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In view of the different needs of different nationalities and individuals for make-up color, 110 kinds of toners of pant color card were used as the basis of color matching, and four kinds of toners, such as titanium dioxide, iron oxide yellow, iron oxide red and iron oxide black, were selected for color matching. The LAB of the palette samples was tested separately, and then the models were modeled by means of linear regression, polynomial regression and mixture design. The comparison results showed that the adjusted R-squares of linear regression results were all greater than 0.914, and p values were all less than 0.01; the adjusted R-squares of polynomial regression results were all greater than 0.920, and p values were all less than 0.01; while the R-squares of mixture design simulation results were all greater than 0.989, and p values were all less than 0.01. The results showed that the simulation values and the measured values of the model had good fitting, which could be used as the key reference model in the color matching of the formula, and indicative of accurate prediction. [ABSTRACT FROM AUTHOR]