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BACKGROUND: Autism spectrum disorder is characterized by atypical developmental changes during brain maturation, but regional brain functional changes that occur with age and across different frequency bands are unknown. Therefore, the current study aimed to explore potential age and frequency band-related changes in the regional brain activities in autism. METHODS: A total of 65 participants who met the DSM-IV criteria for autistic disorder and 55 typically developed (TD) participants (both age 6–30 years) were recruited in the current study. The two groups were matched in age (t=−1.314, P=0.191) and gender (χ(2)=2.760, P=0.097). The amplitude of low-frequency fluctuations (ALFF) was employed to explore the effect of development on spontaneous brain activity in individuals with autism and in TD participants across slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), and slow-3 (0.073–0.1 Hz) frequency bands. The diagnosis-by-age interaction effect in the whole brain voxels in autism and TD groups was investigated. RESULTS: Autism individuals showed significantly higher ALFF in the dorsal striatum in childhood (Caudate cluster: t=3.626, P=0.001; Putamen cluster: t=2.839, P=0.007) and remarkably lower ALFF in the dorsal striatum in adulthood (Caudate cluster: t=−2.198, P=0.038; Putamen cluster: t=−2.314, P=0.030) relative to TD, while no significant differences were observed in adolescence (all P>0.05). In addition, abnormal ALFF amplitudes were specific to the slow-4 (0.027–0.073 Hz) frequency band in the clusters above. CONCLUSIONS: The current study indicated abnormal development patterns in the spontaneous activity of the dorsal striatum in autism and highlighted the potential role of the slow-4 frequency band in the pathology of autism. Also, the potential brain mechanism of autism was revealed, suggesting that autism-related variations should be investigated in a specific frequency.

The efficacy and safety of proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease (ASCVD).This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention (PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events (MACE) over six months were compared between two groups. A propensity score-matched (PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol (LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81% (In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study.

Background The efficacy and safety of PCSK-9 inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China is unknown. Objective To describe the real world effectiveness of initiated with PCSK-9 inhibitors combined with statins compared with statins among patients with very high risk of ASCVD and underwent percutaneous coronary intervention (PCI). Methods This is a prospective study, enrolled patients from 32 hospitals between January to June 2019. The lipid control rate and incidence of cardiovascular events over 6 months were compared between two groups. A propensity score-matched analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for cardiovascular events. Results In a total of 3063 patients, 89.91% had received moderate or high-intensity statin therapy before PCI, but only 9.47% had LDL levels below 1.4mmol/L at baseline. In the PSM selected patients, LDL level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81% (P

Source camera identification has been well studied in laboratory environment where the training and test samples are all original images without recompression. However, image compression is quite common in the real world, when the training and test images are double JPEG compressed with different quantization tables, the identification accuracy of existing methods decreases dramati- cally. To address this challenge, we propose a novel iterative algorithm namely joint first and second order statistics matching (JSM) to learn a feature projection that projects the training and test fea- tures into a low dimensional subspace to reduce the shift caused by image recompression. Inspired by transfer learning, JSM aims to learn a new feature representation from original feature space by simultaneously matching the first and second order statistics between training and test features in a principled dimensionality reduction procedure. After the feature projection, the divergence between training and test features caused by recompression is reduced while the discriminative properties are preserved. Extensive experiments on public Dresden Image Database verify that JSM significantly outperforms several state-of-the-art methods on camera model identification of recompressed images.

Transparent conductive Al-doped ZnO (AZO) thin films used as transparent conductive oxide (TCO) electrode layers for thin film solar cells were deposited on quartz substrate by radio frequency (RF) magnetron sputtering. After deposition, the samples were annealed at various temperatures. The structural, electrical, and optical properties of these films have been analyzed as a function of the annealing temperature. All of these samples exhibit strong (002) diffraction peaks and the average transmittance in visible range is about 85%. The crystallinity of films together with some changes of the electrical resistance has been improved after thermal annealing. The best characteristics have been obtained at 400 °C, where the lowest resistivity is 2.4×10-3 Ω cm and the optical band gap is 3.22 eV.

An actinomycete, strain D34T, was isolated from a soil sample collected from the rhizosphere of Stipa grandis at Yunwu Mountain in Ningxia, north-west China. Strain D34T showed highest 16S rRNA gene sequence similarity to Saccharothrix espanaensis DSM 44229T (99.0 %), Saccharothrix texasensis NRRL B-16107T (98.7 %) and Saccharothrix variisporea NRRL B-16296T (98.6 %). The strain contained meso-diaminopimelic acid, alanine, glycine and glutamic acid as major cell-wall amino acids. Mannose, rhamnose and galactose were the characteristic whole-cell sugars. The fatty acid profile consisted predominantly of iso-C15 : 0, iso-C16 : 0, iso-C16 : 1, C17 : 1ω6c, anteiso-C17 : 0 and anteiso-C15 : 0. The phospholipid profile included phosphatidylethanolamine (typical of phospholipid pattern type II). Furthermore, a combination of some physiological and biochemical properties and low DNA–DNA relatedness values indicated that strain D34T was differentiated from members of closely related species. On the basis of these phenotypic, genotypic and chemotaxonomic data, strain D34T represents a novel species of the genus Saccharothrix, for which the name Saccharothrix stipae sp. nov. is proposed. The type strain is D34T ( = JCM 30560T = ACCC19714T).

Although many studies have focused on abnormal patterns of brain functional connectivity in Autism spectrum disorder (ASD), one important factor, the developmental effect of brain networks was largely overlooked. To clarify the abnormal developmental trajectory of brain functional connectivity in ASD, we focused on the age-related changes in three “core” neurocognitive networks: default mode network (DMN), salience network (SN) and central executive network (CEN, also divided into left and right CEN, i.e., lCEN and rCEN). The development of intrinsic functional connectivity (iFC) within and between these networks were analyzed in 107 Chinese participants, including children, adolescents, and adults (54 patients with ASD and 53 typically developed (TD) participants; ages 6-30 years). We found that diagnosis-related distinctions in age-related changes suggest three maturation patterns in networks’ or nodes’ iFC: delayed (iFC between SN and rCEN), ectopic (iFC between SN and DMN, and iFC between posterior cingulate cortex (PCC) and right anterior insula/dorsal anterior cingulate cortex (dACC)), and failure maturation (iFC between dACC and ventral medial prefrontal cortex). Compared with age-matched TD participants, ASD patients in children and adolescents exhibited hypo-connectivity, while that in adults showed hyper-connectivity. In addition, an independent verification based on Autism Brain Imaging Data Exchange (ABIDE) datasets confirmed our findings of developmental trajectories in ASD group, which also showed unchanged functional connectivity with age between DMN and SN and increasing iFC between rCEN and SN. The conspicuous differences in the development of three “core” networks in ASD were demonstrated, which may lead a nuanced understanding towards the abnormal brain network maturation trajectory of autism.

Hyperlipidemia can be harmful to the pancreas and β3-adrenoceptor agonist can improve lipid metabolism disorder. We aimed to study the effects of β3-adrenoceptor activation on glucose, insulin and the expression of pancreatic adrenoceptors and angiotensin II receptors. Ten C57BL/6J mice at the age of 10 weeks served as normal control, and forty age-matched apolipoprotein E knockout (ApoE(-/-)) mice were randomly divided into hyperlipidaemia model group, low-dose and high-dose β3-adrenoceptor agonist group and β3-adrenoceptor antagonist group. After 26 weeks of high-fat diet, treatments were given for 12 weeks. Serum glucose and insulin levels in 48 weeks old mice were measured using an automatic biochemical detector. Quantitative rt-PCR and Western blot were used to analyze the mRNA and protein expression of α1A-, α2A-, β2-, β3-adrenoceptors and angiotensin II type 1 and type 2 receptors in pancreas. We found that β3-adrenoceptor agonist could decrease serum glucose and insulin levels in aged ApoE(-/-) mice (P0.01) and down-regulate the expression of α1A-adrenoceptor and angiotensin II type 1 receptor which were significantly increased in model mice (P0.05, P0.01). Compared with the model mice, α2A-, β2-, β3-adrenoceptor and angiotensin II type 2 receptor expression were up-regulated in β3-adrenoceptor agonist treat mice (P0.05, P0.01). These results suggest that chronic β3-adrenoceptor activation regulated the expression of adrenoceptors and angiontensin II receptors towards contrary direction, which indicates that there are interactions between β3-adrenoceptor and subtypes of adrenoceptor and angiotensin II receptor, and these interactions may play a protective role in pancreas and improve glucose metabolism disorders.

Objective To describe the revolution and research status of Advances in Psychological Science . Methods A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with the information visualization method using Citespace software from the aspects of publications, cited frequency and downloads, funding, organizations, authors and keywords. Results The results showed that the amount of literature published annually had an upward tendency, and 49.4% of the papers were supported by national or provincial projects. Institutions such as the Chinese Academy of Sciences (CAS) and the normal universities were rated in the forefront of the scientific research output. Xiting Huang, Hong Li and Yuejia Luo were at the top of the list of prolific authors. Conclusions A new pattern of cooperative development of the theory and application in the field of psychological research is forming.

In this paper, we address the issue of enhancing coherence of a state under stochastic strictly incoherent operations. Based on the $l_1$ norm of coherence, we obtain the maximal value of coherence that can be achieved for a state undergoing a stochastic strictly incoherent operation and the maximal probability of obtaining the maximal coherence. Our findings indicate that a pure state can be transformed into a maximally coherent state under a stochastic strictly incoherent operation if and only if all the components of the pure state are nonzero while a mixed state can never be transformed into a maximally coherent state under a stochastic strictly incoherent operation., Comment: 7 pages

The effects of water-potassium interaction on stalk structure and function of high-yield summer maize were studied in the waterproof cultivation pools with Zhengdan 958 (ZD958) as the experimental material. The results showed that the quantity of bleeding sap in stalk was significantly improved by irrigation. Potassium (K) application could reduce the influence of drought stress on the quantity of bleeding sap in stalk to a certain extent. The quantity of bleeding sap in stalks during different growth periods were significantly improved in the treatment of 2250 m³ · hm⁻²2 irrigation amount with K application. The stalk rind penetration strength and stem diameter were significantly improved by water-potassium interactions. Under the irrigation amount of 2250 m³ · hm⁻², the stalk rind penetration strength and stem diameter with K application were respectively increased by 46.0% and 36.4% compared with no K application. Under K application, the stalk rind penetration strength and stem diameter in the irrigation amount 2250 m³ · hm⁻² were respectively increased by 30.7% and 8.6% compared with 450 m³ · hm⁻². The number, area of vascular bundle and the thickness of thick-walled cell, cortex and rind, were significantly improved by the irrigation amount 2250 m³ · hm⁻² with K application. In conclusion, application of 180 kg K₂O · hm⁻² and increasing the irrigation amount properly could increase the lodging resistance and yield of summer maize in this field experiment condition.

Objective In China, elderly make up a large proportion of the society, but their mental health is often overlooked. The aim of this study is to compare mental health and related influencing factors among the empty-nest and the non-empty-nest elderly, and attain the purpose of improving their quality of life. Study design Cross-sectional survey. Methods A cross-sectional survey was conducted among 488 elderly people aged 60–92 years in six districts of Taiyuan, China. A demographic questionnaire and SCL-90-R were employed to collect demographic variables and evaluate mental health, respectively. Multiple regression analysis was performed to estimate factors related to mental health of the elderly. Results The empty-nest elderly were mostly male, married, higher education level, higher income and living in urban areas. The scores of SCL-90-R among the empty-nest elderly were lower than those of the non-empty-nest elderly except for psychoticism. Comparing with scores of national norms, some dimension of SCL-90-R had statistically significant differences. Multiple regression analysis showed that the main risk factors of the empty-nest elderly were gender and income, whereas the main risk factor of the non-empty-nest elderly was chronic diseases. Conclusion The mental health status of the empty-nest elderly was better than that of the non-empty-nest elderly. Overall mental health of the study population was at a high level compared with national norms. The elderly who were male, with younger age, having higher income, and without chronic diseases had better mental health status.

We propose a scheme to implement quantum state transfer between two distant quantum nodes via a hybrid solid–optomechanical interface. The quantum state is encoded on the native superconducting qubit, and transferred to the microwave photon, then the optical photon successively, which afterwards is transmitted to the remote node by cavity leaking, and finally the quantum state is transferred to the remote superconducting qubit. The high efficiency of the state transfer is achieved by controllable Gaussian pulses sequence and numerically demonstrated with theoretically feasible parameters. Our scheme has the potential to implement unified quantum computing–communication–computing, and high fidelity of the microwave–optics–microwave transfer process of the quantum state.

An actinomycete, strain K55T, was isolated from a composite soil sample from a nickel mine, collected from Yueyang, Shaanxi Province, PR China. Strain K55T showed 16S rRNA gene sequence similarities of 98.73 %–98.51 % to species of the genus Micromonospora, including Micromonospora haikouensis 232617T, Micromonospora coxensis 2-30-b(28)T, Micromonospora wenchangensis 2602GPT1-05T, Micromonospora matsumotoense IMSNU 22003T, Micromonospora maoerensis NEAU-MES19T, and Micromonospora humi P0402T. This strain harboured meso-diaminopimelic acid, alanine and glycine as the major cell-wall amino acids, xylose and glucose as the characteristic whole-cell sugars, and iso-C15 : 0 (20.53 %),iso-C17 : 0 (12.74 %), iso-C16 : 0 (12.15 %), anteiso-C17 : 0 (7.97 %), C17 : 1ω8c (7.49 %) and C17 : 0 (6.63 %) as the dominant fatty acids. The major menaquinones were MK-10(H4) and MK-10(H6). The phospholipid profile comprised phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylinositol, phosphatidylglycerol and unknown phosphoglycolipids. The DNA G+C content was 71.4 mol%. A comprehensive analysis of several physiological and biochemical traits and DNA–DNA relatedness indicated that strain K55T was different from closely related species. These phenotypic, genotypic and chemotaxonomic data suggest that strain K55T represents a novel species of the genus Micromonospora, for which the name Micromonospora nickelidurans sp. nov., is proposed. The type strain is K55T ( = JCM 30559T = ACCC19713T).

Rotaviruses (RVs) are an important cause of severe gastroenteritis in children. It has been found that RV may recognize the histo-blood group antigens (HBGAs) as ligands or receptors and bind HBGAs in a type-dependent manner. In this study, we investigated the binding specificity of VP8* proteins from human rotaviruses (RV) that are prevalent in China including genotypes P[4], P[6], and P[8]. Through the saliva- and oligosaccharide-based binding assays, we found that the VP8* proteins of P[4] and P[8] RV showed similar reactivity with the Leb and H type 1 antigens, while P[6] RV weakly bound the Leb antigen. These findings may facilitate further research into RV host specificity and vaccine development.

Quantum contextuality is one of the fundamental notions in quantum mechanics. Proofs of the Kochen-Specker theorem and noncontextuality inequalities are two means for revealing the contextuality phenomenon in quantum mechanics. It has been found that some proofs of the Kochen-Specker theorem, such as those based on rays, can be converted to a state-independent noncontextuality inequality, but it remains open whether it is true in general, i.e., whether any proof of the Kochen-Specker theorem can always be converted to a noncontextuality inequality. In this paper, we address this issue. We prove that all kinds of proofs of the Kochen-Specker theorem, based on rays or any other observables, can always be converted to state-independent noncontextuality inequalities. Besides, our constructive proof also provides a general approach for deriving a state-independent noncontextuality inequality from a proof of the Kochen-Specker theorem., 10 pages, no figure