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286 results on '"Ware, Mark A."'

2. Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis.

Author

Lake, Stephanie, Walsh, Zach, Kerr, Thomas, Cooper, Ziva D, Buxton, Jane, Wood, Evan, Ware, Mark A, and Milloy, MJ

Subjects
Humans, Cannabis, Pain, Opioid-Related Disorders, Analgesics, Analgesics, Opioid, Longitudinal Studies, Prospective Studies, Marijuana Smoking, Adult, Middle Aged, Canada, Female, Male, Pain Management, Chronic Pain, Medical Marijuana, Opioid, Pain Research, Clinical Research, Drug Abuse, Neurosciences, Substance Abuse, 2.1 Biological and endogenous factors, Medical and Health Sciences, General & Internal Medicine
Abstract

BACKGROUND:Ecological research suggests that increased access to cannabis may facilitate reductions in opioid use and harms, and medical cannabis patients describe the substitution of opioids with cannabis for pain management. However, there is a lack of research using individual-level data to explore this question. We aimed to investigate the longitudinal association between frequency of cannabis use and illicit opioid use among people who use drugs (PWUD) experiencing chronic pain. METHODS AND FINDINGS:This study included data from people in 2 prospective cohorts of PWUD in Vancouver, Canada, who reported major or persistent pain from June 1, 2014, to December 1, 2017 (n = 1,152). We used descriptive statistics to examine reasons for cannabis use and a multivariable generalized linear mixed-effects model to estimate the relationship between daily (once or more per day) cannabis use and daily illicit opioid use. There were 424 (36.8%) women in the study, and the median age at baseline was 49.3 years (IQR 42.3-54.9). In total, 455 (40%) reported daily illicit opioid use, and 410 (36%) reported daily cannabis use during at least one 6-month follow-up period. The most commonly reported therapeutic reasons for cannabis use were pain (36%), sleep (35%), stress (31%), and nausea (30%). After adjusting for demographic characteristics, substance use, and health-related factors, daily cannabis use was associated with significantly lower odds of daily illicit opioid use (adjusted odds ratio 0.50, 95% CI 0.34-0.74, p < 0.001). Limitations of the study included self-reported measures of substance use and chronic pain, and a lack of data for cannabis preparations, dosages, and modes of administration. CONCLUSIONS:We observed an independent negative association between frequent cannabis use and frequent illicit opioid use among PWUD with chronic pain. These findings provide longitudinal observational evidence that cannabis may serve as an adjunct to or substitute for illicit opioid use among PWUD with chronic pain.

Published
2019

5. Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto.

Author

Guerin, Megan N., Ellis, TreVaughn S., Ware, Mark J., Manning, Alexandra, Coley, Ariana A., Amini, Ali, Igboanugo, Adaeze G., Rothrock, Amaya P., Chung, George, Gunsalus, Kristin C., and Bracht, John R.

Subjects
BIOLOGICAL evolution, WHOLE genome sequencing, BIOLOGICAL adaptation, BIOLOGICAL fitness, LOW temperatures, CYTOCHROME oxidase, OXYGEN consumption
Abstract

In this study, we report a biological temperature-sensing electrical regulator in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto. This extremophile metazoan was isolated 1.3 km underground in a South African goldmine, where it adapted to heat and potentially to hypoxia, making its mitochondrial sequence a likely target of adaptational change. We obtained the complete mitochondrial genome sequence of this organism and show through dN/dS analysis evidence of positive selection in H. mephisto cytochrome c oxidase subunits. Seventeen of these positively selected amino acid substitutions were located in proximity to the H- and K-pathway proton channels of the complex. Surprisingly, the H. mephisto cytochrome c oxidase completely shuts down at low temperatures (20 °C), leading to a 4.8-fold reduction in the transmembrane proton gradient (ΔΨm) compared to optimal temperature (37 °C). Direct measurement of oxygen consumption found a corresponding 4.6-fold drop at 20 °C compared to 37 °C. Correspondingly, the lifecycle of H. mephisto takes four times longer at low temperature than at higher. This elegant evolutionary adaptation creates a finely-tuned mitochondrial temperature sensor, allowing this ectothermic organism to maximize its reproductive success across varying environmental temperatures. Here, an evolutionary adaptation converting mitochondrial respiration into a thermometer is reported. The adaptive changes center around the proton channels of cytochrome c oxidase. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Cannabis

Author

Ware, Mark A., additional, Pitt, Rebecca, additional, and Ingelmo, Pablo, additional

Published
2021
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10. Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data

Author

Andreae, Michael H, Carter, George M, Shaparin, Naum, Suslov, Kathryn, Ellis, Ronald J, Ware, Mark A, Abrams, Donald I, Prasad, Hannah, Wilsey, Barth, Indyk, Debbie, Johnson, Matthew, and Sacks, Henry S

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Neurodegenerative, Peripheral Neuropathy, Pain Research, Clinical Trials and Supportive Activities, Clinical Research, Substance Misuse, Drug Abuse (NIDA only), Neurological, Administration, Inhalation, Adult, Aged, Bayes Theorem, Cannabis, Female, Humans, Male, Medical Marijuana, Middle Aged, Pain, Peripheral Nervous System, Peripheral Nervous System Diseases, Randomized Controlled Trials as Topic, Young Adult, chronic pain, neuropathy, painful, polyneuropathy, meta-analysis, meta-analysis of individual patient data, Bayesian analysis, human immunodeficiency virus, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology, Clinical sciences, Epidemiology
Abstract

UnlabelledChronic neuropathic pain, the most frequent condition affecting the peripheral nervous system, remains underdiagnosed and difficult to treat. Inhaled cannabis may alleviate chronic neuropathic pain. Our objective was to synthesize the evidence on the use of inhaled cannabis for chronic neuropathic pain. We performed a systematic review and a meta-analysis of individual patient data. We registered our protocol with PROSPERO CRD42011001182. We searched in Cochrane Central, PubMed, EMBASE, and AMED. We considered all randomized controlled trials investigating chronic painful neuropathy and comparing inhaled cannabis with placebo. We pooled treatment effects following a hierarchical random-effects Bayesian responder model for the population-averaged subject-specific effect. Our evidence synthesis of individual patient data from 178 participants with 405 observed responses in 5 randomized controlled trials following patients for days to weeks provides evidence that inhaled cannabis results in short-term reductions in chronic neuropathic pain for 1 in every 5 to 6 patients treated (number needed to treat = 5.6 with a Bayesian 95% credible interval ranging between 3.4 and 14). Our inferences were insensitive to model assumptions, priors, and parameter choices. We caution that the small number of studies and participants, the short follow-up, shortcomings in allocation concealment, and considerable attrition limit the conclusions that can be drawn from the review. The Bayes factor is 332, corresponding to a posterior probability of effect of 99.7%.PerspectiveThis novel Bayesian meta-analysis of individual patient data from 5 randomized trials suggests that inhaled cannabis may provide short-term relief for 1 in 5 to 6 patients with neuropathic pain. Pragmatic trials are needed to evaluate the long-term benefits and risks of this treatment.

Published
2015

11. Anti-drug Antibody Validation Testing and Reporting Harmonization

Author

Myler, Heather, Pedras-Vasconcelos, João, Phillips, Kelli, Hottenstein, Charles Scott, Chamberlain, Paul, Devanaryan, Viswanath, Gleason, Carol, Goodman, Joanne, Manning, Marta Starcevic, Purushothama, Shobha, Richards, Susan, Shen, Honglue, Zoghbi, Jad, Amaravadi, Lakshmi, Barger, Troy, Bowen, Steven, Bowsher, Ronald R., Clements-Egan, Adrienne, Geng, Dong, Goletz, Theresa J., Gunn, George R., Hallett, William, Hodsdon, Michael E., Janelsins, Brian M., Jawa, Vibha, Kamondi, Szilard, Kirshner, Susan, Kramer, Daniel, Liang, Meina, Lindley, Kathryn, Liu, Susana, Liu, ZhenZhen, McNally, Jim, Mikulskis, Alvydas, Nelson, Robert, Ahbari, Mohsen Rajabi, Qu, Qiang, Ruppel, Jane, Snoeck, Veerle, Song, An, Yan, Haoheng, and Ware, Mark

Published
2022
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16. Affect and Dialogue in Collaborative Cross- Disciplinary Research: Developing Interactive Public Art on Cardiff Bay Barrage

Author

Entwistle Alice, Burrows Inga, Carroll Fiona, Thomas Nathan, Ware Mark, and Loudon Gareth

Subjects
interactive public art, site-specificity, affect, human-centred design, social disability, social inclusion, Social sciences (General), H1-99
Abstract

Where Cartesian philosophy distinguishes the perceiving and perceptual mind from the body, phenomenology constitutes the experiential/experiencing body as the subject, giving rise to the affective potential of art. An immersive world of digital connections, smart cities and the Internet of Everything dramatises the centrality of relationship, the intertwining of Self and Other, in the lived environments of human experience. This article addresses the contextual, disciplinary and practical challenges encountered in developing an ambitious interactive public art project embedding SMART technology on the coastal fringes of Cardiff, the capital city of Wales (UK). It examines the processes and problems involved in delivering a stimulating aesthetic experience in and on a complex site, for a complex audience profile. It traces, in particular, the dependence of a multi-disciplinary project team on the theoretical and practical effects of affect in their ongoing effort to produce engaging, provocative, socially inclusive interactive public art, in and through human-centred design techniques.

Published
2017
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17. 2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in Rare Matrices, Complex NAb Assays, Spectral Cytometry, Endogenous Analytes, Extracellular Vesicles Part 2 – Recommendations on Biomarkers/CDx, Flow Cytometry, Ligand-Binding Assays Development & Validation; Emerging Technologies; Critical Reagents Deep Characterization

Author

Sumner, Giane, primary, Keller, Steve, additional, Huleatt, James, additional, Staack, Roland F, additional, Wagner, Leslie, additional, Azadeh, Mitra, additional, Bandukwala, Abbas, additional, Cao, Liching, additional, Du, Xiulian, additional, Salinas, Gabriela Franco, additional, Garofolo, Fabio, additional, Harris, Shannon, additional, Hopper, Shirley, additional, Irwin, Chad, additional, Ji, Qin, additional, Joseph, Julie, additional, King, Lindsay, additional, Kinhikar, Arvind, additional, Lu, Yang, additional, Luo, Rosa, additional, Mabrouk, Omar, additional, Malvaux, Ludovic, additional, Marshall, Jean-Claude, additional, McGuire, Kristina, additional, Mikol, Vincent, additional, Neely, Robert, additional, Qiu, Xiazi, additional, Saito, Yoshiro, additional, Salaun, Bruno, additional, Scully, Ingrid, additional, Smeraglia, John, additional, Solstad, Therese, additional, Stoop, Jeroen, additional, Tang, Huaping, additional, Teixeira, Priscila, additional, Wang, Yixin, additional, Wright, Mike, additional, Mendez, Luis, additional, Beaver, Chris, additional, Eacret, Jacqueline, additional, Au-Yeung, Amelia, additional, Decman, Vilma, additional, Dessy, Francis, additional, Eck, Steven, additional, Goihberg, Polina, additional, Alcaide, Enrique Gomez, additional, Gonneau, Christele, additional, Grugan, Katharine, additional, Hedrick, Michael Nathan, additional, Kar, Sumit, additional, Sehra, Sarita, additional, Stevens, Erin, additional, Stevens, Chad, additional, Sun, Yongliang, additional, McCush, Fred, additional, Williams, LaKenya, additional, Fischer, Sally, additional, Wu, Bonnie, additional, Jordan, Gregor, additional, Burns, Chris, additional, Cludts, Isabelle, additional, Coble, Kelly, additional, Grimaldi, Christine, additional, Henderson, Neil, additional, Joyce, Alison, additional, Lotz, Gregor, additional, Lu, Yanmei, additional, Luo, Linlin, additional, Neff, Florian, additional, Sperinde, Gizette, additional, Stubenrauch, Kay-Gunnar, additional, Wang, Yuting, additional, Ware, Mark, additional, and Xu, Weifeng, additional

Published
2023
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22. The Quebec Low Back Pain Study: a protocol for an innovative 2-tier provincial cohort

Author

Pagé, Gabrielle M., Lacasse, Anaïs, Beaudet, Nicolas, Choinière, Manon, Deslauriers, Simon, Diatchenko, Luda, Dupuis, Laurent, Grégoire, Stéphanie, Hovey, Richard, Leclair, Erwan, Leonard, Guillaume, Meloto, Carolina B., Montagna, Francesca, Parent, Alexandre, Rainville, Pierre, Roy, Jean-Sébastien, Roy, Mathieu, Ware, Mark A., Wideman, Timothy H., and Stone, Laura S.

Published
2020
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26. HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians

Author

Voronin, Yegor, Zinszner, Helene, Karg, Carissa, Brooks, Katie, Coombs, Robert, Hural, John, Holt, Renee, Fast, Pat, Allen, Mary, Busch, Michael, Fruth, Ulrich, Golding, Hana, Khurana, Surender, Mulenga, Joseph, Peel, Sheila, Schito, Marco, Barnabas, Nomampondo, Bentsen, Christopher, Graham, Barney, Gray, Glenda, Levin, Andrew, McCluskey, Margaret, O’Connell, Robert, Snow, Bill, and Ware, Mark

Published
2015
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37. International Olympic Committee consensus statement on pain management in elite athletes

Author

Hainline, Brian, Derman, Wayne, Vernec, Alan, Budgett, Richard, Deie, Masataka, Dvořák, Jiří, Harle, Chris, Herring, Stanley A, McNamee, Mike, Meeuwisse, Willem, Lorimer Moseley, G, Omololu, Bade, Orchard, John, Pipe, Andrew, Pluim, Babette M, Ræder, Johan, Siebert, Christian, Stewart, Mike, Stuart, Mark, Turner, Judith A, Ware, Mark, Zideman, David, and Engebretsen, Lars

Published
2017
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41. 2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/Oral & Multispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (Part 2 – Recommendations on Biomarkers/CDx Assays Development & Validation, Cytometry Validation & Innovation, Biotherapeutics PK LBA Regulated Bioanalysis, Critical Reagents & Positive Controls Generation)

Author

Hersey, Sarah, primary, Keller, Steve, additional, Mathews, Joel, additional, King, Lindsay, additional, Bandukwala, Abbas, additional, Berisha, Flora, additional, Birchler, Mary, additional, Bower, Joe, additional, Clausen, Valerie, additional, Duarte, Jose, additional, Garofolo, Fabio, additional, Hopper, Shirley, additional, Kar, Sumit, additional, Mabrouk, Omar, additional, Marshall, Jean-Claude, additional, McGuire, Kristina, additional, Naughton, Michael, additional, Saito, Yoshiro, additional, Schuhmann, Imelda, additional, Sperinde, Gizette, additional, Teixeira, Priscila, additional, Vitaliti, Alessandra, additional, Wang, Yow-Ming, additional, Wnek, Richard, additional, Zhang, Yan, additional, Spitz, Sue, additional, Decman, Vilma, additional, Eck, Steven, additional, Estevam, Jose, additional, Goihberg, Polina, additional, Alcaide, Enrique Gómez, additional, Gonneau, Christèle, additional, Hedrick, Michael Nathan, additional, Hopkins, Gregory, additional, Junker, Fabian, additional, Nuti, Sandra, additional, Sommer, Ulrike, additional, Standifer, Nathan, additional, Stevens, Chad, additional, Stevens, Erin, additional, Hendricks, Carrie, additional, Wadhwa, Meenu, additional, Torri, Albert, additional, Ma, Mark, additional, Harris, Shannon, additional, Kumar, Seema, additional, Partridge, Michael A, additional, Caiazzo, Teresa, additional, Chilewski, Shannon, additional, Cludts, Isabelle, additional, Coble, Kelly, additional, Gorovits, Boris, additional, Grimaldi, Christine, additional, Jordan, Gregor, additional, Kamerud, John, additional, Leary, Beth, additional, Liang, Meina, additional, Lim, Hanjo, additional, Mayer, Andrew, additional, O'Connor, Ellen, additional, Palackal, Nisha, additional, Poetzl, Johann, additional, Prior, Sandra, additional, Abhari, Mohsen Rajabi, additional, Savoie, Natasha, additional, Soo, Catherine, additional, Ware, Mark, additional, Wu, Bonnie, additional, Xu, Yang, additional, Yang, Tong-Yuan, additional, and Zoghbi, Jad, additional

Published
2022
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43. Predictors of Pain Reduction Among Fibromyalgia Patients Using Medical Cannabis: A Long‐TermProspective Cohort Study

Author

Sotoodeh, Romina, Waldman, Lilach Eyal, Vigano, Antonio, Moride, Yola, Canac‐Marquis, Michelle, Spilak, Tristan, Gamaoun, Rihab, Kalaba, Maja, Hachem, Yasmina, Beaulieu, Pierre, Desroches, Julie, Ware, Mark A., Perez, Jordi, Shir, Yoram, Fitzcharles, Mary‐Ann, and Martel, Marc O.

Abstract

Many patients with fibromyalgia (FM) report using cannabis as a strategy to improve pain. Given that pain often co‐occurs with symptoms of anxiety and depression (i.e., negative affect) and sleep problems among patients with FM, improvements in these symptoms might indirectly contribute to reductions in pain intensity following cannabis use. The main objective of the study was to examine whether changes in pain intensity following initiation of medical cannabis among patients with FM could be attributed to concurrent changes (i.e., reductions) in negative affect and sleep problems. This was a 12‐month prospective cohort study among patients with FM (n = 323) initiating medical cannabis under the care of physicians. Patients were assessed at baseline, and follow‐up assessment visits occurred every 3 months after initiation of medical cannabis. Patients’ levels of pain intensity, negative affect, and sleep problems were assessed across all visits. Multilevel mediation analyses indicated that reductions in patients’ levels of pain intensity were partly explained by concurrent reductions in sleep problems and negative affect (both P< 0.001). This remained significant even when accounting for patients’ baseline characteristics or changes in medical cannabis directives over time (all P> 0.05). Our findings provide preliminary insight into the potential mechanisms of action underlying pain reductions among patients with FM who are using medical cannabis. Given the high attrition rate (i.e., 75%) observed in the present study at 12 months, our findings cannot be generalized to all patients with FM who are using medical cannabis.

Published
2023
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47. Anti-drug Antibody Validation Testing and Reporting Harmonization

Author

Myler, Heather, primary, Pedras-Vasconcelos, João, additional, Phillips, Kelli, additional, Hottenstein, Charles Scott, additional, Chamberlain, Paul, additional, Devanaryan, Viswanath, additional, Gleason, Carol, additional, Goodman, Joanne, additional, Manning, Marta Starcevic, additional, Purushothama, Shobha, additional, Richards, Susan, additional, Shen, Honglue, additional, Zoghbi, Jad, additional, Amaravadi, Lakshmi, additional, Barger, Troy, additional, Bowen, Steven, additional, Bowsher, Ronald R., additional, Clements-Egan, Adrienne, additional, Geng, Dong, additional, Goletz, Theresa J., additional, Gunn, George R., additional, Hallett, William, additional, Hodsdon, Michael E., additional, Janelsins, Brian M., additional, Jawa, Vibha, additional, Kamondi, Szilard, additional, Kirshner, Susan, additional, Kramer, Daniel, additional, Liang, Meina, additional, Lindley, Kathryn, additional, Liu, Susana, additional, Liu, ZhenZhen, additional, McNally, Jim, additional, Mikulskis, Alvydas, additional, Nelson, Robert, additional, Ahbari, Mohsen Rajabi, additional, Qu, Qiang, additional, Ruppel, Jane, additional, Snoeck, Veerle, additional, Song, An, additional, Yan, Haoheng, additional, and Ware, Mark, additional

Published
2021
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