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1. Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Heymer, Emma J., Hawkins, Michael M., Winter, David L., Teepen, Jop C., Sunguc, Ceren, Ronckers, Cécile M., Allodji, Rodrigue S., Alessi, Daniela, Sugden, Elaine, Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Garwicz, Stanislaw, Grabow, Desiree, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Michel, Gisela, Schindera, Christina, Haddy, Nadia, Journy, Neige, Česen Mazić, Maja, Skinner, Roderick, Kok, Judith L., Gunnes, Maria W., Wiebe, Thomas, Sacerdote, Carlotta, Maule, Milena M., Terenziani, Monica, Jakab, Zsuzsanna, Winther, Jeanette F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Haupt, Riccardo, Kuehni, Claudia E., Kremer, Leontien C., de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2024
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2. Risk of severe esophageal stricture among childhood cancer survivors – A population-based case-cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS)

Author

Hansen, Helena K., Asdahl, Peter H., Christensen, Jane, Pedersen, Camilla, Krøyer, Anja, Pontoppidan, Celina S., Holmqvist, Anna S., Hjorth, Lars, Wiebe, Thomas, Gudmundsdottir, Thorgerdur, de fine Licht, Sofie, Lassen-Ramshad, Yasmin, Seiersen, Klaus, Jørgensen, Morten, Laursen, Michael RT, Øfstaas, Hilde, Lähteenmäki, Päivi M., Smith, Susan A., Howell, Rebecca, Rechnitzer, Catherine, Hasle, Henrik, Winther, Jeanette F., and Kenborg, Line

Published
2024
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3. Radiation Doses Received by Major Organs at Risk in Children and Young Adolescents Treated for Cancer with External Beam Radiation Therapy: A Large-scale Study from 12 European Countries

Author

Diallo, Ibrahima, Allodji, Rodrigue S., Veres, Cristina, Bolle, Stéphanie, Llanas, Damien, Ezzouhri, Safaa, Zrafi, Wael, Debiche, Ghazi, Souchard, Vincent, Fauchery, Romain, Haddy, Nadia, Journy, Neige, Demoor-Goldschmidt, Charlotte, Winter, David L., Hjorth, Lars, Wiebe, Thomas, Haupt, Riccardo, Robert, Charlotte, Kremer, Leontien, Bardi, Edit, Sacerdote, Carlotta, Terenziani, Monica, Kuehni, Claudia E., Schindera, Christina, Skinner, Roderick, Winther, Jeanette Falck, Lähteenmäki, Päivi, Byrn, Julianne, Jakab, Zsuzsanna, Cardis, Elisabeth, Pasqual, Elisa, Tapio, Soile, Baatout, Sarah, Atkinson, Mike, Benotmane, Mohammed Abderrafi, Sugden, Elaine, Zaletel, Lorna Zadravec, Ronckers, Cecile, Reulen, Raoul C., Hawkins, Mike M., and de Vathaire, Florent

Published
2024
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4. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garwicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Mazić, Maja Česen, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Gunnes, Maria Winther, Terenziani, Monica, Winther, Jeanette F., Lähteenmäki, Päivi M., Zaletel, Lorna Zadravec, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Published
2023
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6. Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer

Author

Broberg, Olof, Feldreich, Tobias, Weismann, Constance G, Øra, Ingrid, Wiebe, Thomas, Ärnlöv, Johan, Liuba, Petru, Broberg, Olof, Feldreich, Tobias, Weismann, Constance G, Øra, Ingrid, Wiebe, Thomas, Ärnlöv, Johan, and Liuba, Petru

Abstract

INTRODUCTION: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease. METHODS: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index). RESULTS: Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p < 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p < 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p < 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005). CONCLUSION: This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.

Published
2024
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8. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup

Author

Allodji, Rodrigue S., Hawkins, Mike M., Bright, Chloe J., Fidler-Benaoudia, Miranda M., Winter, David L., Alessi, Daniela, Fresneau, Brice, Journy, Neige, Morsellino, Vera, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth (Lieke) AM., Teepen, Jop C., Vu-Bezin, Giao, Rubino, Carole, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Hau, Eva-Maria, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Linge, Helena, Muraca, Monica, Llanas, Damien, Veres, Cristina, Øfstaas, Hilde, Diallo, Ibrahima, Mansouri, Imene, Ronckers, Cecile M., Skinner, Roderick, Terenziani, Monica, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E., Winther, Jeanette F., Michel, Gisela, Kremer, Leontien C.M., Hjorth, Lars, Haddy, Nadia, de Vathaire, Florent, and Reulen, Raoul C.

Published
2019
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10. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer

Author

Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. (Lieke), Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C.M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, LLanas, Damien, Michel, Gisela, Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars

Published
2018
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11. The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries

Author

Grabow, Desiree, Kaiser, Melanie, Hjorth, Lars, Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., de Vathaire, Florent, Feijen, Elizabeth A. M., Garwicz, Stanislaw, Hagberg, Oskar, Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Lähteenmäki, Päivi Maria, Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Zaletel, Lorna Zadravec, and Kaatsch, Peter

Published
2018

13. Ceramides: a potential cardiovascular biomarker in young adult childhood cancer survivors?

Author

Broberg, Olof, Weismann, Constance G., Øra, Ingrid, Wiebe, Thomas, Laaksonen, Reijo, and Liuba, Petru

Subjects
YOUNG adults, CERAMIDES, CHILDHOOD cancer, CANCER survivors, CANCER patients
Abstract

Aims: The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in this cohort. Methods and results: Fifty-seven CCS and 53 healthy controls (age 20-30 years) were studied. Plasma long-chain ceramides, known to be cardiotoxic (C16:0, C18:0, C24:0, and C24:1), were analysed by mass spectrometry. The coronary event risk test 2 (CERT2) score was calculated from the ceramide data. Cardiac and carotid artery ultrasound data and lipid data available from previous studies of this cohort were used to study partial correlations with ceramide and CERT2 score data. All four analysed ceramides were elevated in CCS compared with controls (P ≤ 0.012). The greatest difference was noted for C18:0, which was 33% higher in CCS compared with controls adjusted for sex, age, and body mass index (BMI) (P < 0.001). The CERT2 score was higher in CCS compared with controls (P < 0.001). In the CCS group, 35% had a high to very high CERT2 score (7-12) when compared with 9% in the control group (P < 0.001). The CCS subgroup with a CERT2 score ≥ 7 had higher heart rate, systolic blood pressure, and higher levels of apolipoprotein B compared with CCS with a CERT2 score < 6 (P ≤ 0.011). When adjusted for age, sex, and BMI, CERT2 score was significantly correlated with arterial stiffness, growth hormone, and cranial radiotherapy (P < 0.044). Conclusion: Ceramides could be important biomarkers in understanding the pathophysiology of CVD and in predicting CVD disease risk in young adult CCS. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Risk Factors for Primary Bone Cancer After Childhood Cancer: A PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies Nested Case-Control Study

Author

Reulen, Raoul C., primary, Winter, David L., additional, Diallo, Ibrahim, additional, Veres, Cristina, additional, Llanas, Damien, additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Feijen, Elizabeth A.M., additional, Alessi, Daniela, additional, Fidler-Benaoudia, Miranda M., additional, Høgsholt, Stine, additional, Teepen, Jop C., additional, Linge, Helena, additional, Haddy, Nadia, additional, Byrne, Julianne, additional, Debiche, Ghazi, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Fauchery, Romain, additional, Zrafi, Wael, additional, Michel, Gisela, additional, Øfstaas, Hilde, additional, Kaatsch, Peter, additional, Vu-Bezin, Giao, additional, Jenkinson, Helen, additional, Kaiser, Melanie, additional, Skinner, Roderick, additional, Cole, Trevor, additional, Waespe, Nicolas, additional, Sommer, Grit, additional, Nordenfelt, Susanne, additional, Jankovic, Momcilo, additional, Lähteenmäki Taalas, Tuomas, additional, Maule, Milena M., additional, van der Pal, Helena J.H., additional, Ronckers, Cécile M., additional, van Leeuwen, Flora E., additional, Kok, Judith L., additional, Terenziani, Monica, additional, Winther Gunnes, Maria, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M., additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E., additional, Falck Winther, Jeanette, additional, Kremer, Leontien C.M., additional, Hjorth, Lars, additional, de Vathaire, Florent, additional, and Hawkins, Michael M., additional

Published
2023
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16. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

Author

Fidler, Miranda M., Reulen, Raoul C., Winter, David L., Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Byrne, Julianne, Feijen, Elizabeth A. M., Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kuonen, Rahel, Linge, Helena, Maule, Milena, Merletti, Franco, Øfstaas, Hilde, Ronckers, Cecile M., Skinner, Roderick, Teepen, Jop, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E., Winther, Jeanette F., de Vathaire, Florent, Kremer, Leontien C., Hjorth, Lars, and Hawkins, Michael M.

Published
2018
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17. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

Author

Dudley, Isabelle M., primary, Sunguc, Ceren, additional, Heymer, Emma J., additional, Winter, David L., additional, Teepen, Jop C., additional, Belle, Fabiën N., additional, Bárdi, Edit, additional, Bagnasco, Francesca, additional, Gudmundsdottir, Thorgerdur, additional, Skinner, Roderick, additional, Michel, Gisela, additional, Byrne, Julianne, additional, Øfstaas, Hilde, additional, Jankovic, Momcilo, additional, Mazić, Maja Česen, additional, Mader, Luzius, additional, Loonen, Jaqueline, additional, Garwicz, Stanislaw, additional, Wiebe, Thomas, additional, Alessi, Daniela, additional, Allodji, Rodrigue S., additional, Haddy, Nadia, additional, Grabow, Desiree, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Maule, Milena M., additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Lähteenmäki, Päivi M., additional, Winther, Jeanette F., additional, Hjorth, Lars, additional, Hawkins, Michael M., additional, and Reulen, Raoul C., additional

Published
2022
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18. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, primary, Hawkins, Michael M., additional, Winter, David L., additional, Dudley, Isabelle M., additional, Heymer, Emma J., additional, Teepen, Jop C., additional, Allodji, Rodrigue S., additional, Belle, Fabiën N., additional, Bagnasco, Francesca, additional, Byrne, Julianne, additional, Bárdi, Edit, additional, Ronckers, Cécile M., additional, Haddy, Nadia, additional, Gudmundsdottir, Thorgerdur, additional, Garwicz, Stanislaw, additional, Jankovic, Momcilo, additional, van der Pal, Helena J. H., additional, Mazić, Maja Česen, additional, Schindera, Christina, additional, Grabow, Desiree, additional, Maule, Milena M., additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Fresneau, Brice, additional, Michel, Gisela, additional, Skinner, Roderick, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Gunnes, Maria Winther, additional, Terenziani, Monica, additional, Winther, Jeanette F., additional, Lähteenmäki, Päivi M., additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Kremer, Leontien C., additional, Haupt, Riccardo, additional, de Vathaire, Florent, additional, Hjorth, Lars, additional, and Reulen, Raoul C., additional

Published
2022
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19. Low-dose oral ketamine as a procedural analgesia in pediatric cancer patients undergoing bone marrow aspirations at a resource-limited cancer hospital in India

Author

Rayala, Spandana, Kyander, Melker, Haridass, Vikranth, Palat, Gayatri, Ström, Axel, Wiebe, Thomas, Brun, Eva, and Segerlantz, Mikael

Subjects
Care and treatment, Dosage and administration, Methods, Ketamine -- Dosage and administration, Childhood cancer -- Care and treatment, Bone marrow biopsy -- Methods, Analgesia -- Methods, Pain management, Anesthesia, Pediatrics, Child health, Cancer patients, Children
Published
2019

20. Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

Author

Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garvicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Česen Mazić, Maja, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Winther Gunnes, Maria, Terenziani, Monica, Winter, Jeanne F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, Reulen, Raoul C., Sunguc, Ceren, Hawkins, Michael M., Winter, David L., Dudley, Isabelle M., Heymer, Emma J., Teepen, Jop C., Allodji, Rodrigue S., Belle, Fabiën N., Bagnasco, Francesca, Byrne, Julianne, Bárdi, Edit, Ronckers, Cécile M., Haddy, Nadia, Gudmundsdottir, Thorgerdur, Garvicz, Stanislaw, Jankovic, Momcilo, van der Pal, Helena J. H., Česen Mazić, Maja, Schindera, Christina, Grabow, Desiree, Maule, Milena M., Kaatsch, Peter, Kaiser, Melanie, Fresneau, Brice, Michel, Gisela, Skinner, Roderick, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Winther Gunnes, Maria, Terenziani, Monica, Winter, Jeanne F., Lähteenmäki, Päivi M., Zadravec Zaletel, Lorna, Kuehni, Claudia E., Kremer, Leontien C., Haupt, Riccardo, de Vathaire, Florent, Hjorth, Lars, and Reulen, Raoul C.

Abstract

Background: Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks. Methods: The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence. Results: One hundred and forty-five oral SPNs (64 salivary gland, 38 tongue, 20 pharynx, 2 lip, and 21 other) were ascertained among 143 survivors. Survivors were at 5-fold risk of an oral SPN (95% CI: 4.4–5.6). Survivors of leukaemia were at greatest risk (SIR = 19.2; 95% CI: 14.6–25.2) followed by bone sarcoma (SIR = 6.4, 95% CI: 3.7–11.0), Hodgkin lymphoma (SIR = 6.2, 95% CI: 3.9–9.9) and soft-tissue sarcoma (SIR = 5.0, 95% CI: 3.0–8.5). Survivors treated with radiotherapy were at 33-fold risk of salivary gland SPNs (95% CI: 25.3–44.5), particularly Hodgkin lymphoma (SIR = 66.2, 95% CI: 43.6–100.5) and leukaemia (SIR = 50.5, 95% CI: 36.1–70.7) survivors. Survivors treated with chemotherapy had a substantially increased risk of a tongue SPN (SIR = 15.9, 95% CI: 10.6–23.7). Conclusions: Previous radiotherapy increases the risk of salivary gland SPNs considerably, while chemotherapy increases the risk of tongue SPNs substantially. Awareness of these risks among both health-care professionals and survivors could play a crucial role in detecting oral SPNs early., + ID der Publikation: unilu_61255 + Sprache: Englisch + Letzte Aktualisierung: 2022-11-03 12:45:00

Published
2022

23. Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study.

Author

Dudley, Isabelle M., Sunguc, Ceren, Heymer, Emma J., Winter, David L., Teepen, Jop C., Belle, Fabiën N., Bárdi, Edit, Bagnasco, Francesca, Gudmundsdottir, Thorgerdur, Skinner, Roderick, Michel, Gisela, Byrne, Julianne, Øfstaas, Hilde, Jankovic, Momcilo, Mazić, Maja Česen, Mader, Luzius, Loonen, Jaqueline, Garwicz, Stanislaw, Wiebe, Thomas, and Alessi, Daniela

Subjects
CHILDHOOD cancer, MEDICAL personnel, NEPHROBLASTOMA, OSTEOSARCOMA, HODGKIN'S disease
Abstract

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan‐European Network for Care of Survivors After Childhood and Adolescent Cancer (PanCare) Survivor Care and Follow‐Up Studies (PanCareSurFup) cohort includes 69,460 five‐year survivors of childhood cancer, diagnosed during 1940 through 2008, from 12 European countries. Risks of SPLs were quantified by standardized incidence ratios (SIRs) and relative risks (RRs) using multivariable Poisson regression. Results: Overall, 140 SPLs, including 104 NHLs and 36 HLs, were identified. Survivors were at 60% increased risk of an SPL compared with the general population (SIR, 1.6; 95% confidence interval [CI], 1.4–1.9). Survivors were twice as likely to develop NHL (SIR, 2.3; 95% CI, 1.9–2.8), with the greatest risks among survivors of HL (SIR, 7.1; 95% CI, 5.1–10.0), Wilms tumor (SIR, 3.1; 95% CI, 1.7–5.7), leukemia (SIR, 2.8; 95% CI, 1.8–4.4), and bone sarcoma (SIR, 2.7; 95% CI, 1.4–5.4). Treatment with chemotherapy for any cancer doubled the RR of NHL (RR, 2.1; 95% CI, 1.2–3.9), but treatment with radiotherapy did not (RR, 1.2; 95% CI, 0.7–2.0). Survivors were at similar risk of developing a subsequent HL as the general population (SIR, 1.1; 95% CI, 0.8–1.5). Conclusions: In addition to HL, the authors show here for the first time that survivors of Wilms tumor, leukemia, and bone sarcoma are at risk of NHL. Survivors and health care professionals should be aware of the risk of NHL in these survivors and in any survivors treated with chemotherapy. Using data from 69,460 five‐year survivors of childhood cancer across Europe, the authors investigated the risks of subsequent primary lymphoma within the largest cohort reported to date. Novel findings include the identification of an increased risk of non‐Hodgkin lymphoma among survivors of Wilms tumor, leukemia, and bone sarcoma and in any survivors treated with chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study

Author

Reulen, Raoul C, primary, Wong, Kwok F, additional, Bright, Chloe J, additional, Winter, David L, additional, Alessi, Daniela, additional, Allodji, Rodrigue M, additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Byrne, Julianne, additional, Feijen, Elizabeth AM, additional, Fidler-Benaoudia, Miranda M, additional, Diallo, Ibrahim, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Høgsholt, Stine, additional, Jankovic, Moncilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M, additional, Hau, Eva-Maria, additional, Skinner, Roderick, additional, van Leeuwen, Flora E, additional, Teepen, Jop C, additional, Veres, Cristina, additional, Zrafi, Wael, additional, Debiche, Ghazi, additional, Llanas, Damien, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Sacerdote, Carlotta, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi M, additional, Zadravec Zaletel, Lorna, additional, Kuehni, Claudia E, additional, Winther, Jeanette F, additional, de Vathaire, Florent, additional, Kremer, Leontien C, additional, Hjorth, Lars, additional, and Hawkins, Michael M, additional

Published
2020
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30. Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India

Author

Rayala, Spandana, primary, Bäckdahl, Tim, additional, Reddy, Naresh, additional, Jacob, Jean, additional, Gebre-Medhin, Erik, additional, Karonen, Emil, additional, Palat, Gayatri, additional, Sinha, Sudha, additional, Schyman, Tommy, additional, Wiebe, Thomas, additional, Brun, Eva, additional, and Segerlantz, Mikael, additional

Published
2019
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35. Cancer Treatment and End-of-Life Care

Author

Sinha, Sudha, primary, Matharu, Jaskirt Kaur, additional, Jacob, Jean, additional, Palat, Gayatri, additional, Brun, Eva, additional, Wiebe, Thomas, additional, and Segerlantz, Mikael, additional

Published
2018
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39. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe

Author

Fidler, Miranda M., primary, Reulen, Raoul C., additional, Winter, David L., additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Bright, Chloe J., additional, Byrne, Julianne, additional, Feijen, Elizabeth A. M., additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Maule, Milena, additional, Merletti, Franco, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M., additional, Skinner, Roderick, additional, Teepen, Jop, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Winther, Jeanette F., additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Hjorth, Lars, additional, and Hawkins, Michael M., additional

Published
2017
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40. Risk of digestive cancers in a cohort of 69 460 five-year survivors of childhood cancer in Europe: the PanCareSurFup study

Author

Reulen, Raoul C, Wong, Kwok F, Bright, Chloe J, Winter, David L, Alessi, Daniela, Allodji, Rodrigue M, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth AM, Fidler-Benaoudia, Miranda M, Diallo, Ibrahim, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Høgsholt, Stine, Jankovic, Moncilo, Kaatsch, Peter, Kaiser, Melanie, Kuonen, Rahel, Linge, Helena, Øfstaas, Hilde, Ronckers, Cecile M, Hau, Eva-Maria, Skinner, Roderick, van Leeuwen, Flora E, Teepen, Jop C, Veres, Cristina, Zrafi, Wael, Debiche, Ghazi, Llanas, Damien, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, La¨hteenma¨ki, Pa¨ivi M, Zadravec Zaletel, Lorna, Kuehni, Claudia E, Winther, Jeanette F, de Vathaire, Florent, Kremer, Leontien C, Hjorth, Lars, and Hawkins, Michael M

Abstract

BackgroundSurvivors of childhood cancer are at risk of subsequent primary neoplasms (SPNs), but the risk of developing specific digestive SPNs beyond age 40 years remains uncertain. We investigated risks of specific digestive SPNs within the largest available cohort worldwide.MethodsThe PanCareSurFup cohort includes 69 460 five-year survivors of childhood cancer from 12 countries in Europe. Risks of digestive SPNs were quantified using standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence.Results427 digestive SPNs (214 colorectal, 62 liver, 48 stomach, 44 pancreas, 59 other) were diagnosed in 413 survivors. Wilms tumour (WT) and Hodgkin lymphoma (HL) survivors were at greatest risk (SIR 12.1; 95% CI 9.6 to 15.1; SIR 7.3; 95% CI 5.9 to 9.0, respectively). The cumulative incidence increased the most steeply with increasing age for WT survivors, reaching 7.4% by age 55% and 9.6% by age 60 years (1.0% expected based on general population rates). Regarding colorectal SPNs, WT and HL survivors were at greatest risk; both seven times that expected. By age 55 years, 2.3% of both WT (95% CI 1.4 to 3.9) and HL (95% CI 1.6 to 3.2) survivors had developed a colorectal SPN—comparable to the risk among members of the general population with at least two first-degree relatives affected.ConclusionsColonoscopy surveillance before age 55 is recommended in many European countries for individuals with a family history of colorectal cancer, but not for WT and HL survivors despite a comparable risk profile. Clinically, serious consideration should be given to the implementation of colonoscopy surveillance while further evaluation of its benefits, harms and cost-effectiveness in WT and HL survivors is undertaken.

Published
2021
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44. Predominance of girls with cancer in families with multiple childhood cancer cases.

Author

Karl-Johan, Stjernfelt, von Stedingk, Kristoffer, Wiebe, Thomas, Hjorth, Lars, Olsson, Håkan, Øra, Ingrid, and Stjernfelt, Karl-Johan

Subjects
CHILDHOOD cancer, GENETIC disorders, LEUKEMIA, CENTRAL nervous system, ONCOLOGY, LEUKEMIA epidemiology, CENTRAL nervous system tumors, DISEASE susceptibility, HUMAN reproduction, ACQUISITION of data
Abstract

Background: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities.Methods: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding family history of cancer and blood samples were provided. Reported data were validated and extended by use of the Swedish Population- and Cancer Registries. Demographics in families with one case of childhood cancer (FAM1) were investigated and compared to families with multiple cases of childhood cancer (FAM > 1) as well as to childhood cancer in the general population.Results: Forty-one out of 528 families (7.8%) had more than one case of childhood cancer. In 23 families the affected children were relatives up to a 3rd degree (4.4%). In FAM > 1, 69.2% of the children with leukemia and 60% of those with tumors in the central nervous system (CNS) had a childhood relative with matching diagnosis, both significantly higher than expected. Significantly more female than male patients were observed in FAM > 1 compared to FAM1. This female predominance was most striking in childhood leukemia (77% female) and also, yet to a lesser extent, in CNS tumors (68% female).Conclusions: We conclude that the high proportion of children with leukemia or CNS tumors in FAM > 1 having a childhood relative with the same diagnosis suggests a hereditary background. Moreover, we report a female predominance in childhood leukemia and childhood CNS tumors in FAM > 1, which may indicate a hereditary gender-specific risk factor in these families. [ABSTRACT FROM AUTHOR]

Published
2017
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45. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.

Author

Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, and Reulen RC

Subjects
Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Registries, Risk Factors, Time Factors, Young Adult, Cancer Survivors statistics & numerical data, Neoplasms, Second Primary epidemiology, Sarcoma epidemiology, Soft Tissue Neoplasms epidemiology
Abstract

Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer., Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated., Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma., Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.

Published
2018
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46. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe.

Author

Fidler MM, Reulen RC, Winter DL, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, Byrne J, Feijen EAM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuonen R, Linge H, Maule M, Merletti F, Øfstaas H, Ronckers CM, Skinner R, Teepen J, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuehni CE, Winther JF, de Vathaire F, Kremer LC, Hjorth L, and Hawkins MM

Subjects
Adolescent, Adult, Child, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Male, Osteosarcoma epidemiology, Retinoblastoma epidemiology, Sarcoma epidemiology, Young Adult, Bone Neoplasms epidemiology, Neoplasms, Second Primary epidemiology, Survivors statistics & numerical data
Abstract

Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors., Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided., Results: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk., Conclusions: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer., (© The Author 2017. Published by Oxford University Press.)

Published
2018
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