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Your search keyword '"Wang, Ruxuan"' showing total 11 results
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11 results on '"Wang, Ruxuan"'

4. PROTAC Degraders of Androgen Receptor‐Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration

Author

Wang, Ruxuan, primary, Zhong, Tengjiang, additional, Bian, Qiong, additional, Zhang, Sai, additional, Ma, Xiaolu, additional, Li, Liming, additional, Xu, Yihua, additional, Gu, Yueting, additional, Yuan, Anran, additional, Hu, Weitong, additional, Qin, Chong, additional, and Gao, Jianqing, additional

Published
2022
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6. Correction to A Facile Low-Dose Photosensitizer-Incorporated Dissolving Microneedles-Based Composite System for Eliciting Antitumor Immunity and the Abscopal Effect

Author

Bian, Qiong, primary, Huang, Lingling, additional, Xu, Yihua, additional, Wang, Ruxuan, additional, Gu, Yueting, additional, Yuan, Anran, additional, Ma, Xiaolu, additional, Hu, Jingyi, additional, Rao, Yuefeng, additional, Xu, Donghang, additional, Wang, Hangxiang, additional, and Gao, Jianqing, additional

Published
2022
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8. A Facile Low-Dose Photosensitizer-Incorporated Dissolving Microneedles-Based Composite System for Eliciting Antitumor Immunity and the Abscopal Effect

Author

Bian, Qiong, primary, Huang, Lingling, additional, Xu, Yihua, additional, Wang, Ruxuan, additional, Gu, Yueting, additional, Yuan, Anran, additional, Ma, Xiaolu, additional, Hu, Jingyi, additional, Rao, Yuefeng, additional, Xu, Donghang, additional, Wang, Hangxiang, additional, and Gao, Jianqing, additional

Published
2021
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9. PROTAC Degraders of Androgen Receptor‐Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.

Author

Wang, Ruxuan, Zhong, Tengjiang, Bian, Qiong, Zhang, Sai, Ma, Xiaolu, Li, Liming, Xu, Yihua, Gu, Yueting, Yuan, Anran, Hu, Weitong, Qin, Chong, and Gao, Jianqing

Subjects
*TOPICAL drug administration, *HAIR growth, *ANDROGEN receptors, *BALDNESS, *ANDROGENS, *HAIR follicles
Abstract

Androgenetic alopecia (AGA) is a transracial and cross‐gender disease worldwide with a youth‐oriented tendency, but it lacks effective treatment. The binding of androgen receptor (AR) and androgen plays an essential role in the occurrence and progression of AGA. Herein, novel proteolysis targeting chimera degrader of AR (AR‐PROTAC) is synthesized and integrated with dissolving microneedles (PROTAC‐MNs) to achieve AR destruction in hair follicles for AGA treatment. The PROTAC‐MNs possess adequate mechanical capabilities for precise AR‐PROTAC delivery into the hair follicle‐residing regions for AR degradation. After applying only once topically, the PROTAC‐MNs achieve an accelerated onset of hair regeneration as compared to the daily application of the first‐line topical drug minoxidil. Intriguingly, PROTAC‐MNs via single administration still realize superior hair regeneration in AGA recrudescence, which is the major drawback of minoxidil in clinical practice. With the degradation of AR, the PROTAC‐MNs successfully regulate the signaling cascade related to hair growth and activate hair follicle stem cells. Furthermore, the PROTAC‐MNs do not cause systemic toxicity or androgen deficiency‐related chaos in vivo. Collectively, these AR‐degrading dissolving microneedles with long‐lasting efficacy, one‐step administration, and high biocompatibility provide a great therapeutic potential for AGA treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

Author

Yuan, Anran, primary, Xia, Fan, additional, Bian, Qiong, additional, Wu, Haibin, additional, Gu, Yueting, additional, Wang, Tao, additional, Wang, Ruxuan, additional, Huang, Lingling, additional, Huang, Qiaoling, additional, Rao, Yuefeng, additional, Ling, Daishun, additional, Li, Fangyuan, additional, and Gao, Jianqing, additional

Published
2021
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