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Despite the health benefits of Vitis vinifera L. leaves, its anti-obesity potential has not been fully explored. In this work, we showed that Vitis vinifera L. leaf extract (VLE) inhibits the pancreatic lipase activity. Intragastric administration of VLE to mice led to a significant decrease in the body weight, tissue fat accumulation, levels of cholesterol, low-density lipoprotein and triglyceride compared to mice fed with high fat diet. We also found a lower level of neuropeptide-Y (NPY) in the serum and hypothalamus and a higher level of fibroblast growth factor 15 in mice supplemented with VLE. These results suggested that VLE regulates both the NPY-mediated pathway and the bile acid-FGF15 pathway to control energy metabolism and body weight gain. The composition of VLE was further investigated by a targeted metabolomics approach, which identified 21 compounds including phenolic acids, flavones, flavanols, flavanones, coumarins, and stilbenes. Taken together, we demonstrated the capacity of grape leaves in reducing obesity, which could be mediated by NPY and bile acids. Identification of putative active compounds in VLE also open the path for further studies to determine their effectiveness individually to treat obesity.

Originating from the stochastic nature of the photon emission process, the diffusion of the electron longitudinal coordinate exists even if the global phase slippage of a storage ring is zero, as we cannot zero all the local phase slippages simultaneously. This quantum diffusion is viewed as the most fundamental limit of the lowest bunch length realizable in an electron storage ring from the single-particle dynamics perspective. Here, we present an analysis of this effect using the Courant-Snyder parametrization in the longitudinal dimension. Analytical formulas for the longitudinal emittance, energy spread, and bunch length are derived. The same formalism is used to discuss the application of multiple radio frequency systems for longitudinal strong focusing. The presented work is expected to be useful in the development of novel light source mechanisms like steady-state microbunching, where a short bunch length or small longitudinal emittance is needed.

Low longitudinal emittance means small energy spread and short bunch length, which makes high-power short-wavelength coherent radiation possible. In a storage ring, due to quantum excitation, the equilibrium longitudinal emittance is mainly the overall contribution of all bend-related elements, such as bends, undulators and laser modulators. By introducing longitudinal Twiss function and analyzing the 6D one-turn map in 3D Twiss form, the longitudinal emittance contribution of all these elements is theoretically studied in this paper, and a general method for minimizing the storage ring equilibrium longitudinal emittance is proposed. An integrated optimization of longitudinal beta function shows, the longitudinal emittance scales as the third power of bending angle, and can be as low as subpicometer with a beam energy of 400 MeV in an ultimate state.

The use of particle accelerators as photon sources has enabled advances in science and technology1. Currently the workhorses of such sources are storage-ring-based synchrotron radiation facilities2–4 and linear-accelerator-based free-electron lasers5–14. Synchrotron radiation facilities deliver photons with high repetition rates but relatively low power, owing to their temporally incoherent nature. Free-electron lasers produce radiation with high peak brightness, but their repetition rate is limited by the driving sources. The steady-state microbunching15–22 (SSMB) mechanism has been proposed to generate high-repetition, high-power radiation at wavelengths ranging from the terahertz scale to the extreme ultraviolet. This is accomplished by using microbunching-enabled multiparticle coherent enhancement of the radiation in an electron storage ring on a steady-state turn-by-turn basis. A crucial step in unveiling the potential of SSMB as a future photon source is the demonstration of its mechanism in a real machine. Here we report an experimental demonstration of the SSMB mechanism. We show that electron bunches stored in a quasi-isochronous ring can yield sub-micrometre microbunching and coherent radiation, one complete revolution after energy modulation induced by a 1,064-nanometre-wavelength laser. Our results verify that the optical phases of electrons can be correlated turn by turn at a precision of sub-laser wavelengths. On the basis of this phase correlation, we expect that SSMB will be realized by applying a phase-locked laser that interacts with the electrons turn by turn. This demonstration represents a milestone towards the implementation of an SSMB-based high-repetition, high-power photon source. The mechanism of steady-state electron microbunching is demonstrated, providing a basis that will enable its full implementation in electron storage rings to generate high-repetition, high-power coherent radiation.

The mechanism of steady-state microbunching (SSMB) has been proposed [D. F. Ratner and A. W. Chao, Phys. Rev. Lett. 105, 154801 (2010)PRLTAO0031-900710.1103/PhysRevLett.105.154801] to generate high-power coherent radiation at a high repetition rate or in continuous-wave mode using electron storage rings. In this paper, the related single-particle dynamics are theoretically and numerically studied, and important results are presented. The investigated effects are longitudinal quantum radiation excitation, nonlinear momentum compaction, and linear and nonlinear coupling of the transverse and longitudinal motion. Although this analysis is oriented toward SSMB, some of the analyzed effects are also crucial in cases such as coherent harmonic generation, bunch slicing, bunch compression, free-electron laser beam transport lines, and quasi-isochronous rings, which involve precise longitudinal phase-space manipulations.

This paper reports the observation of beam energy widening and distortion from Gaussian due to a nonvanishing horizontal chromaticity at a quasi-isochronous storage ring. The result originates from an average path-length dependence on the betatron oscillation amplitudes, which is intimately correlated to the transverse chromaticities. It is the first experimental validation of the impact of such a nonlinear transverse-longitudinal coupling effect on the equilibrium beam characteristics in a storage ring. The results could be important for quasi-isochronous rings, steady-state microbunching, nonscaling fixed-field alternate gradient accelerators, etc., where very small momentum compaction or large chromaticity is required.

Based on the laser manipulation of electron beam, the steady-state micro-bunching (SSMB) mechanism promises an electron bunch length six orders of magnitude smaller than that in a conventional storage ring. With the combination of the strong coherent characteristic of the radiation from micro-bunching and the high repetition rate of a storage ring, high-average-power, narrow-band coherent radiation with wavelengths ranging from THz to soft X-ray can be expected from an SSMB ring. Such a novel light source can provide unprecedented opportunities for accelerator photon science and industry applications like extreme ultraviolet (EUV) lithography. In this paper, the SSMB concept and its potential, the progress of SSMB proof-of-principle experiment, the key physics issues and technical challenges of an SSMB ring, the Tsinghua SSMB-EUV light source and its potential revolutionary influence on scientific research and EUV lithography are all reviewed. Some important results of the SSMB research achieved by us are also presented.