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481 results on '"Wilton, Stephen B."'

1. Response shift in coronary artery disease

Author

Lawal, Oluwaseyi A., Awosoga, Oluwagbohunmi A., Santana, Maria J., Ayilara, Olawale F., Wang, Meng, Graham, Michelle M., Norris, Colleen M., Wilton, Stephen B., James, Matthew T., and Sajobi, Tolulope T.

Published
2024
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5. Optimal medical therapy improves outcomes in patients with diabetes mellitus and acute myocardial infarction

Author

Zhang, Dongfeng, Gao, Hai, Song, Xiantao, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Paulo Simao Henriques, Jose, D'Ascenzo, Fabrizio, Saucedo, Jorge, Ramón González-Juanatey, José, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Moretti, Claudio, Huczek, Zenon, Nie, Shaoping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, Southern, Danielle, and Kalpak, Oliver

Published
2023
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6. Antithrombotic Strategy in Secondary Prevention for High-Risk Patients with Previous Acute Coronary Syndrome: Overlap between the PEGASUS Eligibility and the COMPASS Eligibility in a Large Multicenter Registry

Author

Millesimo, Michele, Elia, Edoardo, Marengo, Giorgio, De Filippo, Ovidio, Raposeiras-Roubin, Sergio, Wańha, Wojciech, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Iannaccone, Mario, Henriques, Jose Paulo Simao, Templin, Christian, Wilton, Stephen B., Velicki, Lazar, Xanthopoulou, Ioanna, Correia, Luis, Cerrato, Enrico, Rognoni, Andrea, Nuñez-Gil, Iván, Song, Xiantao, Kawaji, Tetsuma, Quadri, Giorgio, Huczek, Zenon, Paz, Rafael Cobas, Juanatey, José Ramón González, Nie, Shao-Ping, Kawashiri, Masa-aki, Dominguez-Rodriguez, Alberto, Conrotto, Federico, D’Ascenzo, Fabrizio, and De Ferrari, Gaetano Maria

Published
2023
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13. A randomized controlled trial of a "Small Changes" behavioral weight loss treatment delivered in cardiac rehabilitation for patients with atrial fibrillation and obesity: study protocol for the BE-WEL in CR-AF study.

Author

Williamson, Tamara M., Rouleau, Codie R., Wilton, Stephen B., Valdarchi, A. Braiden, Moran, Chelsea, Patel, Stuti, Lutes, Lesley, Aggarwal, Sandeep G., Arena, Ross, and Campbell, Tavis S.

Subjects
SYMPTOM burden, WEIGHT loss, ATRIAL fibrillation, QUALITY of life, RANDOMIZED controlled trials, MORBID obesity
Abstract

Background: Atrial fibrillation (AF) represents a global epidemic. Although international AF practice guidelines indicate weight loss for patients with AF and comorbid obesity (BMI ≥ 30 kg/m2) to alleviate symptom burden and improve prognosis, few cardiac rehabilitation (CR) programs include targeted weight loss treatment. Aims: This RCT protocol will evaluate the efficacy of a "Small Changes" behavioral weight loss treatment (BWLT) to produce clinically relevant (≥ 10%) weight loss among patients with AF and obesity undergoing CR, relative to CR alone. Secondary aims are to establish efficacy of CR + BWLT for improving AF symptoms, AF risk factors, and health-related quality of life. Methods: Adults (18 +) with AF and obesity will be recruited and randomized to receive CR + BWLT (intervention) or CR-only (control). Controls will receive CR consisting of supervised exercise and risk factor self-management for 12 weeks. The intervention group will receive CR plus BWLT (12 weekly, group-based virtual sessions, followed by 12 weeks of follow-up support). Weight and AF-risk factors will be assessed at pre-randomization, 12 weeks, 24 weeks, and 52 weeks. AF burden will be assessed using 30-s ECGs recorded bidaily and with AF symptoms. The primary endpoint of weight loss will be calculated from baseline to 52 weeks as a percentage of starting weight. Intention-to-treat analyses will compare the proportion in each group achieving ≥ 10% weight loss. Assuming success rates of 5% and 30% among controls and intervention groups, respectively, and a 30% loss to follow-up, 120 patients (60 per group) will provide 80% power to detect a difference using a two-sided independent test of proportions (alpha = 5%). Impact: This clinical trial will be the first to demonstrate that adding BWLT to CR promotes clinically meaningful weight loss among patients with AF and comorbid obesity. Findings will inform design and execution of a large efficacy trial of long-term (e.g., 5-year) clinical endpoints (e.g., AF severity, mortality). Implementing weight control interventions designed to target the AF substrate in CR could dramatically reduce morbidity and enhance quality of life among patients living with AF in Canada. Trial registration: ClinicalTrials.gov registration number: NCT05600829. Registered October 31, 2022. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Dose-limiting, adverse event–associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial

Author

Abraham, William T., Piccini, Jonathan P., Dufton, Christopher, Carroll, Ian A., Healey, Jeffrey S., O’Connor, Christopher M., Marshall, Debra, Aleong, Ryan, van Veldhuisen, Dirk J., Rienstra, Michiel, Wilton, Stephen B., White, Michel, Sauer, William H., Anand, Inder S., Huebler, Sophia P., Connolly, Stuart J., and Bristow, Michael R.

Published
2022
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16. Ticagrelor or Clopidogrel After an Acute Coronary Syndrome in the Elderly: A Propensity Score Matching Analysis from 16,653 Patients Treated with PCI Included in Two Large Multinational Registries

Author

Bianco, Matteo, Careggio, Alessandro, Biolè, Carlo Alberto, Quadri, Giorgio, Quiros, Alicia, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solè, Albert, Liebetrau, Christoph, Manzano-Fernàndez, Sergio, Boccuzzi, Giacomo, Henriques, Jose P. S., Spirito, Amanda, Templin, Christian, Wilton, Stephen B., Velicki, Lazar, Correia, Luis, Rognoni, Andrea, Ugo, Fabrizio, Nunez-Gil, Ivàn, Fujii, Toshiharu, Durante, Alessandro, Song, Xiantao, Kawaji, Tetsuma, Alexopoulos, Dimitrios, Huczek, Zenon, Gonzàlez Juanatey, Josè Ramòn, Nie, Shao-Ping, Kawashiri, Masa-Aki, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Destefanis, Paola, Luciano, Alessia, De Ferrari, Gaetano Maria, Varbella, Ferdinando, Montagna, Laura, D’Ascenzo, Fabrizio, and Cerrato, Enrico

Published
2021
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21. Automated Cloud-deployable Pipeline for 3D Cardiac Shape Phenomics FBom 2D Cine Cardiac Magnetic Resonance Imaging

Author

Dykstra, Steven, primary, Marianchuk, Rylan, additional, Labib, Dina, additional, Hasanzadeh, Fereshteh, additional, Farrag, Nadia, additional, Ghosh, Tapotosh, additional, Rivest, Sandra, additional, Flewitt, Jacqueline, additional, Wilton, Stephen B., additional, Alim, Usman, additional, Maleki, Farhad, additional, Greiner, Russell, additional, Gavrilova, Marina, additional, and White, James, additional

Published
2024
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22. Left Atrial 4D Flow Characteristics in Patients with Atrial Fibrillation: Comparison with Healthy Controls and Associations with Left Atrial Remodelling and Contractile Health

Author

Sheitt, Hana, primary, Labib, Dina, additional, Yakimenka, Alena, additional, Serran, Malcolm, additional, Flewitt, Jacqueline, additional, Rivest, Sandra, additional, Dykstra, Steven, additional, Lydell, Carmen P., additional, Howarth, Andrew G., additional, Wilton, Stephen B., additional, White, James, additional, and Garcia, Julio, additional

Published
2024
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23. Response shift in coronary artery disease

Author

Lawal, Oluwaseyi A., primary, Awosoga, Oluwagbohunmi A., additional, Santana, Maria J., additional, Ayilara, Olawale F., additional, Wang, Meng, additional, Graham, Michelle M., additional, Norris, Colleen M., additional, Wilton, Stephen B., additional, James, Matthew T., additional, and Sajobi, Tolulope T., additional

Published
2023
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24. Unsupervised item response theory models for assessing sample heterogeneity in patient-reported outcomes measures

Author

Sajobi, Tolulope T., primary, Sanusi, Ridwan A., additional, Mayo, Nancy E., additional, Sawatzky, Richard, additional, Kongsgaard Nielsen, Lene, additional, Sebille, Veronique, additional, Liu, Juxin, additional, Bohm, Eric, additional, Awosoga, Oluwagbohunmi, additional, Norris, Colleen M., additional, Wilton, Stephen B., additional, James, Matthew T., additional, and Lix, Lisa M., additional

Published
2023
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25. Trajectories of perceived social support in acute coronary syndrome

Author

Wang, Meng, Norris, Colleen M., Graham, Michelle M., Santana, Maria, Liang, Zhiying, Awosoga, Oluwagbohunmi, Southern, Danielle A., James, Matthew T., Wilton, Stephen B., Quan, Hude, Lu, Mingshan, Ghali, William, Knudtson, Merril, and Sajobi, Tolulope T.

Published
2019

26. Efficacy and Safety of Clopidogrel, Prasugrel and Ticagrelor in ACS Patients Treated with PCI: A Propensity Score Analysis of the RENAMI and BleeMACS Registries

Author

Peyracchia, Mattia, Saglietto, Andrea, Biolè, Carloalberto, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Boccuzzi, Giacomo, Henriques, Jose Paulo Simao, Wilton, Stephen B., Velicki, Lazar, Xanthopoulou, Ioanna, Correia, Luis, Rognoni, Andrea, Fabrizio, Ugo, Nuñez-Gil, Iván, Montabone, Andrea, Taha, Salma, Fujii, Toshiharu, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Kawaji, Tetsuma, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Queija, Berenice Caneiro, Huczek, Zenon, Paz, Rafael Cobas, González-Juanatey, José Ramón, Fernández, María Cespón, Nie, Shao-Ping, D’Amico, Maurizio, Pousa, Isabel Muñoz, Kawashiri, Masa-aki, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Lopez-Cuenca, Angel, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, Grossomarra, Walter, Usmiani, Tullio, Rinaldi, Mauro, and D’Ascenzo, Fabrizio

Published
2020
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29. Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial

Author

Piccini, Jonathan P., Abraham, William T., Dufton, Christopher, Carroll, Ian A., Healey, Jeff S., van Veldhuisen, Dirk J., Sauer, William H., Anand, Inder S., White, Michel, Wilton, Stephen B., Aleong, Ryan, Rienstra, Michiel, Krueger, Steven K., Ayala-Paredes, Felix, Khaykin, Yaariv, Merkely, Bela, Miloradović, Vladimir, Wranicz, Jerzy K., Ilkhanoff, Leonard, Ziegler, Paul D., Davis, Gordon, Emery, Laura L., Marshall, Debra, Kao, David P., Bristow, Michael R., and Connolly, Stuart J.

Published
2019
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32. Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Author

Piccini, Jonathan P., Dufton, Christopher, Carroll, Ian A., Healey, Jeff S., Abraham, William T., Khaykin, Yaariv, Aleong, Ryan, Krueger, Steven K., Sauer, William H., Wilton, Stephen B., Rienstra, Michiel, van Veldhuisen, Dirk J., Anand, Inder S., White, Michel, Camm, A. John, Ziegler, Paul D., Marshall, Debra, Bristow, Michael R., and Connolly, Stuart J.

Published
2021
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33. A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial

Author

Piccini, Jonathan P., Connolly, Stuart J., Abraham, William T., Healey, Jeff S., Steinberg, Benjamin A., Al-Khalidi, Hussein R., Dignacco, Patricia, van Veldhuisen, Dirk J., Sauer, William H., White, Michel, Wilton, Stephen B., Anand, Inder S., Dufton, Christopher, Marshall, Debra A., Aleong, Ryan G., Davis, Gordon W., Clark, Richard L., Emery, Laura L., and Bristow, Michael R.

Published
2018
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34. Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome: The BleeMACS score

Author

Raposeiras-Roubín, Sergio, Faxén, Jonas, Íñiguez-Romo, Andrés, Henriques, Jose Paulo Simao, D'Ascenzo, Fabrizio, Saucedo, Jorge, Szummer, Karolina, Jernberg, Tomas, James, Stefan K., Juanatey, José Ramón González, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Moretti, Claudio, Huczek, Zenon, Nie, Shao-Ping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, Caneiro-Queija, Berenice, Cobas-Paz, Rafael, Acuña, José María García, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Giordana, Francesca, Gaita, Fiorenzo, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Yan, Yan, Fan, Jing-Yao, Ikari, Yuji, Nakahayshi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, Kedev, Sasko, Rivera-Asenjo, Daniel, and Abu-Assi, Emad

Published
2018
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35. Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia

Author

Roberts, Jason D., Gollob, Michael H., Young, Charlie, Connors, Sean P., Gray, Chris, Wilton, Stephen B., Green, Martin S., Zhu, Dennis W., Hodgkinson, Kathleen A., Poon, Annie, Li, Qiuju, Orr, Nathan, Tang, Anthony S., Klein, George J., Wojciak, Julianne, Campagna, Joan, Olgin, Jeffrey E., Badhwar, Nitish, Vedantham, Vasanth, Marcus, Gregory M., Kwok, Pui-Yan, Deo, Rahul C., and Scheinman, Melvin M.

Published
2017
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41. A disease-specific comorbidity index for predicting mortality in patients admitted to hospital with a cardiac condition

Author

Azzalini, Lorenzo, Chabot-Blanchet, Malorie, Southern, Danielle A., Nozza, Anna, Wilton, Stephen B., Graham, Michelle M., Gravel, Guillaume Marquis, Bluteau, Jean-Pierre, Rouleau, Jean-Lucien, Guertin, Marie-Claude, and Jolicoeur, E. Marc

Subjects
Coronary heart disease -- Prognosis -- Patient outcomes -- Comparative analysis -- Health aspects, Comorbidity -- Prognosis -- Patient outcomes -- Comparative analysis -- Analysis, Mortality -- Analysis -- Quebec, Novels, Cardiology, Regression analysis, Medical research, Health
Abstract

BACKGROUND: Comorbidity indexes derived from administrative databases are essential tools of research in global health. We sought to develop and validate a novel cardiac-specific comorbidity index, and to compare its accuracy with the generic Charlson-Deyo and Elixhauser comorbidity indexes. METHODS: We derived the cardiac-specific comorbidity index from consecutive patients who were admitted to hospital at a tertiary-care cardiology hospital in Quebec. We used logistic regression analysis and incorporated age, sex and 22 clinically relevant comorbidities to build the index. We compared the cardiac-specific comorbidity index with refitted Charlson-Deyo and Elixhauser comorbidity indexes using the C-statistic and net reclassification improvement to predict in-hospital death, and the Akaike information criterion to predict length of stay. We validated our findings externally in an independent cohort obtained from a provincial registry of coronary disease in Alberta. RESULTS: The novel cardiac-specific comorbidity index outperformed the refitted generic Charlson-Deyo and Elixhauser comorbidity indexes for predicting in-hospital mortality in the derivation population (n = 10 137): C-statistic 0.95 (95% confidence interval [CI] 0.94-0.9) v. 0.81 (95% CI 0.77-0.84) and 0.86 (95% CI 0.82-0.89), respectively. In the validation population (n = 17877), the cardiac-specific comorbidity index was similarly better: C-statistic 0.92 (95% CI 0.89-0.94) v. 0.76 (95% CI 0.71-0.81) and 0.82 (95% CI 0.78-0.86), respectively, and also numerically outperformed the Charlson-Deyo and Elixhauser comorbidity indexes for predicting 1-year mortality (C-statistic 0.78 [95% CI 0.76-0.80] v. 0.75 [95% CI 0.73-0.77] and 0.77 [95% CI 0.75-0.79], respectively). Similarly, the cardiac-specific comorbidity index showed better fit for the prediction of length of stay. The net reclassification improvement using the cardiac-specific comorbidity index for the prediction of death was 0.290 compared with the Charlson-Deyo comorbidity index and 0.192 compared with the Elixhauser comorbidity index. INTERPRETATION: The cardiac-specific comorbidity index predicted in-hospital and 1-year death and length of stay in cardiovascular populations better than existing generic models. This novel index may be useful for research of cardiology outcomes performed with large administrative databases., The processing of large health administrative data sets has been facilitated by the implementation of national comprehensive registries. Successful examples of outcomes research based on these data include randomized trials [...]

Published
2019
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45. Preferences of Patients With Chronic Kidney Disease for Invasive Versus Conservative Treatment of Acute Coronary Syndrome: A Discrete Choice Experiment

Author

Wilson, Todd A., primary, Hazlewood, Glen S., additional, Sajobi, Tolulope T., additional, Wilton, Stephen B., additional, Pearson, Winnie E., additional, Connolly, Carol, additional, Javaheri, Pantea A., additional, Finlay, Juli L., additional, Levin, Adeera, additional, Graham, Michelle M., additional, Tonelli, Marcello, additional, and James, Matthew T., additional

Published
2023
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46. Impact of blood transfusion on in-hospital myocardial infarctions according to patterns of acute coronary syndrome: Insights from the BleeMACS registry

Author

Gili, Sebastiano, D'Ascenzo, Fabrizio, Lococo, Marco Francesco, Moretti, Claudio, Gaita, Fiorenzo, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Henriques, Jose Paulo Simao, Saucedo, Jorge, González-Juanatey, José Ramón, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Huczek, Zenon, Nie, Shao-Ping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, García-Acuña, José María, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Scarano, Silvia, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Yan, Yan, Fan, Jing-Yao, Ikari, Yuji, Nakahashi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, and Kedev, Sasko

Published
2016
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47. Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe

Author

Giordana, Francesca, Montefusco, Antonio, D'Ascenzo, Fabrizio, Moretti, Claudio, Scarano, Silvia, Abu-Assi, Emad, Raposeiras-Roubín, Sergio, Henriques, Jose Paulo Simao, Saucedo, Jorge, González-Juanatey, José Ramón, Wilton, Stephen B., Kikkert, Wouter J., Nuñez-Gil, Iván, Ariza-Sole, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Huczek, Zenon, Nie, Shao-Ping, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, García-Acuña, José María, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Yan, Yan, Fan, Jing-Yao, Ikari, Yuji, Nakahayshi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, Kedev, Sasko, and Gaita, F.

Published
2016
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