Search

Panax notoginseng is a well-known traditional Chinese medicine, and dried flower buds of P. notoginseng (FBP) have also been used as a medicine or tea for a long time. The pharmacological effects of FBP include antihypertensive, anticancer, hepatoprotective, and cardiovascular protective effects. The compounds in FBP include saponins, flavonoids, volatile oils, and polysaccharides. The total saponins are the principal bioactive components. In modern applications, FBP is used to treat hypertension and tinnitus. There have been many studies on FBP and its effects in recent years, and it has attracted much attention in the medical field. This review summarizes the chemical components, pharmacological action, and clinical uses of FBP comprehensively to provide the references of deeper studies.

Objective: To study the effects of video-assisted thoracoscopic surgery and traditional thoracotomy on the systemic inflammatory response and stress response of traumatic hemopneumothorax. Methods: Patients who underwent emergency surgery due to traumatic hemopneumothorax in Chongzuo People's Hospital between May 2013 and April 2017 were selected as the research subjects, the history data were retrospectively analyzed, and the surgical methods were referred to divide the patients into the thoracoscope group and the thoracotomy group who received video-assisted thoracoscopic surgery and traditional thoracotomy respectively. The serum samples were collected the same day after surgery and 3 d after surgery to determine the contents of acute phase proteins CRP, ChE and SAA, inflammatory cytokines TNF-α, IL-1β, IFN-γ, MCP-1 and ICAM-1 as well as stress hormones Cor, NE, Ins and AT-II. Results: The same day after surgery and 3 days after surgery, serum CRP, ChE, SAA, TNF-α, IL-1β, IFN-γ, MCP-1, ICAM-1, Cor, NE, Ins and AT-II levels of thoracoscope group were all significantly lower than those of thoracotomy group. Conclusions: Video-assisted thoracoscopic surgery for traumatic hemopneumothorax is more effective than traditional thoracotomy to relieve the postoperative systemic inflammatory response and stress response, and helps the postoperative recovery.

Vacuum preloading is a soft ground improvement method that has been successfully used by geotechnical engineers and specialists to accelerate the rate of consolidation. However, consolidation effic...

Background Panax notoginseng flower saponins (PNFS) are great contributions towards the biological activity of Panax notoginseng flower (PNF). However, some ginsenoside monomers can be hydrolyzed by the acidic environment in the stomach, resulting in a decrease in their oral bioavailability. Therefore, we created PNFS enteric-coated sustained-release pellets (E-PNFS) to improve their oral bioavailability. Methods The PNFS uncoated pellets (N-PNFS) and E-PNFS were prepared by fluidized bed coating technology using Eudragit NE30D as the sustained-release agent and Opadry as the enteric-coated agent. The single-factor investigation was used to determine the optimal prescription. The E-PNFS were visualized by scanning electron microscopy (SEM) and evaluated for roundness, bulk density, resting angle, hygroscopicity and stability. The plasma drug concentration in SD rats was determined by the UPLC-MS/MS method, and pharmacokinetic parameters were calculated by Phoenix WinNonlin5.2 software. The in vivo absorption fraction was calculated by Wagner-Nelson method The in vivo absorption and in vitro release percentages were linearly regressed by the least square method. Results According to the prescription screened out by the single factor investigation, E-PNFS was successfully prepared, and had good release properties in vitro along with a good measure for roundness, flowability and stability. Compared with N-PNFS, E-PNFS showed decreased Cmax, increased AUC, and an extended MRT and Tmax. Rb1, Rb2, Rb3 and Rc in E-PNFS showed a good correlation between in vitro release and in vivo absorption. Conclusions The successfully prepared E-PNFS were able to improve the oral bioavailability of PNFS in SD rats in general. The in vitro release behaviors of Rb1, Rb2, Rb3 and Rc in E-PNFS correlated well with the in vivo absorption properties.