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The national status and dose trends on the occupational exposure to ionizing radiation in industrial practices for 2009-2018 in China are presented in terms of seven occupational categories. A total of 504,538 industrial radiation workers were monitored for the period 2009-2018, with a continuous increase in the number of workers from 23,789 in 2009 to 66,017 in 2018. The annual average effective doses were 0.399, 0.425, 0.392, 0.376, 0.346, 0.355, 0.312, 0.305, 0.270, and 0.230 mSv from 2009 to 2018, respectively, which were well lower than the recommended occupational dose limit of 20 mSv y-1 for radiation workers. The Mann-Kendall test result shows a statistically significant decreasing trend at a rate of 0.02 mSv y-1 in average annual effective doses (p

Zhou, W., 2020. Economic marketing of marine leisure tourism based on internet of things. In: Li, L. and Huang, X. (eds.), Sustainable Development in Coastal Regions: A Perspective of Environment, Economy, and Technology. Journal of Coastal Research, Special Issue No. 112, pp. 87-89. Coconut Creek (Florida), ISSN 0749-0208.As a result of the implementation and promotion of the marine strategy, the marine leisure tourism economy has achieved rapid development and brought new opportunities to the optimization of the marine economic industry. However, there are still many deficiencies and problems in the current economic marketing of marine leisure tourism, which limit the further development of marine leisure tourism economy and urgently need reform and improvement. Based on this, this paper first analyzes the important role of marine leisure tourism based on the Internet of things, then studies the current situation and problems of economic marketing of marine leisure tourism, and finally gives the economic marketing strategy of marine leisure tourism based on the Internet of things.

Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Science and Chinese National Knowledge Infrastructure for papers published up to 13 November 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed and random effects models. Subgroup and dose‒response analyses were also conducted. This study was registered with PROSPERO (No. CRD42019127761). A total of 28 studies, which included 13,748 lung cancer cases and 23,112 controls, were used for this meta-analysis. The pooled OR indicated that the highest residential radon exposure was significantly associated with an increased risk of lung cancer (OR = 1.48, 95% CI = 1.26–1.73). All histological types of lung cancer were associated with residential radon. Strongest association with small-cell lung carcinoma (OR = 2.03, 95% CI = 1.52–2.71) was found, followed by adenocarcinoma (OR = 1.58, 95% CI = 1.31–1.91), other histological types (OR = 1.54, 95% CI = 1.11–2.15) and squamous cell carcinoma (OR = 1.43, 95% CI = 1.18–1.74). With increasing residential radon levels per 100 Bq/m3, the risk of lung cancer, small-cell lung carcinoma and adenocarcinoma increased by 11%, 19% and 13%, respectively. This meta-analysis provides new evidence for a potential relationship between residential radon and all histological types of lung cancer.

Toll-like receptors (TLRs) are expressed in Sertoli cells and Leydig cells and can initiate testicular innate immune responses. The A-kinase anchor protein 3 (AKAP3), a family of scaffolding protein, was reported to be expressed only in testis and plays important regulatory roles during spermatogenesis. Our present study aimed to investigate the differential expression of TLRs family and AKAP3 in cigarette smoked Kunming mice testis. To check the effect of cigarette smoke, mice were randomly divided (n = 5 each) and exposed to cigarette smoke (2 hr/day with 10 cigarettes) for six consecutive days followed by one exposure-free day. The exposure lasted for zero (control), 1, 3, 5 and 7 months respectively. The IHC results showed that expression of AKAP3 protein is mainly located in sperm cells and the mean density of which was significantly lower than that of control mice. Real-time PCR results showed that expression of AKAP3 was significantly increased at early CS exposure (1 month) and then returned to normal in subsequent months. TLR2-7, TLR13, Myd88 and Traf6 mRNA expression are much lower compared to control, especially after 3-month cigarette smoke exposure, the time of which is almost consistent with sperm cycle. The present study suggests that TLR signal pathway and AKAP3 may play roles in spermatogenesis.

To obtain active lipases for biodiesel production by refolding Proteus sp. lipase inclusion bodies expressed in E. coli. A lipase gene lipPN1 was cloned from Proteus sp. NH 2-2 and expressed in E. coli BL21(DE3). Non-reducing SDS-PAGE revealed that recombinant LipPN1(rLipPN1) were prone to form inclusion bodies as disulfide-linked dimers in E. coli. Site-directed mutagenesis confirmed that Cys85 in LipPN1 was involved in the dimer formation. After optimizing the inclusion body refolding conditions, the maximum lipase activity reached 1662 U/L. The refolded rLipPN1 exhibited highest activity toward p-nitrophenyl butyrate at pH 9.0 and 40 °C. It could be activated by Ca2+ with moderate tolerance to organic solvents. It could also convert soybean oil into biodiesel at a conversion ratio of 91.5%. Preventing the formation of disulfide bond could enhance the refolding efficiency of rLipPN1 inclusion bodies.

Toxic cyanobacterial blooms, which produce cyclic heptapeptide toxins known as microcystins, are worldwide environmental problems. On the other hand, the cyanobacteria protein (30–50%) has been recommended as substitute protein for aquaculture. The present laboratory study verified the feasibility of cyanobacteria protein substitution and risk assessment. Goldfish were fed diets supplemented lyophilised cyanobacteria powder for 16 weeks with the various doses: 0% (control), 10%, 20%, 30% and 40%. Low doses (10% and 20%) promoted growth whereas high doses (30% and 40%) inhibited growth. In cyanobacteria treated fish, the proximate composition of ash, crude fat content and crude protein content decreased in 16 weeks; the saturated fatty acid (SFA) content significantly increased; the n-3 polyunsaturated fatty acid content, collagen content and muscle pH significantly decreased; cooking loss percents increased significantly. Muscle fiber diameter and myofibril length were negatively correlation. Additionally, flavour compounds (e.g., amino acids, nucleotides, organic acids and carnosine) changed significantly in the treated fish and odour compounds geosmin and 2-methylisoborneol increased significantly. The estimated daily intake (EDI) of microcystins in muscle was close to or exceeded the World Health Organization (WHO) tolerable daily intake (TDI), representing a great health risk. Cyanobacterie is not feasible for protein sources use in aquaculture.