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Your search keyword '"Wakitani, Shigeyuki"' showing total 32 results
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32 results on '"Wakitani, Shigeyuki"'

2. Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial

Author

Hashimoto, Yusuke, Nishida, Yohei, Takahashi, Shinji, Nakamura, Hiroaki, Mera, Hisashi, Kashiwa, Kaori, Yoshiya, Shinichi, Inagaki, Yusuke, Uematsu, Kota, Tanaka, Yasuhito, Asada, Shigeki, Akagi, Masao, Fukuda, Kanji, Hosokawa, Yoshiya, Myoui, Akira, Kamei, Naosuke, Ishikawa, Masakazu, Adachi, Nobuo, Ochi, Mitsuo, and Wakitani, Shigeyuki

Published
2019
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11. Long-term results of autologous bone marrow mesenchymal stem cell transplantation for cartilage defects in the patella: Two case reports with more than 18 years of follow-up

Author

Tsujii, Akira, primary, Hiramatsu, Kunihiko, additional, Shimomura, Kazunori, additional, Kobayashi, Masato, additional, Mera, Hisashi, additional, Wakitani, Shigeyuki, additional, Nakamura, Norimasa, additional, Horibe, Shuji, additional, and Mitsuoka, Tomoki, additional

Published
2020
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14. High titer of anti-citrullinated peptide antibody is a risk factor for severe carotid atherosclerotic plaque in patients with rheumatoid arthritis: the TOMORROW study

Author

Okano, Tadashi, primary, Inui, Kentaro, additional, Sugioka, Yuko, additional, Sugioka, Kenichi, additional, Matsumura, Yoshiki, additional, Takahashi, Shinji, additional, Tada, Masahiro, additional, Mamoto, Kenji, additional, Wakitani, Shigeyuki, additional, Koike, Tatsuya, additional, and Nakamura, Hiroaki, additional

Published
2017
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26. Articular Cartilage Endurance and Resistance to Osteoarthritic Changes Require Transcription Factor Erg

Author

Ohta, Yoichi, primary, Okabe, Takahiro, additional, Larmour, Colleen, additional, Di Rocco, Agnese, additional, Maijenburg, Marijke W., additional, Phillips, Amanda, additional, Speck, Nancy A., additional, Wakitani, Shigeyuki, additional, Nakamura, Takashi, additional, Yamada, Yoshihiko, additional, Enomoto-Iwamoto, Motomi, additional, Pacifici, Maurizio, additional, and Iwamoto, Masahiro, additional

Published
2015
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30. Preference of surgical procedure for the forefoot deformity in the rheumatoid arthritis patients-A prospective, randomized, internal controlled study.

Author

Tada, Masahiro, Koike, Tatsuya, Okano, Tadashi, Sugioka, Yuko, Wakitani, Shigeyuki, Mamoto, Kenji, Inui, Kentaro, and Nakamura, Hiroaki

Subjects
RHEUMATOID arthritis, SURGICAL excision, ARTHRODESIS, HALLUX valgus, CALLOSITIES
Abstract

Objectives. The deformed rheumatoid forefoot may be treated with resection of lesser metatarsal heads combined with arthrodesis or resection of the first metatarsophalangeal joint. Recurrent hallux valgus deformity has been reported by resection. We performed a prospective, randomized, internal-controlled study to compare results between arthrodesis and resection. Methods. We resected the lesser metatarsal heads bilaterally and performed arthrodesis of the first metatarsophalangeal joint on one side and resection on the opposite side. We investigated 26 patients (52 feet) who were followed at least one year. Patients were assessed for clinical score, hallux valgus angle (HVA), angle between first and second metatarsals, and angle between first and fifth metatarsals preoperatively, postoperatively and at final follow-up. We evaluated callosities, claw toes, recurrences, and procedure preferences. Results. The mean follow-up period was 4.1 years. No significant differences between arthrodesis and resection were seen, with the exception of HVA. That was significantly less on arthrodesis side (11.5°) than on resection side (17.0°, p < 0.05). Seven callosities on resection side and four on arthrodesis side were observed. On resection side, hallux valgus deformity often recurred (15.3%). Patients expressed a significant preference for arthrodesis over resection ( p = 0.008). Conclusions. Arthrodesis provides better results for maintaining HVA. [ABSTRACT FROM AUTHOR]

Published
2015
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31. Cartilage Repair With Autologous Bone Marrow Mesenchymal Stem Cell Transplantation: Review of Preclinical and Clinical Studies

Author

Yamasaki, Shinya, Mera, Hisashi, Itokazu, Maki, Hashimoto, Yusuke, and Wakitani, Shigeyuki

Abstract

Clinical trials of various procedures, including bone marrow stimulation, mosaicplasty, and autologous chondrocyte implantation, have been explored to treat articular cartilage defects. However, all of them have some demerits. We focused on autologous culture-expanded bone marrow mesenchymal stem cells (BMSC), which can proliferate without losing their capacity for differentiation. First, we transplanted BMSC into the defective articular cartilage of rabbit and succeeded in regenerating osteochondral tissue. We then applied this transplantation in humans. Our previous reports showed that treatment with BMSC relieves the clinical symptoms of chondral defects in the knee and elbow joint. We investigated the efficacy of BMSC for osteoarthritic knee treated with high tibial osteotomy, by comparing 12 BMSC-transplanted patients with 12 cell-free patients. At 16-month follow-up, although the difference in clinical improvement between both groups was not significant, the arthroscopic and histological grading score was better in the cell-transplanted group. At the over 10-year follow-up, Hospital for Special Surgery knee scores improved to 76 and 73 in the BMSC-transplanted and cell-free groups, respectively, which were better than preoperative scores. Additionally, neither tumors nor infections were observed in all patients, and in the clinical study, we have never observed hypertrophy of repaired tissue, thereby guaranteeing the clinical safety of this therapy. Although we have never observed calcification above the tidemark in rabbit model and human histologically, the repair cartilage was not completely hyaline cartilage. To elucidate the optimum conditions for cell therapy, other stem cells, culture conditions, growth factors, and gene transfection methods should be explored.

Published
2014
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32. High frequency of vertebral fracture and low bone quality in patients with rheumatoid arthritis-Results from TOMORROW study.

Author

Okano T, Inui K, Tada M, Sugioka Y, Mamoto K, Wakitani S, Koike T, and Nakamura H

Subjects
Aged, Arthritis, Rheumatoid epidemiology, Female, Humans, Middle Aged, Osteoporosis epidemiology, Arthritis, Rheumatoid complications, Bone Density, Osteoporosis etiology, Spinal Fractures epidemiology
Abstract

Objectives: Osteoporosis is one of the complications in patients with rheumatoid arthritis (RA). In this study, we researched the morbidity of existing vertebral fractures and the risk factors for vertebral fractures in patients with RA., Methods: This study included 413 participants, 208 patients with RA, and 205 age- and sex-matched controls without RA. Clinical data, radiographic assessment of vertebral fracture from T4 to L4 in thoracic and lumber spine, bone mineral density (BMD), and bone metabolic markers (BMM) were analyzed., Results: Vertebral fractures were observed more frequently, severe and multiple in patients with RA. In the logistic regression analysis, age (adjusted odds ratios (OR): 1.07, 95% confidence interval (CI): 1.04-1.09) and RA (adjusted OR: 1.72, 95% CI: 1.04-2.83) were risk factors for existing vertebral fracture. Moreover, two bone matrix-related markers, undercarboxylated osteocalcin (ucOC) (adjusted OR: 1.68, 95% CI: 1.02-2.78), and urinary pentocidine (adjusted OR: 2.51, 95% CI: 1.48-4.24) were associated with existing vertebral fracture., Conclusions: High frequent, multiple, and severe vertebral fractures were found in patients with RA compared to the controls. Low bone quality might be the cause of the frequent prevalence of vertebral fracture in patients with RA.

Published
2017
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