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175 results on '"YAMAGUCHI, TOMOHIKO"'

1. Glycolytic Oscillations in Cancer Cells

Author

Amemiya, Takashi, Shibata, Kenichi, Watanabe, Masatoshi, Nakata, Satoshi, Nakamura, Kazuyuki, Yamaguchi, Tomohiko, Abarbanel, Henry D. I., Series Editor, Braha, Dan, Series Editor, Érdi, Péter, Series Editor, Friston, Karl J., Series Editor, Haken, Hermann, Series Editor, Jirsa, Viktor, Series Editor, Kacprzyk, Janusz, Series Editor, Kaneko, Kunihiko, Series Editor, Kelso, Scott, Founding Editor, Kirkilionis, Markus, Series Editor, Kurths, Jürgen, Series Editor, Menezes, Ronaldo, Series Editor, Nowak, Andrzej, Series Editor, Qudrat-Ullah, Hassan, Series Editor, Reichl, Linda, Series Editor, Schuster, Peter, Series Editor, Schweitzer, Frank, Series Editor, Sornette, Didier, Series Editor, Thurner, Stefan, Series Editor, Stefanovska, Aneta, editor, and McClintock, Peter V. E., editor

Published
2021
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8. N-Myc Downstream Regulated Gene-1 May Play an Important Role in the Prognosis of Ovarian Cancer, in Its Association with Beta-Catenin

Author

TERADA, ATSUMU, primary, TSUDA, NAOTAKE, additional, TASAKI, SHINGO, additional, PARK, JANGMYONG, additional, NASU, HIROKI, additional, TASAKI, KAZUTO, additional, KATSUDA, TAKAHIRO, additional, NISHIO, SHIN, additional, YAMAGUCHI, TOMOHIKO, additional, SANADA, SAKIKO, additional, AKIBA, JUN, additional, KUWANO, MICHIHIKO, additional, ONO, MAYUMI, additional, and USHIJIMA, KIMIO, additional

Published
2023
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10. Data from Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

Author

Kibe, Shiro, primary, Yutani, Shigeru, primary, Motoyama, Satoru, primary, Nomura, Takanobu, primary, Tanaka, Natsuki, primary, Kawahara, Akihiko, primary, Yamaguchi, Tomohiko, primary, Matsueda, Satoko, primary, Komatsu, Nobukazu, primary, Miura, Masatomo, primary, Hinai, Yudai, primary, Hattori, Satoshi, primary, Yamada, Akira, primary, Kage, Masayoshi, primary, Itoh, Kyogo, primary, Akagi, Yoshito, primary, and Sasada, Tetsuro, primary

Published
2023
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11. Supplementary Methods from Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

Author

Kibe, Shiro, primary, Yutani, Shigeru, primary, Motoyama, Satoru, primary, Nomura, Takanobu, primary, Tanaka, Natsuki, primary, Kawahara, Akihiko, primary, Yamaguchi, Tomohiko, primary, Matsueda, Satoko, primary, Komatsu, Nobukazu, primary, Miura, Masatomo, primary, Hinai, Yudai, primary, Hattori, Satoshi, primary, Yamada, Akira, primary, Kage, Masayoshi, primary, Itoh, Kyogo, primary, Akagi, Yoshito, primary, and Sasada, Tetsuro, primary

Published
2023
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12. Supplementary Table S5 from Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

Author

Kibe, Shiro, primary, Yutani, Shigeru, primary, Motoyama, Satoru, primary, Nomura, Takanobu, primary, Tanaka, Natsuki, primary, Kawahara, Akihiko, primary, Yamaguchi, Tomohiko, primary, Matsueda, Satoko, primary, Komatsu, Nobukazu, primary, Miura, Masatomo, primary, Hinai, Yudai, primary, Hattori, Satoshi, primary, Yamada, Akira, primary, Kage, Masayoshi, primary, Itoh, Kyogo, primary, Akagi, Yoshito, primary, and Sasada, Tetsuro, primary

Published
2023
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13. Supplementary Figure S2 from Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

Author

Kibe, Shiro, primary, Yutani, Shigeru, primary, Motoyama, Satoru, primary, Nomura, Takanobu, primary, Tanaka, Natsuki, primary, Kawahara, Akihiko, primary, Yamaguchi, Tomohiko, primary, Matsueda, Satoko, primary, Komatsu, Nobukazu, primary, Miura, Masatomo, primary, Hinai, Yudai, primary, Hattori, Satoshi, primary, Yamada, Akira, primary, Kage, Masayoshi, primary, Itoh, Kyogo, primary, Akagi, Yoshito, primary, and Sasada, Tetsuro, primary

Published
2023
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16. Guidelines for Handling of Cytological Specimens in Cancer Genomic Medicine.

Author

Morii, Eiichi, Hatanaka, Yutaka, Motoi, Noriko, Kawahara, Akihiko, Hamakawa, Shinji, Kuwata, Takeshi, Nagatomo, Tadasuke, Oda, Yoshinao, Okamoto, Aikou, Tanaka, Ryota, Iyoda, Akira, Ichiro, Maeda, Matsuo, Yukiko, Nakamura, Nobuyuki, Nakai, Tokiko, Fukuhara, Mei, Tokita, Kazuya, Yamaguchi, Tomohiko, Takenaka, Masataka, and Kawabata, Ayako

Published
2023
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19. Metabolic Oscillations and Glycolytic Phenotypes of Cancer Cells.

Author

Amemiya, Takashi, Shibata, Kenichi, and Yamaguchi, Tomohiko

Subjects
CANCER cells, FREQUENCIES of oscillating systems, OSCILLATIONS, PHENOTYPES, TUMOR microenvironment
Abstract

Cancer cells show several metabolic phenotypes depending on the cancer types and the microenvironments in tumor tissues. The glycolytic phenotype is one of the hallmarks of cancer cells and is considered to be one of the crucial features of malignant cancers. Here, we show glycolytic oscillations in the concentrations of metabolites in the glycolytic pathway in two types of cancer cells, HeLa cervical cancer cells and DU145 prostate cancer cells, and in two types of cellular morphologies, spheroids and monolayers. Autofluorescence from nicotinamide adenine dinucleotide (NADH) in cells was used for monitoring the glycolytic oscillations at the single-cell level. The frequencies of NADH oscillations were different among the cellular types and morphologies, indicating that more glycolytic cancer cells tended to exhibit oscillations with higher frequencies than less glycolytic cells. A mathematical model for glycolytic oscillations in cancer cells reproduced the experimental results quantitatively, confirming that the higher frequencies of oscillations were due to the higher activities of glycolytic enzymes. Thus, glycolytic oscillations are expected as a medical indicator to evaluate the malignancy of cancer cells with glycolytic phenotypes. [ABSTRACT FROM AUTHOR]

Published
2023
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20. List of Contributors

Author

Abe, Yoshiyuki, primary, Abe, Yutaka, additional, Ando, Jun, additional, Asano, Hitoshi, additional, Chen, Zhihao, additional, Furuya, Masahiro, additional, Haramura, Yoshihiko, additional, Hattori, Yasusuke, additional, Horiuchi, Kazuna, additional, Jiang, Yuyan, additional, Koiwa, Yusuke, additional, Koizumi, Yasuo, additional, Kondou, Chieko, additional, Koyama, Shigeru, additional, Kunugi, Tomoaki, additional, Liu, Wei, additional, Maruyama, Shigeo, additional, Mitutake, Yuichi, additional, Momoki, Satoru, additional, Monde, Masanori, additional, Mori, Shoji, additional, Morooka, Shinichi, additional, Nagai, Niro, additional, Nagatake, Taku, additional, Nagayama, Gyoko, additional, Nakabeppu, Osamu, additional, Ohkubo, Hidetoshi, additional, Ohta, Haruhiko, additional, Ohtake, Hiroyasu, additional, Okawa, Tomio, additional, Okuyama, Kunito, additional, Ono, Naoki, additional, Osawa, Tomohiro, additional, Ozawa, Mamoru, additional, Saiki, Takahito, additional, Saitho, Shinpei, additional, Saito, Yasushi, additional, Sakashita, Hiroto, additional, Savino, Raffaele, additional, Serizawa, Yoshihiro, additional, Shoji, Masahiro, additional, Suzuki, Koichi, additional, Takata, Yasuyuki, additional, Tange, Manabu, additional, Tsuruta, Takaharu, additional, Ueno, Ichiro, additional, Umekawa, Hisashi, additional, Utaka, Yoshio, additional, Yabuki, Tomohide, additional, Yamaguchi, Tomohiko, additional, Yoshida, Hiroyuki, additional, and Yuki, Kazuhisa, additional

Published
2017
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29. Thermal Effect on Deformation of Nanofluid-Encapsulated Double Emulsion Droplets Flowing in a Constricted Microchannel.

Author

Ren, Yong, Huang, Yuning, Xie, Caoyu, Yan, Yuying, Wang, Jing, and Yamaguchi, Tomohiko

Subjects
MICROCHANNEL flow, EMULSIONS, MULTIPHASE flow, DEFORMATIONS (Mechanics), NANOFLUIDS, STRESS concentration
Abstract

Double emulsions have been intensively used as a template to form core/shell structured microcapsules encapsulating and releasing a substance of interest in a controllable way for wide spectrum of chemical and biological applications. Herein a numerical model was established to investigate the thermal effect on breakup dynamics of a double emulsion flowing through a microchannel with a constricted segment which mimics the structure of microcapillaries using two groups of cases. In the first group, double emulsion was formed with water dispersed in oil which is surrounded by water (W/O/W); and in the second group, double emulsion was formed with water dispersed in oil which is surrounded by nanofluids where single-wall carbon nanotubes (SWCN) was dispersed in an ethylene glycol (EG) solution with volume fraction of 0.05% (W/O/SWCN-EG). In both groups, the thermal effect study was extended to other temperature dependent physical properties such as viscosity, density, and thermal conductivity. Thermal effects on the shear stress distribution in the constricted microchannel will lead to significant difference in deformation between the two groups. The investigation provides new insights to understanding the thermal effect in multiphase flow through complex microstructures where nanofluids have found significant increase in biomedical applications. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Promotion and inhibition of synchronous glycolytic oscillations in yeast by chitosan

Author

Shibata, Kenichi, Amemiya, Takashi, Kawakita, Yu, Obase, Kohei, Itoh, Kiminori, Takinoue, Masahiro, Nakata, Satoshi, Yamaguchi, Tomohiko, Shibata, Kenichi, Amemiya, Takashi, Kawakita, Yu, Obase, Kohei, Itoh, Kiminori, Takinoue, Masahiro, Nakata, Satoshi, and Yamaguchi, Tomohiko

Abstract

Synchronous rhythmic activities play crucial roles in diverse biological systems. Glycolytic oscillations in yeast cells have been studied for 50 years with the aim of elucidating the mechanisms underlying the intracellular oscillations and their synchronization. We investigated the effects of chemical disturbances on the individual and collective glycolytic oscillations in yeast cells encapsulated in alginate microparticles, and demonstrated that the addition of chitosan, an antimicrobial agent, decreased the duration of these oscillations. In contrast, the periods and the synchronicity states showed two different responses to the chitosan treatments. The periods were shown to be prolonged following the treatment with 5-50 mg·L^(-1) and shortened at 75 mg·L^(-1) of chitosan. Collective oscillations became more synchronized at 5 mg·L^(-1) of chitosan, and desynchronized at 25-75 mg·L^(-1) of this compound. These findings can be explained by the balance between two chitosan features, increasing cell membrane permeability and acetaldehyde scavenging. At low concentrations, chitosan presumably acts as a synchronization promoter that does not mediate the synchronization itself but induces an increase in intercellular coupling. We believe that our findings may provide new insights into the synchronous rhythmic activities in biological systems., This is the peer reviewed version of the following article: [Promotion and inhibition of synchronous glycolytic oscillations in yeast by chitosan], which has been published in final form at [https://doi.org/10.1111/febs.14513]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Published
2019

36. Modeling studies of heterogeneities in glycolytic oscillations in HeLa cervical cancer cells

Author

Amemiya, Takashi, Shibata, Kenichi, Du, Yichen, Nakata, Satoshi, Yamaguchi, Tomohiko, Amemiya, Takashi, Shibata, Kenichi, Du, Yichen, Nakata, Satoshi, and Yamaguchi, Tomohiko

Abstract

Previous experiments demonstrated that a population of HeLa cells starved of glucose or both glucose and serum exhibited a strong heterogeneity in the glycolytic oscillations in terms of the number of oscillatory cells, periods of oscillations, and duration of oscillations. Here, we report numerical simulations of this heterogeneous oscillatory behavior in HeLa cells by using a newly developed mathematical model. It is simple enough that we can apply a mathematical analysis, but capture the core of the glycolytic pathway and the activity of the glucose transporter (GLUT). Lognormal distributions of the values of the four rate constants in the model were obtained from the experimental distributions in the periods of oscillations. Thus, the heterogeneity in the periods of oscillations can be attributed to the difference in the rate constants of the enzymatic reactions. The activity of GLUT is found to determine whether the HeLa cells were oscillatory or non-oscillatory under the same experimental conditions. Simulation with the log-normal distribution of the maximum uptake velocity of glucose and the four randomized rate constants based on the log-normal distributions successfully reproduced the time-dependent number of oscillatory cells (oscillatory ratios) under the two starving conditions. The difference in the initial values of the metabolites has little effect on the simulated results., This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in (citation of published article) and may be found at [https://doi.org/10.1063/1.5087216].

Published
2019

37. Insulinoma‐associated protein1 expression in pancreatic neuroendocrine tumours in endoscopic ultrasound‐guided fine‐needle aspiration cytology: An analysis of 14 patients

Author

Takase, Yorihiko, primary, Naito, Yoshiki, additional, Okabe, Yoshinobu, additional, Ishida, Yusuke, additional, Yamaguchi, Tomohiko, additional, Abe, Hideyuki, additional, Murata, Kazuya, additional, Ito, Takaaki, additional, Tanigawa, Masahiko, additional, Kawahara, Akihiko, additional, Yano, Hirohisa, additional, and Akiba, Jun, additional

Published
2018
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40. Correction to NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes

Author

Tani, Osamu, primary, Akutsu, Yukie, additional, Ito, Shinji, additional, Suzuki, Takayuki, additional, Tateishi, Yukihiro, additional, Yamaguchi, Tomohiko, additional, Niimi, Tatsuya, additional, Namatame, Ichiji, additional, Chiba, Yasunori, additional, Sakashita, Hitoshi, additional, Kubota, Tomomi, additional, Yanagi, Tetsuo, additional, Mizukami, Shusaku, additional, Hirayama, Kenji, additional, Furukawa, Koji, additional, and Yamasaki, Kazuhiko, additional

Published
2018
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42. NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes

Author

Tani, Osamu, primary, Akutsu, Yukie, additional, Ito, Shinji, additional, Suzuki, Takayuki, additional, Tateishi, Yukihiro, additional, Yamaguchi, Tomohiko, additional, Niimi, Tatsuya, additional, Namatame, Ichiji, additional, Chiba, Yasunori, additional, Sakashita, Hitoshi, additional, Kubota, Tomomi, additional, Yanagi, Tetsuo, additional, Mizukami, Shusaku, additional, Hirayama, Kenji, additional, Furukawa, Koji, additional, and Yamasaki, Kazuhiko, additional

Published
2018
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43. The expression of programed death ligand-1 could be related with unfavorable prognosis in salivary duct carcinoma

Author

Sato, Fumihiko, primary, Akiba, Jun, additional, Kawahara, Akihiko, additional, Naito, Yoshiki, additional, Ono, Takeharu, additional, Takase, Yorihiko, additional, Murata, Kazuya, additional, Abe, Hideyuki, additional, Yamaguchi, Tomohiko, additional, Miyoshi, Hiroaki, additional, Abe, Yushi, additional, Mihara, Yutaro, additional, Tanikawa, Masahiko, additional, Akashi, Momoko, additional, Kurose, Hirofumi, additional, Umeno, Hirohito, additional, and Yano, Hirohisa, additional

Published
2018
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47. Petahertz optical drive with wide-bandgap materials

Author

Mashiko, Hiroki, primary, Oguri, Katsuya, additional, Chisuga, Yuta, additional, Masuda, Hiroyuki, additional, Yamaguchi, Tomohiko, additional, Suda, Akira, additional, Katayama, Ikufumi, additional, Takeda, Jun, additional, and Gotoh, Hideki, additional

Published
2017
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