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Base-catalyzed Michael addition of nitroalkane to conjugated nitroalkene suffers serious practical difficulties due to the formation of oligomeric byproduct. Given its importance for synthesis of pharmacologically relevant organic compounds, a scalable synthesis of 1,3-dinitroalkane is developed by addition of nitroalkane to nitroalkene in aqueous phosphate buffer at pH 7.0 with no added traditional base catalyst. Key words: 1,3-dinitroalkanes, Michael addition, phosphate buffer, base free, diastereoselective. La reaction de Michael catalysee par une base pour effectuer l'addition d'un nitroalcane a un nitroalcene conjugue pose des difficultes pratiques majeures en raison de la formation de sous-produits oligomeriques. Etant donne son importance pour la synthese de composes possedant une activite pharmacologique, nous avons elabore une synthese de 1,3-dinitroalcanes adaptable a grande echelle qui procede par addition d'un nitroalcane a un nitroalcene dans un tampon aqueux de phosphate a pH 7,0, sans catalyseur basique. [Traduit par la Redaction] Mots-cles: 1,3-dinitroalkanes, addition de Michael, tampon phosphate, sans base, diastereoselective., Introduction In organic synthesis, methods for the development of carbon-carbon bond forming reactions are considered as the cornerstone of building complex molecular architechture. (1-5) Many of such C-C bond forming [...]