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600 results on '"Xu, Hongzhi"'

4. Numerical Simulation of Two-Phase Fluid-Structure Interaction in Fractured Formation Under Drilling Conditions

Author

Zhao, Yige, Wang, Zhiyuan, Xu, Hongzhi, Shen, Jiayi, Zhang, Jianbo, Liu, Hui, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Sun, Baojiang, editor, Sun, Jinsheng, editor, Wang, Zhiyuan, editor, Chen, Litao, editor, and Chen, Meiping, editor

Published
2024
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5. Experimental Study of Fracture Toughness in Simulated Cores of Natural Gas Hydrate Sediments

Author

Xu, Hongzhi, Ni, Deshui, Wang, Zizhen, Wang, Chengwen, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Sun, Baojiang, editor, Sun, Jinsheng, editor, Wang, Zhiyuan, editor, Chen, Litao, editor, and Chen, Meiping, editor

Published
2024
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6. Numerical Simulation Study on Gravel Packing Parameters of Horizontal Wells in Natural Gas Hydrate Reservoirs

Author

Deng, Junyu, Zhang, Rui, Guan, Liyong, Xu, Hongzhi, Han, Jindong, Zhang, Zizhen, Guo, Tiankui, Du, Weigang, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Sun, Baojiang, editor, Sun, Jinsheng, editor, Wang, Zhiyuan, editor, Chen, Litao, editor, and Chen, Meiping, editor

Published
2024
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7. A Study of Identification of Chinese VO Idioms with Statistical Measures

Author

Wen, Xueyi, Li, Yi, Zhao, Yuanbing, Xu, Hongzhi, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Dong, Minghui, editor, Hong, Jia-Fei, editor, Lin, Jingxia, editor, and Jin, Peng, editor

Published
2024
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8. Role of NLRP3/Caspase-1/IL-1β inflammasome pathway in formation of aortic dissection in mice

Author

XIANG Jun, HE Ling, and XU Hongzhi

Subjects
aortic dissection, aortic aneurysm, nlrp3, signaling pathway, Medicine (General), R5-920
Abstract

Objective To investigate the role and mechanism of NLRP3/Caspase-1/IL-1β inflammasome pathway in the formation of aortic dissection in mice. Methods Fifty male C57BL/6 mice (3 weeks old, body weight 10~13 g) were divided into control group (n=10, normal diet), β-aminopropionitrile (BAPN) group [n=20, drink water containing 1 g/(kg·d) BAPN], and BAPN+ MCC950 group [n=20, drink water containing 1 g/(kg·d) BAPN and intraperitoneal injection of 20 mg/(kg·d) NLRP3 inhibitor, MCC950] by random sampling. Water intake, body weight, incidence of aortic dissection and aortic dissection-related mortality were recorded. The inflammatory infiltration in the aorta was observed with HE staining, elastic fiber breakage was observed by elastic Van Gieson (EVG) staining, average fluorescence intensity of NLRP3, IL-1β, α-SMA and OPN was detected by immunofluorescence assay, and protein expression levels of NLRP3, Caspase-1, ASC, IL-1β, α-SMA and OPN were measured with Western blotting. Results No aortic dissection or death was observed in the control group. The BAPN group had an incidence of aortic dissection of 80%, aortic dissection-related mortality of 35%, and obvious broken elastic fibers and inflammatory infiltrate in the aortic wall, and increased expression levels of NLRP3, Caspase-1, ASC and IL-1β, decreased contractile α-SMA and increased synthetic protein OPN when compared with the control group (P < 0.05). While MCC950 treatment decreased the incidence of aortic dissection (80% vs 35%, P=0.004) and aortic dissection-related mortality (35% vs 15%, P=0.144), alleviated the broken elastic fibers and inflammatory infiltrate in the aortic wall, and down-regulated the expression of NLRP3, Caspase-1, ASC and IL-1β, enhanced contractile α-SMA and decreased the synthetic protein when compared with the BAPN group (P < 0.05). Conclusion The occurrence of aortic dissection in mice is associated with activation of NLRP3/Caspase-1/IL-1β inflammasome pathway. NLRP3 inhibitor, MCC950, can reduce the occurrence of aortic dissection and show a protective effect on blood vessels.

Published
2024
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14. Real-time landmark detection for precise endoscopic submucosal dissection via shape-aware relation network

Author

Wang, Jiacheng, Jin, Yueming, Cai, Shuntian, Xu, Hongzhi, Heng, Pheng-Ann, Qin, Jing, and Wang, Liansheng

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

We propose a novel shape-aware relation network for accurate and real-time landmark detection in endoscopic submucosal dissection (ESD) surgery. This task is of great clinical significance but extremely challenging due to bleeding, lighting reflection, and motion blur in the complicated surgical environment. Compared with existing solutions, which either neglect geometric relationships among targeting objects or capture the relationships by using complicated aggregation schemes, the proposed network is capable of achieving satisfactory accuracy while maintaining real-time performance by taking full advantage of the spatial relations among landmarks. We first devise an algorithm to automatically generate relation keypoint heatmaps, which are able to intuitively represent the prior knowledge of spatial relations among landmarks without using any extra manual annotation efforts. We then develop two complementary regularization schemes to progressively incorporate the prior knowledge into the training process. While one scheme introduces pixel-level regularization by multi-task learning, the other integrates global-level regularization by harnessing a newly designed grouped consistency evaluator, which adds relation constraints to the proposed network in an adversarial manner. Both schemes are beneficial to the model in training, and can be readily unloaded in inference to achieve real-time detection. We establish a large in-house dataset of ESD surgery for esophageal cancer to validate the effectiveness of our proposed method. Extensive experimental results demonstrate that our approach outperforms state-of-the-art methods in terms of accuracy and efficiency, achieving better detection results faster. Promising results on two downstream applications further corroborate the great potential of our method in ESD clinical practice.

Published
2021

31. Experimental Study on Strength Characteristics of Hydrate Argillaceous Siltstone Under Immersion of Drilling Fluid

Author

Wang, Yubin, Sun, Baojiang, Xu, Hongzhi, Gong, Zhenggang, Wang, Zhiyuan, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Sun, Baojiang, editor, Sun, Jinsheng, editor, Wang, Zhiyuan, editor, Chen, Litao, editor, and Chen, Meiping, editor

Published
2022
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32. Artificial Intelligence–Assisted Colonoscopy for Colorectal Cancer Screening: A Multicenter Randomized Controlled Trial

Author

Xu, Hong, Tang, Raymond S.Y., Lam, Thomas Y.T., Zhao, Guijun, Lau, James Y.W., Liu, Yunpeng, Wu, Qi, Rong, Long, Xu, Weiran, Li, Xue, Wong, Sunny H., Cai, Shuntian, Wang, Jing, Liu, Guanyi, Ma, Tantan, Liang, Xiong, Mak, Joyce W.Y., Xu, Hongzhi, Yuan, Peng, Cao, Tingting, Li, Fudong, Ye, Zhenshi, Shutian, Zhang, and Sung, Joseph J.Y.

Published
2023
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39. Introduction

Author

Xu, Hongzhi, Hu, Kaibao, Series Editor, Ding, Hongwei, Series Editor, and Xu, Hongzhi

Published
2021
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