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50 results on '"Yang, Tzu-Sen"'

21. Surface Properties and Biocompatibility of Anodized Titanium with a Potential Pretreatment for Biomedical Applications

Author

Huang, Bai-Hung, primary, Lu, Yi-Jung, additional, Lan, Wen-Chien, additional, Ruslin, Muhammad, additional, Lin, Hung-Yang, additional, Ou, Keng-Liang, additional, Saito, Takashi, additional, Tsai, Hsin-Yu, additional, Lee, Chen-Han, additional, Cho, Yung-Chieh, additional, Yang, Tzu-Sen, additional, Liu, Chung-Ming, additional, and Hou, Ping-Jen, additional

Published
2021
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23. An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model

Author

Syam, Syamsiah, primary, Chang, Chun-Wei, additional, Lan, Wen-Chien, additional, Ou, Keng-Liang, additional, Huang, Bai-Hung, additional, Lin, Yu-Yeong, additional, Saito, Takashi, additional, Tsai, Hsin-Yu, additional, Chuo, Yen-Chun, additional, Yang, Tzu-Sen, additional, Liu, Chung-Ming, additional, and Hou, Ping-Jen, additional

Published
2021
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27. Calcium Release from Different Toothpastes after the Incorporation of Tricalcium Phosphate and Amorphous Calcium Phosphate

Author

Hou, Ping-Jen, primary, Lee, Chang-Yu, additional, Ou, Keng-Liang, additional, Lan, Wen-Chien, additional, Chuo, Yen-Chun, additional, Lin, Hung-Yang, additional, Chao, Hsiao-Wei, additional, Huang, Bai-Hung, additional, Saito, Takashi, additional, Tsai, Hsin-Yu, additional, Yang, Tzu-Sen, additional, Walinski, Christopher J., additional, and Ruslin, Muhammad, additional

Published
2021
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28. A Tailored Biomimetic Hydrogel as Potential Bioink to Print a Cell Scaffold for Tissue Engineering Applications: Printability and Cell Viability Evaluation

Author

Chen, Shyuan-Yow, primary, Cho, Yung-Chieh, additional, Yang, Tzu-Sen, additional, Ou, Keng-Liang, additional, Lan, Wen-Chien, additional, Huang, Bai-Hung, additional, Saito, Takashi, additional, Tsai, Chi-Hsun, additional, Peng, Bou-Yue, additional, Chuo, Yen-Chun, additional, Lin, Hung-Yang, additional, Chao, Hsiao-Wei, additional, Walinski, Christopher J., additional, and Ruslin, Muhammad, additional

Published
2021
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31. Surfactin induces ER stress‐mediated apoptosis via IRE1‐ASK1‐JNK signaling in human osteosarcoma.

Author

Wang, Guo‐Shou, Chen, Ji‐Ying, Chen, Wei‐Cheng, Wei, I‐Chin, Lin, Szu‐Wei, Liao, Kuang‐Wen, Yang, Tzu‐Sen, and Liu, Ju‐Fang

Subjects
BCL-2 proteins, SURFACTIN, OSTEOSARCOMA, APOPTOSIS, DRUG resistance, TUMORS in children, YOUNG adults, GLUCOSE-regulated proteins
Abstract

Osteosarcoma, one of primary bone tumor in children and young adults, has poor prognosis and drug resistances to chemotherapy. In order to reinforce the conventional therapies and antagonize the osteosarcoma in patients, a novel strategy is required for developing a new treatment. In this study, surfactin, a natural product from Bacillus subtilis, showed the efficiency of cell death in osteosarcoma, but not in normal cells. Surfactin triggers ER stress mechanism by promoting the aberrant Ca2+ release from ER lumen and ER‐signaling to mitochondrial dysfunction following caspases activation mediating cell apoptosis. Surfactin‐induced ER stress not only upregulated of glucose‐regulated protein 78/94 and IRE1‐ASK1‐JNK pathway but also leading to calpains and Bcl‐2 proteins family involving the release of cytochrome c. The releases into cytosol trigger the cleavage of caspase‐9 and caspase‐3 to induce cell apoptosis. In this study, surfactin demonstrated the potential functions to trigger the ER stress, ER stress‐associated IRE1‐ASK1‐JNK signaling pathway, mitochondrial dysfunction, and caspase activations leading to programmed cell apoptosis. Importantly, implicating the signaling pathway that regulates the connection between ER stress and mitochondrial dysfunction causing apoptosis associated with surfactin. These results indicated a potential application of surfactin strengthen current conventional therapies. [ABSTRACT FROM AUTHOR]

Published
2022
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35. A Novel Sol-Gel Bi 2-x HfxO 3+x/2 Radiopacifier for Mineral Trioxide Aggregates (MTA) as Dental Filling Materials.

Author

Yang, Tzu-Sen, Chen, May-Show, Huang, Cheng-Jyun, Chen, Chin-Yi, Brangule, Agnese, Zarkov, Aleksej, Kareiva, Aivaras, Lin, Chung-Kwei, and Yang, Jen-Chang

Subjects
FILLER materials, MINERAL aggregates, DENTAL fillings, RADIOPACITY, DENTAL materials, CALCIUM sulfate, TRANSMISSION electron microscopy
Abstract

Mineral trioxide aggregate (MTA) is well known as an effective root canal filling material for endodontics therapy. Within MTA, bismuth oxide (Bi2O3) serving as the radiopacifier still has biocompatibility concerns due to its mild cytotoxicity. In the present study, we tried to modify the Bi2O3 radiopacifier by doping hafnium ions via the sol-gel process and investigated the effects of different doping ratios (Bi2-xHfxO3+x/2, x = 0–0.3) and calcination temperatures (400–800 °C). We mixed various precursor mixtures of bismuth nitrate (Bi(NO3)3·5H2O) and hafnium sulfate (Hf(SO4)2) and controlled the calcination temperatures. The as-prepared Hf-doped Bi2O3 radiopacifier powders were investigated by thermogravimetric analysis (TGA), X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Portland cement/radiopacifier/calcium sulfate (75/20/5) were mixed and set by deionized water (powder to water ratio = 3:1). Changes in radiopacity, diametral tensile strength (DTS), and in vitro cell viability of the hydrated MTA-like cement were carried out. The experimental results showed that the group containing radiopacifier from sol-gelled Bi/Hf (90/10) exhibited significantly higher radiopacity (6.36 ± 0.34 mmAl), DTS (2.54 ± 0.29 MPa), and cell viability (84.0±8.1%) (p < 0.05) when compared to that of Bi/Hf (100/0) powders. It is suggested that the formation of β-Bi7.78Hf0.22O12.11 phase with hafnium addition and calcining at 700 °C can prepare novel bismuth/hafnium composite powder that can be used as an alternative radiopacifier for root canal filling materials. [ABSTRACT FROM AUTHOR]

Published
2021
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39. The preferential accumulation and the settling velocity of small heavy particles in Taylor–Couette flows

Author

Yang, Tzu-Sen and Shy, Shenqyang (Steven)

Abstract

In a gap between two concentric cylinders, we discover that the small heavy particle settling velocity (Vs) is greater than its associated terminal velocity (Vt) in featureless turbulence that is generated by counter-rotating inner and outer cylinders simultaneously. The peak enhancement of Vsoccurs at St× (Vt/u′) ∼ 1, where u′and Stare, respectively, the r.m.s. turbulence fluctuation velocity and the Stokes number defined as the ratio between the particle response time to the Kolmogorov turbulence time. The present (Vs− Vt)/u′ data as a function of St measured by the high-speed particle imaging velocimetry are compared with previous experimental results obtained from different turbulent flow configurations in an attempt to gain further understandings of the complicated interactions between small heavy particles and featureless turbulence with negligible mean velocities. Moreover, it is found that small heavy particles are preferentially accumulated around the edges of an array of counter-rotating turbulent Taylor vortices with the inner cylinder rotation alone when a time ratio between particle response and Taylor vortices is near unity. These experimental results are interesting that may deserve to disseminate in our fluid mechanics community.

Published
2020
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40. Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size

Author

Tsai,Dah-Shyang, Yang,Tzu-Sen, Huang,Yu-Sheng, Peng,Pei-Wen, Ou,Keng-Liang, Tsai,Dah-Shyang, Yang,Tzu-Sen, Huang,Yu-Sheng, Peng,Pei-Wen, and Ou,Keng-Liang

Abstract

Dah-Shyang Tsai,1 Tzu-Sen Yang,2,3 Yu-Sheng Huang,1 Pei-Wen Peng,2,4 Keng-Liang Ou3,4 1Department of Chemical Engineering, National Taiwan University of Science and Technology, 2School of Dental Technology, 3Graduate Institute of Biomedical Materials and Tissue Engineering, 4Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan Abstract: Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8–9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level. Keywords: ceria nanoparticle, antibacterial activity, cytotoxicity, oxygen vacancy, reactive oxygen species

Published
2016

47. Correction: Ou et al. Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute. Appl. Sci. 2020, 10 , 6239.

Author

Ou, Keng-Liang, Hou, Ping-Jen, Huang, Bai-Hung, Chou, Hsin-Hua, Yang, Tzu-Sen, Huang, Chiung-Fang, and Ueno, Takaaki

Subjects
BONE substitutes, BONE grafting, RABBITS, BONE regeneration, TOMOGRAPHY
Abstract

Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute. Reference 1 Ou K.-L., Hou P.-J., Huang B.-H., Chou H.-H., Yang T.-S., Huang C.-F., Ueno T. Bone Healing and Regeneration Potential in Rabbit Cortical Defects Using an Innovative Bioceramic Bone Graft Substitute. The authors declare that this correction does not change the micro-computed tomographic analysis results and statements in the Results and Discussion sections of the research paper I Appl. Sci i . [Extracted from the article]

Published
2022
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48. Comparative In Vitro Osteoinductivity Study of HA and α- TCP/ HA Bicalcium Phosphate.

Author

Chan, Yu‐Hao, Chang, Yushan‐Sophie, Shen, Yun‐Dun, Yang, Tzu‐Sen, Ou, Shih‐Fu, Hsu, Ya‐Ju, Huang, Mao‐Suan, and Ou, Keng‐Liang

Subjects
OSTEOINDUCTION, HYDROXYAPATITE, CALCIUM phosphate, BIOCERAMICS, CHEMICAL sample preparation, SINTERING
Abstract

A bicalcium phosphate ( BCP) bioceramic comprising α-tricalcium phosphate (α- TCP) and hydroxyapatite ( HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising α- TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Disinfection effects of undoped and silver-doped ceria powders of nanometer crystallite size.

Author

Tsai DS, Yang TS, Huang YS, Peng PW, and Ou KL

Subjects
Anti-Infective Agents pharmacology, Crystallization, Dynamic Light Scattering, Escherichia coli drug effects, Escherichia coli growth & development, Ions, Microbial Sensitivity Tests, Microbial Viability drug effects, Microscopy, Fluorescence, Nephelometry and Turbidimetry, Powders, Spectrum Analysis, Raman, Staphylococcus aureus drug effects, Staphylococcus aureus growth & development, Cerium pharmacology, Disinfection methods, Nanoparticles chemistry, Particle Size, Silver pharmacology
Abstract

Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8-9 nm in size using an inexpensive precipitation method and evaluated their disinfecting aptitudes with the turbidimetric and plate count methods. Among the samples being analyzed, the silver-doped ceria exhibits the highest sterilization ability, yet the undoped ceria is the most intriguing. The disinfection effect of undoped ceria is moderate in magnitude, demanding a physical contact between the ceria surface and bacteria cell wall, or the redox catalysis that can damage the cell wall and result in the cell killing. Evidently, this effect is short-range and depends strongly on dispersion of the nanoparticles. In contrast, the disinfection effects of silver-doped ceria reach out several millimeters since it releases silver ions to poison the surrounding microorganisms. Additionally, the aliovalent silver substitution creates more ceria defects. The synergetic combination, silver poisoning and heterogeneous redox catalysis, lifts and extends the disinfecting capability of silver-doped ceria to a superior level.

Published
2016
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50. An RFID-based on-lens sensor system for long-term IOP monitoring.

Author

Hsu SH, Chiou JC, Liao YT, Yang TS, Kuei CK, Wu TW, and Huang YC

Subjects
Equipment Design, Monitoring, Ambulatory instrumentation, Radio Frequency Identification Device, Tonometry, Ocular instrumentation, Wireless Technology instrumentation
Abstract

In this paper, an RFID-based on-lens sensor system is proposed for noninvasive long-term intraocular pressure monitoring. The proposed sensor IC, fabricated in a 0.18um CMOS process, consists of capacitive sensor readout circuitry, RFID communication circuits, and digital processing units. The sensor IC is integrated with electroplating capacitive sensors and a receiving antenna on the contact lens. The sensor IC can be wirelessly powered, communicate with RFID compatible equipment, and perform IOP measurement using on-lens capacitive sensor continuously from a 2cm distance while the incident power from an RFID reader is 20 dBm. The proposed system is compatible to Gen2 RFID protocol, extending the flexibility and reducing the self-developed firmware efforts.

Published
2015
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