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Information and communication Technologies (ICT) have significantly changed the workplace environment. The rise of remote work and online business processes, especially in the post-pandemic period, has blurred the boundary between work and life balance for many employees, especially academics. The need to respond quickly to messages, e-mails, and work using information and communication technologies has led to an increase in Workplace Telepressure on academics. Increasing demand for information and networks to mitigate the impact of telepressure has led to an increase in workplace FOMO. These two sources of stress have contributed to the burnout experienced by academicians. In this study, the relationship between academicians' WPT, WFOMO, and burnout levels was examined. Data were collected from 286 academicians working in public and private universities using the convenience sampling method. The data were analyzed using SPSS 22 and Smart PLS 4 programs. The study results reveal that the Workplace Telepressure (WPT) levels of academicians have a significant effect on Burnout and Workplace-Fear of Missing Out (WFOMO). Additionally, WFOMO acts as a mediator role in the relationship between WPT and Burnout. These findings expand the existing literature on WPT and WFOMO, two emerging stress factors in the workplace, and provide recommendations for managers and policymakers.

Introduction: As the life expectancy at birth improved, the increase in the elderly population, one of the most vulnerable groups in society, brings about some problems. Frailty is a condition that increases the risk of progressive deterioration in physiological functioning, hypersensitivity to stress and adverse health outcomes. Frailty is quite common in older people. In frail older people, recovery from illnesses is delayed and the likelihood of sequelae is increased. If frailty is recognized early, the likelihood of disease sequelae and mortality can be reduced. Objectives: This study was conducted to determine the relationship between psychological resilience and quality of life on frailty in individuals aged 65 years and older admitted to hospital. Methods: The study group of this cross-sectional study consisted of 504 people who applied to an outpatient clinic at a university hospital. The Tilburg Frailty Scale, the Connor Davidson Psychological Resilience Scale Short Form and the EQ-5D-3L General Quality of Life Scale were used. The Kolmogorov-Simirnov test, the chi-square test, the Spearman correlation analysis and the multivariate logistic regression were used to analyse the data. Results: 292 of the participants in the study group were men. Their ages ranged from 65 to 90 years, and the mean was 70.5±4.9 years. Scores on the Tilburg Frail Scale ranged from 0 to 14, and the mean was 6.3±2.7 points. In the study, 71.1% of participants were classified as frail. It was determined that there was a moderate negative correlation between the results of the Tilburg Frailty Scale and the results of the Connor Davidson Psychological Resilience Scale (r= -0.436) and the EQ-5D-3L VAS Scale (r=-0.608) and a strong positive correlation between the results of the EQ-5D-3L Index Scale (r=0.729)(for each p<0.001). According to multivariate logistic regression, people who did not exercise regularly were 2,33 times more frail than those who did, and people who had a health problem that required bed rest were 2,18 times more frail than those who did not. Conclusions: It was found that the frailty of people aged 65 and over is at a moderate level. An improvement in psychological resilience and general quality of life as well as an improvement in general health reduces frailty. It is recommended that people aged 65 and over to be physically active and to protect from situations that may require prolonged bed rest. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Acute lymphoblastic leukemia (ALL) is a malignant disease of hematopoietic stem cells. B cell ALL (B-ALL) is characterized by highly proliferative and poorly differentiated progenitor B cells in the bone marrow. Chromosomal rearrangements, aberrant cell signaling, and mutations lead to dysregulated cell cycle and clonal proliferation of abnormal B cell progenitors. In this study, we aimed to examine hot spot genetic variations in the RUNX1, IDH2, and IL2RA genes in a group of (n=52) pediatric B-ALL. Sanger sequencing results revealed a rare RUNX1 variant p.Leu148Gln in one B-ALL patient with disease recurrence. Additionally, common intronic variations rs12358961 and rs11256369 of IL2RA were determined in two patients. None of the patients had the IDH2 variant. RUNX1, IDH2, and IL2RA variations were rare events in ALL. This study detected a novel pathogenic RUNX1 variation in a patient with a poor prognosis. Examining prognostically important genetic anomalies of childhood lymphoblastic leukemia patients and the signaling pathway components will pilot more accurate prognosis estimations.

Rare disease patients constitute a significant part of the healthcare system of all countries. However, the information on the experiences during disease processes and daily life of rare disease patients is still limited. So far, there is a small number of studies conducted in Türkiye, and they mainly cover specific issues like education or anxiety. Here we present a comprehensive survey analysis conducted among the patients and their families within the scope of the Istanbul Solution Platform for Undiagnosed and Rare Diseases-ISTisNA project. A total of 498 individuals responded to the survey, and 58% of the participants answered all questions. The majority of the patients were in the age range of 1–10 years (44.7%), and 91% of all the patients had a precise diagnosis. The diagnosis rate in the first 6 months was 69%, and almost 10% of the patients remained undiagnosed. The mothers were the primary caregivers (72%). Nearly 30% of the caregivers had to quit their jobs and 25% of the patients (0–18 years) had to leave school. Accessing physicians with relevant specialization and reaching treatments/medications/supplements were the two main obstacles the participants mentioned, with a frequency of 81% and 73%, respectively. Around 50% of participants noted that they commonly faced difficulties at work/school and in their social lives. The highest expectation or priority was the establishment of rare disease-specific diagnosis and treatment centers, accurate and detailed information on diseases in the Turkish language, and easy access to physicians, treatments, and supportive therapies. To the best of our knowledge, this is the most comprehensive survey conducted on the rare disease community in Türkiye. These results show that regardless of the country, the individuals affected by rare diseases and their families have similar problems and expectations. On the other hand, regional and country-specific issues are still in the line to be solved. These studies can provide a deeper insight into rare diseases and guide the activities of Türkiye's national rare disease action plan.

Ovarian cancer forms 4% of all cancers and approximately 23% of all gynecological cancers in women and is responsible for the 47% of deaths related to cancers of the genital tract of women. Tumor markers are the biochemical substances which can be detected in the presence of tumors. Generally they are either the products of tumoral tissues or secreted from the normal cells which are in the interaction with tumoral ones. The present authors attempted to determine the efficacy of the tumor marker CA-125 and HE4 to differentiate the malign cases from the benign adnexal masses. A total of 76 patients with the appropriate criteria were included in the study. They were divided into three groups; healthy control group (n=31), ones with benign masses (n=23), and ones with malign ovarian masses (n=22). In the study, when the cut-off values were accepted as 55I U/ml for CA-125 and 150 pM for HE4 in differentiation of benign and malign groups, the sensitivity was found as 59.09%, specificity 91.3%, PPV 86.67% and NPV 70% LR = +6.8. This combination gives one false positive result to every five positive cases which were detected as high. With the combination of CA-125 and HE4, the value of sensitivity was found decreased as expected, although the value of the specificity increased. [ABSTRACT FROM AUTHOR]

Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the clinical findings. Materials and Methods: Fifty diagnostic bone marrow samples of childhood T-ALL cases were investigated for the hotspot regions of the PTEN and AKT1 genes by targeted next-generation sequencing. Results: A total of five PTEN variations were found in three of the 50 T-ALL cases (6%). Three of the PTEN variations were first reported in this study. Furthermore, one patient clearly had two different mutant clones for PTEN. Two intronic single-nucleotide variations were found in AKT1 and none of the patients carried pathogenic AKT1 variations. Conclusion: Targeted deep sequencing allowed us to detect both lowlevel variations and clonal diversity. Low-level PTEN/AKT1 variation frequency makes it harder to investigate the clinical associations of the variants. On the other hand, characterization of the PTEN/ AKT signaling members is important for improving case-specific therapeutic strategies.

Purpose: To model CML progression in vitro and generate a blast crisis (BC-CML) model in vitro in order to identify new targets. Methods: Three different CML-derived iPSC lines were mutagenized with the alkylating agent ENU on a daily basis for 60 days. Cells were analyzed at D12 of hematopoietic differentiation for their phenotype, clonogenicity, and transcriptomic profile. Single-cell RNA-Seq analysis has been performed at three different time points during hematopoietic differentiation in ENU-treated and untreated cells. Results: One of the CML-iPSCs, compared to its non-mutagenized counterpart, generated myeloid blasts after hematopoietic differentiation, exhibiting monoblastic patterns and expression of cMPO, CD45, CD34, CD33, and CD13. Single-cell transcriptomics revealed a delay of differentiation in the mutated condition as compared to the control with increased levels of MSX1 (mesodermal marker) and a decrease in CD45 and CD41. Bulk transcriptomics analyzed along with the GSE4170 GEO dataset reveal a significant overlap between ENU-treated cells and primary BC cells. Among overexpressed genes, CD25 was identified, and its relevance was confirmed in a cohort of CML patients. Conclusions: iPSCs are a valuable tool to model CML progression and to identify new targets. Here, we show the relevance of CD25 identified in the iPSC model as a marker of CML progression.

Agricultural developments mostly depend on rapidly increasing world population. Tomato is a highly nutritious vegetable. Post-harvest technologies are often applied to prolong the consumption periods of tomato. Drying is one of the oldest methods of conservation. In this study, five different drying methods (oven drying, vacuum oven drying, sensitive drying, shaded-open atmosphere drying and sun drying) was used. Drying processes were carried out with dryers at 55°C, 60°C, 65°C and 70°C temperatures. All drying trials were performed in three replications. Drying performance (drying duration, final moisture content), drying kinetics, colour analysis, energy consumption, chemical analyses were performed for all drying methods. Fresh samples reached to desired moisture contents in 20-300 hours. To define time-dependent changes in moisture contents, Page, Logarithmic and Midilli-Küçük equations were used. Page equation yielded the worst estimations. There were not significant differences in “a” redness values of fresh samples, 65-70C of oven dryer and all temperatures of sensitive dryer. Sensitive dryer yielded the closet pH values to fresh samples. Based on current findings, it was concluded that oven drying, and sensitive drying were suitable for drying Selinus tomato variety.

Anayasal iktisat kavramı, devletin güç ve yetkilerinin nasıl sınırlandırılabileceğini ve nasıl sınırlandırılması gerektiğini araştıran bir düşünce türüdür. Anayasal iktisadın temel amaçları mali ve parasal disiplini sağlamak, siyasetçilerin seçim ekonomisi ve popülist politikalar uygulamalarını engellemek, devletin sınırlandırılması ile bireylerin iktisadi hak ve özgürlüklerini korumak ve garanti altına almaktır. 2008 Krizi’yle başlayan ve Avro Bölgesi Borç Krizi’yle devam eden süreçte, AB (Avrupa Birliği) ülkelerinin mali disiplini sağlayamadıkları görülmüştür. Bu sebeple çalışmada Avro Bölgesi borç krizinin derinden etkilerini hisseden ülkelerin mali kural olarak nitelendirilen Maastricht Kriterleri’ne uyumunun değerlendirilmesi amaçlanmıştır The concept of constitutional economics is a notion that analyse how the power and authorities of a state can be and must be limited. The basic aims of constitutional economy are to ensure financial and monetary discipline, prevent politicians from implementing an election economics and populist policies and protect and guarantee economic rights and freedoms of individuals. It has been seen that the EU (European Union) countries could not maintain the fiscal discipline during the term starting with 2008 crisis and continuing with the Euro Zone Debt Crisis. For this reason, the aim of the study was to evaluate the compliance of the countries deeply affected by the Euro Sovereign debt crisis to the Maastricht Criteria

In this study, we investigated the relationship between industrial diversification and firm performance using a market-based performance measure and an accounting measure. We used the data of the firms listed on Borsa Istanbul during the period between 2006 and 2012. The results of the panel data indicate that there is a significant positive relationship between diversification and performance. We found that diversified firms outperformed the single firms. As is compatible with a resource-based approach, it was found that diversified firms tended to use their resources more efficiently compared to single firms.

Communication in organizations, within the limits specified and configured in accordance with certain rules arising from the formal channels of communication and interpersonal relationships, and are not included in any configuration takes place through informal channels of communication. Known as the world's oldest media rumor and gossip is the size of the informal communication process. Kalınamayan everyday life, away from the gossip and rumors, sometimes complained, but in a way, sometimes including the Red Crescent owned social media. In fact, rumor and gossip is a way of communication. Despite being one of the most common activities in organizations gossip much studied in the literature of the Turkish government issue. Examine this issue, a descriptive framework in order to contribute to the relevant literature is presented. In this study, informal and non-viral rumor that the perception of a means of communication, the functions of individual and organizational point of view, attitudes were assessed on individual merits.

In our study, the social skills, academic competence and problem behaviors of children with cochlear implants in primary school first, second and third grade were compared with their normal peers and the relationships between social skills, academic competence, problem behaviors and language skills were investigated. For this purpose, 32 cochlear implanted (research group) and 160 healthy classmates (control group) were included. In this study, Social Skills Rating System (SSRS) Inventory Teacher version, standardized to Turkish by Sucuoğlu and Özokçu (2005), applied by teachers of children. Also, receptive and expressive language skills of cochlear implanted children assessed with Turkish Expressive and Receptive Language Test (TİFALDİ). As a result of statistical analysis, significant differences were found in favor of the control group between the SSRS subscales of the study group and the control group. The study group was divided into two groups as early (before 2 years) and late (after 2 years) implants, and when SSRS subscale scores of 3 groups were statistically compared, the difference between the study group and the control group was found as late cochlear implant group. In the analysis of the correlation between TİFALDİ Receptive Language, Expressive Language subtests and SSRS subscales of the study group, a significant positive correlation was found between the scores of the Receptive Language Subtest and the Academic Competence subscale while a significant positive correlations were found between the scores of the Expression Language Subtests and Social Skills and Academic Competence Subscales. It was also found that the scores of SSRS subscales showed significant correlations among themselves. [ABSTRACT FROM AUTHOR]

Adult cochlear implant users' expectations and outcomes are varied among them. The factors impact on cochlear implant outcomes also differentiates than the pediatric group. Such as duration of hearing loss, the configuration of hearing loss, and duration of hearing aid use are essential in pre-implant assessment. However, there are other essential variables that involve cognitive abilities for example verbal learning, visual memory, and auditory memory. In the rehabilitation process, holistic approach is appropriate for comprehensive evaluation. Materials and Methods:In this study, 15 cochlear implant users, who are older than 18 years old, were participated. In the inclusion criteria is using cochlea implant at least 6 months regularly. Before and after cochlear implantation following tests were used: adult sentence recognition test, word identification test, auditory memory test, Auditory- Verbal Learning Test, Glasgow Benefit Inventory, Montreal Cognitive Assessment and Draw a Clock Test. Result: All patients showed significant improvement in all tests. Sentence recognition and word recognition scores were improved as expected. The patients also reported that their life quality increased after cochlear implantation. Patients' adaptation was improved to memory tests after CI. Some of them still need rehabilitation support for memory. The holistic approach is needed to increase cochlear implant users' satisfaction after surgery. This approach helps us to understand patients' needs and expectations. After surgery optimal development can be achieved in all cognitive areas and quality of life in adults. [ABSTRACT FROM AUTHOR]

This study aimed to optimize an alternative frozen dessert formulation using the response surface method (RSM). The formulation utilized oat-based milk substitute (OBMS) due to its desirable texture, sensory appeal, and nutritional benefits for vegans and lactose intolerant individuals. Xanthan gum (XG) was also incorporated to enhance the rheological properties of the dessert. With a coefficient of consistency of 192.58 Pa.s and a hysteresis field of 10,999 Pa/s, the ice cream formulation with the greatest rheological structure was discovered to be the combination of 20% oats, 0.5% xanthan gum (XG), and pasteurized at 65 °C. It also showed <10% melting in the first 10 min, confirming that it has a very stable structure. At the same pasteurization conditions and XG ratios, it was observed that rheological stability decreased with increasing oat milk addition. However, the shear thinning behavior of frozen dessert was improved by creating a more complex network structure with increasing XG concentration. The overrun values of the frozen desserts ranged from 21.55% to 34.63%, with the majority being statistically similar. The vegan frozen dessert formulation obtained with 40% oats, 0.37% XG and pasteurization at 60 °C showed a high level of sensory acceptance. This research contributes to the field of vegan food product development by providing innovative rheological and sensory alternatives to traditional frozen desserts using oats and XG., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

It has been reported that the clinical symptoms of functional dyspepsia (FD) exacerbate upon stress while the gender-related factors have been incompletely understood. This study aims to investigate the role of sex in chronic heterotypic stress (CHS)-induced autonomic and gastric motor dysfunction. For CHS, the rats were exposed to the combination of different stressors for 7 consecutive days. Subsequently, electrocardiography was recorded in anesthetized rats to evaluate heart rate variability (HRV) for the determination of autonomic outflow and sympathovagal balance. Solid gastric emptying (GE) was measured in control and CHS-loaded male and female rats. The immunoreactivities of catecholaminergic cell marker tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), corticotropin releasing factor (CRF), and estrogen receptor (ER-α/β) were evaluated in medullary and pontine brainstem sections by immunohistochemistry. Compared with the controls, CHS significantly delayed GE in males but not in females. There was no significant sex-related difference in parasympathetic indicator HF under either control or CHS conditions. Sympathetic indicator LF was significantly higher in control females compared to the males. The higher sympathetic output in females was found to be attenuated upon CHS; in contrast, the elevated sympathetic output was detected in CHS-loaded males. No sex- or stress-related effect was observed on ChAT immunoreactivity in the dorsal motor nucleus of N.vagus (DMV). In males, greater number of TH-ir cells was observed in the caudal locus coeruleus (LC), while they were more densely detected in the rostral LC of females. Regardless of sex, CHS elevated immunoreactivity of TH throughout the LC. Under basal conditions, greater number of TH-ir cells was detected in the rostral ventrolateral medulla (RVLM) of females. In contrast, CHS remarkably increased the number of TH-ir cells in the RVLM of males which was found to be decreased in females. There was no sex-related alteration in TH immunoreactivity in the nucleus tractus solitarius (NTS) of control rats, while CHS affected both sexes in a similar manner. Compared with females, CRF immunoreactivity was prominently observed in control males, while both of which were stimulated by CHS. ER-α/β was found to be co-expressed with TH in the NTS and LC which exhibit no alteration related to either sex or stress status. These results indicate a sexual dimorphism in the catecholaminergic and the CRF system in brainstem which might be involved in the CHS-induced autonomic and visceral dysfunction occurred in males., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Background: Antimicrobial resistance is a major global public health challenge, particularly with the rise of carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA). This study aimed to describe the characteristics of CRE and CRPA infections in Eastern Europe, focusing on Bulgaria, Croatia, Czechia, Greece, Hungary, Poland, Romania, Serbia, Slovakia, and Slovenia., Methods: Following MOOSE and PRISMA guidelines, a systematic literature review of articles published between 1 November 2017 and 1 November 2023 was conducted using the MEDLINE, Embase, Web of Science, CDSR, DARE, and CENTRAL databases. The search strategy used a combination of free text and subject headings to gather pertinent literature regarding the incidence and treatment patterns of CRE and CRPA infections. A total of 104 studies focusing on infections in both children and adults were included in this review., Results: This review revealed a significant prevalence of carbapenem-resistant Gram-negative isolates and underscored the effectiveness of imipenem/relebactam and ceftazidime/avibactam (CAZ/AVI) against Klebsiella pneumoniae carbapenemase-producing Enterobacterales and of ceftolozane/tazobactam, imipenem/relebactam and ceftazidime/avibactam against non-metallo-β-lactamase-producing CRPA strains., Conclusions: This study highlights the urgent need for comprehensive measures to combat the escalating threat of CRE and CRPA infections in Eastern European countries. At the same time, it shows the activity of the standard of care and new antimicrobials against carbapenem-resistant Gram-negative pathogens in Eastern Europe. Clinical real-world data on the treatment of carbapenem-resistant infections in Eastern Europe are needed.

Background: Allergen-specific immunotherapy, a unique inducer of tolerance, may result in T cell exhaution., Aims: To investigate how the duration of house dust mite (HDM) subcutaneous immunotherapy (SCIT) affects the expression of major immune checkpoint (ICP) molecules on the surface of CD4 + T-helper and regulatory T (Treg) cells., Study Design: Cross-sectional study., Methods: We enrolled 28 children with HDM-induced allergic rhinitis (AR) and six controls. The study participants were divided into six groups: one group each of patients in their first, second, and third years of HDM-SCIT; one group each comprising those in the first year following HDM-SCIT and those on pharmacotherapy; and the control group. The expression of ICPs on CD4 + T and Treg cells was determined using flow cytometry, and plasma levels of soluble ICPs were estimated by ELISA., Results: Our results revealed a significant increase in the expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and lymphocyte activation gene 3 (LAG-3) on CD4 + T cells during the second and third years of SCIT, respectively. Additionally, a strong correlation was observed between the expression of CTLA-4 and T cell immunoglobulin and mucin domain containing molecule-3 in CD4 + T cells. Furthermore, we observed a significant correlation between the expressions of programmed cell death protein-1, CTLA-4, T cell Immunoreceptor with Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Motif domain, and LAG-3 on both CD4 + T and Treg cells. A robust correlation was observed between the plasma levels of soluble ICPs., Conclusion: HDM-SCIT induces CD4 + T cell exhaution, which may contribute to tolerance induction in children with AR., Competing Interests: Conflict of Interest: The authors declare that they have no conflict of interest.