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This paper sketched the basic principles of ceramic materials radioactivity measurement and mathematical calculation formula of testing time. When the sample measurement conditions and the way of data analysis are constant, using sodium iodide gamma spectrometer for getting the radioactive spectra data of 5 groups of samples. In condition of the background count time tb or sample measurement time ts increasing gradually, study the radioactivity specific activity measurement error range of all samples. It is derived when the background count rate of nb and sample counting rate ns is constant, the measurement error ν2 and the sum of reciprocal of the background count time tb and reciprocal of the sample measuring time ts for approximately linear positive correlation. The measurement error of 226Ra, 232Th, 40K radioactive specific activity of different ceramic samples presents the corresponding fluctuations as their initial energy spectrum count rate differences. This study for coordination of the contradiction between ceramic materials radioactive measurement time and the uncertainty has certainly theoretical and practical value.

Introduction: long non-coding RNAs (lncRNAs) are emerging as new regulators in the cancer paradigm, the involvement of lncRNAs in urothelial carcinoma of the bladder (UCB) is just beginning to be studied. In this study, we focused on lncRNA SPRY4-IT1 and investigated its expression pattern, clinical significance, and biological function in UCB., Methods: SPRY4-IT1 expression in UCB tissues was examined by quantitative Real-time PCR (qRT-PCR) and its correlation with clinicopathological features and patient prognosis was later analyzed. Moreover, in vitro assays were performed to explore its role in bladder cancer progression., Results: SPRY4-IT1 expression was elevated in UCB tissues, and SPRY4-IT1 levels were highly positively correlated with histological grade, tumor stage, and lymph node metastasis and reduced overall survival. A multivariate analysis showed that SPRY4-IT1 expression is an independent prognostic factor of overall survival in patients with UCB. Additionally, the results of in vitro assays showed that the suppression of SPRY4-IT1 expression in bladder cancer cells significantly inhibit cell proliferation, migration, and invasion., Conclusions: Our data suggested that lncRNA SPRY4-IT1 is a novel molecule involved in bladder cancer progression, which provide a potential prognostic biomarker and therapeutic target.