25 results on '"Wage Rick"'
Search Results
2. Long-term clinical outcomes and cost-effectiveness of catheter vs thoracoscopic surgical ablation in long-standing persistent atrial fibrillation using continuous cardiac monitoring: CASA-AF randomized controlled trial
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Yahdev, Rashmi, Rahman-Halley, Shelley, Wong, Joyce, Opel, Aaisha, Kaba, Riyaz, Nyktari, Eva, Cambronero-Cortinas, Esther, Izgi, Cemil, Fairbairn, Timothy, Benton, Joanne, Chester, Ruth, Cunliffe, Eliane, Edmondson, Lucy, Gill, Matthew, Griffiths, Vicky, Harman, Rebecca, Huggett, Catherine, Keegan, Jenny, Kirby, Kevin, Lascelles, Karen, Manivarmane, Ramasamy, Munteanu, Iulia, O’Brien, Karen, Phyl, Tess, Rahneva, Tsveta, Riley, Cheryl, Rogers, Paula, Smith, Katherine, Wage, Rick, West, Cathy, Yakupoglu, Yakup, Yang, Guang, Audraite, Audra, Belchambers, Sandra, Hughes, Susan, Morgan, Maureen, Ronayne, Christina, Shaw, Rob, Simkus, Paulinus, Taylerson, Clive, Bruce, Chloe, McGregor, Andrew, Thomson, Catherine, Granville, Hollie, Snell, Alice, John, Sophia, Monteiro, Christiana, Augustine, Grace, Sutton, Nichola, Boyalla, Vennela, Haldar, Shouvik, Khan, Habib, Kralj-Hans, Ines, Banya, Winston, Lord, Joanne, Satishkumar, Anitha, Bahrami, Toufan, De Souza, Anthony, Clague, Jonathan R., Francis, Darrel P., Hussain, Wajid, Jarman, Julian W., Jones, David G., Chen, Zhong, Mediratta, Neeraj, Hyde, Jonathan, Lewis, Michael, Mohiaddin, Raad, Salukhe, Tushar V., Markides, Vias, McCready, James, Gupta, Dhiraj, and Wong, Tom
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- 2024
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3. Fully Automatic Segmentation and Objective Assessment of Atrial Scars for Longstanding Persistent Atrial Fibrillation Patients Using Late Gadolinium-Enhanced MRI
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Yang, Guang, Zhuang, Xiahai, Khan, Habib, Haldar, Shouvik, Nyktari, Eva, Li, Lei, Wage, Rick, Ye, Xujiong, Slabaugh, Greg, Mohiaddin, Raad, Wong, Tom, Keegan, Jennifer, and Firmin, David
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Purpose: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is correlated with increased morbidity and mortality. It is associated with atrial fibrosis, which may be assessed non-invasively using late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) where scar tissue is visualised as a region of signal enhancement. In this study, we proposed a novel fully automatic pipeline to achieve an accurate and objective atrial scarring segmentation and assessment of LGE MRI scans for the AF patients. Methods: Our fully automatic pipeline uniquely combined: (1) a multi-atlas based whole heart segmentation (MA-WHS) to determine the cardiac anatomy from an MRI Roadmap acquisition which is then mapped to LGE MRI, and (2) a super-pixel and supervised learning based approach to delineate the distribution and extent of atrial scarring in LGE MRI. Results: Both our MA-WHS and atrial scarring segmentation showed accurate delineations of cardiac anatomy (mean Dice = 89%) and atrial scarring (mean Dice =79%) respectively compared to the established ground truth from manual segmentation. Compared with previously studied methods with manual interventions, our innovative pipeline demonstrated comparable results, but was computed fully automatically. Conclusion: The proposed segmentation methods allow LGE MRI to be used as an objective assessment tool for localisation, visualisation and quantification of atrial scarring., Comment: 39 pages, 8 figure, 2 tables, submitted to MRM journal
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- 2017
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4. Two-center validation of Pilot Tone based cardiac triggering of a comprehensive cardiovascular magnetic resonance examination
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Pan, Yue, primary, Varghese, Juliet, additional, Tong, Matthew S., additional, Yildiz, Vedat O., additional, Azzu, Alessia, additional, Gatehouse, Peter, additional, Wage, Rick, additional, Nielles-Vallespin, Sonia, additional, Pennell, Dudley J., additional, Jin, Ning, additional, Bacher, Mario, additional, Hayes, Carmel, additional, Speier, Peter, additional, and Simonetti, Orlando P., additional
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- 2023
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5. Cardiovascular magnetic resonance normal values in children for biventricular wall thickness and mass
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Krupickova, Sylvia, Risch, Julian, Gati, Sabiha, Caliebe, Amke, Sarikouch, Samir, Beerbaum, Philipp, Puricelli, Filippo, Daubeney, Piers E. F., Barth, Courtney, Wage, Rick, Boroni Grazioli, Simona, Uebing, Anselm, Pennell, Dudley J., and Voges, Inga
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- 2021
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6. Abstract 15167: Short-term Sequalae of Children With Paediatric Inflammatory Multisystem Syndrome Temporarily Associated With Sars-cov-2 Infection (pims-ts) Assessed by Cardiovascular Magnetic Resonance
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Bermejo Altamar, Ivan, Whittaker, Elisabeth, herberg, jethro, Fraisse, Alain, Bautista, Carles, Kang, Heechan, Giselle, Rowlinson, Wage, Rick, Lane, Mary, Piccinelli, Enrico, Di Salvo, Giovanni, Mohiaddin, Raad, Pennell, Dudley J, and Krupickova, Sylvia J
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- 2020
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7. Left Atrial Scarring Segmentation from Delayed-Enhancement Cardiac MRI Images: A Deep Learning Approach
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Yang, Guang, primary, Zhuang, Xiahai, additional, Khan, Habib, additional, Nyktari, Eva, additional, Haldar, Shouvik, additional, Li, Lei, additional, Wage, Rick, additional, Ye, Xujiong, additional, Slabaugh, Greg, additional, Mohiaddin, Raad, additional, Wong, Tom, additional, Keegan, Jennifer, additional, and Firmin, David, additional
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- 2018
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8. Myocardial deformation assessed by CMR in children after multisystem inflammatory syndrome (MIS-C)
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Krupickova, Sylvia, primary, Bautista-Rodriguez, Carles, additional, Hatipoglu, Suzan, additional, Kang, Heechan, additional, Fraisse, Alain, additional, Di Salvo, Giovanni, additional, Piccinelli, Enrico, additional, Rowlinson, Giselle, additional, Lane, Mary, additional, Altamar Bermejo, Ivan, additional, Moscatelli, Sara, additional, Wage, Rick, additional, Mohiaddin, Raad, additional, Pennell, Dudley J., additional, and Voges, Inga, additional
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- 2022
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9. Abstract 10960: Genetic Overlap of Acute Myocarditis and Inherited Cardiomyopathy
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Lota, Amrit S, primary, Hazebroek, Mark, additional, Theotokis, Pantazis, additional, Wassall, Rebecca, additional, Salmi, Sara, additional, Halliday, Brian, additional, Tayal, Upasana, additional, Verdonschot, Job, additional, Meena, Devendra, additional, de Marvao, Antonio, additional, Iacob, Alma, additional, Hammersley, Daniel, additional, Jones, Richard, additional, Wage, Rick, additional, Buchan, Rachel, additional, Yazdani, Momina, additional, Noseda, Michela, additional, Mittal, Tarun, additional, Wong, Joyce, additional, Robertus, Jan Lukas, additional, Baksi, John, additional, Vassiliou, Vassilios, additional, Tzoulaki, Ioanna, additional, Pantazis, Antonios, additional, Cleland, John, additional, Barton, Paul J, additional, cook, stuart, additional, Pennell, Dudley J, additional, Garcia-Pavia, Pablo, additional, Cooper, Leslie T, additional, Heymans, Stephane, additional, Ware, James S, additional, and Prasad, Sanjay K, additional
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- 2021
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10. 1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence
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Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, and Prasad, Sanjay
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- 2016
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11. Additional file 1 of Cardiovascular magnetic resonance normal values in children for biventricular wall thickness and mass
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Krupickova, Sylvia, Risch, Julian, Gati, Sabiha, Caliebe, Amke, Sarikouch, Samir, Beerbaum, Philipp, Puricelli, Filippo, Daubeney, Piers E. F., Barth, Courtney, Wage, Rick, Grazioli, Simona Boroni, Uebing, Anselm, Pennell, Dudley J., and Voges, Inga
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Data_FILES - Abstract
Additional file 1. Additional tables.
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- 2021
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12. Initial investigation of free-breathing 3D whole-heart stress myocardial perfusion MRI
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Fair, Merlin J, primary, Gatehouse, Peter D, additional, Reyes, Eliana, additional, Adluru, Ganesh, additional, Mendes, Jason, additional, Khan, Tina, additional, De Silva, Ranil, additional, Wage, Rick, additional, DiBella, Edward V, additional, and Firmin, David N, additional
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- 2020
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13. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial
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Halliday, Brian P., Wassall, Rebecca, Lota, Amrit S., Khalique, Zohya, Gregson, John, Newsome, Simon, Jackson, Robert, Rahneva, Tsveta, Wage, Rick, Smith, Gillian, Venneri, Lucia, Tayal, Upsana, Auger, Dominique, Midwinter, William, Whiffin, Nicola, Rajani, Ronak, Dungu, Jason N., Pantazis, Antonis, Cook, Stuart A., Ware, James S., Baksi, A. John, Pennell, Dudley J., Rosen, Stuart D., Cowie, Martin R., Cleland, John G.F., and Prasad, Sanjay K.
- Abstract
Background: \ud Patients with dilated cardiomyopathy whose symptoms and cardiac function have recovered often ask whether their medications can be stopped. The safety of withdrawing treatment in this situation is unknown.\ud \ud Methods: \ud We did an open-label, pilot, randomised trial to examine the effect of phased withdrawal of heart failure medications in patients with previous dilated cardiomyopathy who were now asymptomatic, whose left ventricular ejection fraction (LVEF) had improved from less than 40% to 50% or greater, whose left ventricular end-diastolic volume (LVEDV) had normalised, and who had an N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) concentration less than 250 ng/L. Patients were recruited from a network of hospitals in the UK, assessed at one centre (Royal Brompton and Harefield NHS Foundation Trust, London, UK), and randomly assigned (1:1) to phased withdrawal or continuation of treatment. After 6 months, patients in the continued treatment group had treatment withdrawn by the same method. The primary endpoint was a relapse of dilated cardiomyopathy within 6 months, defined by a reduction in LVEF of more than 10% and to less than 50%, an increase in LVEDV by more than 10% and to higher than the normal range, a two-fold rise in NT-pro-BNP concentration and to more than 400 ng/L, or clinical evidence of heart failure, at which point treatments were re-established. The primary analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT02859311.\ud \ud Findings: \ud Between April 21, 2016, and Aug 22, 2017, 51 patients were enrolled. 25 were randomly assigned to the treatment withdrawal group and 26 to continue treatment. Over the first 6 months, 11 (44%) patients randomly assigned to treatment withdrawal met the primary endpoint of relapse compared with none of those assigned to continue treatment (Kaplan-Meier estimate of event rate 45·7% [95% CI 28·5–67·2]; p=0·0001). After 6 months, 25 (96%) of 26 patients assigned initially to continue treatment attempted its withdrawal. During the following 6 months, nine patients met the primary endpoint of relapse (Kaplan-Meier estimate of event rate 36·0% [95% CI 20·6–57·8]). No deaths were reported in either group and three serious adverse events were reported in the treatment withdrawal group: hospital admissions for non-cardiac chest pain, sepsis, and an elective procedure.\ud \ud Interpretation: \ud Many patients deemed to have recovered from dilated cardiomyopathy will relapse following treatment withdrawal. Until robust predictors of relapse are defined, treatment should continue indefinitely.\ud \ud Funding: \ud British Heart Foundation, Alexander Jansons Foundation, Royal Brompton Hospital and Imperial College London, Imperial College Biomedical Research Centre, Wellcome Trust, and Rosetrees Trust.
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- 2019
14. Diffusion Tensor Cardiovascular Magnetic Resonance of Microstructural Recovery in Dilated Cardiomyopathy
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Khalique, Zohya, primary, Ferreira, Pedro F., additional, Scott, Andrew D., additional, Nielles-Vallespin, Sonia, additional, Wage, Rick, additional, Firmin, David N., additional, and Pennell, Dudley J., additional
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- 2018
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15. 2 Assessment of the microstructure in recovered dilated cardiomyopathy with diffusion tensor cardiovascular magnetic resonance
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Khalique, Zohya, primary, Ferreira, Pedro F, additional, Scott, Andrew D, additional, Nielles-Vallespin, Sonia, additional, Wage, Rick, additional, Firmin, David N, additional, and Pennell, Dudley J, additional
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- 2018
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16. Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron
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Alam, Mohammed H., primary, Auger, Dominique, additional, McGill, Laura-Ann, additional, Smith, Gillian C., additional, He, Taigang, additional, Izgi, Cemil, additional, Baksi, A. John, additional, Wage, Rick, additional, Drivas, Peter, additional, Firmin, David N., additional, and Pennell, Dudley J., additional
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- 2016
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17. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1.
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Tayal, Upasana, primary, Kallifatidis, Alexandros, primary, Garg, P., primary, Beitzke, D., primary, Funk, Stephanie, primary, Kolker, Shimon, primary, Rutz, Tobias, primary, Safdar, Komal S, primary, Valente, F., primary, Murdoch, R., primary, Macaione, F., primary, Dastidar, Amardeep Ghosh, primary, Pontone, Gianluca, primary, Grigoratos, Chrysanthos, primary, Meloni, Antonella, primary, Pedrotti, Patrizia, primary, De Garate, Estefania, primary, Careri, Giulia, primary, Kockova, R., primary, Oebel, S., primary, Nazir, Sheraz A., primary, Barison, A, primary, Swoboda, Peter P, primary, Bulluck, Heerajnarain, primary, Broncano, J., primary, Desroche, L.M., primary, Bermejo, Zorba Blázquez, primary, Kozor, Rebecca, primary, Scott, Andrew D, additional, Wage, Rick, additional, Ferreira, Pedro, additional, Pennell, Dudley, additional, Zhong, Xiaodong, additional, Epstein, Fred, additional, Firmin, David, additional, Prasad, Sanjay, additional, Prousalis, Anastasios, additional, Mouratoglou, Sophia-Anastasia, additional, Giannakoulas, George, additional, Deligianni, Xenia, additional, Bakaloudis, Michail, additional, Magganaris, Nikolaos, additional, Sianos, George, additional, Karvounis, Haralampos, additional, Santini, Francesco, additional, Aziz, R., additional, Foley, J.R.J., additional, Fent, G., additional, Musa, T.A., additional, Haaf, P., additional, Dobson, L., additional, Swoboda, P.P., additional, Greenwood, J.P., additional, Plein, S., additional, Geest, R.J.V.D., additional, Westenberg, J.J.M., additional, Rasul, S., additional, Wadsak, W., additional, Mitterhauser, M., additional, Nolz, R., additional, Stelzmueller, M., additional, Loewe, C., additional, Hacker, M., additional, Kermer, Josephine, additional, Dogangüzel, Serkan, additional, von Knobelsdorff-Brenkenhoff, Florian, additional, Schulz-Menger, Jeanette, additional, Weisz, Giora, additional, Bogot, Naama, additional, Halpern, Irit Hadas, additional, Wolak, Arik, additional, Ginami, Giulia, additional, Piccini, Davide, additional, Coppo, Simone, additional, Vincenti, Gabriella, additional, Stuber, Matthias, additional, Schwitter, Jürg, additional, Gao, Xuexin, additional, Ambach, Stephanie, additional, Taylor, Michal D, additional, Moore, Ryan, additional, Taylor, Robin J, additional, Toro-Salazar, Olga, additional, Jeffries, John L, additional, Bartone, Cheryl, additional, Raman, Subha V, additional, Mazur, Wojciech, additional, Rodriguez-Palomares, J.F., additional, Gutierrez, L., additional, Pineda, V., additional, Agliano, B., additional, Galian, L., additional, Teixido, G., additional, Gonzalez-Alujas, M.T., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Gandy, S., additional, Nicholas, R., additional, Houston, G., additional, Martin, P., additional, Muir, J., additional, Matthew, S., additional, Ramkumar, P. Guntur-, additional, Cavin, I., additional, Barison, A., additional, Pescetelli, I., additional, Pali, F., additional, Pizzino, F., additional, Terrizzi, A., additional, Di Lisi, D., additional, Novo, G., additional, Todiere, G., additional, Assennato, P., additional, Novo, S., additional, Aquaro, G.D., additional, McAlindon, Elisa, additional, Rodrigues, Jonathan, additional, Baritussio, Anna, additional, Scatteia, Alessandra, additional, De Garate, Estefania, additional, Benny Lawton, Chris, additional, Erdei, Tamas, additional, Szantho, Gergely, additional, Hamilton, Mark, additional, Bucciarelli-Ducci, Chiara, additional, Andreini, Daniele, additional, Rota, Cristina, additional, Guglielmo, Marco, additional, Mushtaq, Saima, additional, Baggiano, Andrea, additional, Beltrama, Virginia, additional, Solbiati, Anna, additional, Guaricci, Andrea I., additional, Pepi, Mauro, additional, Bratis, Konstantinos, additional, Henningson, Markus, additional, Dell'Omodarme, Matteo, additional, Puntmann, Valentina O., additional, Nagel, Eike, additional, Giunta, Nicola, additional, Giuliano, Pietro, additional, Neri, Maria Giovanna, additional, Restaino, Gennaro, additional, Renne, Stefania, additional, Quota, Alessandra, additional, Positano, Vincenzo, additional, De Marchi, Daniele, additional, Pepe, Alessia, additional, Campadello, Paola, additional, Masciocco, Gabriella, additional, Facchetti, Rita, additional, Milazzo, Angela, additional, Quattrocchi, Giuseppina, additional, Giannattasio, Cristina, additional, Frigerio, Maria, additional, Roghi, Alberto, additional, Rimoldi, Ornella, additional, Ghosh Dastidar, Amardeep, additional, Amadu, Antonio, additional, Venuti, Giuseppe, additional, Rodrigues, Jonathan C., additional, Castelvecchio, Serenella, additional, Camporeale, Antonia, additional, Secchi, Francesco, additional, Menicanti, Lorenzo, additional, Lombardi, Massimo, additional, Sedlacek, K., additional, Wichterle, D., additional, Sikula, V., additional, Tintera, J., additional, Sukupova, L., additional, Kautznerova, D., additional, Segetova, M., additional, Praveckova, A., additional, Langova, R., additional, Kryze, L., additional, El-Husseini, W., additional, Kautzner, J., additional, Dinov, B., additional, Arya, A., additional, Hilbert, S., additional, Sommer, P., additional, Bollmann, A., additional, Hindricks, G., additional, Paetsch, I., additional, Jahnke, C., additional, Greenwood, John P., additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Gershlick, Anthony, additional, McCann, Gerry P., additional, Liga, Riccardo, additional, Bennatti, Elena, additional, Barison, Andrea, additional, Todiere, Giancarlo, additional, Aquaro, Giovanni Donato, additional, Emdin, Michele, additional, Masci, Pier Giorgio, additional, Ortalda, A, additional, Todiere, G, additional, Grigoratos, C, additional, Vergaro, G, additional, Mirizzi, G, additional, Martini, N, additional, De Marchi, D, additional, Keilberg, P, additional, Passino, C, additional, Aquaro, GD, additional, Emdin, M, additional, McDiarmid, Adam K, additional, Erhayiem, Bara, additional, Fent, Graham J, additional, Dobson, Laura E, additional, Garg, Pankaj, additional, Musa, Tarique A, additional, Foley, James R, additional, Page, Stephen P, additional, Greenwood, John P, additional, Plein, Sven, additional, Rosmini, Stefania, additional, Abdel-Gadir, Amna, additional, Bhuva, Anish, additional, Treibel, Thomas A, additional, White, Steven K, additional, Fontana, Marianna, additional, Ramlall, Manish, additional, Hamarneh, Ashraf, additional, Sirker, Alex, additional, Herrey, Anna, additional, Manisty, Charlotte, additional, Yellon, Derek M, additional, Kellman, Peter, additional, Moon, James C, additional, Hausenloy, Derek J, additional, Luna, A., additional, Noguerol, T. Martin –, additional, Caro, P., additional, Toro-Cebada, R., additional, Gonzalez, J. Sanchez –, additional, Milleron, O., additional, Safar, B., additional, Lavie-Badie, Y., additional, Millischer, D., additional, Abtan, J., additional, Jondeau, G., additional, Cuesta, Emilio, additional, Rosillo, Sandra O., additional, Guzmán, Gabriela, additional, Pinilla, Inmaculada, additional, González, Óscar, additional, Caro, Juan, additional, Ponz, Inés, additional, López, Teresa, additional, Refoyo, Elena, additional, Nordin, Sabrina, additional, Castelleti, Silvia, additional, Captur, Gabriella, additional, Steeds, Rick, additional, Baig, Shanat, additional, Grieve, Stuart M, additional, Figtree, Gemma A, additional, Singhal, Priyanka, additional, Strange, Julian, additional, Nightingale, Angus, additional, Baumbach, Andreas, additional, Johnson, Tom, additional, and Delgado, Victoria, additional
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- 2016
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18. Validation of T2* in-line analysis for tissue iron quantification at 1.5 T
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Alam, Mohammed H., primary, He, Taigang, additional, Auger, Dominique, additional, Smith, Gillian C., additional, Drivas, Peter, additional, Wage, Rick, additional, Izgi, Cemil, additional, Symmonds, Karen, additional, Greiser, Andreas, additional, Spottiswoode, Bruce S., additional, Anderson, Lisa, additional, Firmin, David, additional, and Pennell, Dudley J., additional
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- 2016
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19. T1 at 1.5T and 3T compared with conventional T2* at 1.5T for cardiac siderosis
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Alam, Mohammed H., primary, Auger, Dominique, additional, Smith, Gillian C., additional, He, Taigang, additional, Vassiliou, Vassilis, additional, Baksi, A. John, additional, Wage, Rick, additional, Drivas, Peter, additional, Feng, Yanqiu, additional, Firmin, David N., additional, and Pennell, Dudley J., additional
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- 2015
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20. Abstract 10159: Myocardial Remodelling Following Heart Failure Therapy Withdrawal in Patients With Dilated Cardiomyopathy and Improved Left Ventricular Ejection Fraction - Results From TRED-HF
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Halliday, Brian, Vassiliou, Vassilios, Wassall, Rebecca, Lota, Amrit, Khalique, Zohya, Wage, Rick, Smith, Gillian, Tayal, Upasana, Hammersley, Daniel, Jones, Richard, Baksi, John, Pennell, Dudley J, Cleland, John G, and Prasad, Sanjay K
- Abstract
Introduction:TRED-HF shows that for many patients with recovered dilated cardiomyopathy, withdrawal of therapy leads to relapse. Insight into tissue changes that accompany remodelling improves understanding of mechanisms. Parametric mapping using cardiovascular magnetic resonance (CMR) enables estimation of changes in myocardial cell and matrix volume.Hypothesis:Relapse of DCM is associated with cellular rather than interstitial changes.Methods:35 patients from TRED-HF who had therapy withdrawn (TW), in either the randomised or cross-over phases, and 18 who continued therapy (CT) completed CMR with parametric mapping at baseline and follow-up. Native and post-contrast T1 maps were acquired in short-axis planes, using a 5-3-3 modified Look-Locker inversion recovery sequence. Global myocardial T1 values were analysed and extracellular volume fraction (ECV) was calculated. Cell and matrix volume were derived from ECV and left ventricular (LV) mass. Serial changes within and between groups were examined using paired and independent t-tests.Results:Comparing scans before and after TW, there was an increase in cell and matrix volume and in LV mass (Fig 1A&D).The increases in cell volume and LV mass were greater amongst those who had TW compared to those who CT (Fig 1A). Of those who had TW, 14 met the criteria for relapse and 21 did not. Changes in cell and matrix volume were greater amongst patients who relapsed, however, there was an increase in matrix volume and similar trends in changes in cell volume and LV mass amongst those who did not (Fig 1B). Neither cell nor matrix volume at baseline were associated with relapse after TW (Fig 1C).Conclusion:After TW, both cellular hypertrophy and interstitial expansion occur in patients with recovered DCM and this is most obvious amongst those who relapse. However, remodelling was also observed amongst patients who had TW but did not relapse within 6 months, suggesting that more patients may relapse with longer follow-up.
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- 2019
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21. Abstract 13262: Impaired Myocardial Perfusion Reserve is Associated With Adverse Cardiovascular Events in Patients With Dilated Cardiomyopathy
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Hammersley, Daniel, Halliday, Brian, Gulati, Ankur, Ismail, Tevfik F, Ali, Aamir, Hsu, Li-Yueh, Jones, Richard, Tayal, Upasana, Lota, Amrit, Wage, Rick, Gatehouse, Peter, Firmin, David, Auger, Dominique, Owen, Ruth, Pennell, Dudley J, Arai, Andrew E, and Prasad, Sanjay K
- Abstract
Introduction:Stress perfusion cardiovascular magnetic resonance (CMR) and PET data suggest the presence of microvascular dysfunction in non-ischaemic dilated cardiomyopathy (DCM) but its impact on clinical outcomes is unknown.Hypothesis:Impaired global stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) are associated with increased risk of adverse cardiovascular (CV) events.Methods:Adenosine stress perfusion CMR was undertaken on consecutive DCM patients.Stress and rest global MBF and MPR were derived using a modified Fermi-constrained deconvolution algorithm and follow-up data was collected. The primary outcome was a composite of CV death, CV hospitalization and major arrhythmic events. Cumulative incidence curves were constructed for the primary endpoint, stratified by the median value for stress MBF and a threshold of 1.5 for MPR, selected due to prognostic significance in other cardiac conditions. Cox proportional hazards modelling was performed, adjusting for age, sex, LVEF and midwall fibrosis.Results:Of 97 patients (63 men, median age 51 years, median LVEF 43%) followed up for median 1661 days, 17 met the primary endpoint. Stress MBF and MPR increased in line with a rise in LVEF (both p=0.01); there was no trend between rest MBF and LVEF (p=0.77). MBF below median and MPR<1.5 were significantly associated with increased cumulative incidence of the primary endpoint (log-rank p=0.02 and p=0.01, Fig 1). On multivariable modelling, a decreased rate of the primary outcome was associated with increased MPR (HR 0.44; 95%CI 0.2-0.96; p=0.04), with a non-significant increase in stress MBF (HR 0.69; 95%CI 0.46-1.06; p=0.09) and had no association with rest MBF (HR 1.08; 95%CI 0.47-2.46; p=0.86).Conclusion:Impaired MPR, driven by reduced stress MBF is associated with an increased risk of CV events, even after adjusting for LVEF. MPR may be a useful adjunct for DCM risk stratification and as a putative therapeutic target.
- Published
- 2019
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22. Abstracts
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- Abstract
Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.
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- 2016
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23. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial.
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Wassall, Rebecca, Jackson, Robert, Rahneva, Tsveta, Wage, Rick, Smith, Gillian, Venneri, Lucia, Auger, Dominique, Pantazis, Antonis, Halliday, Brian P., Lota, Amrit S., Khalique, Zohya, Tayal, Upasana, Midwinter, William, Baksi, A. John, Pennell, Dudley J., Cowie, Martin R., Prasad, Sanjay K., Whiffin, Nicola, Ware, James S., and Cook, Stuart A.
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CARDIOVASCULAR agents , *COMPARATIVE studies , *DRUG administration , *LEFT heart ventricle , *HEART physiology , *HEART failure , *RESEARCH methodology , *MEDICAL cooperation , *PEPTIDE hormones , *PEPTIDES , *PROGNOSIS , *RESEARCH , *RESEARCH funding , *STATISTICAL sampling , *DISEASE relapse , *PILOT projects , *EVALUATION research , *RANDOMIZED controlled trials , *TREATMENT effectiveness , *DISEASE remission , *PASSIVE euthanasia , *DILATED cardiomyopathy , *STROKE volume (Cardiac output) , *KAPLAN-Meier estimator , *DISEASE complications , *PHARMACODYNAMICS - Abstract
Background: Patients with dilated cardiomyopathy whose symptoms and cardiac function have recovered often ask whether their medications can be stopped. The safety of withdrawing treatment in this situation is unknown.Methods: We did an open-label, pilot, randomised trial to examine the effect of phased withdrawal of heart failure medications in patients with previous dilated cardiomyopathy who were now asymptomatic, whose left ventricular ejection fraction (LVEF) had improved from less than 40% to 50% or greater, whose left ventricular end-diastolic volume (LVEDV) had normalised, and who had an N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) concentration less than 250 ng/L. Patients were recruited from a network of hospitals in the UK, assessed at one centre (Royal Brompton and Harefield NHS Foundation Trust, London, UK), and randomly assigned (1:1) to phased withdrawal or continuation of treatment. After 6 months, patients in the continued treatment group had treatment withdrawn by the same method. The primary endpoint was a relapse of dilated cardiomyopathy within 6 months, defined by a reduction in LVEF of more than 10% and to less than 50%, an increase in LVEDV by more than 10% and to higher than the normal range, a two-fold rise in NT-pro-BNP concentration and to more than 400 ng/L, or clinical evidence of heart failure, at which point treatments were re-established. The primary analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT02859311.Findings: Between April 21, 2016, and Aug 22, 2017, 51 patients were enrolled. 25 were randomly assigned to the treatment withdrawal group and 26 to continue treatment. Over the first 6 months, 11 (44%) patients randomly assigned to treatment withdrawal met the primary endpoint of relapse compared with none of those assigned to continue treatment (Kaplan-Meier estimate of event rate 45·7% [95% CI 28·5-67·2]; p=0·0001). After 6 months, 25 (96%) of 26 patients assigned initially to continue treatment attempted its withdrawal. During the following 6 months, nine patients met the primary endpoint of relapse (Kaplan-Meier estimate of event rate 36·0% [95% CI 20·6-57·8]). No deaths were reported in either group and three serious adverse events were reported in the treatment withdrawal group: hospital admissions for non-cardiac chest pain, sepsis, and an elective procedure.Interpretation: Many patients deemed to have recovered from dilated cardiomyopathy will relapse following treatment withdrawal. Until robust predictors of relapse are defined, treatment should continue indefinitely.Funding: British Heart Foundation, Alexander Jansons Foundation, Royal Brompton Hospital and Imperial College London, Imperial College Biomedical Research Centre, Wellcome Trust, and Rosetrees Trust. [ABSTRACT FROM AUTHOR]- Published
- 2019
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24. Two-center validation of Pilot Tone Based Cardiac Triggering of a Comprehensive Cardiovascular Magnetic Resonance Examination.
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Pan Y, Varghese J, Tong MS, Yildiz VO, Azzu A, Gatehouse P, Wage R, Nielles-Vallespin S, Pennell D, Jin N, Bacher M, Hayes C, Speier P, and Simonetti OP
- Abstract
Background: The electrocardiogram (ECG) signal is prone to distortions from gradient and radiofrequency interference and the magnetohydrodynamic effect during cardiovascular magnetic resonance imaging (CMR). Although Pilot Tone Cardiac (PTC) triggering has the potential to overcome these limitations, effectiveness across various CMR techniques has yet to be established., Purpose: To evaluate the performance of PTC triggering in a comprehensive CMR exam., Methods: Fifteen volunteers and twenty patients were recruited at two centers. ECG triggered images were collected for comparison in a subset of sequences. The PTC trigger accuracy was evaluated against ECG in cine acquisitions. Two experienced readers scored image quality in PTC-triggered cine, late gadolinium enhancement (LGE), and T1- and T2-weighted dark-blood turbo spin echo (DB-TSE) images. Quantitative cardiac function, flow, and parametric mapping values obtained using PTC and ECG triggered sequences were compared., Results: Breath-held segmented cine used for trigger timing analysis was collected in 15 volunteers and 14 patients. PTC calibration failed in three volunteers and one patient; ECG trigger recording failed in one patient. Out of 1987 total heartbeats, three mismatched trigger PTC-ECG pairs were found. Image quality scores showed no significant difference between PTC and ECG triggering. There was no significant difference found in quantitative measurements in volunteers. In patients, the only significant difference was found in post-contrast T1 (p = 0.04). ICC showed moderate to excellent agreement in all measurements., Conclusion: PTC performance was equivalent to ECG in terms of triggering consistency, image quality, and quantitative image measurements across multiple CMR applications., Competing Interests: Competing interests Authors MB, CH, and PS are employees of Siemens Healthcare GmbH, Erlangen, Germany. Author NJ is an employee of Siemens Medical Solutions, USA, Malvern, PA. Author OPS receives institutional research support from Siemens Medical Solutions, USA.
- Published
- 2023
- Full Text
- View/download PDF
25. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial.
- Author
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Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S, Jackson R, Rahneva T, Wage R, Smith G, Venneri L, Tayal U, Auger D, Midwinter W, Whiffin N, Rajani R, Dungu JN, Pantazis A, Cook SA, Ware JS, Baksi AJ, Pennell DJ, Rosen SD, Cowie MR, Cleland JGF, and Prasad SK
- Subjects
- Biomarkers blood, Cardiomyopathy, Dilated complications, Cardiomyopathy, Dilated physiopathology, Cardiovascular Agents pharmacology, Drug Administration Schedule, Female, Heart Failure etiology, Heart Failure physiopathology, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Pilot Projects, Prognosis, Recurrence, Remission Induction, Stroke Volume drug effects, Treatment Outcome, Ventricular Function, Left drug effects, Cardiomyopathy, Dilated drug therapy, Cardiovascular Agents administration & dosage, Heart Failure drug therapy, Withholding Treatment
- Abstract
Background: Patients with dilated cardiomyopathy whose symptoms and cardiac function have recovered often ask whether their medications can be stopped. The safety of withdrawing treatment in this situation is unknown., Methods: We did an open-label, pilot, randomised trial to examine the effect of phased withdrawal of heart failure medications in patients with previous dilated cardiomyopathy who were now asymptomatic, whose left ventricular ejection fraction (LVEF) had improved from less than 40% to 50% or greater, whose left ventricular end-diastolic volume (LVEDV) had normalised, and who had an N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) concentration less than 250 ng/L. Patients were recruited from a network of hospitals in the UK, assessed at one centre (Royal Brompton and Harefield NHS Foundation Trust, London, UK), and randomly assigned (1:1) to phased withdrawal or continuation of treatment. After 6 months, patients in the continued treatment group had treatment withdrawn by the same method. The primary endpoint was a relapse of dilated cardiomyopathy within 6 months, defined by a reduction in LVEF of more than 10% and to less than 50%, an increase in LVEDV by more than 10% and to higher than the normal range, a two-fold rise in NT-pro-BNP concentration and to more than 400 ng/L, or clinical evidence of heart failure, at which point treatments were re-established. The primary analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT02859311., Findings: Between April 21, 2016, and Aug 22, 2017, 51 patients were enrolled. 25 were randomly assigned to the treatment withdrawal group and 26 to continue treatment. Over the first 6 months, 11 (44%) patients randomly assigned to treatment withdrawal met the primary endpoint of relapse compared with none of those assigned to continue treatment (Kaplan-Meier estimate of event rate 45·7% [95% CI 28·5-67·2]; p=0·0001). After 6 months, 25 (96%) of 26 patients assigned initially to continue treatment attempted its withdrawal. During the following 6 months, nine patients met the primary endpoint of relapse (Kaplan-Meier estimate of event rate 36·0% [95% CI 20·6-57·8]). No deaths were reported in either group and three serious adverse events were reported in the treatment withdrawal group: hospital admissions for non-cardiac chest pain, sepsis, and an elective procedure., Interpretation: Many patients deemed to have recovered from dilated cardiomyopathy will relapse following treatment withdrawal. Until robust predictors of relapse are defined, treatment should continue indefinitely., Funding: British Heart Foundation, Alexander Jansons Foundation, Royal Brompton Hospital and Imperial College London, Imperial College Biomedical Research Centre, Wellcome Trust, and Rosetrees Trust., (Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
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