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To evaluate the safety of the domestic 13-valent pneumococcal polysaccharide conjugate vaccine-tetanus toxoid protein (PCV13-TT) after its licensure. The adverse event following immunization (AEFI) and the vaccination data of PCV13-TT in Zhejiang province from July 2020 to October 2021 were collected from national adverse event following immunization surveillance system and Zhejiang provincial immunization information system. Descriptive epidemiological method was used for this analysis. From July 2020 to October 2021, 302 317 doses of PCV13-TT were administered in children under 6 years old in Zhejiang Province and 636 AEFI case reports were received, with a reporting rate of 21.04 per 10 000 doses. Of these AEFI cases, 97.17% were mild vaccine product-related reaction (20.54 per 10 000 doses) and 95.44% occurred in the 0-1 d after vaccination (20.08 per 10 000 doses). The most common clinical diagnoses of AEFI included fever (224 cases), redness (204 cases), and induration (190 cases), while allergic rash (11 cases) was the most common diagnosis among the abnormal reactions. In conclusion,the present results bolstered that the domestic PCV13-TT was generally well tolerated in children under 6 years old in Zhejiang Province.评价国产13价肺炎球菌多糖结合疫苗（PCV13-TT）上市后使用的安全性。采用横断面描述性研究方法，由浙江省疾病预防控制中心收集国家疑似预防接种异常反应（AEFI）信息管理系统中2020年7月至2021年10月期间浙江省PCV13-TT的AEFI报告数据；从浙江省疫苗管理和预防接种信息综合管理系统中统计同期PCV13-TT的接种数据。采用描述流行病学方法对PCV13-TT的AEFI报告发生情况进行描述性分析。结果显示，2020年7月至2021年10月期间，浙江省5岁及以下儿童中PCV13-TT共接种302 317剂次，报告AEFI共636例（报告发生率为21.04/万剂次），97.17%为一般反应（20.54/万剂次），95.44%发生在接种后0~1 d内（20.08/万剂次）。一般反应中最常见的为发热（224例）、局部红肿（204例）及硬结（190例），异常反应中报告最多的是过敏性皮疹（11例）。综上，浙江地区PCV13-TT上市后在5岁及以下儿童中接种具有较好的安全性。.

Laughing gas (Nitrogen monoxide) is currently abused due to its low price and easy availability. This article discussed the clinical manifestations of a patient with subacute combined degeneration of the spinal cord caused by inhalation of laughing gas. The patient developed numbness of extremities, unstable walking, and decreased serum vitamin B(12) level. MRI of the cervical spine showed abnormal signals in the lateral and posterior cords of the cervical spinal cord (C2-6) , neuroelectrophysiological examination showed peripheral nerve damage in the extremities. After treatment with vitamin B(12) supplementation, the patient's condition gradually improved. Clinicians diagnose subacute combined degeneration of the spinal cord, especially when the patient has no gastrointestinal disease, diet, malnutrition, etc., they need to carefully inquire about the history of nitrous oxide inhalation to avoid missed diagnosis.笑气（一氧化二氮）因价格低廉、容易获得，目前存在滥用情况。本文探讨1例吸食笑气致脊髓亚急性联合变性患者的临床表现，患者出现四肢麻木、步态不稳，血清维生素B(12)水平降低，颈椎MRI提示颈髓（C2-6）侧索及后索内节段性异常信号；神经电生理检查示四肢周围神经损害。经补充维生素B(12)治疗，患者病情逐渐好转。临床医生诊断脊髓亚急性联合变性，尤其患者无消化道疾病、节食、营养不良等情况时，需仔细询问有无吸食笑气史，避免漏诊。.

The ability to hand over objects to humans is an important skill for service robots. However, determining the proper object pose for handover is a challenging task. Our approach, based on observations of a set of natural human handovers, addresses three related challenges in teaching robots how to hand over objects: (1) how to compute mathematically an appropriate ‘standard’ or ‘mean’ handover orientation, (2) how to ascertain whether an observed set is of good or poor quality, and (3) using (1) and (2), how to compute an appropriate handover orientation from a set, in a manner that is robust to the quality of the set. We first compare three methods for computing mean orientations and show that our proposed distance minimization based method yields the best results. Next, we show that using the concept of affordance axes, we can evaluate the quality of a set of observed orientations. Finally, using affordance axes together with random sample consensus, we devise a method for computing an appropriate handover orientation from a set of observed natural handover orientations. User study data verified that our methods are successful in identifying both good and poor quality sets of handover orientations and in computing appropriate handover orientations from observed natural handover orientations. These results enable robots to automatically learn proper handover orientations for various objects.

This paper investigates the use of kinematic motions recognized by a support vector machine (SVM) for the automatic detection of object handovers from the perspective of an object receiver. The cla...

We present a system for fast and robust handovers with a robot character, together with a user study investigating the effect of robot speed and reaction time on perceived interaction quality. The system can match and exceed human speeds and confirms that users prefer human-level timing.The system has the appearance of a robot character, with a bear-like head and a soft anthropomorphic hand and uses Bezier curves to achieve smooth minimum-jerk motions. Fast timing is enabled by low latency motion capture and real-time trajectory generation: the robot initially moves towards an expected handover location and the trajectory is updated on-the-fly to converge smoothly to the actual handover location. A hybrid automaton provides robustness to failure and unexpected human actions.In a 3x3 user study, we vary the speed of the robot and add variable sensorimotor delays. We evaluate the social perception of the robot using the Robot Social Attribute Scale (RoSAS). Inclusion of a small delay, mimicking the delay of the human sensorimotor system, leads to an improvement in perceived qualities over both no delay and long delay conditions. Specifically, with no delay the robot is perceived as more discomforting, and with a long delay it is perceived as less warm.

This paper presents a future-focused approach for robot programming based on augmented trajectories. Using a mixed reality head-mounted display (Microsoft Hololens) and a 7-DOF robot arm, we designed an augmented reality (AR) robotic interface with four interactive functions to ease the robot programming task: 1) Trajectory specification. 2) Virtual previews of robot motion. 3) Visualization of robot parameters. 4) Online reprogramming during simulation and execution. We validate our AR-robot teaching interface by comparing it with a kinesthetic teaching interface in two different scenarios as part of a pilot study: creation of contact surface path and free space path. Furthermore, we present an industrial case study that illustrates our AR manufacturing paradigm by interacting with a 7-DOF robot arm to reduce wrinkles during the pleating step of the carbon-fiber-reinforcement-polymer vacuum bagging process in a simulated scenario.

This work explores social perceptions of robots within the domain of human-to-robot handovers. Using the Robotic Social Attributes Scale (RoSAS), we explore how users socially judge robot receivers as three factors are varied: initial position of the robot arm prior to handover, grasp method employed by the robot when receiving a handover object trading off perceived object safety for time efficiency, and retraction speed of the arm following handover. Our results show that over multiple handover interactions with the robot, users gradually perceive the robot receiver as being less discomforting and having more emotional warmth. Additionally, we have found that by varying grasp method and retraction speed, users may hold significantly different judgments of robot competence and discomfort. With these results, we recognize empirically that users are able to develop social perceptions of robots which can change through modification of robot receiving behaviour and through repeated interaction with the robot. More widely, this work suggests that measurement of user social perceptions should play a larger role in the design and evaluation of human-robot interactions and that the RoSAS can serve as a standardized tool in this regard.

We present a system enabling users to accurately catch a real ball while immersed in a virtual reality environment. We examine three visualizations: rendering a matching virtual ball, the predicted trajectory of the ball, and a target catching point lying on the predicted trajectory. In our demonstration system, we track the projectile motion of a ball as it is being tossed between users. Using Unscented Kalman Filtering, we generate predictive estimates of the ball's motion as it approaches the catcher. The predictive assistance visualizations effectively increases the user's senses but can also alter the user's strategy in catching.

Through quantitatively analyzing the implementation of the sponge city concept in urban green space systems, this research explored the role of urban green spaces in collecting and using rainwater in a urban landscaping. By combining the ecological and recreational functions of the urban green spaces, as well as appropriate quantitative indexes, reasonable approaches for applying rainwater collection, infiltration and retention technologies in urban green space design and construction are suggested. Thus, the implementation of the sponge city concept in the initial planning stage of green spaces was considered. The Taihu New City in Wuxi was chosen as study case. Thus, this paper combined current planning status between green space and rainwater collection systems and analyzed them. As result, usable green spaces for the sponge city construction were obtained. Also, details on the construction characteristics of various usable green spaces were acquired. The role of these green spaces in the sponge city construction were classified and quantitatively assessed and compared with relevant standards. On the basis of guaranteeing green space intended purposes, this paper analyzed the results of coordinating the green space areas with rainwater collection systems and specified the role of various green spaces in the rainwater collection.

Epipremnum pinnatum Engl. is a flowering plant in the family Araceae. In southern China, it is often cultivated for medicinal and ornamental purposes. A distinct leaf blotch was observed on E. pinnatum in October 2017. Symptoms included gray or tan irregular blotches, with reddish to yellow margins. Portions of the symptomatic leaves were surface sterilized in 70% ethanol for 30 s and then in 2% NaClO for 1 min, rinsed three times in sterile distilled water, and plated onto potato dextrose agar (PDA). Seven strains (GUCC 8601 to GUCC 8607) from four diseased E. pinnatum plants were obtained by single spore selection. Fungal colonies on PDA reached 70 to 75 mm in diameter after 7 days, were velvety to slightly powdery, and were gray olivaceous to olivaceous black both top and reverse. Conidiophores were single or in groups, septate, straight or flexuous, and geniculate. Conidiogenous cells were smooth walled to finely verruculose, terminal or intercalary, proliferating sympodially, pale brown to brown, subcylindrical to swollen, and 6 to 14 × 3 to 5 μm (n = 30). Conidia were curved, pale brown to brown, 3 to 4 distoseptate, 23 × 9 μm (n = 50) with a protuberant hilum; morphology was consistent with Curvularia asianensis Manamgoda, L. Cai & K. D. Hyde, isolated from a dried Panicum sp. leaf in northern Thailand (Manamgoda et al. 2012). The internal transcribed spacer (ITS) region and partial sequences of two protein-coding genes, namely, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and translation elongation factor 1-α (TEF1), were amplified using primers ITS1 and ITS4 (White et al. 1990), gpd1 and gpd2 (Berbee et al. 1999), and EF983F and 2218R (Schoch et al. 2009). The ITS, GAPDH, and TEF1 sequences were compared with entries in GenBank database, through nucleotide BLAST search, and our isolates showed higher than 99% identity to the ex-type strain (MFLUCC 10-0711) of C. asianensis (ITS, JX256424; GAPDH, JX276436; and TEF1, JX266593) for these three gene regions. The three gene regions were combined into a multigene phylogenetic tree. On the basis of morphological characteristics and nucleotide homology, our isolates were confirmed as C. asianensis. For pathogenicity tests, mycelial disks (5 mm in diameter) cut from 1-week-old PDA cultures of two strains (GUCC 8601 and GUCC 8602) were placed on four healthy leaves (two inoculated points on every leaf) of an E. pinnatum plant under natural conditions on 20 November 2017 and removed after 48 h. Leaves inoculated with sterile PDA disks served as controls. Within 24 h after discs were removed, tan lesions began to appear on the leaves. Seven days after inoculation, all inoculated leaves developed blotch symptoms consistent with what was observed in nature. C. asianensis strains were reisolated from infected tissues and confirmed by the methods mentioned above. Controls remained healthy. To our knowledge, this is the first report of C. asianensis causing leaf blotch disease on E. pinnatum in China.

To enable robots to learn handover orientations from observing natural handovers, we conduct a user study to measure and compare natural handover orientations with giver-centered and receiver-centered handover orientations for twenty common objects. We use a distance minimization approach to compute mean handover orientations. We posit that, computed means of receiver-centered orientations could be used by robot givers to achieve more efficient and socially acceptable handovers. Furthermore, we introduce the notion of affordance axes for comparing handover orientations, and offer a definition for computing them. Observable patterns were found in receiver-centered handover orientations. Comparisons show that depending on the object, natural handover orientations may not be receiver-centered; thus, robots may need to distinguish between good and bad handover orientations when learning from natural handovers.

A robot that can fluently hand over objects to people can be useful in many applications. In an effort to develop a fluent robot-to-human handover system, this work investigates people's behavioural responses to a robot that hands over objects to them while using different types of gaze cues. In our previous work, we found empirical evidence that the use of a robot's head gaze can affect a person's timing of reaching towards the offered object. In this paper, we investigate this effect further by exploring the manner in which human's reaching and gaze behaviours are affected by a robot's head gaze. We conducted a video-based investigation of 97 naive participants' behavioural responses to robot-to-human handovers. Through a frame-by-frame analysis, we recorded a detailed timeline of the robot's and human's gaze and reaching behaviours. Results confirm the finding from our previous study that the robot's head gaze can significantly impact the timing of human receiver's reaching behaviour during handovers. In addition, our results demonstrate that the robot's head gaze affects human's gaze behaviour during handovers, and this effect explains some unexpected findings in our previous work.