50 results on '"Van Iersel, M."'
Search Results
2. MO-0470 IMPT reduces esophageal and pulmonary toxicity compared to VMAT in stage II-IV NSCLC patients
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Hessels, A., primary, Stoffers, R., additional, Niezink, A., additional, Chouvalova, O., additional, Ubbels, F., additional, van der Leest, A., additional, Woltman - van Iersel, M., additional, Deseyne, P., additional, Elzinga, H., additional, Haan - Stijntjes, E., additional, Korevaar, E., additional, Pisciotta, P., additional, Langendijk, H., additional, and Wijsman, R., additional
- Published
- 2023
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- View/download PDF
3. SENS-U: continuous home monitoring of natural nocturnal bladder filling in children with nocturnal enuresis – a feasibility study
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Kwinten, W.M.J., van Leuteren, P.G., van Duren – van Iersel, M., Dik, P., and Jira, P.E.
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- 2020
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4. Introduction of IMPT for NSCLC patients: the learning curve in practice
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Wijsman, R., Chouvalova, O., Klinker, P., Niezink, A., van der Leest, A., Ubbels, F., Woltman-van Iersel, M., Both, S., Korevaar, E., Langendijk, J., Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)
- Published
- 2022
5. Durvalumab increases the risk of radiation pneumonitis in non-small-cell lung cancer patients
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Stoffers, R., Niezink, A. G., Chouvalova, O., van der Leest, A. H., Ubbels, J. F., Woltman-van Iersel, M., Langendijk, J. A., Wijsman, R., Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
- Published
- 2022
6. PD-0667 Introduction of IMPT for NSCLC patients: the learning curve in practice.
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Wijsman, R., primary, Chouvalova, O., additional, Klinker, P., additional, Niezink, A., additional, Van der Leest, A., additional, Ubbels, F., additional, Woltman-van Iersel, M., additional, Both, S., additional, Korevaar, E., additional, and Langendijk, J., additional
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- 2022
- Full Text
- View/download PDF
7. MO-0387 Durvalumab increases the risk of radiation pneumonitis in non-small-cell lung cancer patients
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Stoffers, R., primary, Niezink, A.G., additional, Chouvalova, O., additional, van der Leest, A.H., additional, Ubbels, J.F., additional, Woltman-van Iersel, M., additional, Langendijk, J.A., additional, and Wijsman, R., additional
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- 2022
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8. Introduction of IMPT for (N)SCLC patients: NTCP model based selection of patients and first results
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Wijsman, R., Chouvalova, O., Klinker, P., Niezink, A., Van der Leest, A., Ubbels, F., Woltman-Van Iersel, M., Both, S., Korevaar, E., Langendijk, J., Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
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- 2021
9. Prospective quality of life in 682 lung cancer patients treated with radiotherapy: real life data
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Nies, M., Wijsman, R., Chouvalova, O., Ubbels, F. J., Elzinga, H. J., Haan-Stijntjes, E., Woltman-van Iersel, M., van der Leest, A. H., Langendijk, J. A., Niezink, A. G., Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)
- Published
- 2021
10. PH-0272 Prospective quality of life in 682 lung cancer patients treated with radiotherapy: real life data
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Nies, M., primary, Wijsman, R., additional, Chouvalova, O., additional, Ubbels, F.J., additional, Elzinga, H.J., additional, Haan-Stijntjes, E., additional, Woltman-van Iersel, M., additional, van der Leest, A.H., additional, Langendijk, J.A., additional, and Niezink, A.G., additional
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- 2021
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11. OC-0193 Introduction of IMPT for (N)SCLC patients: NTCP model based selection of patients and first results
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Wijsman, R., primary, Chouvalova, O., additional, Klinker, P., additional, Niezink, A., additional, Van der Leest, A., additional, Ubbels, F., additional, Woltman- Van Iersel, M., additional, Both, S., additional, Korevaar, E., additional, and Langendijk, J., additional
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- 2021
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12. Nursing education for community care: Effect of curriculum-redesign on students’ perceptions and choices in caregiving
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van Iersel, M., Scholte op Reimer, Wilma J M, Kirschner, P.A., Latour, C.H.M., de Vos, R., Faculteit der Geneeskunde, Scholte op Reimer, Wilma J. M., Kirschner, Paul A., Latour, C. H. M., de Vos, Rien, APH - Methodology, APH - Quality of Care, Amsterdam Cardiovascular Sciences, Nursing, Graduate School, Kirschner, Paul, Latour, Corine, and Faculteit Gezondheid
- Abstract
Community care is becoming increasingly important. In the Netherlands, the percentage of people over the age of 65 is expected to increase to 22% by 2025, leading to more elderly patients, often with long-term and complex health problems (multimorbidity). Because many of these patients continue to live at home until a very old age, nurses are increasingly working outside of institutions. The 17 Dutch Bachelor nursing programmes responded to this development with a new national education profile 'Bachelor Nursing 2020 (BN2020)’ with more elements of community care. However, despite the increase in extramural care, the Dutch labour market has a shortage of community nurses with higher professional education qualifications, partly because most nursing students focus on the general hospital setting as the environment for their future career. Whether this is based on a perception of community care that deters making this choice has never been systematically investigated. It is also unclear whether a more community-oriented curriculum will better equip students for working in community care. In response to these issues, the nursing programme at the Amsterdam University of Applied Sciences (AUAS) redesigned its curriculum to include more elements of community care. Three perspectives were chosen for the redesign: (1) the influence of lecturers as role models, (2) positive placement experiences, and (3) five new ‘community-based’ themes in education. These new themes are as follows: patient self-management, shared decision-making, collaboration with the patients’ social system, healthcare technology, and allocation of care. The redesign also includes a ‘paved way’ into community care in the form of a coherent and attractive programme for interested students. This thesis describes whether and how the curriculum-redesign within higher professional education in nursing can be effective in terms of (1) stimulating a positive perception of community care and (2) realising a form of community care in line with the new themes in BN2020. In other words, that students will base choices in their actions/nursing interventions on these new themes in the education profile.
- Published
- 2021
13. SENS-U: continuous home monitoring of natural nocturnal bladder filling in children with nocturnal enuresis - a feasibility study
- Author
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Urologie Onderzoek, Other research (not in main researchprogram), Urologie Medisch Kinderen, Kwinten, W M J, van Leuteren, P G, van Duren-van Iersel, M, Dik, P, Jira, P E, Urologie Onderzoek, Other research (not in main researchprogram), Urologie Medisch Kinderen, Kwinten, W M J, van Leuteren, P G, van Duren-van Iersel, M, Dik, P, and Jira, P E
- Published
- 2020
14. An Automated System for Irrigation Control in Containerized Ornamental Crop Production
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Roberts B, Schnipke D, and van Iersel M
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0106 biological sciences ,Agronomy ,Crop production ,Ornamental plant ,Environmental science ,Irrigation control ,04 agricultural and veterinary sciences ,0405 other agricultural sciences ,01 natural sciences ,040501 horticulture ,010606 plant biology & botany - Published
- 2018
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15. The Scale on COmmunity care PErceptions (SCOPE) for nursing students:a development and psychometric validation study
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van Iersel, M. (Margriet), de Vos, R. (Rien), Latour, C. (Corine), Kirschner, P. A. (Paul A.), Scholte op Reimer, W. (Wilma), van Iersel, M. (Margriet), de Vos, R. (Rien), Latour, C. (Corine), Kirschner, P. A. (Paul A.), and Scholte op Reimer, W. (Wilma)
- Abstract
The aim of this study was to develop a valid instrument to measure student nurses’ perceptions of community care (SCOPE). DeVellis’ staged model for instrument development and validation was used. Scale construction of SCOPE was based on existing literature. Evaluation of its psychometric properties included exploratory factor analysis and reliability analysis. After pilot-testing, 1062 bachelor nursing students from six institutions in the Netherlands (response rate 81%) took part in the study. SCOPE is a 35-item scale containing: background variables, 11 measuring the affective component, 5 measuring community care perception as a placement, 17 as a future profession, and 2 on the reasons underlying student preference. Principal axis factoring yielded two factors in the affective component scale reflecting ‘enjoyment’ and ‘utility’, two in the placement scale reflecting ‘learning possibilities’ and ‘personal satisfaction’, and four in the profession scale: ‘professional development’, ‘collaboration’, ‘caregiving’, and ‘complexity and workload’. Cronbach’s α of the complete scale was 0.892 and of the subscales 0.862, 0.696, and 0.810 respectively. SCOPE is a psychometrically sound instrument for measuring students’ perceptions of community care. By determining these perceptions, it becomes possible to positively influence them with targeted curriculum redesign, eventually contributing to decreasing the workforce shortage in community nursing.
- Published
- 2018
16. Factors underlying perceptions of community care and other healthcare areas in first-year baccalaureate nursing students:a focus group study
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van Iersel, M. (Margriet), Latour, C. H. (Corine H.M.), van Rijn, M. (Marjon), de Vos, R. (Rien), Kirschner, P. A. (Paul A.), Scholte op Reimer, W. J. (Wilma J.M.), van Iersel, M. (Margriet), Latour, C. H. (Corine H.M.), van Rijn, M. (Marjon), de Vos, R. (Rien), Kirschner, P. A. (Paul A.), and Scholte op Reimer, W. J. (Wilma J.M.)
- Abstract
Background: Despite the increasing labour market shortage of well-educated community nurses, few baccalaureate nursing students choose for a career in community care. Obtaining knowledge of how students perceive healthcare areas early in their education is important to take meaningful steps in counteracting any existing misconceptions with targeted curriculum redesign. Objective: Determination of factors underlying perceptions of healthcare areas in first-year baccalaureate nursing students. Design: A descriptive qualitative study using focus group inquiry. Methods: This study follows up on a large-sample quantitative multicentre survey study. Fourteen first-year nursing students at a university of applied sciences in the Netherlands participated in focus group discussions in October 2014. Transcripts of the discussions were coded by two independent researchers at three levels — open, axial and selective coding — on the basis of two templates. The codes were sorted into categories and assigned to suitable main codes in the templates. The number of sub-codes per category and code were added together. Results: Eight main themes were formulated, to wit (1) variety and diversity, (2) challenges, (3) improving people’s health, (4) collaboration, (5) role models, (6) patient- or environment-based perceptions, (7) self-efficacy and (8) immediate vicinity. Data suggest that first-year students have clear ideas about the characteristics which they consider important in professional practice. Their perceptions do not necessarily reflect the actual situation, as they expect the hospital to possess all desired characteristics while community nursing seems to be undervalued. Conclusion: To remedy students’ misperceptions, four recommendations are formulated for curriculum redesign strategies deriving from the eight themes. These recommendations are based on collaboration between school and care organisations as well as on themes related to in-depth knowledge within the
- Published
- 2018
17. Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease
- Author
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Cornely, Oliver A., Robertson, Michael N., Haider, Shariq, Grigg, Andrew, Geddes, Michelle, Aoun, Mickael, Heinz, Werner J., Raad, Issam, Schanz, Urs, Meyer, Ralf G., Hammond, Sarah P., Mullane, Kathleen M., Ostermann, Helmut, Ullmann, Andrew J., Zimmerli, Stefan, Van Iersel, M. L. P. S., Hepler, Deborah A., Waskin, Hetty, Kartsonis, Nicholas A., Maertens, Johan, Cornely, Oliver A., Robertson, Michael N., Haider, Shariq, Grigg, Andrew, Geddes, Michelle, Aoun, Mickael, Heinz, Werner J., Raad, Issam, Schanz, Urs, Meyer, Ralf G., Hammond, Sarah P., Mullane, Kathleen M., Ostermann, Helmut, Ullmann, Andrew J., Zimmerli, Stefan, Van Iersel, M. L. P. S., Hepler, Deborah A., Waskin, Hetty, Kartsonis, Nicholas A., and Maertens, Johan
- Abstract
Objectives: A two-part (Phase 1B/3), sequential, open-label, multicentre study evaluated the pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as antifungal prophylaxis to neutropenic patients with AML or myelodysplastic syndrome (MDS) or to recipients at risk of invasive fungal disease (IFD) after allogeneic HSCT. Methods: Patients (N=237) received 300mg of posaconazole iv twice daily on day 1, followed by 300mg of posaconazole iv once daily for 4-28 days. After at least 5 days, patients were randomly assigned to receive posaconazole oral suspension, 400mg twice daily or 200mg three times daily, to complete a 28 day treatment course. Primary PK parameters were steady-state average concentration over the dosing interval (C-avg) and posaconazole trough levels (C-min). Results: Mean posaconazole C-min was 1320 ng/mL (day 6) and 1297 ng/mL (day 8); steady-state C-min was 1090 ng/mL (day 10). Mean steady-state posaconazole C-avg was 1500 ng/mL (day 10 or 14) and was similar in HSCT recipients (1560 ng/mL) and AML/MDS patients (1470 ng/mL). The most commonly reported treatment-related adverse events were diarrhoea (8%), nausea (5%) and rash (5%). IFD was reported in 3/237 patients (1%; 2 proven, 1 probable). Conclusions: Intravenous posaconazole at 300mg was well tolerated, resulted in adequate steady-state systemic exposure and was associated with a low incidence of IFD in this population at high risk.
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- 2017
18. Erratum to Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease [J Antimicrob Chemother 2016; 71: 718-726]
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Cornely, O. A., Duarte, R. F., Haider, S., Chandrasekar, P., Helfgott, D., Jimenez, J. L., Candoni, A., Raad, I., Laverdiere, M., Langston, A., Kartsonis, N., Van Iersel, M., Connelly, N., and Waskin, H.
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- 2016
19. Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease
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Cornely, Oliver A, primary, Robertson, Michael N, additional, Haider, Shariq, additional, Grigg, Andrew, additional, Geddes, Michelle, additional, Aoun, Mickael, additional, Heinz, Werner J, additional, Raad, Issam, additional, Schanz, Urs, additional, Meyer, Ralf G, additional, Hammond, Sarah P, additional, Mullane, Kathleen M, additional, Ostermann, Helmut, additional, Ullmann, Andrew J, additional, Zimmerli, Stefan, additional, Van Iersel, M L P S, additional, Hepler, Deborah A, additional, Waskin, Hetty, additional, Kartsonis, Nicholas A, additional, and Maertens, Johan, additional
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- 2017
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20. EP-1232: Patient-reported toxicity in twice-daily (BID) versus once-daily (OD) chemoradiotherapy for LS-SCLC
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Lodeweges, J., primary, Niezink, A., additional, Elzinga, H., additional, Haan-Stijntjes, E., additional, Dollekamp, N., additional, Chouvalova, O., additional, Ubbels, J., additional, Woltman-van Iersel, M., additional, Van der Leest, A., additional, Langendijk, J., additional, and Widder, J., additional
- Published
- 2017
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21. The influence of meteorological parameters on dynamic infrared signatures
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van Iersel, M., additional, Veerman, H. E. T., additional, Cohen, L. H., additional, Benoist, K. W., additional, van Binsbergen, S. A., additional, van Riggelen, F., additional, and Peet, B. J. A., additional
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- 2016
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22. The impact of age on changes in quality of life among breast cancer survivors treated with breast-conserving surgery and radiotherapy
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Bantema-Joppe, E.J., Bock, de, G.H., Woltman-van Iersel, M., Busz, D.M., Ranchor, A.V., Langendijk, J.A., Maduro, J.H., Heuvel, van den, E.R., Bantema-Joppe, E.J., Bock, de, G.H., Woltman-van Iersel, M., Busz, D.M., Ranchor, A.V., Langendijk, J.A., Maduro, J.H., and Heuvel, van den, E.R.
- Abstract
Background: The purpose of the study was to determine the impact of young age on health-related quality of life (HRQoL) by comparing HRQoL of younger and older breast cancer patients, corrected for confounding, and of young patients and a general Dutch population. Methods: The population consisted of breast cancer survivors (stage 0-III) after breast-conserving surgery and radiotherapy. Health-related quality of life was prospectively assessed using the EORTC QLQ-C30 and QLQ-BR23 questionnaires. The association between age (less than or equal to50; 51–70; greater than or equal to70 years) and HRQoL over time was analysed with mixed modelling. The clinical relevance of differences between/within age groups was estimated with Cohen’s D and consensus-based guidelines. The HRQoL data from the young patient cohort were compared with Dutch reference data at 3 years after radiotherapy. Results: A total of 1420 patients completed 3200 questionnaires. Median follow-up was 34 (range 6–70) months. Median age was 59 (range 28–85) years. Compared with older subjects, young women reported worse HRQoL in the first year after radiotherapy, but clinical relevance was limited. Three years after radiotherapy, HRQoL values in the younger group were equal to those in the reference population. Pain and fatigue after radiotherapy improved, with medium clinical relevance. Conclusions: Three years after radiotherapy for breast cancer, young age was not a risk factor for decreased HRQoL. Keywords: health-related quality of life; breast-conserving therapy; radiotherapy; young; breast cancer
- Published
- 2015
23. Target acquisition modeling over the exact optical path: extending the EOSTAR TDA with the TOD sensor performance model.
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Dijk, J., Bijl, P., Oppeneer, M., ten Hove, R. J. M., and van Iersel, M.
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- 2017
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24. Infrared signature evolution of a CUBI
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van Iersel, M., additional, van Eijk, A. M. J., additional, Veerman, H. E. T., additional, Benoist, K. W., additional, and Cohen, L. H., additional
- Published
- 2015
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25. The impact of age on changes in quality of life among breast cancer survivors treated with breast-conserving surgery and radiotherapy
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Bantema-Joppe, E J, primary, de Bock, G H, additional, Woltman-van Iersel, M, additional, Busz, D M, additional, Ranchor, A V, additional, Langendijk, J A, additional, Maduro, J H, additional, and van den Heuvel, E R, additional
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- 2015
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26. Target acquisition modeling over the exact optical path: extending the EOSTAR TDA with the TOD sensor performance model
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Stein, Karin U., Schleijpen, Ric, Dijk, J., Bijl, P., Oppeneer, M., ten Hove, R.J.M., and van Iersel, M.
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- 2017
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27. Infrared signature evolution of a CUBI
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van Eijk, Alexander M. J., Davis, Christopher C., Hammel, Stephen M., van Iersel, M., van Eijk, A. M. J., Veerman, H. E. T., Benoist, K. W., and Cohen, L. H.
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- 2015
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28. External validation of NTCP-models for radiation pneumonitis in lung cancer patients treated with chemoradiotherapy.
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Niezink AGH, van der Schaaf A, Wijsman R, Chouvalova O, van der Wekken AJ, Rutgers SR, Pieterman RM, van Putten JWG, de Hosson SM, van der Leest AHD, Ubbels JF, Woltman-van Iersel M, Widder J, Langendijk JA, and Muijs CT
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- Humans, Prospective Studies, Probability, Chemoradiotherapy adverse effects, Radiotherapy Dosage, Radiation Pneumonitis diagnosis, Radiation Pneumonitis epidemiology, Radiation Pneumonitis etiology, Lung Neoplasms radiotherapy
- Abstract
Purpose: Normal tissue complication probability (NTCP) models can be used to estimate the risk of radiation pneumonitis (RP). The aim of this study was to externally validate the most frequently used prediction models for RP, i.e., the QUANTEC and APPELT models, in a large cohort of lung cancer patients treated with IMRT or VMAT. [1-2] METHODS AND MATERIALS: This prospective cohort study, included lung cancer patients treated between 2013 and 2018. A closed testing procedure was performed to test the need for model updating. To improve model performance, modification or removal of variables was considered. Performance measures included tests for goodness of fit, discrimination, and calibration., Results: In this cohort of 612 patients, the incidence of RP ≥ grade 2 was 14.5%. For the QUANTEC-model, recalibration was recommended which resulted in a revised intercept and adjusted regression coefficient (from 0.126 to 0.224) of the mean lung dose (MLD),. The APPELT-model needed revision including model updating with modification and elimination of variables. After revision, the New RP-model included the following predictors (and regression coefficients): MLD (B = 0.250), age (B = 0.049, and smoking status (B = 0.902). The discrimination of the updated APPELT-model was higher compared to the recalibrated QUANTEC-model (AUC: 0.79 vs. 0.73)., Conclusions: This study demonstrated that both the QUANTEC- and APPELT-model needed revision. Next to changes of the intercept and regression coefficients, the APPELT model improved further by model updating and performed better than the recalibrated QUANTEC model. This New RP-model is widely applicable containing non-tumour site specific variables, which can easily be collected., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
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29. Applications of Lasers for Sensing and Free Space Communications: introduction to the feature issue.
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Spencer MF, Bose-Pillai S, Fuerbach A, Riviere N, Toselli I, van Iersel M, and Watson EA
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This feature issue highlights the latest developments in laser-based sensing and free space communications. In total, 15 papers were published in Applied Optics, including an invited review paper that celebrates the legacy of David L. Fried.
- Published
- 2023
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30. Development of an Anticipatory Triage-Ranking Algorithm Using Dynamic Simulation of the Expected Time Course of Patients With Trauma: Modeling and Simulation Study.
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Sigle M, Berliner L, Richter E, van Iersel M, Gorgati E, Hubloue I, Bamberg M, Grasshoff C, Rosenberger P, and Wunderlich R
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- Humans, Computer Simulation, Models, Theoretical, Algorithms, Triage methods, Emergency Medical Services
- Abstract
Background: In cases of terrorism, disasters, or mass casualty incidents, far-reaching life-and-death decisions about prioritizing patients are currently made using triage algorithms that focus solely on the patient's current health status rather than their prognosis, thus leaving a fatal gap of patients who are under- or overtriaged., Objective: The aim of this proof-of-concept study is to demonstrate a novel approach for triage that no longer classifies patients into triage categories but ranks their urgency according to the anticipated survival time without intervention. Using this approach, we aim to improve the prioritization of casualties by respecting individual injury patterns and vital signs, survival likelihoods, and the availability of rescue resources., Methods: We designed a mathematical model that allows dynamic simulation of the time course of a patient's vital parameters, depending on individual baseline vital signs and injury severity. The 2 variables were integrated using the well-established Revised Trauma Score (RTS) and the New Injury Severity Score (NISS). An artificial patient database of unique patients with trauma (N=82,277) was then generated and used for analysis of the time course modeling and triage classification. Comparative performance analysis of different triage algorithms was performed. In addition, we applied a sophisticated, state-of-the-art clustering method using the Gower distance to visualize patient cohorts at risk for mistriage., Results: The proposed triage algorithm realistically modeled the time course of a patient's life, depending on injury severity and current vital parameters. Different casualties were ranked by their anticipated time course, reflecting their priority for treatment. Regarding the identification of patients at risk for mistriage, the model outperformed the Simple Triage And Rapid Treatment's triage algorithm but also exclusive stratification by the RTS or the NISS. Multidimensional analysis separated patients with similar patterns of injuries and vital parameters into clusters with different triage classifications. In this large-scale analysis, our algorithm confirmed the previously mentioned conclusions during simulation and descriptive analysis and underlined the significance of this novel approach to triage., Conclusions: The findings of this study suggest the feasibility and relevance of our model, which is unique in terms of its ranking system, prognosis outline, and time course anticipation. The proposed triage-ranking algorithm could offer an innovative triage method with a wide range of applications in prehospital, disaster, and emergency medicine, as well as simulation and research., (©Manuel Sigle, Leon Berliner, Erich Richter, Mart van Iersel, Eleonora Gorgati, Ives Hubloue, Maximilian Bamberg, Christian Grasshoff, Peter Rosenberger, Robert Wunderlich. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 15.06.2023.)
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- 2023
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31. The effect of a more community-oriented curriculum on nursing students' intervention choice in community care: A quasi-experimental cohort study.
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van Iersel M, de Vos R, van Rijn M, Latour CHM, Kirschner PA, and Scholte Op Reimer WJM
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- Cohort Studies, Curriculum, Delivery of Health Care, Humans, Education, Nursing, Baccalaureate, Students, Nursing
- Abstract
Aim: The aim of this study is to investigate the effect of a more 'community-oriented' baccalaureate nursing curriculum on students' intervention choice in community care., Background: Following a healthcare shift with increased chronic diseases in an ageing patient population receiving care at home, nursing education is revising its curricula with new themes (e.g., self-management) on community care. Although it seems obvious that students incorporate these themes in their nursing care interventions, this is unclear. This study investigates the effect of a redesigned curriculum on students' care intervention choice in community nursing., Design: A quasi-experimental quantitative study., Methods: This study with an historic control group (n = 328; study cohorts graduating in 2016 and 2017; response rate 83 %) and an intervention group n = 152; graduating in 2018; response rate 80 %) was performed at a University of Applied Sciences in the Netherlands. The intervention group experienced a curriculum-redesign containing five new themes related to community care (e.g., enhancing self-management, collaboration with the patients' social network, shared decision making, using health technology and care allocation). The primary outcome 'intervention choice in community nursing' was assessed with a specially developed vignette instrument 'Assessment of Intervention choice in Community Nursing' (AICN). Through multiple regression analyses we investigated the effect of the curriculum-redesign on students' intervention choice (more 'traditional' interventions versus interventions related to the five new themes). The control and intervention groups were compared on the number of interventions per theme and on the number of students choosing a theme, with a chi-square or T-test., Results: Students who studied under the more community-oriented curriculum chose interventions related to the new themes significantly more often, F(1461) = 14.827, p = <0.001, R
2 = .031. However, more traditional interventions are still favourite (although less in the intervention group): 74.5 % of the chosen interventions in the historic control group had no relation with the new curriculum-themes, vs. 71.3 % in the intervention group; p = .055)., Conclusions: Students who experienced a more 'community-oriented' curriculum were more likely, albeit to a limited extent, to choose the new community care themes in their caregiving. Seeing this shift in choices as a step in the right direction, it can be expected that the community care field in the longer term will benefit from these better skilled graduates., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2022
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32. Sensing optical phase distortion via beatnote detection of a dual probe beam encoded with orbital angular momentum.
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Ferlic NA, Laux AE, Cochenour BM, Mullen LJ, van Iersel M, and Davis CC
- Abstract
Laser based optical applications such as imaging, ranging, and wireless communications are susceptible to environmental distortions. Inferring the strength of these optical distortions is crucial to obtaining information about the environment in which the system is operating. Our technique of inferring environmental distortion strength leverages the spreading of light's orbital angular momentum (OAM) spectrum combined with heterodyne detection. A laser encoded with OAM can be decomposed into a basis set of helical modes that spreads upon interaction with optical distortions. This mode spreading is quantified using the OAM spectrum that can be measured using mode projection or mode sorting techniques. This new technique, to the best of our knowledge, provides benefits compared to the latter two OAM detection methods such as: low-frequency noise rejection, a simpler optical receiver, lower noise floor, and an inherent optical phase component. Central to the method is the heterodyne detection of the zeroth-order OAM coefficient of a superimposed two-beam, two-frequency, probe. The measured heterodyne signal power is seen to be proportional to the coupling power of each beam's OAM spectra. To test the idea, wave-optic simulations and experiments using spatial light modulators are implemented using a simplified optical turbulence model to represent the environment. The experimental implementation agrees well with simulated and theoretical results.
- Published
- 2022
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33. Weak turbulence effects on different beams carrying orbital angular momentum.
- Author
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Ferlic NA, van Iersel M, and Davis CC
- Abstract
The study of beams carrying orbital angular momentum (OAM) has been of interest for its use in free-space optical communications (FSOC), directed energy applications, and remote sensing (RS). For FSOC and RS, it is necessary to measure the wavefront of the beam to recover transmitted or environmental information, respectively. In this computational study, common OAM beams such as the Laguerre-Gaussian (LG), Bessel-Gaussian (BG), and Bessel beams are propagated through atmospheric turbulence and compared to their Gaussian beam counterpart. The turbulence is simulated using multiple phase screens within the framework of a split-step method. Beam metrics used to quantify beam propagation will include the spatial coherence radius, OAM spectrum, on-axis intensity, spot size, divergence, and on-axis scintillation. Atmospheric turbulence along the path is limited to the weak scintillation limit, where beam parameters can be predicted analytically using the Rytov approximation. The results show that BG beams and multiplexed BG beams retain more OAM information than their LG and Bessel beam counterparts. The LG beam on-axis intensity and on-axis scintillation are seen to be independent of OAM mode. The scintillation of the LG beam is less than a BG, Bessel, and Gaussian beam across low- and high-order OAM modes. Insight into these results is discussed through studying the beam divergence, while the initial spot sizes of the Gaussian, LG, and BG beams are limited to the same spatial extent.
- Published
- 2021
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34. Why Far-Red Photons Should Be Included in the Definition of Photosynthetic Photons and the Measurement of Horticultural Fixture Efficacy.
- Author
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Zhen S, van Iersel M, and Bugbee B
- Abstract
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
- Published
- 2021
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35. How nursing students' placement preferences and perceptions of community care develop in a more 'community-oriented' curriculum: a longitudinal cohort study.
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van Iersel M, Latour CHM, van Rijn M, de Vos R, Kirschner PA, and Scholte Op Reimer WJM
- Abstract
Background: Extramuralisation in healthcare has influenced medical and nursing curricula internationally with the incorporation of themes related to primary/ community care. Despite this, students do not easily change their career preferences. The hospital is still favourite, leading to labour market shortages in extramural care. This study investigates how baccalaureate nursing students' perceptions of community care and placement preferences develop over time in a more 'community-care-oriented' curriculum, to gain insights on which curriculum elements potentially influence career choices., Methods: A nursing student cohort of a University of Applied Sciences in the Netherlands ( n = 273) underwent a new four-year curriculum containing extended elements of community care. The primary outcome was assessed with the Scale on Community Care Perceptions (SCOPE). Data were collected each year of study. Descriptive statistics were used to investigate students' placement preferences and perceptions, and linear mixed model techniques (LMMs) for measuring how students' perceptions develop over time. Patterns of placement preferences at individual level were visualised., Results: Students' perceptions of community care, as measured with SCOPE, show a slight decrease between year 1 and 4, while items mutually differ substantially. In contrast, the preference of community care for a placement increases from 2.6% in year 1 tot 8.2% in year 4. The hospital is favourite in year 1 (79.8%), and remains most popular. At individual level, students often change placement preferences, although a preference for the hospital is more consistent. The LMMs indicates that, at the four time-points, the estimated marginal means of students' perceptions fluctuate between 6 and 7 (range 1-10). A placement in community care did not positively influence students' perceptions, and an intensive 1 week theoretical programme was only temporarily influential., Conclusions: Although interest for placement in community care increased substantially, it was not clear which curriculum elements stimulated this, nor did the curriculum positively influence students' perceptions. As most students do not look forward to the high responsibility of the field, other curricula with educational tracks for more mature students/ nurses with a vocational training may be an alternative contribution to solving the labour market problems in community care., Competing Interests: Competing interestsThe authors declare that they have no competing interests., (© The Author(s) 2020.)
- Published
- 2020
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36. Measuring the turbulence profile in the lower atmospheric boundary layer.
- Author
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van Iersel M, Paulson DA, Wu C, Ferlic NA, Rzasa JR, Davis CC, Walker M, Bowden M, Spychalsky J, and Titus F
- Abstract
Optical turbulence can have a severe effect on the propagation of laser beams through the atmosphere. In free space optics and directed energy applications, these laser beams quite often propagate along a slant or vertical path. In these cases, the refractive index structure function parameter cannot be assumed constant, since it varies with height. How it varies with height, especially in the first few meters above the ground, is not well behaved. Turbulence height profiles have been measured since the 1970s, mainly for astronomical observations. These profiles are usually measured for the atmospheric boundary layer (the layer of air from the ground up to approx. 1 km during day and 100 m during night) and some kilometers above it. We have measured the temperature fluctuations in the first few meters above ground level using a system containing eight resistance thermometer devices, mounted in a row at different spacings. Measurements were made flying this system under a tethered balloon or mounted on a telescoping mast. The temperature structure function parameter, CT2, can be estimated from the temperature fluctuations measured by the 28 different probe pairs and the unique distances between the two probes. Finally, Cn2 is estimated from this temperature structure function parameter and compared to values predicted by a turbulence profile model.
- Published
- 2019
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37. Influencing nursing students' perceptions of community care with curriculum-redesign; a quasi-experimental cohort study.
- Author
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van Iersel M, de Vos R, van Rijn M, Latour CHM, Kirschner PA, and Scholte Op Reimer WJM
- Subjects
- Adult, Attitude of Health Personnel, Cohort Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Netherlands, Young Adult, Community Health Services, Curriculum, Education, Nursing, Baccalaureate, Students, Nursing psychology
- Abstract
Background: The shift in healthcare to extramural leads to more patients with complex health problems receiving nursing care at home. However, the interest of baccalaureate nursing students for community nursing is moderate, which contributes to widespread labour-market shortages. This study investigates the effect of a more 'community-care-oriented' curriculum on nursing students' perceptions of community care., Methods: A quasi-experimental quantitative survey study with a historic control group (n = 477; study cohorts graduating in 2015, 2016, and 2017; response rate 90%) and an intervention group (n = 170; graduating in 2018; response rate 93%) was performed in nursing students of a University of Applied Sciences in a large city in the Netherlands. The intervention group underwent a new curriculum containing extended elements of community care. The primary outcome was assessed with the Scale on Community Care Perceptions (SCOPE). The control and intervention group were compared on demographics, placement preferences and perceptions with a chi-square or T-test. Multiple regression was used to investigate the effect of the curriculum-redesign on nursing students' perceptions of community care., Results: The comparison between the control and intervention group on students' perceptions of community care shows no significant differences (mean 6.18 vs 6.21 [range 1-10], respectively), nor does the curriculum-redesign have a positive effect on students' perceptions F (1,635) = .021, p = .884, R
2 = < .001. The comparison on placement preferences also shows no significant differences and confirms the hospital's popularity (72.7% vs 76.5%, respectively) while community care is less often preferred (9.2% vs 8.2%, respectively). The demographics 'working in community care' and 'belonging to a church/religious group' appear to be significant predictors of more positive perceptions of community care., Conclusions: Graduating students who experienced a more 'community-care-oriented' curriculum did not more often prefer community care placement, nor did their perceptions of community care change. Apparently, four years of education and placement experiences have only little impact and students' perceptions are relatively static. It would be worth a try to conduct a large-scale approach in combination with a carefully thought out strategy, based on and tying in with the language and culture of younger people.- Published
- 2019
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38. European postgraduate curriculum in geriatric medicine developed using an international modified Delphi technique.
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Roller-Wirnsberger R, Masud T, Vassallo M, Zöbl M, Reiter R, Van Den Noortgate N, Petermans J, Petrov I, Topinkova E, Andersen-Ranberg K, Saks K, Nuotio M, Bonin-Guillaume S, Lüttje D, Mestheneos E, Szekacs B, Jonsdottir AB, O'Neill D, Cherubini A, Macijauskiene J, Leners JC, Fiorini A, van Iersel M, Ranhoff AH, Kostka T, Duque S, Prada GI, Davidovic M, Krajcik S, Kolsek M, Del Nozal JM, Ekdahl AW, Münzer T, Savas S, Knight P, Gordon A, and Singler K
- Subjects
- Aged, Curriculum, Delphi Technique, Education, Medical, Graduate methods, Education, Medical, Graduate standards, Europe, Geriatrics standards, Humans, Geriatrics education
- Abstract
Background: the European Union of Medical Specialists (UEMS-GMS) recommendations for training in Geriatric Medicine were published in 1993. The practice of Geriatric Medicine has developed considerably since then and it has therefore become necessary to update these recommendations., Methods: under the auspices of the UEMS-GMS, the European Geriatric Medicine Society (EuGMS) and the European Academy of Medicine of Ageing (EAMA), a group of experts, representing all member states of the respective bodies developed a new framework for education and training of specialists in Geriatric Medicine using a modified Delphi technique. Thirty-two expert panel members from 30 different countries participated in the process comprising three Delphi rounds for consensus. The process was led by five facilitators., Results: the final recommendations include four different domains: 'General Considerations' on the structure and aim of the syllabus as well as quality indicators for training (6 sub-items), 'Knowledge in patient care' (36 sub-items), 'Additional Skills and Attitude required for a Geriatrician' (9 sub-items) and a domain on 'Assessment of postgraduate education: which items are important for the transnational comparison process' (1 item)., Conclusion: the current publication describes the development of the new recommendations endorsed by UEMS-GMS, EuGMS and EAMA as minimum training requirements to become a geriatrician at specialist level in EU member states., (© The Author(s) (2019). Published by Oxford University Press on behalf of the British Geriatrics Society.)
- Published
- 2019
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39. Small bowel obstruction in the elderly: a plea for comprehensive acute geriatric care.
- Author
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Ozturk E, van Iersel M, Stommel MM, Schoon Y, Ten Broek RR, and van Goor H
- Subjects
- Clinical Competence standards, Fluid Therapy methods, Geriatrics methods, Humans, Intestinal Obstruction diagnosis, Lower Body Negative Pressure methods, Palliative Care methods, Palliative Care standards, Physical Examination methods, Physical Examination standards, Quality of Life psychology, Tomography, X-Ray Computed methods, Withholding Treatment, Geriatrics standards, Intestinal Obstruction therapy
- Abstract
Small bowel obstruction is one of the most frequent emergencies in general surgery, commonly affecting elderly patients. Morbidity and mortality from small bowel obstruction in elderly is high. Significant progress has been made in the diagnosis and management of bowel obstruction in recent years. But little is known whether this progress has benefitted outcomes in elderly patients, particularly those who are frail or have a malignancy as cause of the obstruction, and when considering quality of life and functioning as outcomes. In this review, we discuss the specific challenges and needs of elderly in diagnosis and treatment of small bowel obstruction. We address quality of life aspects and explore how the concept of geriatric assessment can be utilized to improve decision-making and outcomes for elderly patients with a small bowel obstruction., Competing Interests: Not applicableNot applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
- Published
- 2018
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40. Interactive online learning on perioperative management of elderly patients.
- Author
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Ozturk E, van Iersel M, van Loon K, den Rooijen C, van Dongen E, van Wijngaarden RL, Klaase J, and van Goor H
- Subjects
- Aged, Clinical Competence, Curriculum, Female, Humans, Male, Retrospective Studies, Education, Distance methods, Education, Medical, Graduate methods, General Surgery education, Geriatrics education, Internet, Internship and Residency methods, Perioperative Care education
- Abstract
Introduction: Surgical specialists and residents lack knowledge to adequately manage frail older patients. This study aims to evaluate the effects of an interactive online course regarding attitude, self-confidence and knowledge in perioperative management of the elderly patient., Methods: The six-weeks course consisted of expert videos, literature readings, quizzes and forum discussions. Surgical consultants with geriatric expertise and geriatricians moderated online discussions and stimulated interaction. Knowledge, self-confidence and attitude of course participants were compared at the beginning and end of the course., Results: 206 medical practitioners started the course. Knowledge scores improved significantly from 49% to 65% (p < 0.005). Participants felt more secure (p < 0.005) in the treatment of the older patient at the end of the course. A better attitude correlated with a higher total knowledge score in surgeons and surgical residents (p = 0.02)., Conclusion: A six-week interactive online course on perioperative management of elderly patients increases relevant geriatric knowledge and improves self-confidence of residents and faculty., (Copyright © 2018. Published by Elsevier Inc.)
- Published
- 2018
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41. Erratum to "The Scale on COmmunity care PErceptions (SCOPE) for nursing students: A development and psychometric validation study" [Nurse Educ. Pract. 31 July 2018 61-67].
- Author
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van Iersel M, de Vos R, Latour C, Kirschner PA, and Scholte Op Reimer W
- Published
- 2018
- Full Text
- View/download PDF
42. The Scale on COmmunity care PErceptions (SCOPE) for nursing students: A development and psychometric validation study.
- Author
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van Iersel M, de Vos R, Latour C, Kirschner PA, and Scholte Op Reimer W
- Subjects
- Adolescent, Curriculum, Female, Humans, Learning, Male, Netherlands, Reproducibility of Results, Community Networks, Perception, Psychometrics, Students, Nursing psychology, Surveys and Questionnaires
- Abstract
The aim of this study was to develop a valid instrument to measure student nurses' perceptions of community care (SCOPE). DeVellis' staged model for instrument development and validation was used. Scale construction of SCOPE was based on existing literature. Evaluation of its psychometric properties included exploratory factor analysis and reliability analysis. After pilot-testing, 1062 bachelor nursing students from six institutions in the Netherlands (response rate 81%) took part in the study. SCOPE is a 35-item scale containing: background variables, 11 measuring the affective component, 5 measuring community care perception as a placement, 17 as a future profession, and 2 on the reasons underlying student preference. Principal axis factoring yielded two factors in the affective component scale reflecting 'enjoyment' and 'utility', two in the placement scale reflecting 'learning possibilities' and 'personal satisfaction', and four in the profession scale: 'professional development', 'collaboration', 'caregiving', and 'complexity and workload'. Cronbach's α of the complete scale was 0.892 and of the subscales 0.862, 0.696, and 0.810 respectively. SCOPE is a psychometrically sound instrument for measuring students' perceptions of community care. By determining these perceptions, it becomes possible to positively influence them with targeted curriculum redesign, eventually contributing to decreasing the workforce shortage in community nursing., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
43. Factors underlying perceptions of community care and other healthcare areas in first-year baccalaureate nursing students: A focus group study.
- Author
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van Iersel M, Latour CHM, van Rijn M, de Vos R, Kirschner PA, and Scholte Op Reimer WJM
- Subjects
- Curriculum, Education, Nursing, Baccalaureate, Female, Focus Groups, Humans, Netherlands, Qualitative Research, Surveys and Questionnaires, Young Adult, Career Choice, Community Health Nursing, Students, Nursing psychology
- Abstract
Background: Despite the increasing labour market shortage of well-educated community nurses, few baccalaureate nursing students choose for a career in community care. Obtaining knowledge of how students perceive healthcare areas early in their education is important to take meaningful steps in counteracting any existing misconceptions with targeted curriculum redesign., Objective: Determination of factors underlying perceptions of healthcare areas in first-year baccalaureate nursing students., Design: A descriptive qualitative study using focus group inquiry., Methods: This study follows up on a large-sample quantitative multicentre survey study. Fourteen first-year nursing students at a university of applied sciences in the Netherlands participated in focus group discussions in October 2014. Transcripts of the discussions were coded by two independent researchers at three levels - open, axial and selective coding - on the basis of two templates. The codes were sorted into categories and assigned to suitable main codes in the templates. The number of sub-codes per category and code were added together., Results: Eight main themes were formulated, to wit (1) variety and diversity, (2) challenges, (3) improving people's health, (4) collaboration, (5) role models, (6) patient- or environment-based perceptions, (7) self-efficacy and (8) immediate vicinity. Data suggest that first-year students have clear ideas about the characteristics which they consider important in professional practice. Their perceptions do not necessarily reflect the actual situation, as they expect the hospital to possess all desired characteristics while community nursing seems to be undervalued., Conclusion: To remedy students' misperceptions, four recommendations are formulated for curriculum redesign strategies deriving from the eight themes. These recommendations are based on collaboration between school and care organisations as well as on themes related to in-depth knowledge within the educational programme. The interventions will potentially help to strengthen the focus on community care, which will foster a more optimistic and realistic career outlook on this field., (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2018
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44. Perceptions of community care and placement preferences in first-year nursing students: A multicentre, cross-sectional study.
- Author
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van Iersel M, Latour CHM, de Vos R, Kirschner PA, and Scholte Op Reimer WJM
- Subjects
- Adult, Aged, Attitude of Health Personnel, Cross-Sectional Studies, Education, Nursing, Baccalaureate, Female, Humans, Male, Netherlands, Surveys and Questionnaires, Career Choice, Community Health Nursing methods, Students, Nursing psychology
- Abstract
Background: Despite increasing shortages of highly educated community nurses, far too few nursing students choose community care. This means that a strong societal problem is emerging that desperately needs resolution., Objectives: To acquire a solid understanding of the causes for the low popularity of community care by exploring first-year baccalaureate nursing students' perceptions of community care, their placement preferences, and the assumptions underlying these preferences., Design: A quantitative cross-sectional design., Settings: Six universities of applied sciences in the Netherlands., Participants: Nursing students in the first semester of their 4-year programme (n=1058)., Methods: Data were collected in September-December 2014. The students completed the 'Scale on Community Care Perceptions' (SCOPE), consisting of demographic data and three subscales measuring the affective component of community care perception, perceptions of a placement and a profession in community care, and students' current placement preferences. Descriptive statistics were used., Results: For a practice placement, 71.2% of first-year students prefer the general hospital and 5.4% community care, whereas 23.4% opt for another healthcare area. Students consider opportunities for advancement and enjoyable relationships with patients as most important for choosing a placement. Community care is perceived as a 'low-status-field' with many elderly patients, where students expect to find little variety in caregiving and few opportunities for advancement. Students' perceptions of the field are at odds with things they believe to be important for their placement., Conclusion: Due to misconceptions, students perceive community care as offering them few challenges. Strategies to positively influence students' perceptions of community nursing are urgently required to halt the dissonance between students' preference for the hospital and society's need for highly educated community nurses., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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45. [Heterogeneity of delirium cannot be captured by a simple diagnostic instrument].
- Author
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Oudenes JH, van Iersel MB, and Olde Rikkert MGM
- Subjects
- Coma, Dementia, Humans, Biomarkers analysis, Delirium diagnosis
- Abstract
The latest criteria for delirium (DSM-5) still encompass a very heterogeneous group of patients, as both risk factors and causes differ greatly between patients. This makes it unlikely that a single biomarker (e.g. an EEG signal) can be a valid and reliable diagnostic tool in clinical practice. Researchers should be very aware of this heterogeneity, as striving for uniform biomarkers would otherwise result in a considerable waste of research effort. In clinical practice, the delineation of delirium syndrome from dementia and coma using these DSM-5 criteria remains challenging. We state that patient outcomes can probably be improved most by interprofessional, personalised management and the monitoring of vulnerable patients during their individual disease trajectories.
- Published
- 2017
46. Nursing students' perceptions of community care and other areas of nursing practice - A review of the literature.
- Author
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van Iersel M, Latour CH, de Vos R, Kirschner PA, and Scholte Op Reimer WJ
- Subjects
- Humans, Community Health Nursing, Students, Nursing psychology
- Abstract
Objectives: To review recent literature on student nurses' perceptions of different areas of nursing practice, in particular community care. Healthcare is changing from care delivery in institutional settings to care to patients in their own homes. Problematic is that nursing students do not see community care as an attractive line of work, and their perceptions of community care do not reflect the realities of the profession. Understanding the factors influencing the perception of the professional field is important to positively influence students' willingness to see community nursing as a future profession., Design: Literature search with accompanying narrative synthesis of primary research., Data Sources: ERIC(®), PsycInfo(®), Pubmed(®), and CINAHL(®) (2004-2014) databases using the search terms: 'nursing student', 'student nurse', 'community care', 'community nurse', 'image', 'attitude', and 'perception'., Review Methods: After screening 522 retrieved article titles with abstracts, the number of articles was reduced based upon specified inclusion/exclusion criteria leading to inclusion of 34. Evaluation of the references in those articles yielded an additional 5 articles. A narrative synthesis of those articles was created to uncover students' perception of community care, other areas of professional practice, and the factors influencing those perceptions., Results: 39 articles were selected. Results show that many nursing students begin their education with a lay person's conception of the profession, shaped by media representations. Work placements in different settings offer clinical experience that helps students orient themselves towards a future profession. Students prefer hospitals as a place of work, because of the acute nature and technologically advanced level of care offered there. Few students perceive mental health and elderly care as appealing. Perceptions of community care can vary widely, the most prevalent view being that it is unattractive because of its chronic care profile, with little technical skill, untrained workers, and a high workload. However, another view is that it offers challenging and meaningful work because of the variety of caregiving roles and the opportunity to work independently., Conclusions: Few nursing students choose community nursing as a future profession. They have a limited and often mistaken view of community care, and they underestimate the field's complexity because it is less visible than in the environment of acute care. Providing students with specific curricular content and employing a structured approach to preparation for work placement could help build a more positive perception of community care, leading to more students seeing/choosing community care as a desirable field of work., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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47. Leaf ontogeny strongly influences photosynthetic tolerance to drought and high temperature in Gossypium hirsutum.
- Author
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Chastain DR, Snider JL, Choinski JS, Collins GD, Perry CD, Whitaker J, Grey TL, Sorensen RB, van Iersel M, Byrd SA, and Porter W
- Subjects
- Chlorophyll metabolism, Droughts, Gossypium anatomy & histology, Hot Temperature, Photosystem II Protein Complex metabolism, Plant Leaves anatomy & histology, Plant Leaves physiology, Seasons, Stress, Physiological, Water metabolism, Gossypium physiology, Photosynthesis physiology
- Abstract
Temperature and drought are major abiotic limitations to crop productivity worldwide. While abiotic stress physiology research has focused primarily on fully expanded leaves, no studies have investigated photosynthetic tolerance to concurrent drought and high temperature during leaf ontogeny. To address this, Gossypium hirsutum plants were exposed to five irrigation treatments, and two different leaf stages were sampled on three dates during an abnormally dry summer. Early in the growing season, ontogenic PSII heat tolerance differences were observed. Photosystem II was more thermotolerant in young leaves than mature leaves. Later in the growing season, no decline in young leaf net photosynthesis (P
N ) was observed as leaf temperature increased from 31 to 37°C, as average midday leaf water potential (ΨMD ) declined from -1.25 to -2.03MPa. In contrast, mature leaf PN declined 66% under the same conditions. Stomatal conductance (gs ) accounted for 84-98% of variability in leaf temperature, and gs was strongly associated with ΨMD in mature leaves but not in young leaves. We conclude that young leaves are more photosynthetically tolerant to heat and drought than mature leaves. Elucidating the mechanisms causing these ontogenic differences will likely help mitigate the negative impacts of abiotic stress in the future., (Copyright © 2016 Elsevier GmbH. All rights reserved.)- Published
- 2016
- Full Text
- View/download PDF
48. Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease.
- Author
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Cornely OA, Duarte RF, Haider S, Chandrasekar P, Helfgott D, Jiménez JL, Candoni A, Raad I, Laverdiere M, Langston A, Kartsonis N, Van Iersel M, Connelly N, and Waskin H
- Published
- 2016
- Full Text
- View/download PDF
49. An instrument dedicated for modelling of pulmonary radiotherapy.
- Author
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Niezink AG, Dollekamp NJ, Elzinga HJ, Borger D, Boer EJ, Ubbels JF, Woltman-van Iersel M, van der Leest AH, Beijert M, Groen HJ, Kraan J, Hiltermann TJ, van der Wekken AJ, van Putten JW, Rutgers SR, Pieterman RM, de Hosson SM, Roenhorst AW, Langendijk JA, and Widder J
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Imaging, Three-Dimensional, Lung pathology, Male, Middle Aged, Prospective Studies, Quality of Life, Radiotherapy adverse effects, Radiotherapy methods, Lung Neoplasms radiotherapy, Radiotherapy instrumentation
- Abstract
Background and Purpose: Radiotherapy plays a pivotal role in lung cancer treatment. Selection of patients for new (radio)therapeutic options aiming at improving outcomes requires reliable and validated prediction models. We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling., Materials and Methods: ProPED-LUNG was designed to comprise relevant baseline and follow up data of patients receiving pulmonary radiotherapy with curative intent. Patient characteristics, diagnostic and staging information, treatment parameters including full dose-volume-histograms, tumour control, survival, and toxicity are scored. Besides physician-rated data, a range of patient-rated data regarding symptoms and health-related quality-of-life are collected., Results: After 18 months of accrual, 315 patients have been included (accrual rate, 18 per month). Of the first hundred patients included, 70 received conformal (chemo)radiotherapy and 30 underwent stereotactic radiotherapy. Compliance at 3 and 6 months follow-up was 96-100% for patient-rated, and 81-94% for physician-rated assessments. For data collection, 0.4 FTE were allocated in a 183 FTE department (0.2%)., Conclusions: ProPED-LUNG is feasible with high compliance rates and yields a large amount of high quality prospective disease-related, treatment-related, patient- and physician-rated data which can be used to evaluate new developments in pulmonary radiotherapy., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
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50. Description of modular devices for the measurement of external dosimetry in radiation protection.
- Author
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Genicot JL, Boogers E, and Van Iersel M
- Subjects
- Aluminum Oxide chemistry, Carbon chemistry, Humans, Luminescent Measurements, Optics and Photonics, Radiation Dosage, Thermoluminescent Dosimetry methods, Radiation Protection instrumentation, Radiometry, Thermoluminescent Dosimetry instrumentation
- Abstract
In 2002 the Group of Radiation Dosimetry and Calibration of the Belgian Nuclear Research Centre (SCK•CEN) has developed an experimental device based on the optically stimulated luminescence (OSL) working with Al2O3:C detectors (TLD-500 and Luxel) stimulated with an argon laser. A set of devices made from different modules have been developed to permit external dosimetry measurements with thermoluminescence (TL) and OSL techniques under different conditions. This study describes these measurement devices that can be made with these modules and some of the characteristics of the different systems. These devices present several advantages in terms of measurement possibilities: a small number of modules allow the use of different detection materials (Al2O3:C, BeO, quartz electronic components and tiles) and different measurement methods (TL, CW-OSL and pulsed OSL). Some applications are commented., (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
- Full Text
- View/download PDF
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