$_{6}$O has attracted widespread attention. However, the signature of superconductivity is later attributed to the Cu$_{2}$S impurity formed during the multiple-step synthesis procedure. Here we report a simple one-step approach to synthesize single-phase chloride analogue Cu-doped Pb$_{10}$(PO$_{4}$)$_{6}$Cl$_{2}$ using PbO, PbCl$_{2}$, CuCl$_{2}$, and NH$_{4}$H$_{2}$PO$_{4}$ as starting materials. Irrespective of the initial stoichiometry, the Cu doping always leads to a lattice expansion in Pb$_{10}$(PO$_{4}$)$_{6}$Cl$_{2}$. This indicates that Cu prefers to reside in the hexagonal channels rather than substitutes at the Pb site, and the chemical formula is expressed as Pb$_{10}$(PO$_{4}$)$_{6}$Cu$_{x}$Cl$_{2}$. All the Pb$_{10}$(PO$_{4}$)$_{6}$Cu$_{x}$Cl$_{2}$ (0 $\leq$ $x$ $\leq$ 1.0) samples are found to be semiconductors with wide band gaps of 4.46-4.59 eV, and the Cu-doped ones ($x$ = 0.5 and 1.0) exhibit a paramagnetic behavior without any phase transition between 400 and 1.8 K. Our study calls for a reinvestigation of the Cu location in Pb$_{10-x}$Cu$_{x}$(PO$_{4}$)$_{6}$O, and supports the absence of superconductivity in this oxyapatite., Comment: 8 pages, 6 figures

Published
2024
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5. Data quality control system and long-term performance monitor of the LHAASO-KM2A

Author

Cao, Zhen, Aharonian, F., Axikegu, Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Bian, W., Bukevich, A. V., Cao, Q., Cao, W. Y., Cao, Zhe, Chang, J., Chang, J. F., Chen, A. M., Chen, E. S., Chen, H. X., Chen, Liang, Chen, Lin, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, M. Y., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Dong, X. Q., Duan, K. K., Fan, J. H., Fan, Y. Z., Fang, J., Fang, J. H., Fang, K., Feng, C. F., Feng, H., Feng, L., Feng, S. H., Feng, X. T., Feng, Y., Feng, Y. L., Gabici, S., Gao, B., Gao, C. D., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Giacinti, G., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., Hasan, M., He, H. H., He, H. N., He, J. Y., He, Y., Hor, Y. K., Hou, B. W., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S. C., Huang, D. H., Huang, T. Q., Huang, W. J., Huang, X. T., Huang, X. Y., Huang, Y., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, X. W., Jiang, Z. J., Jin, M., Kang, M. M., Karpikov, I., Kuleshov, D., Kurinov, K., Li, B. B., Li, C. M., Li, Cheng, Li, Cong, Li, D., Li, F., Li, H. B., Li, H. C., Li, Jian, Li, Jie, Li, K., Li, S. D., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, D. B., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Luo, Q., Luo, Y., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Min, Z., Mitthumsiri, W., Mu, H. J., Nan, Y. C., Neronov, A., Ou, L. J., Pattarakijwanich, P., Pei, Z. Y., Qi, J. C., Qi, M. Y., Qiao, B. Q., Qin, J. J., Raza, A., Ruffolo, D., Sáiz, A., Saeed, M., Semikoz, D., Shao, L., Shchegolev, O., Sheng, X. D., Shu, F. W., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, D. X., Sun, Q. N., Sun, X. N., Sun, Z. B., Takata, J., Tam, P. H. T., Tang, Q. W., Tang, R., Tang, Z. B., Tian, W. W., Wang, C., Wang, C. B., Wang, G. W., Wang, H. G., Wang, H. H., Wang, J. C., Wang, Kai, Wang, L. P., Wang, L. Y., Wang, P. H., Wang, R., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, Q. W., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, Y. L., Xing, Y., Xiong, D. R., Xiong, Z., Xu, D. L., Xu, R. F., Xu, R. X., Xu, W. L., Xue, L., Yan, D. H., Yan, J. Z., Yan, T., Yang, C. W., Yang, C. Y., Yang, F., Yang, F. F., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, W. X., Yao, Y. H., Yao, Z. G., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zha, M., Zhang, B. B., Zhang, F., Zhang, H., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, Li, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zhao, X. H., Zheng, F., Zhong, W. J., Zhou, B., Zhou, H., Zhou, J. N., Zhou, M., Zhou, P., Zhou, R., Zhou, X. X., Zhu, B. Y., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., Zou, Y. C., and Zuo, X.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The KM2A is the largest sub-array of the Large High Altitude Air Shower Observatory (LHAASO). It consists of 5216 electromagnetic particle detectors (EDs) and 1188 muon detectors (MDs). The data recorded by the EDs and MDs are used to reconstruct primary information of cosmic ray and gamma-ray showers. This information is used for physical analysis in gamma-ray astronomy and cosmic ray physics. To ensure the reliability of the LHAASO-KM2A data, a three-level quality control system has been established. It is used to monitor the status of detector units, stability of reconstructed parameters and the performance of the array based on observations of the Crab Nebula and Moon shadow. This paper will introduce the control system and its application on the LHAASO-KM2A data collected from August 2021 to July 2023. During this period, the pointing and angular resolution of the array were stable. From the observations of the Moon shadow and Crab Nebula, the results achieved using the two methods are consistent with each other. According to the observation of the Crab Nebula at energies from 25 TeV to 100 TeV, the time averaged pointing errors are estimated to be $-0.003^{\circ} \pm 0.005^{\circ}$ and $0.001^{\circ} \pm 0.006^{\circ}$ in the R.A. and Dec directions, respectively., Comment: 15 pages, 9 figures

Published
2024

6. Variability of EGFR exon 20 insertions in 24 468 Chinese lung cancer patients and their divergent responses to EGFR inhibitors

Author

YanRu Qin, Hong Jian, Xiaoling Tong, Xue Wu, Fufeng Wang, Yang W. Shao, and Xinmin Zhao

Subjects
EGFR exon 20 insertion, lung cancer, osimertinib, poziotinib, tyrosine kinase inhibitor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

EGFR exon 20 insertions (EGFR e20ins) account for up to 10% of EGFR mutations in lung cancer; however, tumors with EGFR e20ins had poor response rates to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib, erlotinib, afatinib, and osimertinib, and the heterogeneity of EGFR e20ins further complicates the clinical studies. Here, we retrospectively screened next‐generation sequencing (NGS) data from 24 468 lung cancer patients, and a total of 85 unique EGFR e20ins variants were identified in 547 cases (2.24%), with p.A767_V769dup (25.1%) and p.S768_D770dup (17.6%) being the most prevalent ones. Comprehensive genomic profiling revealed that TP53 mutations frequently coexisted with p.H773dup (77.8%, P = 0.0558) and p.A767_V769dup (62.8%, P = 0.0325), while RB1 mutations usually co‐occurred with p.H773_V774insAH (33.3%, P = 0.0551), implying that different EGFR e20ins variants might require distinct genomic context for tumorigenesis and/or maintenance. Despite that treatment regimens were highly diverse for EGFR e20ins‐positive patients, we observed an overall response rate of 14% and a disease control rate (DCR) of 38.4% in 65 patients who received at least one EGFR TKI. The progression‐free survival (PFS) differs significantly in six representative EGFR e20ins variants (P = 0.017), and EGFR p.A763_Y764insFQEA was associated with better PFS than other EGFR e20ins when treating with various EGFR TKIs. Some EGFR e20ins variants showed at least partial response to first‐generation EGFR TKIs, including p.A767_V769dup, p.S768_D770dup, p.N771_H773dup, p.A763_Y764insFQEA, and p.D770_N771insG. Poziotinib achieved higher DCR for p.S768_D770dup than for p.A767_V769dup, whereas osimertinib showed limited effects for these two insertions when used as the first‐line treatment. Overall, our results demonstrated that EGFR e20ins were highly diversified in terms of insertion patterns and co‐occurring mutations and these EGFR e20ins variants showed different clinical responses to various EGFR TKIs, suggesting the clinical importance of selecting proper EGFR TKI treatment based on the specific EGFR e20ins type.

Published
2020
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7. Clinical and molecular characteristics of Chinese non‐small cell lung cancer patients with ERBB2 transmembrane domain mutations

Author

Yun Fan, Jinrong Qiu, Ruoying Yu, Ran Cao, Xiaoxi Chen, Qiuxiang Ou, Xue Wu, Yang W. Shao, Misako Nagasaka, Jiexia Zhang, and Sai‐Hong Ignatius Ou

Subjects
comprehensive genomic profiling, ERBB2, NSCLC, TMD, transmembrane domain mutation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Transmembrane domain (TMD) mutations of ERBB2 have previously been reported in lung cancer patients in addition to well‐studied kinase domain (KD) mutations, which may stabilize ERBB2 heterodimerization with other EGFR family members and favor a kinase active conformation. However, the frequency and clinical significance of ERBB2 TMD mutations in Chinese population is unknown. We prospectively analyzed the next‐generation sequencing data of 34 368 Chinese lung cancer patients with different sample types, including tumor tissue, plasma, cerebrospinal fluid, and pleural effusion. Patients' clinical characteristics and treatment history were retrieved from the database for further evaluation. Our findings show that ERBB2 V659/G660 mutations were detected at a frequency of 0.13% (45/34 368), of which the most frequent was V659D/E (88.9%), with a trend in nonsmokers and male. Moreover, 18% of patients (8/45) showed EGFR and/or ERBB2 amplification, whereas nine patients presented EGFR L858R or exon19 deletion. Interestingly, novel ERBB3 TMD mutation I646R was found coexisting in three patients with ERBB2 V659D and one patient with ERBB2 G660D, which might influence its heterodimerization with ERBB2 and further activate ERBB2. Four ERBB2 TMD mutation‐positive patients received afatinib monotherapy or combination therapy, but showed variable responses. One patient with V659E responded well to ERBB2 inhibitor lapatinib plus capecitabine as well as subsequent afatinib treatment upon progression. Our study provides valuable insights into the distribution of ERBB2 TMD mutations by employing the largest Asian lung cancer cohort thus far. Patients with ERBB2 TMD mutations who received afatinib, a pan‐ERBB inhibitor, demonstrated mixed responses, posing the urgent need to develop more effective therapeutic strategy for patients who carry ERBB2 TMD mutations.

Published
2020
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8. Quantitative characterization of tumor cell-free DNA shortening

Author

Juntang Guo, Kefeng Ma, Hua Bao, Xiangyuan Ma, Yang Xu, Xue Wu, Yang W. Shao, Mei Jiang, and Jin Huang

Subjects
Cell-free DNA, Cancer, Fragment size, Next generation sequencing, Chromatin structure, Nucleosome, Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA and improve its usage in early cancer diagnosis and treatment monitoring; however, the underlying mechanism of shortened tumor cfDNA was still unknown, which potentially limits its further clinical application. Results Using targeted sequencing of cfDNA in a large cohort of solid tumor patient, sequencing reads harboring tumor-specific somatic mutations were isolated to examine the exact size distribution of tumor cfDNA. For the majority of studied cases, 166 bp remained as the peak size of tumor cfDNA, with tumor cfDNA showing an increased proportion of short fragments (100-150 bp). Less than 1% of cfDNA samples were found to be peaked at 134/144 bp and independent of tumor cfDNA purity. Using whole-genome sequencing of cfDNA, we discovered a positive correlation between cfDNA shortening and the magnitude of chromatin inaccessibility, as measured by transcription, DNase I hypersensitivity, and histone modifications. Tumor cfDNA shortening occurred simultaneously at both 5′ and 3′ ends of the DNA wrapped around nucleosomes. Conclusions Tumor cfDNA shortening exhibited two distinctive modes. Tumor cfDNA purity and chromatin inaccessibility were contributing factors but insufficient to trigger a global transition from 166 bp dominant to 134/144 bp dominant phenotype.

Published
2020
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9. YAP1 amplification as a prognostic factor of definitive chemoradiotherapy in nonsurgical esophageal squamous cell carcinoma

Author

Honghai Dai, Yang W. Shao, Xiaoling Tong, Xue Wu, Jiaohui Pang, Alei Feng, and Zhe Yang

Subjects
chemoradiation therapy, esophageal squamous cell carcinoma, local recurrence‐free survival, next‐generation sequencing, YAP1 amplification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Definitive chemoradiation therapy (dCRT) is the standard treatment for patients with nonsurgical esophageal squamous cell carcinoma (ESCC), yet patients have demonstrated great variations in their responses to dCRT and inevitably progressed following treatment. Methods To identify prognostic biomarkers, we performed targeted next‐generation sequencing of 416 cancer‐related genes on primary tumors from 47 nonsurgical ESCC patients prior to dCRT treatment. The association between genetic alterations and patients' local recurrence‐free survival (LRFS), progression‐free survival (PFS), and overall survival (OS) was analyzed. Results TP53 (78% of patients), NOTCH1 (32%), ARID1A (13%), FAT1 (13%), and CDKN2A (13%) were commonly mutated in ESCC patients, while gene amplifications frequently occurred in MCL1 (36%), FGF19 (34%), MYC (32%), CCND1 (27%), ZNF217 (15%), CDKN2A (13%), and YAP1 (11%). Univariate and multivariate analyses of clinical factors and genetic alterations indicated that sex is an independent prognostic factor, with males tending to have better LRFS (hazard ratio [HR], 0.25; 95%CI, 0.08‐0.77, P = .015) and progression‐free survival (PFS) (HR, 0.35; 95%CI, 0.13‐0.93, P = .030) following dCRT. Meanwhile, YAP1 amplification (n = 7) was an adverse prognostic factor, and patients with this alteration demonstrated a tendency toward worse outcomes with shorter LRFS (HR, 4.06; 95%CI, 1.26‐13.14, P = .019) and OS (HR, 2.78; 95%CI, 0.95‐8.17, P = .062). In a subgroup analysis, while sex and M‐stage were controlled, a much stronger negative effect of YAP1 amplification vs wild‐type in LRFS was observed (log‐rank P = .0067). Conclusion The results suggested that YAP1 amplification is a potentially useful biomarker for predicting treatment outcomes and identifying patients with a high risk of relapse who should be closely monitored.

Published
2020
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11. Unique Genomic Alterations of Cerebrospinal Fluid Cell-Free DNA Are Critical for Targeted Therapy of Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Author

Yongsheng Wang, Feng Jiang, Ruixue Xia, Ming Li, Chengyun Yao, Yan Li, Hui Li, Qi Zhao, Mingke Shi, Yanzhe Yu, Yang W. Shao, Guoren Zhou, Hongping Xia, Liyun Miao, and Hourong Cai

Subjects
non-small cell lung cancer, leptomeningeal metastasis, cerebrospinal fluid, liquid biopsy, cell-free DNA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices. We performed next-generation panel sequencing of primary tumor tissue, plasma, and CSF from 131 NSCLC patients with LM and observed high somatic copy number variations (CNV) in CSF of NSCLC patients with LM. The status of EGFR-activating mutations was highly concordant between CSF, plasma, and primary tumors. ALK translocation was detected in 8.3% of tumor tissues but only 2.4% in CSF and 2.7% in plasma. Others such as ROS1 rearrangement, RET fusion, HER2 mutation, NTRK1 fusion, and BRAF V600E mutation were detected in 7.9% of CSF and 11.1% of tumor tissues but only 4% in plasma. Our study has shed light on the unique genomic variations of CSF and demonstrated that CSF might represent better liquid biopsy for NSCLC patients with LM.

Published
2021
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12. Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report

Author

Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao, and Jun Chen

Subjects
Lung cancer, Pulmonary sarcomatoid carcinoma, Mutation profiling, Tumor evolution, NTRK1 fusion, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and progresses. Case presentation A 66-year-old male was initially diagnosed with stage IIIa lung cancer containing both adenocarcinoma (ADC) and SC. Adjuvant chemotherapy was administrated post-surgery, however, recurrence with SC only soon followed. Mutation profiling of the patient’s microdissected ADC and SC components of the primary lesion and recurrent tumor was performed by targeted next-generation sequencing (NGS) of 416 cancer-relevant genes. Our data showed that primary SC/ADC and the recurrent SC shared multiple gene mutations including EGFR, NF1, TP53, CDKN2B, and SMARCA4, while both primary and recurrent SCs had a unique TP53 exon 4 splicing mutation frequently observed in sarcoma. Interestingly, a novel PHF20-NTRK1 fusion was acquired in the recurrent SC, which may be a potential driver for SC recurrence. Conclusions The molecular genetic characteristics of tumor tissues at different stages reveals a linear tumor evolution model in this case, and support that the primary SC derived from the original lung ADC during the evolution of the tumor. We also identified a novel PHF20-NTRK1 fusion, which may contribute to the disease recurrence, and that can be potentially targeted with NTRK1 inhibitors for treatment.

Published
2019
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13. Short-Term Responders of Non–Small Cell Lung Cancer Patients to EGFR Tyrosine Kinase Inhibitors Display High Prevalence of TP53 Mutations and Primary Resistance Mechanisms

Author

Yanjun Xu, Xiaoling Tong, Junrong Yan, Xue Wu, Yang W. Shao, and Yun Fan

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Non–small cell lung cancer (NSCLC) with activating EGFR mutations in exon 19 and 21 typically responds to EGFR tyrosine kinase inhibitors (TKI); however, for some patients, responses last only a few months. The underlying mechanisms of such short responses have not been fully elucidated. Here, we sequenced the genomes of 16 short-term responders (SR) that had progression-free survival (PFS) of less than 6 months on the first-generation EGFR TKI and compared them to 12 long-term responders (LR) that had more than 24 months of PFS. All patients were diagnosed with advanced lung adenocarcinoma and harbored EGFR 19del or L858R mutations before treatment. Paired tumor samples collected before treatment and after relapse (or at the last follow-up) were subjected to targeted next-generation sequencing of 416 cancer-related genes. SR patients were significantly younger than LR patients (P < .001). Collectively, 88% of SR patients had TP53 variations compared to 13% of LR patients (P < .001). Additionally, 37.5% of SR patients carried EGFR amplifications compared to 8% of LR patients. Other potential primary resistance factors were also identified in the pretreatment samples of 12 SR patients (75%), including PTEN loss; BIM deletion polymorphism; and amplifications of EGFR, ERBB2, MET, HRAS, and AKT2. Comparatively, only three LR patients (25%) were detected with EGFR or AKT1 amplifications that could possibly exert resistance. The diverse preexisting resistance mechanisms in SR patients revealed the complexity of defining treatment strategies even for EGFR-sensitive mutations.

Published
2018
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14. Discovery of widespread non-metastable ammonia masers in the Milky Way

Author

Yan, Y. T., Henkel, C., Menten, K. M., Wilson, T. L., Wootten, A., Gong, Y., Wyrowski, F., Yang, W., Brunthaler, A., Kraus, A., and Winkel, B.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present the results of a search for ammonia maser emission in 119 Galactic high-mass star-forming regions (HMSFRs) known to host 22 GHz H$_2$O maser emission. Our survey has led to the discovery of non-metastable NH$_3$ inversion line masers toward 14 of these sources. This doubles the number of known non-metastable ammonia masers in our Galaxy, including nine new very high excitation ($J,K$)~=~(9,6) maser sources. These maser lines, including NH$_3$ (5,4), (6,4), (6,5), (7,6), (8,6), (9,6), (9,8), (10,8), and (11,9), arise from energy levels of 342 K, 513 K, 465 K, 606 K, 834 K, 1090 K, 942 K, 1226 K, and 1449 K above the ground state. Additionally, we tentatively report a new metastable NH$_3$ (3,3) maser in G048.49 and an NH$_3$ (7,7) maser in G029.95. Our observations reveal that all of the newly detected NH$_3$ maser lines exhibit either blueshifted or redshifted velocities with respect to the source systemic velocities. Among the non-metastable ammonia maser lines, larger velocity distributions, offset from the source systemic velocities, are found in the ortho-NH$_3$ ($K=3n$) than in the para-NH$_3$ ($K\neq3n$) transitions., Comment: 14 pages, 4 tables, 9 figures. Accepted for publication in A&A

Published
2024
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19. Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of External Ventricular and Lumbar Drainage-Associated Ventriculitis and Meningitis

Author

Lingye Qian, Yijun Shi, Fangqiang Li, Yufei Wang, Miao Ma, Yanfang Zhang, Yang W. Shao, Guanghui Zheng, and Guojun Zhang

Subjects
metagenomic next-generation sequencing (mNGS), diagnosis, EVD, LD, ventriculitis and meningitis, Microbiology, QR1-502
Abstract

Metagenomic next-generation sequencing (mNGS) has become a widely used technology that can accurately detect individual pathogens. This prospective study was performed between February 2019 and September 2019 in one of the largest clinical neurosurgery centers in China. The study aimed to evaluate the performance of mNGS on cerebrospinal fluid (CSF) from neurosurgical patients for the diagnosis of external ventricular and lumbar drainage (EVD/LD)-associated ventriculitis and meningitis (VM). We collected CSF specimens from neurosurgical patients with EVD/LD for more than 24 h to perform conventional microbiological studies and mNGS analyses in a pairwise manner. We also investigated the usefulness of mNGS of CSF for the diagnosis of EVD/LD-associated VM. In total, 102 patients were enrolled in this study and divided into three groups, including confirmed VM (cVM) (39), suspected VM (sVM) (49), and non-VM (nVM) (14) groups. Of all the patients, mNGS detected 21 Gram-positive bacteria, 20 Gram-negative bacteria, and five fungi. The three primary bacteria detected were Staphylococcus epidermidis (9), Acinetobacter baumannii (5), and Staphylococcus aureus (3). The mNGS-positive coincidence rate of confirmed EVD/LD-associated VM was 61.54% (24/39), and the negative coincidence rate of the nVM group was 100% (14/14). Of 15 VM pathogens not identified by mNGS in the cVM group, eight were negative with mNGS and seven were inconsistent with the conventional microbiological identification results. In addition, mNGS identified pathogens in 22 cases that were negative using conventional methods; of them, 10 patients received a favorable clinical treatment; thus, showing the benefit of mNGS-guided therapy.

Published
2020
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20. Durable Complete Response to Alectinib in a Lung Adenocarcinoma Patient With Brain Metastases and Low-Abundance EML4-ALK Variant in Liquid Biopsy: A Case Report

Author

Yingying Zhu, Ran Jia, Yang W. Shao, Liuqing Zhu, Qiuxiang Ou, Man Yu, Xue Wu, and Yanbei Zhang

Subjects
lung adenocarcinoma, ALK rearrangement, alectinib, liquid biopsy, brain metastases, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

EML4-ALK fusions are targetable oncogenic drivers in a subset of advanced non-small cell lung cancer (NSCLC) patients that can benefit from selected ALK inhibitors. Precise detection of ALK fusions may yield critical information for selection of appropriate therapy and hence improve patient survival. Analysis of circulating tumor DNA (ctDNA) in liquid biopsies using next generation sequencing (NGS) prior to or during treatment hold great promise for disease monitoring and treatment guidance of various cancers including NSCLC. Herein, we report a case of a 21-year-old advanced lung adenocarcinoma patient with a low abundance (0.03%) of EML4-ALK rearrangement identified in plasma ctDNA upon progression on two lines of chemotherapy that demonstrated long-term complete response to alectinib (>13 months) including metastatic brain tumors. Patient's clinical and pathologic characteristics, computerized tomography (CT) scans and brain magnetic resonance imaging (MRI) were reviewed retrospectively. Taken together, our report not only reinforces the translational utility of NGS-based genomic sequencing of liquid biopsy in guiding clinical practice, but also highlights the superior efficacy of alectinib than chemotherapy in ALK+ NSCLC with brain metastases, albeit at a low variant allele abundance.

Published
2020
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22. SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

Author

Zhu Mei, Yang W. Shao, Peinan Lin, Xiaomin Cai, Biao Wang, Yan Ding, Xiangyuan Ma, Xue Wu, Yewei Xia, Dongqin Zhu, Yongqian Shu, Zan Fu, and Yanhong Gu

Subjects
SMAD4, NF1, Metastatic colorectal cancer, Cetuximab, Prognosis, Next-generation sequencing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Cetuximab, an anti-EGFR monoclonal antibody, is used in combination with chemotherapy in clinic to enhance the outcome in metastatic colorectal cancer (mCRC) patients with only ~ 20% response rate. To date only activating mutations in KRAS and NRAS have been identified as poor prognosis biomarkers in cetuximab-based treatment, which makes an urgent need for identification of novel prognosis biomarkers to precisely predict patients’ response in order to maximize the benefit. Methods In this study, we analysed the mutation profiles of 33 Chinese mCRC patients using comprehensive next-generation sequencing (NGS) targeting 416 cancer-relevant genes before cetuximab treatment. Upon receiving cetuximab-based therapy, patients were evaluated for drug response, and the progression-free survival (PFS) was monitored. The association of specific genetic alterations and cetuximab efficacy was analyzed. Results Patients carrying SMAD4 mutations (SMAD4 mut, n = 8) or NF1 mutations (NF1 mut, n = 4) had significantly shorter PFS comparing to those carrying wildtype SMAD4 (SMAD4 wt, n = 25) (P = 0.0081) or wildtype NF1 (NF1 wt, n = 29) (P = 0.0028), respectively. None of the SMAD4 mut or NF1 mut patients showed response to cetuximab when assessed at 12-week post-treatment. Interestingly, two patients carrying both SMAD4 mut and NF1 mut showed the shortest PFS among all the patients. Conclusions Our results demonstrated that SMAD4 and NF1 mutations can serve as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese mCRC patients.

Published
2018
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23. Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

Author

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, and Weimin Mao

Subjects
Esophageal sarcomatoid carcinoma, Next generation sequencing, Mutation profiling, Targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown. Methods Here we performed targeted next generation sequencing (NGS) on a pan-cancer gene panel in 15 ESC tumors to explore their genetic alterations, and aimed to identify clinically actionable mutations for future treatment instructions. Results TP53 alterations were identified in all patients. Alterations in receptor tyrosine kinases (RTK) were identified in 10 out of 15 patients. Members of downstream RAS and PI3-kinase pathways are also mutated in 10 patients, and PIK3CA is the top mutated gene in these pathways. In addition, we identified mutations on histone modification genes in 5 patients, including histone acetyltransferase gene EP300 and its homologue CREBBP, lysine methyltransferase genes KMT2A and KMT2B, and lysine demethylase gene KDM5A. Finally, mismatch repair (MMR) genes and proofreading gene POLE all together were mutated in one third of the ESC patients. Conclusions This is the first study to unravel the mutational profile of ESC tumors. Our findings could match 9 patients to the targeted therapies currently available in clinical practice or in active clinical trials, suggesting the potential utility of targeted therapies for this rare disease in the future.

Published
2018
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24. Hidden mechanical oscillatory state in a carbon nanotube revealed by noise

Author

Belardinelli, P., Yang, W., Bachtold, A., Dykman, M. I., and Alijani, F.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Carbon nanotubes are devices of choice for investigating the interplay between electronic transport and nanomechanical motion. In this work, we report the co-existence of thermal vibrations and large-amplitude self-sustained oscillations in a carbon nanotube that originates from electron tunneling and thermal effects. The measured transitions between the two states are described by a Poisson process, revealing that the interstate switching is induced by noise. We observe the coexistence of the stable low-amplitude thermal state and the stable large-amplitude state (limit cycle) over a finite parameter range, which points to an isola bifurcation. We propose a minimalistic model based on nonlinear friction to account for the isola. Our work provides evidence for a new type of bifurcation leading to self-sustained oscillations that largely differs from the classical Hopf bifurcation, since these large-amplitude oscillations are a hidden state that can be unveiled via stochastic switching. We envision that this new dynamical regime and the means to reveal it will be of interest for various mesoscopic vibrational systems.

Published
2023

25. Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types

Author

Yongqian Shu, Xue Wu, Xiaoling Tong, Xiaonan Wang, Zhili Chang, Yu Mao, Xiaofeng Chen, Jing Sun, Zhenxin Wang, Zhuan Hong, Liangjun Zhu, Chunrong Zhu, Jun Chen, Ying Liang, Huawu Shao, and Yang W. Shao

Subjects
Medicine, Science
Abstract

Abstract Cancer is a disease of complex genetic alterations, and comprehensive genetic diagnosis is beneficial to match each patient to appropriate therapy. However, acquisition of representative tumor samples is invasive and sometimes impossible. Circulating tumor DNA (ctDNA) is a promising tool to use as a non-invasive biomarker for cancer mutation profiling. Here we implemented targeted next generation sequencing (NGS) with a customized gene panel of 382 cancer-relevant genes on 605 ctDNA samples in multiple cancer types. Overall, tumor-specific mutations were identified in 87% of ctDNA samples, with mutation spectra highly concordant with their matched tumor tissues. 71% of patients had at least one clinically-actionable mutation, 76% of which have suggested drugs approved or in clinical trials. In particular, our study reveals a unique mutation spectrum in Chinese lung cancer patients which could be used to guide treatment decisions and monitor drug-resistant mutations. Taken together, our study demonstrated the feasibility of clinically-useful targeted NGS-based ctDNA mutation profiling to guide treatment decisions in cancer.

Published
2017
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26. Enhanced electrochemical performances of LiNi0.5Mn1.5O4 by surface modification with Cu nanoparticles

Author

Zhao G., Lin Y., Zhu W., Yang W., and Huang Z.

Subjects
Lithium-ion battery, Cathode, Surface modification, LiNi0.5Mn1.5O4, Mining engineering. Metallurgy, TN1-997
Abstract

5V spinel LiNi0.5Mn1.5O4 cathode is prepared by traditional solid-state method and nano-Cu particles were derived from a chemical reduction process. The effect of Cu-coating on the electrochemical performances of LiNi0.5Mn1.5O4 cells, in a wide operation temperature range (-10°C, 25°C, 60°C), is investigated systematically by the charge/discharge testing, cyclic voltammograms and impedance spectroscopy, respectively. The results demonstrate that the modified material exhibits remarkably enhanced electrochemical reversibility and stability. Cu-coated material has much lower surface and charge transfer resistances and shows a higher lithium diffusion rate. The Cu coating layer as a highly efficient lithium ion conductor, acted as a highly efficient protector to restrain the contact loss.

Published
2017
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27. Dual-targeting strategy using trastuzumab and lapatinib in a patient with HER2 gene amplification in recurrent metachronous metastatic gallbladder carcinoma

Author

Minfeng Ye, Jieqing Lv, Guangen Xu, Wei Wang, Yuanming Jing, Aijing Sun, Zengxin Lu, Xue Wu, Yichuan Liu, Yang W. Shao, Fang Liu, and Feng Tao

Subjects
Medicine (General), R5-920
Abstract

Gallbladder carcinoma (GBC) is a rare and highly aggressive tumor. Early diagnosis is challenging, which results in a poor prognosis using systemic therapy. Recent studies have identified a subset of GBC patients with HER2 gene (ERBB2) amplification that could benefit from HER2-targeted therapy. Here, we report one patient with recurrent metachronous GBC with metastasis, who received the combination of trastuzumab and lapatinib. This approach achieved a partial response for both the brain and the lung metastases. This study demonstrated that HER2 inhibition is a promising therapeutic strategy for GBC with HER2 amplification and, combined with lapatinib, it can effectively target brain metastasis.

Published
2019
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32. Sulfur isotope ratios in the Large Magellanic Cloud

Author

Gong, Y., Henkel, C., Menten, K. M., Chen, C. -H. R., Zhang, Z. Y., Yan, Y. T., Weiss, A., Langer, N., Wang, J. Z., Mao, R. Q., Tang, X. D., Yang, W., Ao, Y. P., and Wang, M.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Sulfur isotope ratios have emerged as a promising tool for tracing stellar nucleosynthesis, quantifying stellar populations, and investigating the chemical evolution of galaxies. While extensively studied in the Milky Way, in extragalactic environments they remain largely unexplored. We focus on investigating the sulfur isotope ratios in the Large Magellanic Cloud (LMC) to gain insights into sulfur enrichment in this nearby system and to establish benchmarks for such ratios in metal-poor galaxies. We conducted pointed observations of CS and its isotopologues toward N113, one of the most prominent star-formation regions in the LMC, utilizing the Atacama Pathfinder EXperiment 12~m telescope. We present the first robust detection of C$^{33}$S in the LMC by successfully identifying two C$^{33}$S transitions on a large scale of $\sim$5 pc. Our measurements result in an accurate determination of the $^{34}$S/$^{33}$S isotope ratio, which is 2.0$\pm$0.2. Our comparative analysis indicates that the $^{32}$S/$^{33}$S and $^{34}$S/$^{33}$S isotope ratios are about a factor of 2 lower in the LMC than in the Milky Way. Our findings suggest that the low $^{34}$S/$^{33}$S isotope ratio in the LMC can be attributed to a combination of the age effect, low metallicity, and star formation history., Comment: 6 pages, 1 figures, 2 tables, accepted for publication in A&A, adjusted to the final version

Published
2023
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33. Protonated hydrogen cyanide as a tracer of pristine molecular gas

Author

Gong, Y., Du, F. J., Henkel, C., Jacob, A. M., Belloche, A., Wang, J. Z., Menten, K. M., Yang, W., Quan, D. H., Bop, C. T., Ortiz-León, G. N., Tang, X. D., Rugel, M. R., and Liu, S.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Protonated hydrogen cyanide, HCNH$^{+}$, plays a fundamental role in astrochemistry because it is an intermediary in gas-phase ion-neutral reactions within cold molecular clouds. However, the impact of the environment on the chemistry of HCNH$^{+}$ remains poorly understood. With the IRAM-30 m and APEX-12 m observations, we report the first robust distribution of HCNH$^{+}$ in the Serpens filament and in Serpens South. Our data suggest that HCNH$^{+}$ is abundant in cold and quiescent regions, but is deficit in active star-forming regions. The observed HCNH$^{+}$ fractional abundances relative to H$_{2}$ range from $3.1\times 10^{-11}$ in protostellar cores to $5.9\times 10^{-10}$ in prestellar cores, and the HCNH$^{+}$ abundance generally decreases with increasing H$_{2}$ column density, which suggests that HCNH$^{+}$ coevolves with cloud cores. Our observations and modeling results suggest that the abundance of HCNH$^{+}$ in cold molecular clouds is strongly dependent on the H$_{2}$ number density. The decrease in the abundance of HCNH$^{+}$ is caused by the fact that its main precursors (e.g., HCN and HNC) undergo freeze-out as the number density of H$_{2}$ increases. However, current chemical models cannot explain other observed trends, such as the fact that the abundance of HCNH$^{+}$ shows an anti-correlation with that of HCN and HNC, but a positive correlation with that of N$_{2}$H$^{+}$ in the southern part of the Serpens South northern clump. This indicates that additional chemical pathways have to be invoked for the formation of HCNH$^{+}$ via molecules like N$_{2}$ in regions in which HCN and HNC freeze out. Both the fact that HCNH$^{+}$ is most abundant in molecular cores prior to gravitational collapse and the fact that low-$J$ HCNH$^{+}$ transitions have very low H$_{2}$ critical densities make this molecular ion an excellent probe of pristine molecular gas., Comment: 25 pages, 26 figures, accepted for publication in A&A

Published
2023
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34. A Case of Adult Hereditary Spherocytosis Concomitant with Gilbert Syndrome Caused by Mutations in SPTB and UGT1A1

Author

Gou Y, Wang P, Yang W, Feng Y, Peng X, Liu H, Liu S, and Zhang X

Subjects
hereditary spherocytosis, gilbert syndrome, sptb, ugt1a1, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Yang Gou,1,2 Ping Wang,1,2 Wucheng Yang,1,2 Yimei Feng,1,2 Xiangui Peng,1,2 Hong Liu,1,2 Shuiqing Liu,1,2 Xi Zhang1,2 1Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, People’s Republic of China; 2Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, People’s Republic of ChinaCorrespondence: Hong Liu; Shuiqing Liu, Email 1241580141@qq.com; liushuiqing062@tmmu.edu.cnAbstract: Hereditary spherocytosis (HS) is the most common hereditary hemolytic disease with defects in red blood cells (RBC) membrane proteins caused by mutations in membrane protein genes, like SPTB, SPTA1 and ANK1. Gilbert syndrome (GS) is a disease characterized by a mild deficiency of uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) enzyme activity and unconjugated hyperbilirubinemia, largely caused by UGT1A1 mutations. The two inherited diseases HS and GS are rarely occurred in the same patient and are easy to be misdiagnosed, resulting in excessive diagnosis and treatment. Here, we report a rare case of HS combined with GS due to mutations in the SPTB and UGT1A1 genes. A 50-year-old man who had an over 40-year history of jaundice was admitted to our hospital owing to fatigue and fever. His blood analysis showed low hemoglobin (74 g/L), high reticulocyte (23.5%) and high serum bilirubin (65 μmol/L); abdominal ultrasound revealed calculous cholecystitis and splenomegaly. Considering a possible diagnosis of hemolytic anemia, further examinations showed 42% spherocytes in blood smears and high erythroid lineage hyperplasia in bone marrow. Subsequently, 151 jaundice-related genes panel sequencing was done and results showed SPTB p.N1260fs and UGT1A1 p.G71R mutations. Then the patient was diagnosed with HS complicated with GS. Anti-infection and supportive treatments were providing to the patient, while infection removed, the hemoglobin recovered to normal, and no additional treatment was given. These findings of this report indicate that patients who are considered hemolytic anemia presenting with jaundice and anemia, genetic testing is a crucial method for the final diagnosis and bilirubin metabolic disease should also be concerned.Keywords: hereditary spherocytosis, Gilbert syndrome, SPTB, UGT1A1

Published
2024

35. The semi-inclusive deeply inelastic scattering in the eN collinear frame

Author

Yang, W.

Subjects
High Energy Physics - Phenomenology
Abstract

The deeply inelastic scattering is one of the most important processes in studying the nucleon structure. Theoretical calculations for both the inclusive one and the semi-inclusive one are generally carried out in the virtual photon-nucleon collinear frame in which virtual photon does not have the transverse components. Expressions in this frame are written in relatively simple forms. Nevertheless, it is also meaningful to calculate the scattering process in the electron-nucleon collinear frame where new measurement schemes are obtained. In the present paper, we reconsider the semi-inclusive deeply inelastic scattering process in the electron-nucleon collinear frame and present the results of azimuthal asymmetries and quark intrinsic asymmetries. We find that the differential cross sections in these two frames are the same at leading twist level but different at higher twist level. Azimuthal asymmetries and intrinsic asymmetries in these two frames have the same forms but different kinematic factors. For the sake of completeness, both the electromagnetic and weak interactions are considered in our calculations. The neutral current measurements in the scattering process could be used as electroweak precision tests which can provide new accurate determinations of the electroweak couplings., Comment: 13 pages and 6 figures

Published
2023

36. ATLASGAL: 3-mm class I methanol masers in high-mass star formation regions

Author

Yang, W., Gong, Y., Menten, K. M., Urquhart, J. S., Henkel, C., Wyrowski, F., Csengeri, T., Ellingsen, S. P., Bemis, A. R., and Jang, J.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

We analyzed the 3-mm wavelength spectral line survey of 408 ATLASGAL clumps observed with the IRAM 30m-telescope, focusing on the class I methanol masers with frequencies near 84, 95 and 104.3 GHz. We detect narrow, maser-like features towards 54, 100 and 4 sources in the maser lines near 84, 95 and 104.3 GHz, respectively. Among them, fifty 84 GHz masers, twenty nine 95 GHz masers and four rare 104.3 GHz masers are new discoveries. The new detections increase the number of known 104.3 GHz masers from 5 to 9. The 95 GHz class I methanol maser is generally stronger than the 84 GHz maser counterpart. We find 9 sources showing class I methanol masers but no SiO emission, indicating that class I methanol masers might be the only signpost of protostellar outflow activity in extremely embedded objects at the earliest evolutionary stage. Class I methanol masers that are associated with sources that show SiO line wings are more numerous and stronger than those without such wings. The total integrated intensity of class I methanol masers is well correlated with the integrated intensity and velocity coverage of the SiO (2--1) emission. The properties of class I methanol masers are positively correlated with the bolometric luminosity, clump mass, peak H$_2$ column density of their associated clumps but uncorrelated with the luminosity-to-mass ratio, dust temperature, and mean H$_2$ volume density. We suggest that the properties of class I masers are related to shocks traced by SiO. Based on our observations, we conclude that class I methanol masers at 84 and 95 GHz can trace a similar evolutionary stage as H$_2$O maser, and appear prior to 6.7 and 12.2 GHz methanol and OH masers. Despite their small number, the 104.3 GHz class I masers appear to trace a short and more evolved stage compared to the other class I masers. [abridged], Comment: 23 pages, 27 figures, 8 tables, accepted for publication in A&A

Published
2023
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37. The Effelsberg survey of FU~Orionis and EX~Lupi objects II. -- H$_2$O maser observations

Author

Szabó, Zs. M., Gong, Y., Yang, W., Menten, K. M., Bayandina, O. S., Cyganowski, C. J., Kóspál, Á., Ábrahám, P., Belloche, A., and Wyrowski, F.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

FU Orionis (FUor) and EX Lupi (EXor) type objects are two groups of peculiar and rare pre-main sequence low-mass stars that are undergoing powerful accretion outbursts during their early stellar evolution. Water masers are widespread in star forming regions and are powerful probes of mass accretion and ejection, but little is known about the prevalence of them toward FUors/EXors. We perform the first systematic search for the 22.2 GHz water maser line in FUors/EXors to determine its overall incidence to perform follow-up high angular resolution observations. We used the Effelsberg 100-m radio telescope to observe the 22.2 GHz H2O maser toward a sample of 51 objects. We detect 5 water masers; 3 are associated with eruptive stars, resulting in a 6% detection rate for eruptive sources. These detections include one EXor, V512 Per (also known as SVS 13 or SVS 13A), and two FUors, Z CMa and HH 354 IRS. This is the first reported detection of water maser emission towards HH 354 IRS. We detect water maser emission in our pointing towards the FUor binary RNO 1B/1C, which most likely originates from the nearby deeply embedded source IRAS 00338+6312 (~4'', from RNO 1B/1C). Emission was also detected from H$_2$O(B) (also known as SVS 13C), a Class 0 source ~30'', from the EXor V512 Per. The peak flux density of H$_2$O(B) in our observations, 498.7 Jy, is the highest observed to date. In addition to the two non-eruptive Class 0 sources (IRAS 00338+6312 and H$_2$O(B) /SVS 13C), we detect maser emission towards one Class 0/I (HH 354 IRS) and two Class I (V512 Per and Z CMa) eruptive stars. We demonstrate the presence of 22.2 GHz water maser emission in FUor/EXor systems, opening the way to radio interferometric observations to study these eruptive stars on small scales. Comparing our data with historical observations suggest that multiple water maser flares have occurred in both V512 Per and H$_2$O(B)., Comment: 12 pages, 8 figures, accepted for publication in Astronomy & Astrophysics

Published
2023
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38. Discovery of Two Cyclotron Resonance Scattering Features in X-ray Pulsar Cen X-3 by Insight-HXMT

Author

Yang, W., Wang, W., Liu, Q., Chen, X., Wu, H. J., Tian, P. F., and Chen, J. S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract

We present the results of the neutron star X-ray binary system Cen X-3 performed by $Insight$-HXMT with two observations during 2017 and 2018. During these two observations, the source reached a X-ray luminosity of $\sim 10^{38}$ erg s$^{-1}$ from 2 -- 105 keV. The analysis of the broadband X-ray spectrum reports the presence of two cyclotron resonance scattering features (CRSFs) with the fundamental line at $\sim$ 28 keV and the harmonic line at $\sim 47 $ keV. The multiple lines exist by fittings with different continuum models, like the absorbed NPEX model and a power-law with high energy exponential cutoff model. This is the first time that both fundamental and harmonic lines are detected in Cen X-3. We also show evidence of two cyclotron lines in the phase-resolved spectrum of Cen X-3. The CRSF and continuum spectral parameters show evolution with the pulse profile, and the two line centroid energy ratio does not change significantly and locates in a narrow value range of $1.6-1.7$ over the pulse phase. The implications of the discovering two cyclotron absorption features and phase-resolved spectral properties are discussed., Comment: 8 pages, MNRAS, 2023, 519, 5402-5409

Published
2023
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39. A phase Ib/II dose expansion study of subcutaneous sasanlimab in patients with locally advanced or metastatic non-small-cell lung cancer and urothelial carcinoma.

Author

Cho, B, Penkov, K, Bondarenko, I, Kurochkin, A, Pikiel, J, Ahn, H, Korożan, M, Osipov, M, Odintsova, S, Braiteh, F, Grilley-Olson, J, Lugowska, I, Bonato, V, Damore, M, Yang, W, Jacobs, I, Bowers, M, Li, M, Johnson, M, and Ribas, Antoni

Subjects
PD-1, non-small-cell lung cancer, phase I, sasanlimab, urothelial carcinoma, Humans, B7-H1 Antigen, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Immune Checkpoint Inhibitors, Lung Neoplasms, Urinary Bladder Neoplasms, Adolescent, Adult
Abstract

BACKGROUND: Sasanlimab is an antibody to the programmed cell death protein 1 receptor. We report updated data of subcutaneous sasanlimab in non-small-cell lung cancer (NSCLC) and urothelial carcinoma dose expansion cohorts from a first-in-human phase Ib/II study. PATIENTS AND METHODS: Patients were ≥18 years of age with NSCLC or urothelial carcinoma, and no prior immunotherapies, who progressed on or were intolerant to systemic therapy, or for whom systemic therapy was refused or unavailable. Patients received subcutaneous sasanlimab at 300 mg every 4 weeks (q4w). Primary objectives were to evaluate safety, tolerability, and clinical efficacy by objective response rate (ORR). RESULTS: Sixty-eight and 38 patients with NSCLC and urothelial carcinoma, respectively, received subcutaneous sasanlimab. Overall, sasanlimab was well tolerated; 13.2% of patients experienced grade ≥3 treatment-related adverse events. Confirmed ORR was 16.4% and 18.4% in the NSCLC and urothelial carcinoma cohorts, respectively. ORR was generally higher in patients with high programmed death-ligand 1 (PD-L1) expression (≥25%) and high tumor mutational burden (TMB; >75%). In the NSCLC and urothelial carcinoma cohorts, median progression-free survival (PFS) was 3.7 and 2.9 months, respectively; corresponding median overall survival (OS) was 14.7 and 10.9 months. Overall, longer median PFS and OS correlated with high PD-L1 expression and high TMB. Longer median PFS and OS were also associated with T-cell inflamed gene signature in the urothelial carcinoma cohort. CONCLUSIONS: Subcutaneous sasanlimab at 300 mg q4w was well tolerated with promising clinical efficacy observed. Phase II and III clinical trials of sasanlimab are ongoing to validate clinical benefit. Subcutaneous sasanlimab may be a potential treatment option for patients with NSCLC or urothelial carcinoma.

Published
2023

40. Effects of Grain Size on Deformation Inhomogeneity of Hot-Deformed AA7075

Author

Su, B. Y., Guo, N., Tang, B. T., Yang, W. X., Liu, G. Q., Liu, Z., Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Mocellin, Katia, editor, Bouchard, Pierre-Olivier, editor, Bigot, Régis, editor, and Balan, Tudor, editor

Published
2024
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43. A monitoring campaign (2013-2020) of ESA's Mars Express to study interplanetary plasma scintillation

Author

Kummamuru, P., Calvés, G. Molera, Cimò, G., Pogrebenko, S. V., Bocanegra-Bahamón, T. M., Duev, D. A., Said, M. D. Md, Edwards, J., Ma, M., Quick, J., Neidhardt, A., de Vicente, P., Haas, R., Kallunki, J., Maccaferri, 1 G., Colucci, G., Yang, W. J., Hao, L. F., Weston, S., Kharinov, M. A., Mikhailov, A. G., and Jung, T.

Subjects
Physics - Space Physics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The radio signal transmitted by the Mars Express (MEX) spacecraft was observed regularly between the years 2013-2020 at X-band (8.42 GHz) using the European Very Long Baseline Interferometry (EVN) network and University of Tasmania's telescopes. We present a method to describe the solar wind parameters by quantifying the effects of plasma on our radio signal. In doing so, we identify all the uncompensated effects on the radio signal and see which coronal processes drive them. From a technical standpoint, quantifying the effect of the plasma on the radio signal helps phase referencing for precision spacecraft tracking. The phase fluctuation of the signal was determined for Mars' orbit for solar elongation angles from 0 - 180 deg. The calculated phase residuals allow determination of the phase power spectrum. The total electron content (TEC) of the solar plasma along the line of sight is calculated by removing effects from mechanical and ionospheric noises. The spectral index was determined as $-2.43 \pm 0.11$ which is in agreement with Kolomogorov's turbulence. The theoretical models are consistent with observations at lower solar elongations however at higher solar elongation ($>$160 deg) we see the observed values to be higher. This can be caused when the uplink and downlink signals are positively correlated as a result of passing through identical plasma sheets., Comment: The paper has 13 figures and one table. It has been accepted for publication in PASA and the article will receive its DOI in a week's time

Published
2023
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44. Momentum-independent magnetic excitation continuum in the honeycomb iridate H$_3$LiIr$_2$O$_6$

Author

de la Torre, A., Zager, B., Bahrami, F., Upton, M. H., Kim, J., Fabbris, G., Lee, G. -H., Yang, W., Haskel, D., Tafti, F., and Plumb, K. W.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

In the search for realizations of Quantum Spin Liquids (QSL), it is essential to understand the interplay between inherent disorder and the correlated fluctuating spin ground state. H$_3$LiIr$_2$O$_6$ is regarded as a spin liquid proximate to the Kitaev-limit (KQSL) in which H zero-point motion and stacking faults are known to be present. Bond disorder has been invoked to account for the existence of unexpected low-energy spin excitations. Controversy remains about the nature of the underlying correlated state and if any KQSL physics survives. Here, we use resonant X-ray spectroscopies to map the collective excitations in H$_3$LiIr$_2$O$_6$ and characterize its magnetic state. We uncover a broad bandwidth and momentum-independent continuum of magnetic excitations at low temperatures that are distinct from the paramagnetic state. The center energy and high-energy tail of the continuum are consistent with expectations for dominant ferromagnetic Kitaev interactions between dynamically fluctuating spins. The absence of a momentum dependence to these excitations indicates a broken translational invariance. Our data support an interpretation of H$_3$LiIr$_2$O$_6$ as a disordered topological spin liquid in close proximity to bond-disordered versions of the KQSL. Our results shed light on how random disorder affects topological magnetic states and have implications for future experimental and theoretical works toward realizing the Kitaev model in condensed matter systems

Published
2023
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45. The Effelsberg survey of FU Orionis and EX Lupi objects I. -- Host environments of FUors/EXors traced by NH$_3$

Author

Szabó, Zs. M., Gong, Y., Menten, K. M., Yang, W., Cyganowski, C. J., Kóspál, Á., Ábrahám, P., Belloche, A., and Wyrowski, F.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

FU Orionis (FUor) and EX Lupi (EXor) type objects represent two small, but rather spectacular groups of low-mass, young eruptive stars. Outbursts of several magnitudes are observed, attributed to enhanced accretion from the circumstellar disk onto the central protostar. The host molecular environments of FUors/EXors are poorly explored due to the scarcity of systematic molecular line observations. We carried out the first dedicated survey of the molecular environments of a large sample of FUors/EXors, observing a total of 51 sources with the aim of studying the ammonia (NH$_3$) emission in their host environments. We observed the ammonia (J,K)=(1,1), (2,2), and (3,3) inversion transitions using the Effelsberg 100-m radio telescope. We derived H$_2$ column densities and dust temperatures using archival Herschel SPIRE data. We detected the (1,1) transition toward 28 sources and the (2,2) transition toward 12 sources, while the (3,3) transition was detected toward only two sources. We find kinetic temperatures between ~12 K and 21 K, ammonia column densities from $5.2\times10^{13}\,cm^{-2}$ to $3.2\times10^{15}\,cm^{-2}$, and fractional ammonia abundances with respect to H$_{2}$ from $4.7\times10^{-9}$ to $1.5\times10^{-7}$. The results are comparable to those found in infrared dark clouds (IRDCs). Kinetic analysis suggests that most of the eruptive stars in our sample reside in rather quiescent (sonic or transonic) host environments. Our NH$_3$ observations and analysis of the SPIRE dust-based H$_2$ column density maps confirm the presence of dense material toward 7 sources in our sample; additional sources might also harbour dense gas based on their NH$_2$ (2,2) detections, might indicate an earlier phase than originally classified. Based on our results, we suggest observations targeting additional molecular lines would help to refine the evolutionary classification of eruptive stars., Comment: 20 pages, 2 figures, accepted for publication in A&A

Published
2023
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47. Semi-inclusive deeply inelastic neutrino and antineutrino nucleus scattering

Author

Yang, X. and Yang, W.

Subjects
High Energy Physics - Phenomenology
Abstract

The (anti)neutrino nucleus scattering plays a very important role in probing the hadronic structure as well as the electroweak phenomenologies. To this end, we calculate the jet production semi-inclusive deeply inelastic (anti)neutrino nucleus scattering process. The initial (anti)neutrino is assumed to be scattered off by a target particle with spin 1. Due to the limitation of the factorization theorem, calculations are carried out in the quantum chromodynamics parton model framework up to tree level twist-3. We consider both the neutral current and the charged current processes and write them into a unified form due to the similar interaction forms. Considering the angular modulations and polarizations of the cross section, we calculate the complete azimuthal asymmetries. We also calculate the intrinsic asymmetries which reveal the imbalance in the distribution of the intrinsic transverse momentum of the quark. We find that these asymmetries can be expressed in terms of the transverse momentum-dependent parton distribution functions (TMD PDFs) and the electroweak couplings. With the determined couplings, these asymmetries can be used to extract the TMD PDFs and further to study the hadronic structures., Comment: 8 figures

Published
2022
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48. Nonlinear nanomechanical resonators approaching the quantum ground state

Author

Samanta, C., De Bonis, S. L., Møller, C. B., Tormo-Queralt, R., Yang, W., Urgell, C., Stamenic, B., Thibeault, B., Jin, Y., Czaplewski, D. A., Pistolesi, F., and Bachtold, A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

An open question in mechanics is whether mechanical resonators can be made nonlinear with vibrations approaching the quantum ground state. This requires engineering a mechanical nonlinearity far beyond what has been realized thus far. Here we discovered a mechanism to boost the Duffing nonlinearity by coupling the vibrations of a nanotube resonator to single-electron tunneling and by operating the system in the ultrastrong coupling regime. Remarkably, thermal vibrations become highly nonlinear when lowering the temperature. The average vibration amplitude at the lowest temperature is 13 times the zero-point motion, with approximately 42% of the thermal energy stored in the anharmonic part of the potential. Our work paves the way for realizing mechanical Schrodinger cat states [1], mechanical qubits [2, 3], and quantum simulators emulating the electron-phonon coupling [4].

Published
2022
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49. The hadron pair forward-backward asymmetry in the electron positron annihilation process

Author

Yang, W. and Li, C.

Subjects
High Energy Physics - Phenomenology
Abstract

The forward-backward asymmetry is an important measurable quantity which can enable independent determination of the neutral-current couplings of fermions. In this paper, we extend the definition of the asymmetry from the partonic level to the hadronic level by calculating this asymmetry of the hadron pair in the semi-inclusive electron position annihilation process. Semi-inclusive implies that a back-to-back jet is also measured in addition to the hadron pair. Due to the limitation of the factorization theorem, we calculate this process up to leading order twist-4 level by applying the collinear expansion formalism. After obtaining the differential cross section, we calculate the forward-backward asymmetries and show them in terms of the corresponding di-hadron fragmentation functions. Di-hadron fragmentation functions are introduced to describe the hadron pair productions in the fragmentation process. With available parameterization of the functions, we present a numerical estimation of the forward-backward asymmetry. On the flip side, measurements of the forward-backward asymmetry would give strict restrictions of parameterizations of the di-hadron fragmentation functions. We also present a numerical estimation of the twist-4 di-hadron fragmentation functions in order to illustrate their contributions., Comment: arXiv admin note: text overlap with arXiv:2205.04068

Published
2022
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50. Momentum-independent magnetic excitation continuum in the honeycomb iridate H3LiIr2O6

Author

de la Torre, A, Zager, B, Bahrami, F, Upton, MH, Kim, J, Fabbris, G, Lee, G-H, Yang, W, Haskel, D, Tafti, F, and Plumb, KW

Subjects
Quantum Physics, Physical Sciences
Abstract

Understanding the interplay between the inherent disorder and the correlated fluctuating-spin ground state is a key element in the search for quantum spin liquids. H3LiIr2O6 is considered to be a spin liquid that is proximate to the Kitaev-limit quantum spin liquid. Its ground state shows no magnetic order or spin freezing as expected for the spin liquid state. However, hydrogen zero-point motion and stacking faults are known to be present. The resulting bond disorder has been invoked to explain the existence of unexpected low-energy spin excitations, although data interpretation remains challenging. Here, we use resonant X-ray spectroscopies to map the collective excitations in H3LiIr2O6 and characterize its magnetic state. In the low-temperature correlated state, we reveal a broad bandwidth of magnetic excitations. The central energy and the high-energy tail of the continuum are consistent with expectations for dominant ferromagnetic Kitaev interactions between dynamically fluctuating spins. Furthermore, the absence of a momentum dependence to these excitations are consistent with disorder-induced broken translational invariance. Our low-energy data and the energy and width of the crystal field excitations support an interpretation of H3LiIr2O6 as a disordered topological spin liquid in close proximity to bond-disordered versions of the Kitaev quantum spin liquid.

Published
2023

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