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Your search keyword '"Wang, Minglian"' showing total 26 results
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26 results on '"Wang, Minglian"'

7. Recent Advances of Magnetic Gold Hybrids and Nanocomposites, and Their Potential Biological Applications

Author

Elmi, Gul Rehman, Saleem, Kalsoom, Baig, Mirza Muhammad Faran Ashraf, Aamir, Muhammad Naeem, Wang, Minglian, Gao, Xiuli, Abbas, Muhammad, Rehman, Masood Ur, Elmi, Gul Rehman, Saleem, Kalsoom, Baig, Mirza Muhammad Faran Ashraf, Aamir, Muhammad Naeem, Wang, Minglian, Gao, Xiuli, Abbas, Muhammad, and Rehman, Masood Ur

Abstract

Magnetic gold nanoparticles (mGNP) have become a great interest of research for nano-material scientists because of their significant magnetic and plasmonic properties applicable in biomedical applications. Various synthetic approaches and surface modification techniques have been used for mGNP including the most common being the coprecipitation, thermal decomposition, and microemulsion methods in addition to the Brust Schiffrin technique, which involves the reduction of metal precursors in a two-phase system (water and toluene) in the presence of alkanethiol. The hybrid magnetic–plasmonic nanoparticles based on iron core and gold shell are being considered as potential theranostic agents. In this critical review, in addition to future works, we have summarized recent developments for synthesis and surface modification of mGNP with their applications in modern biomedical science such as drug and gene delivery, bioimaging, biosensing, and neuro-regeneration, neuro-degenerative and arthritic disorders. This review includes techniques and biological applications of mGNP majorly based on research from the previous six years.

Published
2022

8. Nanostructured lipid carriers based delivery of pioglitazone for treatment of type-2 diabetes

Author

Ilyas, Umair, Asif, Muhammad, Wang, Minglian, Altaf, Reem, Zafar, Hajra, Baig, Mirza Muhammad Faran Ashraf, Paiva-santos, Ana Cláudia, Abbas, Muhammad, Ilyas, Umair, Asif, Muhammad, Wang, Minglian, Altaf, Reem, Zafar, Hajra, Baig, Mirza Muhammad Faran Ashraf, Paiva-santos, Ana Cláudia, and Abbas, Muhammad

Abstract

Pioglitazone (PGZ) is utilized as a therapeutic agent in the management of (type 2) diabetes to control blood glucose levels. The existing research work was intended to make and optimize PGZ-containing NLCs (nanostructured lipid carriers). The fabricated nanostructured lipid carrier preparation was optimized by using different concentrations of the surfactants (Tween 80 and Span 80) and solid lipid (Compritol® 888 ATO) and liquid lipid (Labrasol®) while keeping the concentration of drug (PGZ), and co-surfactants (poloxamer 188) the same. The optimized NLC formulation (PGZ-NLCs) was further assessed for physical and chemical characterization, in vitro PGZ release, and stability studies. The optimized PGZ-NLCs have shown an average diameter of 150.4 nm, EE of 92.53%, PDI value of 0.076, and zeta-potential of −29.1 mV, correspondingly. The DSC thermal analysis and XRD diffractograms had not presented the spectrum of PGZ, confirming the comprehensive encapsulation of PGZ in the lipid core. PGZ-NLCs showed significantly extended release (51% in 24 h) compared to the unformulated PGZ. Our study findings confirmed that PGZ-NLCs can be a promising drug delivery system for the treatment of type 2 diabetes. Copyright © 2022 Ilyas, Asif, Wang, Altaf, Zafar, Faran Ashraf Baig, Paiva-Santos and Abbas.

Published
2022

26. Oxidative changes and apoptosis induced by 1800-MHz electromagnetic radiation in NIH/3T3 cells.

Author

Hou, Qingxia, Wang, Minglian, Wu, Shuicai, Ma, Xuemei, An, Guangzhou, Liu, Huan, and Xie, Fei

Subjects
*APOPTOSIS, *ELECTROMAGNETIC radiation, *CELL phones, *PHYSIOLOGICAL effects of radiation, *FIBROBLASTS, *LABORATORY mice, *PHYSIOLOGY
Abstract

To investigate the potential adverse effects of mobile phone radiation, we studied reactive oxygen species (ROS), DNA damage and apoptosis in mouse embryonic fibroblasts (NIH/3T3) after intermittent exposure (5 min on/10 min off, for various durations from 0.5 to 8 h) to an 1800-MHz GSM-talk mode electromagnetic radiation (EMR) at an average specific absorption rate of 2 W/kg. A 2′,7′-dichlorofluorescin diacetate fluorescence probe was used to detect intracellular ROS levels, immunofluorescence was used to detect γH2AX foci as a marker for DNA damage, and flow cytometry was used to measure apoptosis. Our results showed a significant increase in intracellular ROS levels after EMR exposure and it reached the highest level at an exposure time of 1 h ( p < 0.05) followed by a slight decrease when the exposure continued for as long as 8 h. No significant effect on the number of γH2AX was detected after EMR exposure. The percentage of late-apoptotic cells in the EMR-exposed group was significantly higher than that in the sham-exposed groups ( p < 0.05). These results indicate that an 1800-MHz EMR enhances ROS formation and promotes apoptosis in NIH/3T3 cells. [ABSTRACT FROM AUTHOR]

Published
2015
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