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34 results on '"Wu, Chao-Chien"'

11. BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters

Author

Hsu, Yuan‐Ting, primary, Wu, Chao‐Chien, additional, Wang, Chin‐Chou, additional, Chung, Wen‐Yu, additional, Sheu, Chau‐Chyun, additional, Yang, Yi‐Hsin, additional, Cheng, Ming‐Yen, additional, Lai, Ruay‐Sheng, additional, Leung, Sum‐Yee, additional, Lin, Chi‐Cheng, additional, Wei, Yu‐Feng, additional, Lin, Ching‐Hsiung, additional, Lin, Sheng‐Hao, additional, Hsu, Jeng‐Yuan, additional, Huang, Wei‐Chang, additional, Tseng, Chia‐Cheng, additional, Lai, Yung‐Fa, additional, Cheng, Meng‐Hsuan, additional, Chen, Huang‐Chi, additional, Yang, Chih‐Jen, additional, Su, Chian‐Heng, additional, Wang, Chien‐Jen, additional, Hsu, Shih‐Chang, additional, Hung, Chih‐Hsing, additional, Lee, Chon‐Lin, additional, Huang, Ming‐Shyan, additional, and Huang, Shau‐Ku, additional

Published
2023
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12. Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

Author

Chen, Yung-Che, Lin, Meng-Chih, Lee, Chih-Hung, Liu, Shih-Feng, Wang, Chin-Chou, Fang, Wen-Feng, Chao, Tung-Ying, Wu, Chao-Chien, Wei, Yu-Feng, Chang, Huang-Chih, Tsen, Chia-Cheng, Chen, Hung-Chen, and Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group

Published
2018
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13. Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Author

Wu, Chao-Chien, primary, Wang, Chin-Chou, additional, Chung, Wen-Yu, additional, Sheu, Chau-Chyun, additional, Yang, Yi-Hsin, additional, Cheng, Ming-Yen, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lin, Ching-Hsiung, additional, Lin, Sheng-Hao, additional, Hsu, Jeng-Yuan, additional, Huang, Wei-Chang, additional, Tseng, Chia-Cheng, additional, Lai, Yung-Fa, additional, Cheng, Meng-Hsuan, additional, Chen, Huang-Chi, additional, Yang, Chih-Jen, additional, Hsu, Shih-Chang, additional, Su, Chian-Heng, additional, Wang, Chien-Jen, additional, Liu, Huei-Ju, additional, Chen, Hua-Ling, additional, Hsu, Yuan-Ting, additional, Hung, Chih-Hsing, additional, Lee, Chon-Lin, additional, Huang, Ming-Shyan, additional, and Huang, Shau-Ku, additional

Published
2022
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16. Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Author

Wu, Chao-Chien, Wang, Chin-Chou, Chung, Wen-Yu, Sheu, Chau-Chyun, Yang, Yi-Hsin, Cheng, Ming-Yen, Lai, Ruay-Sheng, Leung, Sum-Yee, Lin, Chi-Cheng, Wei, Yu-Feng, Lin, Ching-Hsiung, Lin, Sheng-Hao, Hsu, Jeng-Yuan, Huang, Wei-Chang, Tseng, Chia-Cheng, Lai, Yung-Fa, Cheng, Meng-Hsuan, Chen, Huang-Chi, Yang, Chih-Jen, Hsu, Shih-Chang, Su, Chian-Heng, Wang, Chien-Jen, Liu, Huei-Ju, Chen, Hua-Ling, Hsu, Yuan-Ting, Hung, Chih-Hsing, Lee, Chon-Lin, Huang, Ming-Shyan, and Huang, Shau-Ku

Abstract

BackgroundAdult asthma is phenotypically heterogeneous with unclear aetiology. We aimed to evaluate the potential contribution of environmental exposure and its ensuing response to asthma and its heterogeneity.MethodsEnvironmental risk was evaluated by assessing the records of National Health Insurance Research Database (NHIRD) and residence-based air pollution (particulate matter with diameter less than 2.5 micrometers (PM2.5) and PM2.5-bound polycyclic aromatic hydrocarbons (PAHs)), integrating biomonitoring analysis of environmental pollutants, inflammatory markers and sphingolipid metabolites in case–control populations with mass spectrometry and ELISA. Phenotypic clustering was evaluated by t-distributed stochastic neighbor embedding (t-SNE) integrating 18 clinical and demographic variables.FindingsIn the NHIRD dataset, modest increase in the relative risk with time-lag effect for emergency (N=209 837) and outpatient visits (N=638 538) was observed with increasing levels of PM2.5and PAHs. Biomonitoring analysis revealed a panel of metals and organic pollutants, particularly metal Ni and PAH, posing a significant risk for current asthma (ORs=1.28–3.48) and its severity, correlating with the level of oxidative stress markers, notably Nε-(hexanoyl)-lysine (r=0.108–0.311, p<0.05), but not with the accumulated levels of PM2.5exposure. Further, levels of circulating sphingosine-1-phosphate and ceramide-1-phosphate were found to discriminate asthma (p<0.001 and p<0.05, respectively), correlating with the levels of PAH (r=0.196, p<0.01) and metal exposure (r=0.202–0.323, p<0.05), respectively, and both correlating with circulating inflammatory markers (r=0.186–0.427, p<0.01). Analysis of six phenotypic clusters and those cases with comorbid type 2 diabetes mellitus (T2DM) revealed cluster-selective environmental risks and biosignatures.InterpretationThese results suggest the potential contribution of environmental factors from multiple sources, their ensuing oxidative stress and sphingolipid remodeling to adult asthma and its phenotypic heterogeneity.

Published
2023
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17. Environmental Risks and Sphingolipid Signatures in Adult Asthma and Its Phenotypic Clusters: A Multi-Center Exploratory Study

Author

Wu, Chao-Chien, primary, Wang, Chin-Chou, additional, Chung, Wen-Yu, additional, Sheu, Chau-Chyun, additional, Yang, Yi-Hsin, additional, Cheng, Ming-Yen, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lin, Ching-Hsiung, additional, Lin, Sheng-Hao, additional, Hsu, Jeng-Yuan, additional, Huang, Wei-Chang, additional, Zheng, Jia-Cheng, additional, Lai, Yung-Fa, additional, Cheng, Meng-Hsuan, additional, Chen, Huang-Chi, additional, Yang, Zhi-Ren, additional, Hsu, Shih-Chang, additional, Su, Chian-Heng, additional, Wang, Chien-Jen, additional, Liu, Huei-Ju, additional, Chen, Hua-Ling, additional, Hsu, Yuan-Ting, additional, Hung, Chih-Hsing, additional, Lee, Chon-Lin, additional, Huang, Ming-Shyan, additional, Huang, Shau-Ku, additional, and Study, The Consortium for Taiwan Asthma, additional

Published
2021
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18. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1

Author

Chen, Yung-Che, primary, Lee, Chiu Ping, additional, Hsiao, Chang-Chun, additional, Hsu, Po-Yuan, additional, Wang, Ting-Ya, additional, Wu, Chao-Chien, additional, Chao, Tung-Ying, additional, Leung, Sum-Yee, additional, Chang, Yu-Ping, additional, and Lin, Meng-Chih, additional

Published
2020
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19. Comparative analysis of the drug-drug interaction between immunosuppressants, safety and efficacy of rifabutin from rifampicin-based Anti-TB treatment in living donor liver transplant recipients with active tuberculosis

Author

Wang, Yu-Chen, primary, Salvador, Noruel Gerard, additional, Lin, Chih-Che, additional, Wu, Chao-Chien, additional, Lin, Ting-Lung, additional, Lee, Wei-Feng, additional, Chan, Yi-Chia, additional, Chen, Chao-Long, additional, Co, Jeffrey Samuel, additional, and Encarnacion, Domelle Dave, additional

Published
2020
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20. Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9/miR-505/RASGRP4/GNG12 Gene Methylation and Clinical Phenotypes

Author

Chen, Yung-Che, primary, Hsiao, Chang-Chun, additional, Chen, Ting-Wen, additional, Wu, Chao-Chien, additional, Chao, Tung-Ying, additional, Leung, Sum-Yee, additional, Eng, Hock-Liew, additional, Lee, Chiu-Ping, additional, Wang, Ting-Ya, additional, and Lin, Meng-Chih, additional

Published
2020
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21. Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes.

Author

Chen, Yung-Che, Tsai, Ying-Huang, Wang, Chin-Chou, Liu, Shih-Feng, Chen, Ting-Wen, Fang, Wen-Feng, Lee, Chiu-Ping, Hsu, Po-Yuan, Chao, Tung-Ying, Wu, Chao-Chien, Wei, Yu-Feng, Chang, Huang-Chih, Tsen, Chia-Cheng, Chang, Yu-Ping, Lin, Meng-Chih, Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group, Yu, Chong-Jen, Wang, Hao-Chien, Chiang, Chi-Huei, and Perng, Diahn-Warng

Subjects
LUNG diseases, DNA methylation, DNA microarrays, DISEASE exacerbation, CIGARETTE smoke
Abstract

We hypothesized that epigenetics is a link between smoking/allergen exposures and the development of Asthma and chronic obstructive pulmonary disease (ACO). A total of 75 of 228 COPD patients were identified as ACO, which was independently associated with increased exacerbations. Microarray analysis identified 404 differentially methylated loci (DML) in ACO patients, and 6575 DML in those with rapid lung function decline in a discovery cohort. In the validation cohort, ACO patients had hypermethylated PDE9A (+ 30,088)/ZNF323 (− 296), and hypomethylated SEPT8 (− 47) genes as compared with either pure COPD patients or healthy non-smokers. Hypermethylated TIGIT (− 173) gene and hypomethylated CYSLTR1 (+ 348)/CCDC88C (+ 125,722)/ADORA2B (+ 1339) were associated with severe airflow limitation, while hypomethylated IFRD1 (− 515) gene with frequent exacerbation in all the COPD patients. Hypermethylated ZNF323 (− 296) / MPV17L (+ 194) and hypomethylated PTPRN2 (+ 10,000) genes were associated with rapid lung function decline. In vitro cigarette smoke extract and ovalbumin concurrent exposure resulted in specific DNA methylation changes of the MPV17L / ZNF323 genes, while 5-aza-2′-deoxycytidine treatment reversed promoter hypermethylation-mediated MPV17L under-expression accompanied with reduced apoptosis and decreased generation of reactive oxygen species. Aberrant DNA methylations may constitute a determinant for ACO, and provide a biomarker of airflow limitation, exacerbation, and lung function decline. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease

Author

Chen, Yung-Che, Chao, Tung-Ying, Leung, Sum-Yee, Chen, Chung-Jen, Wu, Chao-Chien, Fang, Wen-Feng, Wang, Yi-Hsi, Chang, Huang-Chih, Wang, Ting-Ya, Lin, Yong-Yong, Zheng, Yi-Xin, Lin, Meng-Chih, and Hsiao, Chang-Chun

Subjects
Original Article
Abstract

The aim of this study is to determine the roles of global histone acetylation (Ac)/methylation (me), their modifying enzymes, and gene-specific histone enrichment in active pulmonary tuberculosis (TB) disease. Global histone H3K27me3, H3K27me2, H3K9me3, H3K9Ac, and H3K14Ac expressions, and their modifying enzyme expressions, including KDM1A, KDM6B, EZH2, HDAC1, and HDAC2, were assessed in blood leukocytes from 81 patients with active pulmonary TB disease and 44 matched healthy subjects (HS). TLR2, TNF-α, IFN-γ, and IL12B-specific histone enrichment of peripheral blood mononuclear cells was measured by chromatin immunoprecipitation method. We found that Global H3K14Ac was decreased and H3K27me2 was increased in TB patients as compared with that in HS. TB patients with low H3K14Ac had lower one-year survival. Global H3K27me3 was increased in TB patients with high bacterial burden, or systemic symptoms as compared with that in those without the attribute or HS. HDAC1 gene/protein expressions were increased in TB patients as compared with that in HS, whereas KDM6B gene/protein expressions were decreased. Global H3K27me2, HDAC1 and KDM6B protein expressions were all reversed to normal after 6-month anti-TB treatment. TNF-α/IL12B promoter-specific H3K14Ac and TNF-α/IL12B/IFN-γ promoter-specific H3K27me2 enrichment were all decreased in 10 TB patients as compared with that in 10 HS. Among them, IL12B-specific H3K27me2 enrichment was reversed to normal after treatment, while the other 4 remained depressed. In conclusions, H3K14 hypoacetylation and H3K27 hypermethylation play a role in the development of active pulmonary TB disease or its clinical phenotypes, probably through up-regulation of HDAC1 and down-regulation of KDM6B, respectively.

Published
2017

24. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Author

Wong, Tzu-Hsuan, primary, Lee, Chon-Lin, additional, Su, Hsiang-Han, additional, Lee, Chin-Lai, additional, Wu, Chao-Chien, additional, Wang, Chin-Chou, additional, Sheu, Chau-Chyun, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Wang, Chien-Jen, additional, Lin, Yu-Chun, additional, Chen, Hua-Ling, additional, Huang, Ming-Shyan, additional, Yen, Jeng-Hsien, additional, Huang, Shau-Ku, additional, and Suen, Jau-Ling, additional

Published
2018
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25. Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma

Author

Hung, Chih-Hsing, primary, Wang, Chin-Chou, additional, Suen, Jau-Ling, additional, Sheu, Chau-Chyun, additional, Kuo, Chang-Hung, additional, Liao, Wei-Ting, additional, Yang, Yi-Hsin, additional, Wu, Chao-Chien, additional, Leung, Sum-Yee, additional, Lai, Ruay-Sheng, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lee, Chong-Yeh, additional, Huang, Ming-Shyan, additional, and Huang, Shau-Ku, additional

Published
2018
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26. A randomized clinical trial of neurally adjusted ventilatory assist versus conventional weaning mode in patients with COPD and prolonged mechanical ventilation

Author

Kuo,Nai-Ying, Tu,Mei-Lien, Hung,Tsai-Yi, Liu,Shih-Feng, Chung,Yu-Hsiu, Lin,Meng-Chih, Wu,Chao-Chien, Kuo,Nai-Ying, Tu,Mei-Lien, Hung,Tsai-Yi, Liu,Shih-Feng, Chung,Yu-Hsiu, Lin,Meng-Chih, and Wu,Chao-Chien

Abstract

Nai-Ying Kuo,1,2 Mei-Lien Tu,1,3 Tsai-Yi Hung,1 Shih-Feng Liu,4 Yu-Hsiu Chung,4 Meng-Chih Lin,4 Chao-Chien Wu41Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital; 2Kaohsiung Medical University; 3Respiratory Care, Chang Gung University of Science and Technology, Chiayi, Taiwan; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanBackground: Patient-ventilator asynchrony is a common problem in mechanically ventilated patients; the problem is especially obvious in COPD. Neutrally adjusted ventilatory assist (NAVA) can improve patient-ventilator asynchrony; however, the effect in COPD patients with prolonged mechanical ventilation is still unknown. The goals of this study are to evaluate the effect of NAVA and conventional weaning mode in patients with COPD during prolonged mechanical ventilation.Methods: The study enrolled a total of 33 COPD patients with ventilator dependency for more than 21 days in the weaning center. A diaphragm electrical activity (Edi) catheter was inserted in patients within 24 hours after admission to the respiratory care center, and patients were randomly allocated to NAVA or conventional group. A spontaneous breathing trial was performed every 24 hours. The results correlated with the clinical parameters.Results: There were significantly higher asynchrony incidence rates in the whole group after using Edi catheter (before vs post-Edi catheter insertion =60.6% vs 87.9%, P<0.001). Asynchrony index: before vs post-Edi catheter insertion =7.4%±8.5% vs 13.2%±13.5%, P<0.01. Asynchrony incidence: NAVA vs conventional =0% vs 84.2%, P<0.001. Asynchrony index: NAVA vs conventional =0 vs 11.9±11.2 (breath %), P<0.001. The most common asynchrony events were ineffective trigger and delayed trigger. Conclusion: Compared to conventional mode

Published
2016

29. Protective effects of elafin against adult asthma

Author

Tsai, Yi-Shan, primary, Tseng, Yu-Ting, additional, Chen, Pei-Shih, additional, Lin, Meng-Chih, additional, Wu, Chao-Chien, additional, Huang, Ming-Shyan, additional, Wang, Chin-Chou, additional, Chen, Kang-Shin, additional, Lin, Yuan-Chung, additional, and Wang, Tsu-Nai, additional

Published
2016
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32. Exploring Occupational Asthmagen‐Related Asthma Phenotypes: A Cluster Analysis and Machine Learning Study.

Author

Liao, Tzu‐Ching, Tsai, Pei‐Chien, Lin, Meng‐Chih, Wu, Chao‐Chien, Chen, Hung‐Chen, Chen, Pei‐Shih, Lin, Yuan‐Chung, Chen, Kang‐Shin, and Wang, Tsu‐Nai

Subjects
*OCCUPATIONAL asthma, *EMERGENCY room visits, *TOBACCO smoke pollution, *MEDICAL sciences, *ASTHMATICS, *ADOLESCENT smoking
Abstract

The article "Exploring Occupational Asthmagen-Related Asthma Phenotypes: A Cluster Analysis and Machine Learning Study" investigates different phenotypes of work-related asthma (WRA) using cluster analysis and machine learning. The study identifies distinct phenotypes of WRA based on occupational exposure and asthma characteristics, linking phenotype understanding to practical applications. The research aims to enhance patient care for asthmatics by predicting severe asthma and understanding the impact of occupational exposure on asthma outcomes. [Extracted from the article]

Published
2024
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33. Comparative analysis of the drug-drug interaction between immunosuppressants, safety and efficacy of rifabutin from rifampicin-based Anti-TB treatment in living donor liver transplant recipients with active tuberculosis

Author

Wang, Yu-Chen, Salvador, Noruel Gerard, Lin, Chih-Che, Wu, Chao-Chien, Lin, Ting-Lung, Lee, Wei-Feng, Chan, Yi-Chia, Chen, Chao-Long, Co, Jeffrey Samuel, and Encarnacion, Domelle Dave

Abstract

The Interaction between anti-tuberculous and immunosuppressive drugs which may increase the risk of graft rejections is a major challenge in managing transplant recipients with tuberculosis (TB). Instead of rifampicin (RFM), most guidelines recommended the use of rifabutin (RFB) because of its reduced capacity to induce immunosuppressant metabolism while maintaining the same efficacy as RFM against TB. However, there has been no available data directly comparing the outcome of RFB from RFM-based anti-TB regimens in liver transplant patients with TB. This study aimed to compare the effects of RFB from RFM-based treatment in terms of the drug interaction with immunosuppressants, as well as the safety, efficacy and clinical outcomes of living donor liver transplant (LDLT) recipients with active TB.

Published
2022
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34. Histone H3K14 hypoacetylation and H3K27 hypermethylation along with HDAC1 up-regulation and KDM6B down-regulation are associated with active pulmonary tuberculosis disease.

Author

Chen YC, Chao TY, Leung SY, Chen CJ, Wu CC, Fang WF, Wang YH, Chang HC, Wang TY, Lin YY, Zheng YX, Lin MC, and Hsiao CC

Abstract

The aim of this study is to determine the roles of global histone acetylation (Ac)/methylation (me), their modifying enzymes, and gene-specific histone enrichment in active pulmonary tuberculosis (TB) disease. Global histone H3K27me3, H3K27me2, H3K9me3, H3K9Ac, and H3K14Ac expressions, and their modifying enzyme expressions, including KDM1A, KDM6B, EZH2, HDAC1, and HDAC2, were assessed in blood leukocytes from 81 patients with active pulmonary TB disease and 44 matched healthy subjects (HS). TLR2 , TNF-α , IFN-γ , and IL12B -specific histone enrichment of peripheral blood mononuclear cells was measured by chromatin immunoprecipitation method. We found that Global H3K14Ac was decreased and H3K27me2 was increased in TB patients as compared with that in HS. TB patients with low H3K14Ac had lower one-year survival. Global H3K27me3 was increased in TB patients with high bacterial burden, or systemic symptoms as compared with that in those without the attribute or HS. HDAC1 gene/protein expressions were increased in TB patients as compared with that in HS, whereas KDM6B gene/protein expressions were decreased. Global H3K27me2, HDAC1 and KDM6B protein expressions were all reversed to normal after 6-month anti-TB treatment. TNF-α/IL12B promoter-specific H3K14Ac and TNF-α/IL12B/IFN-γ promoter-specific H3K27me2 enrichment were all decreased in 10 TB patients as compared with that in 10 HS. Among them, IL12B -specific H3K27me2 enrichment was reversed to normal after treatment, while the other 4 remained depressed. In conclusions, H3K14 hypoacetylation and H3K27 hypermethylation play a role in the development of active pulmonary TB disease or its clinical phenotypes, probably through up-regulation of HDAC1 and down-regulation of KDM6B, respectively., Competing Interests: None.

Published
2017

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