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1. IBD-associated dysplastic lesions show more chromosomal instability than sporadic adenomas

Author

Wanders, L.K., Cordes, M., Voorham, Q., Sie, D., Vries, S.D. de, d'Haens, G.R.A.M., Boer, N.K.H. de, Ylstra, B., Grieken, N.C.T. van, Meijer, G.A., Dekker, E., and Carvalho, B.

Abstract

Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer. However, histologically, it is challenging to distinguish between IBD-associated dysplasia from sporadic adenomas. We have molecularly characterized these precursor lesions and show that IBD-associated dysplasia lesions are genomically much more unstable.

Published
2020

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