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Your search keyword '"Wu, Chi-Chung"' showing total 28 results
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28 results on '"Wu, Chi-Chung"'

2. BMP signaling promotes heart regeneration via alleviation of replication stress

Author

Dalvoy Vasudevarao, Mohankrishna, primary, Posadas-pena, Denise Silvia, additional, Ihle, Michaela, additional, Bongiovanni, Chiara, additional, Maity, Pallab, additional, Redaelli, Simone, additional, Happ, Kathrin, additional, Geissler, Dominik, additional, Mohammadi, Hossein Falah, additional, Rall-Scharpf, Melanie, additional, Wu, Chi-Chung, additional, Beisaw, Arica, additional, Scharffetter-Kochanek, Karin, additional, D'Uva, Gabriele, additional, Wiesmueller, Lisa, additional, and Weidinger, Gilbert, additional

Published
2024
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5. Cardiomyocyte maturation and its reversal during cardiac regeneration.

Author

Beisaw, Arica and Wu, Chi‐Chung

Subjects
CARDIAC regeneration, REGENERATION (Biology), MYOCARDIAL infarction, HEART failure, CAUSES of death
Abstract

Cardiovascular disease is a leading cause of death worldwide. Due to the limited proliferative and regenerative capacity of adult cardiomyocytes, the lost myocardium is not replenished efficiently and is replaced by a fibrotic scar, which eventually leads to heart failure. Current therapies to cure or delay the progression of heart failure are limited; hence, there is a pressing need for regenerative approaches to support the failing heart. Cardiomyocytes undergo a series of transcriptional, structural, and metabolic changes after birth (collectively termed maturation), which is critical for their contractile function but limits the regenerative capacity of the heart. In regenerative organisms, cardiomyocytes revert from their terminally differentiated state into a less mature state (ie, dedifferentiation) to allow for proliferation and regeneration to occur. Importantly, stimulating adult cardiomyocyte dedifferentiation has been shown to promote morphological and functional improvement after myocardial infarction, further highlighting the importance of cardiomyocyte dedifferentiation in heart regeneration. Here, we review several hallmarks of cardiomyocyte maturation, and summarize how their reversal facilitates cardiomyocyte proliferation and heart regeneration. A detailed understanding of how cardiomyocyte dedifferentiation is regulated will provide insights into therapeutic options to promote cardiomyocyte de‐maturation and proliferation, and ultimately heart regeneration in mammals. Key Findings: We reviewed key features of cardiomyocyte maturation, including myofibril, metabolism, and polyploidy.We reviewed recent advances in the role of cardiomyocyte dedifferentiation in cardiac repair/regeneration in both regenerative and non‐regenerative models.We reviewed recent advances in cardiomyocyte regeneration, including cardiomyocyte invasion of injured tissue and cardiomyocyte re‐differentiation following proliferation. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Rnf20 shapes the endothelial control of heart morphogenesis and function

Author

Kessler, Linda, primary, Gao, Rui, additional, Tetik-Elsherbiny, Nalan, additional, Lityagina, Olga, additional, Zhailauova, Azhar, additional, Ren, Yonggang, additional, Trogisch, Felix A., additional, Cordero, Julio, additional, Dou, Yanliang, additional, Wang, Yinuo, additional, Chichelnitskiy, Evgeny, additional, Kraske, Joscha Alexander, additional, Schäfer, Patricia Laura, additional, Wu, Chi-Chung, additional, Barreto, Guillermo, additional, Potente, Michael, additional, Wieland, Thomas, additional, Ola, Roxana, additional, Heineke, Joerg, additional, and Dobreva, Gergana, additional

Published
2022
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13. Is zebrafish heart regeneration 'complete'?: Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts

Author

Medische Fysiologie, Circulatory Health, Cardiologie onderzoek 2, Onderzoek, Bertozzi, Alberto, Wu, Chi-Chung, Nguyen, Phong D, Vasudevarao, Mohankrishna Dalvoy, Mulaw, Medhanie A, Koopman, Charlotte D, de Boer, Teun P, Bakkers, Jeroen, Weidinger, Gilbert, Medische Fysiologie, Circulatory Health, Cardiologie onderzoek 2, Onderzoek, Bertozzi, Alberto, Wu, Chi-Chung, Nguyen, Phong D, Vasudevarao, Mohankrishna Dalvoy, Mulaw, Medhanie A, Koopman, Charlotte D, de Boer, Teun P, Bakkers, Jeroen, and Weidinger, Gilbert

Published
2021

14. Is zebrafish heart regeneration 'complete'?: Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts

Author

Bertozzi, Alberto, Wu, Chi-Chung, Nguyen, Phong D, Vasudevarao, Mohankrishna Dalvoy, Mulaw, Medhanie A, Koopman, Charlotte D, de Boer, Teun P, Bakkers, Jeroen, Weidinger, Gilbert, Bertozzi, Alberto, Wu, Chi-Chung, Nguyen, Phong D, Vasudevarao, Mohankrishna Dalvoy, Mulaw, Medhanie A, Koopman, Charlotte D, de Boer, Teun P, Bakkers, Jeroen, and Weidinger, Gilbert

Abstract

Adult zebrafish are frequently described to be able to "completely" regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since only indirect evidence for cardiomyocyte proliferation exists. We established stereological methods to quantify the number of cardiomyocytes at several time-points post cryoinjury. Intriguingly, after cryoinjuries that killed about 1/3 of the ventricular cardiomyocytes, pre-injury cardiomyocyte numbers were restored already within 30 days. Yet, many hearts retained small residual scars, and a subset of cardiomyocytes bordering these fibrotic areas remained smaller, lacked differentiated sarcomeric structures, and displayed defective calcium signaling. Thus, a subset of regenerated cardiomyocytes failed to fully mature. While lineage-tracing experiments have shown that regenerating cardiomyocytes are derived from differentiated cardiomyocytes, technical limitations have previously made it impossible to test whether cardiomyocyte trans-differentiation contributes to regeneration of non-myocyte cell lineages. Using Cre responder lines that are expressed in all major cell types of the heart, we found no evidence for cardiomyocyte transdifferentiation into endothelial, epicardial, fibroblast or immune cell lineages. Overall, our results imply a refined answer to the question whether zebrafish can completely regenerate the heart: in response to cryoinjury, preinjury cardiomyocyte numbers are indeed completely regenerated, while restoration of cardiomyocyte differentiation and function, as well as resorption of scar tissue, is less robustly achieved.

Published
2020

15. Is zebrafish heart regeneration “complete”? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts

Author

Bertozzi, Alberto, primary, Wu, Chi-Chung, additional, Nguyen, Phong D., additional, Vasudevarao, Mohankrishna Dalvoy, additional, Mulaw, Medhanie A., additional, Koopman, Charlotte D., additional, de Boer, Teun P., additional, Bakkers, Jeroen, additional, and Weidinger, Gilbert, additional

Published
2020
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19. Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

Author

Wu, Chi Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., Van Oudenaarden, Alexander, Weidinger, Gilbert, Bakkers, Jeroen, Wu, Chi Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., Van Oudenaarden, Alexander, Weidinger, Gilbert, and Bakkers, Jeroen

Published
2016

20. Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration

Author

Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, Medische Fysiologie, Circulatory Health, Wu, Chi Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., Van Oudenaarden, Alexander, Weidinger, Gilbert, Bakkers, Jeroen, Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, Medische Fysiologie, Circulatory Health, Wu, Chi Chung, Kruse, Fabian, Vasudevarao, Mohankrishna Dalvoy, Junker, Jan Philipp, Zebrowski, David C., Fischer, Kristin, Noël, Emily S., Grün, Dominic, Berezikov, Eugene, Engel, Felix B., Van Oudenaarden, Alexander, Weidinger, Gilbert, and Bakkers, Jeroen

Published
2016

23. Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

Author

Zebrowski, David C, primary, Vergarajauregui, Silvia, additional, Wu, Chi-Chung, additional, Piatkowski, Tanja, additional, Becker, Robert, additional, Leone, Marina, additional, Hirth, Sofia, additional, Ricciardi, Filomena, additional, Falk, Nathalie, additional, Giessl, Andreas, additional, Just, Steffen, additional, Braun, Thomas, additional, Weidinger, Gilbert, additional, and Engel, Felix B, additional

Published
2015
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25. Author response: Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

Author

Zebrowski, David C, primary, Vergarajauregui, Silvia, additional, Wu, Chi-Chung, additional, Piatkowski, Tanja, additional, Becker, Robert, additional, Leone, Marina, additional, Hirth, Sofia, additional, Ricciardi, Filomena, additional, Falk, Nathalie, additional, Giessl, Andreas, additional, Just, Steffen, additional, Braun, Thomas, additional, Weidinger, Gilbert, additional, and Engel, Felix B, additional

Published
2015
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