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2. A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma

Author

van Bladel, Diede A. G., Stevens, Wendy B. C., Kroeze, Leonie I., de Groen, Ruben A. L., de Groot, Fleur A., van der Last-Kempkes, Jessica L. M., Berendsen, Madeleine R., Rijntjes, Jos, Luijks, Jeroen A. C. W., Bonzheim, Irina, van der Spek, Ellen, Plattel, Wouter J., Pruijt, Johannes F. M., de Jonge-Peeters, Susan D. P. W. M., Velders, Gerjo A., Lensen, Chantal, van Bladel, Esther R., Federmann, Birgit, Hoevenaars, Brigiet M., Pastorczak, Agata, van der Werff ten Bosch, Jutte, Vermaat, Joost S. P., Nooijen, Peet T. G. A., Hebeda, Konnie M., Fend, Falko, Diepstra, Arjan, van Krieken, J Han J. M., Groenen, Patricia J. T. A., van den Brand, Michiel, and Scheijen, Blanca

Published
2023
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3. A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL

Author

Xu-Monette, Zijun Y, Zhang, Hongwei, Zhu, Feng, Tzankov, Alexandar, Bhagat, Govind, Visco, Carlo, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D, You, Hua, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés JM, Møller, Michael B, Parsons, Benjamin M, van Krieken, J Han, Piris, Miguel A, Winter, Jane N, Hagemeister, Fredrick B, Shahbaba, Babak, De Dios, Ivan, Zhang, Hong, Li, Yong, Xu, Bing, Albitar, Maher, and Young, Ken H

Subjects
Orphan Drug, Human Genome, Hematology, Cancer, Rare Diseases, Lymphoma, Biotechnology, Genetics, Generic health relevance, Good Health and Well Being, Artificial Intelligence, B-Lymphocytes, Germinal Center, High-Throughput Nucleotide Sequencing, Humans, Lymphoma, Large B-Cell, Diffuse
Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of B-cell lymphoma. Cell-of-origin (COO) classification of DLBCL is required in routine practice by the World Health Organization classification for biological and therapeutic insights. Genetic subtypes uncovered recently are based on distinct genetic alterations in DLBCL, which are different from the COO subtypes defined by gene expression signatures of normal B cells retained in DLBCL. We hypothesize that classifiers incorporating both genome-wide gene-expression and pathogenetic variables can improve the therapeutic significance of DLBCL classification. To develop such refined classifiers, we performed targeted RNA sequencing (RNA-Seq) with a commercially available next-generation sequencing (NGS) platform in a large cohort of 418 DLBCLs. Genetic and transcriptional data obtained by RNA-Seq in a single run were explored by state-of-the-art artificial intelligence (AI) to develop a NGS-COO classifier for COO assignment and NGS survival models for clinical outcome prediction. The NGS-COO model built through applying AI in the training set was robust, showing high concordance with COO classification by either Affymetrix GeneChip microarray or the NanoString Lymph2Cx assay in 2 validation sets. Although the NGS-COO model was not trained for clinical outcome, the activated B-cell-like compared with the germinal-center B-cell-like subtype had significantly poorer survival. The NGS survival models stratified 30% high-risk patients in the validation set with poor survival as in the training set. These results demonstrate that targeted RNA-Seq coupled with AI deep learning techniques provides reproducible, efficient, and affordable assays for clinical application. The clinical grade assays and NGS models integrating both genetic and transcriptional factors developed in this study may eventually support precision medicine in DLBCL.

Published
2020

4. Detection of Second Primary Lymphoma in Late Diffuse Large B-cell Lymphoma Recurrences

Author

Berendsen, Madeleine R., Bladel, Diede A.G. van, Hesius, Eva, de Groot, Fleur A., Kroeze, Leonie I., Rijntjes, Jos, Luijks, Jeroen A.C.W., Hoevenaars, Brigiet, Halilovic, Altuna, Nooijen, Peet, Bladel, Esther van, Jonge-Peeters, Susan de, Lensen, Chantal, Pruijt, Hans, van der Spek, Ellen, Vermaat, Joost S.P., Hess, Corine, Hebeda, Konnie M., Stevens, Wendy B.C., van Krieken, J. Han J.M., van den Brand, Michiel, Groenen, Patricia J.T.A., and Scheijen, Blanca

Published
2023
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6. Self-supervised learning reveals clinically relevant histomorphological patterns for therapeutic strategies in colon cancer.

Author

Liu, Bojing, Polack, Meaghan, Coudray, Nicolas, Claudio Quiros, Adalberto, Sakellaropoulos, Theodore, Le, Hortense, Karimkhan, Afreen, Crobach, Augustinus S. L. P., van Krieken, J. Han J. M., Yuan, Ke, Tollenaar, Rob A. E. M., Mesker, Wilma E., and Tsirigos, Aristotelis

Abstract

Self-supervised learning (SSL) automates the extraction and interpretation of histopathology features on unannotated hematoxylin-eosin-stained whole slide images (WSIs). We train an SSL Barlow Twins encoder on 435 colon adenocarcinoma WSIs from The Cancer Genome Atlas to extract features from small image patches (tiles). Leiden community detection groups tiles into histomorphological phenotype clusters (HPCs). HPC reproducibility and predictive ability for overall survival are confirmed in an independent clinical trial (N = 1213 WSIs). This unbiased atlas results in 47 HPCs displaying unique and shared clinically significant histomorphological traits, highlighting tissue type, quantity, and architecture, especially in the context of tumor stroma. Through in-depth analyses of these HPCs, including immune landscape and gene set enrichment analyses, and associations to clinical outcomes, we shine light on the factors influencing survival and responses to treatments of standard adjuvant chemotherapy and experimental therapies. Further exploration of HPCs may unveil additional insights and aid decision-making and personalized treatments for colon cancer patients. Histomorphological phenotype clustering (HPC) is a self-supervised machine learning methodology enabling automatic feature extraction from whole slide images (WSI) in pathology. Here, the authors demonstrate the utility of this approach in colon adenocarcinoma WSIs and investigate the links between the HPCs and patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2025
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12. Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms

Author

Albitar, Maher, Zhang, Hong, Goy, Andre, Xu-Monette, Zijun Y., Bhagat, Govind, Visco, Carlo, Tzankov, Alexandar, Fang, Xiaosheng, Zhu, Feng, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D., Hagemeister, Fredrick B., Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Parsons, Benjamin M., van Krieken, J. Han, Piris, Miguel A., Winter, Jane N., Li, Yong, Xu, Bing, and Young, Ken H.

Published
2022
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14. Self-Supervised Learning Reveals Clinically Relevant Histomorphological Patterns for Therapeutic Strategies in Colon Cancer

Author

Liu, Bojing, primary, Polack, Meaghan, additional, Coudray, Nicolas, additional, Quiros, Adalberto Claudio, additional, Sakellaropoulos, Theodore, additional, Crobach, Augustinus S.L.P., additional, van Krieken, J. Han J.M., additional, Yuan, Ke, additional, Tollenaar, Rob A.E.M., additional, Mesker, Wilma E., additional, and Tsirigos, Aristotelis, additional

Published
2024
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16. Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe

Author

Keppens, Cleo, Palma, John F., Das, Partha M., Scudder, Sidney, Wen, Wei, Normanno, Nicola, van Krieken, J. Han, Sacco, Alessandra, Fenizia, Francesca, Gonzalez de Castro, David, Hönigschnabl, Selma, Kern, Izidor, Lopez-Rios, Fernando, Lozano, Maria D., Marchetti, Antonio, Halfon, Philippe, Schuuring, Ed, Setinek, Ulrike, Sorensen, Boe, Taniere, Phillipe, Tiemann, Markus, Vosmikova, Hana, and Dequeker, Elisabeth M.C.

Published
2018
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17. Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma

Author

Wang, Xiaoxiao, Cao, Xin, Sun, Ruifang, Tang, Charlene, Tzankov, Alexandar, Zhang, Jun, Manyam, Ganiraju C., Xiao, Min, Miao, Yi, Jabbar, Kausar, Tan, Xiaohong, Pang, Yuyang, Visco, Carlo, Xie, Yan, Dybkaer, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L., Hsi, Eric D., Choi, William W.L., van Krieken, J. Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J.M., Møller, Michael B., Parsons, Ben M., Winter, Jane N., Piris, Miguel A., Li, Shaoying, Miranda, Roberto N., Medeiros, L. Jeffrey, Li, Yong, Xu-Monette, Zijun Y., and Young, Ken H.

Published
2018
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19. PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Program

Author

Li, Ling, Sun, Ruifang, Miao, Yi, Tran, Thai, Adams, Lisa, Roscoe, Nathan, Xu, Bing, Manyam, Ganiraju C., Tan, Xiaohong, Zhang, Hongwei, Xiao, Min, Tzankov, Alexandar, Visco, Carlo, Dybkaer, Karen, Bhagat, Govind, Tam, Wayne, Hsi, Eric D., van Krieken, J. Han, You, Hua, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Piris, Miguel A., Zhang, Mingzhi, Winter, Jane N., Medeiros, L. Jeffrey, Rassidakis, George Z., Vaupel, Christine A., Li, Yong, Dakappagari, Naveen, Xu-Monette, Zijun Y., and Young, Ken H.

Published
2019
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20. e-Learning for Instruction and to Improve Reproducibility of Scoring Tumor-Stroma Ratio in Colon Carcinoma: Performance and Reproducibility Assessment in the UNITED Study

Author

Smit, Marloes A, van Pelt, Gabi W, Dequeker, Elisabeth MC, Al Dieri, Raed, Tollenaar, Rob AEM, van Krieken, J Han JM, and Mesker, Wilma E

Subjects
Medicine
Abstract

BackgroundThe amount of stroma in the primary tumor is an important prognostic parameter. The tumor-stroma ratio (TSR) was previously validated by international research groups as a robust parameter with good interobserver agreement. ObjectiveThe Uniform Noting for International Application of the Tumor-Stroma Ratio as an Easy Diagnostic Tool (UNITED) study was developed to bring the TSR to clinical implementation. As part of the study, an e-Learning module was constructed to confirm the reproducibility of scoring the TSR after proper instruction. MethodsThe e-Learning module consists of an autoinstruction for TSR determination (instruction video or written protocol) and three sets of 40 cases (training, test, and repetition sets). Scoring the TSR is performed on hematoxylin and eosin–stained sections and takes only 1-2 minutes. Cases are considered stroma-low if the amount of stroma is ≤50%, whereas a stroma-high case is defined as >50% stroma. Inter- and intraobserver agreements were determined based on the Cohen κ score after each set to evaluate the reproducibility. ResultsPathologists and pathology residents (N=63) with special interest in colorectal cancer participated in the e-Learning. Forty-nine participants started the e-Learning and 31 (63%) finished the whole cycle (3 sets). A significant improvement was observed from the training set to the test set; the median κ score improved from 0.72 to 0.77 (P=.002). Conclusionse-Learning is an effective method to instruct pathologists and pathology residents for scoring the TSR. The reliability of scoring improved from the training to the test set and did not fall back with the repetition set, confirming the reproducibility of the TSR scoring method. Trial RegistrationThe Netherlands Trial Registry NTR7270; https://www.trialregister.nl/trial/7072 International Registered Report Identifier (IRRID)RR2-10.2196/13464

Published
2021
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22. Gastric Antrum (Distal Stomach)

Author

van der Post, Chella R. S., van Krieken, J. Han, van Krieken, J. H. J. M., Series Editor, Carneiro, Fátima, editor, Chaves, Paula, editor, and Ensari, Arzu, editor

Published
2017
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23. Ménétrier’s Disease

Author

van der Post, Chella R. S., van Krieken, J. Han, van Krieken, J. H. J. M., Series Editor, Carneiro, Fátima, editor, Chaves, Paula, editor, and Ensari, Arzu, editor

Published
2017
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24. Autoimmune Gastritis

Author

van der Post, Chella R. S., van Krieken, J. Han, van Krieken, J. H. J. M., Series Editor, Carneiro, Fátima, editor, Chaves, Paula, editor, and Ensari, Arzu, editor

Published
2017
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25. Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma

Author

Berendsen, Madeleine R., primary, van Bladel, Diede A.G., additional, Hesius, Eva, additional, Berganza Irusquieta, Cristina, additional, Rijntjes, Jos, additional, van Spriel, Annemiek B., additional, van der Spek, Ellen, additional, Pruijt, Johannes F.M., additional, Kroeze, Leonie I., additional, Hebeda, Konnie M., additional, Croockewit, Sandra, additional, Stevens, Wendy B.C., additional, van Krieken, J Han J.M., additional, Groenen, Patricia J.T.A., additional, van den Brand, Michiel, additional, and Scheijen, Blanca, additional

Published
2023
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27. AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma

Author

Wang, Jinfen, Xu-Monette, Zijun Y., Jabbar, Kausar J., Shen, Qi, Manyam, Ganiraju C., Tzankov, Alexandar, Visco, Carlo, Wang, Jing, Montes-Moreno, Santiago, Dybkær, Karen, Tam, Wayne, Bhagat, Govind, Hsi, Eric D., van Krieken, J. Han, Ponzoni, Maurilio, Ferreri, Andrés J.M., Wang, Shi, Møller, Michael B., Piris, Miguel A., Medeiros, L. Jeffrey, Li, Yong, Pham, Lan V., and Young, Ken H.

Published
2017
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28. XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53

Author

Deng, Manman, Zhang, Mingzhi, Xu-Monette, Zijun Y., Pham, Lan V., Tzankov, Alexandar, Visco, Carlo, Fang, Xiaosheng, Bhagat, Govind, Zhu, Feng, Dybkaer, Karen, Chiu, April, Tam, Wayne, Zu, Youli, Hsi, Eric D., Choi, William W. L., Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Parsons, Benjamin M., van Krieken, J. Han, Piris, Miguel A., Winter, Jane N., Hagemeister, Fredrick, Alinari, Lapo, Li, Yong, Andreeff, Michael, Xu, Bing, and Young, Ken H.

Published
2020
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29. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

Author

Rindi, Guido, Klimstra, David S., Abedi-Ardekani, Behnoush, Asa, Sylvia L., Bosman, Frederik T., Brambilla, Elisabeth, Busam, Klaus J., de Krijger, Ronald R., Dietel, Manfred, El-Naggar, Adel K., Fernandez-Cuesta, Lynnette, Klöppel, Günter, McCluggage, W. Glenn, Moch, Holger, Ohgaki, Hiroko, Rakha, Emad A., Reed, Nicholas S., Rous, Brian A., Sasano, Hironobu, Scarpa, Aldo, Scoazec, Jean-Yves, Travis, William D., Tallini, Giovanni, Trouillas, Jacqueline, van Krieken, J. Han, and Cree, Ian A.

Published
2018
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30. Gastric Cardia (Proximal Stomach)

Author

van der Post, Chella R. S., van Krieken, J. Han, van Krieken, J. H. J. M., Series Editor, Carneiro, Fátima, editor, Chaves, Paula, editor, and Ensari, Arzu, editor

Published
2017
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34. Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

Author

Xu-Monette, Zijun Y., Li, Jianyong, Xia, Yi, Crossley, Beryl, Bremel, Robert D., Miao, Yi, Xiao, Min, Snyder, Thomas, Manyam, Ganiraju C., Tan, Xiaohong, Zhang, Hongwei, Visco, Carlo, Tzankov, Alexandar, Dybkaer, Karen, Bhagat, Govind, Tam, Wayne, You, Hua, Hsi, Eric D., van Krieken, J. Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J. M., Møller, Michael B., Piris, Miguel A., Winter, Jane N., Medeiros, Jeffrey T., Xu, Bing, Li, Yong, Kirsch, Ilan, and Young, Ken H.

Published
2019
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35. Consensus molecular subtype transition during progression of colorectal cancer

Author

MS Medische Oncologie, Cancer, van de Weerd, Simone, Torang, Arezo, Zwager, Liselotte W., Koelink, Pim J., Koster, Jan, Bastiaansen, Barbara A.J., Lammers, Veerle, Longobardi, Ciro, Roodhart, Jeanine M.L., van Krieken, J. Han, Farina Sarasqueta, Arantza, Dekker, Evelien, Medema, Jan Paul, MS Medische Oncologie, Cancer, van de Weerd, Simone, Torang, Arezo, Zwager, Liselotte W., Koelink, Pim J., Koster, Jan, Bastiaansen, Barbara A.J., Lammers, Veerle, Longobardi, Ciro, Roodhart, Jeanine M.L., van Krieken, J. Han, Farina Sarasqueta, Arantza, Dekker, Evelien, and Medema, Jan Paul

Published
2023

36. Supplementary Tables from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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37. Data from Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents

Author

Deng, Manman, primary, Xu-Monette, Zijun Y., primary, Pham, Lan V., primary, Wang, Xudong, primary, Tzankov, Alexandar, primary, Fang, Xiaosheng, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, You, Hua, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, Hagemeister, Fredrick, primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Liu, Phillip, primary, and Young, Ken H., primary

Published
2023
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38. Data from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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39. Supplementary Tables 1-5 and Supplementary Figures 1-8 from Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents

Author

Deng, Manman, primary, Xu-Monette, Zijun Y., primary, Pham, Lan V., primary, Wang, Xudong, primary, Tzankov, Alexandar, primary, Fang, Xiaosheng, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, You, Hua, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, Hagemeister, Fredrick, primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Liu, Phillip, primary, and Young, Ken H., primary

Published
2023
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40. EBV-positive DLBCL frequently harbors somatic mutations associated with clonal hematopoiesis of indeterminate potential

Author

Li, Yong, primary, Xu-Monette, Zijun Y., additional, Abramson, Jeremy, additional, Sohani, Aliyah R., additional, Bhagat, Govind, additional, Tzankov, Alexandar, additional, Visco, Carlo, additional, Zhang, Shanxiang, additional, Dybkaer, Karen, additional, Pan, Zenggang, additional, Xu, Min, additional, Tam, Wayne, additional, Zu, Youli, additional, Hsi, Eric D., additional, Hagemeister, Fredrick B., additional, Go, Heounjeong, additional, van Krieken, J. Han, additional, Winter, Jane N., additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J. M., additional, Møller, Michael B., additional, Piris, Miguel A., additional, Wang, Yingjun, additional, Zhang, Mingzhi, additional, and Young, Ken H., additional

Published
2023
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41. Supplementary Figures 1-3 from Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Author

Xu-Monette, Ziju Y., primary, Xiao, Min, primary, Au, Qingyan, primary, Padmanabhan, Raghav, primary, Xu, Bing, primary, Hoe, Nicholas, primary, Rodríguez-Perales, Sandra, primary, Torres-Ruiz, Raul, primary, Manyam, Ganiraju C., primary, Visco, Carlo, primary, Miao, Yi, primary, Tan, Xiaohong, primary, Zhang, Hongwei, primary, Tzankov, Alexandar, primary, Wang, Jing, primary, Dybkær, Karen, primary, Tam, Wayne, primary, You, Hua, primary, Bhagat, Govind, primary, Hsi, Eric D., primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Piris, Miguel A., primary, van Krieken, J. Han, primary, Winter, Jane N., primary, Westin, Jason R., primary, Pham, Lan V., primary, Medeiros, L. Jeffrey, primary, Rassidakis, George Z., primary, Li, Yong, primary, Freeman, Gordon J., primary, and Young, Ken H., primary

Published
2023
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42. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP

Author

Xu-Monette, Zijun Y, Dabaja, Bouthaina S, Wang, Xiaoxiao, Tu, Meifeng, Manyam, Ganiraju C, Tzankov, Alexander, Xia, Yi, Zhang, Li, Sun, Ruifang, Visco, Carlo, Dybkaer, Karen, Yin, Lihui, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L, Hsi, Eric D, Choi, William WL, van Krieken, J Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés JM, Møller, Michael B, Parsons, Ben M, Zhao, Xiaoying, Winter, Jane N, Piris, Miguel A, McDonnell, Timothy J, Miranda, Roberto N, Li, Yong, Medeiros, L Jeffrey, and Young, Ken H

Published
2015
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44. Prognostic and biological significance of survivin expression in patients with diffuse large B-cell lymphoma treated with rituximab-CHOP therapy

Author

Liu, Zhiyu, Xu-Monette, Zijun Y, Cao, Xin, Manyam, Ganiraju C, Wang, Xiaoxiao, Tzankov, Alexandar, Xia, Yi, Li, Xin, Visco, Carlo, Sun, Ruifang, Zhang, Li, Montes-Moreno, Santiago, Dybkær, Karen, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L, Hsi, Eric D, Choi, William WL, van Krieken, J Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés JM, Parsons, Ben M, Møller, Michael B, Piris, Miguel A, Winter, Jane N, O'Malley, Dennis P, Medeiros, L Jeffrey, and Young, Ken H

Published
2015
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45. Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1

Author

van der Post, Rachel S., Vogelaar, Ingrid P., Manders, Peggy, van der Kolk, Lizet E., Cats, Annemieke, van Hest, Liselotte P., Sijmons, Rolf, Aalfs, Cora M., Ausems, Margreet G.E.M., Gómez García, Encarna B., Wagner, Anja, Hes, Frederik J., Arts, Neeltje, Mensenkamp, Arjen R., van Krieken, J. Han, Hoogerbrugge, Nicoline, and Ligtenberg, Marjolijn J.L.

Published
2015
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46. Evaluation of NF-κB subunit expression and signaling pathway activation demonstrates that p52 expression confers better outcome in germinal center B-cell-like diffuse large B-cell lymphoma in association with CD30 and BCL2 functions

Author

Ok, Chi Young, Xu-Monette, Zijun Y, Li, Ling, Manyam, Ganiraju C, Montes-Moreno, Santiago, Tzankov, Alexandar, Visco, Carlo, Dybkær, Karen, Routbort, Mark J, Zhang, Li, Chiu, April, Orazi, Attilio, Zu, Youli, Bhagat, Govind, Richards, Kristy L, Hsi, Eric D, Choi, William W L, van Krieken, J Han, Huh, Jooryung, Ponzoni, Maurilio, Ferreri, Andrés J M, Parsons, Ben M, Rao, Huilan, Møller, Michael B, Winter, Jane N, Piris, Miguel A, Wang, Sa A, Medeiros, L Jeffrey, and Young, Ken H

Published
2015
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48. Supplmentary Documents including Methods, Tables, and Legends for Supplementary Figures, and Supplementary Figure S1-S5 from Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma

Author

Xu-Monette, Zijun Y., primary, Deng, Qipan, primary, Manyam, Ganiraju C., primary, Tzankov, Alexander, primary, Li, Ling, primary, Xia, Yi, primary, Wang, Xiao-xiao, primary, Zou, Dehui, primary, Visco, Carlo, primary, Dybkær, Karen, primary, Li, Jun, primary, Zhang, Li, primary, Liang, Han, primary, Montes-Moreno, Santiago, primary, Chiu, April, primary, Orazi, Attilio, primary, Zu, Youli, primary, Bhagat, Govind, primary, Richards, Kristy L., primary, Hsi, Eric D., primary, Choi, William W.L., primary, van Krieken, J. Han, primary, Huh, Jooryung, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Parsons, Ben M., primary, Møller, Michael B., primary, Wang, Sa A., primary, Miranda, Roberto N., primary, Piris, Miguel A., primary, Winter, Jane N., primary, Medeiros, L. Jeffrey, primary, Li, Yong, primary, and Young, Ken H., primary

Published
2023
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49. Supplementary Figure from Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma

Author

Xu-Monette, Zijun Y., primary, Wei, Li, primary, Fang, Xiaosheng, primary, Au, Qingyan, primary, Nunns, Harry, primary, Nagy, Máté, primary, Tzankov, Alexandar, primary, Zhu, Feng, primary, Visco, Carlo, primary, Bhagat, Govind, primary, Dybkaer, Karen, primary, Chiu, April, primary, Tam, Wayne, primary, Zu, Youli, primary, Hsi, Eric D., primary, Hagemeister, Fredrick B., primary, Sun, Xiaoping, primary, Han, Xin, primary, Go, Heounjeong, primary, Ponzoni, Maurilio, primary, Ferreri, Andrés J.M., primary, Møller, Michael B., primary, Parsons, Benjamin M., primary, van Krieken, J. Han, primary, Piris, Miguel A., primary, Winter, Jane N., primary, Li, Yong, primary, Xu, Bing, primary, Albitar, Maher, primary, You, Hua, primary, and Young, Ken H., primary

Published
2023
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50. Supplementary Table 1 from T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines

Author

Vasaturo, Angela, primary, Halilovic, Altuna, primary, Bol, Kalijn F., primary, Verweij, Dagmar I., primary, Blokx, Willeke A.M., primary, Punt, Cornelis J.A., primary, Groenen, Patricia J.T.A., primary, van Krieken, J. Han J.M., primary, Textor, Johannes, primary, de Vries, I. Jolanda M., primary, and Figdor, Carl G., primary

Published
2023
Full Text
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