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Your search keyword '"Välimaa, Hannamari"' showing total 28 results
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28 results on '"Välimaa, Hannamari"'

4. Generalized infections of putative oral origin in Helsinki University Hospital in 2012 to 2017.

Author

Hotti, Sari, Helenius-Hietala, Jaana, Välimaa, Hannamari, Järvinen, Asko, Salonen, Johan, Furuholm, Jussi, Rita, Ville, Meurman, Jukka H., and Ruokonen, Hellevi

Subjects
AORTIC valve surgery, MITRAL valve surgery, BACTEREMIA, ACADEMIC medical centers, ACQUISITION of data methodology, RESEARCH methodology, ORAL diseases, RETROSPECTIVE studies, PATIENT readmissions, DENTAL care, DENTAL extraction, SOCIOECONOMIC factors, RISK assessment, HOSPITAL mortality, MEDICAL records, DESCRIPTIVE statistics, DATA analysis software, DISEASE risk factors, DISEASE complications
Abstract

Objective: Bacteria entering the bloodstream through oral mucosa cause bacteremia, which can lead to septic or distant infections. The underlying factors and need for dental treatment in patients referred for oral examination because of septic infection were investigated. It was expected that general diseases and poor socioeconomic status of patients would increase the risk of bacteremia. Method and materials: This descriptive retrospective study included patients (N = 128) referred from medical clinics of the Helsinki University Hospital (HUH), during 2012 to 2017, to the Department of Oral and Maxillofacial Diseases due to bacteremia suspected to be of oral origin. Data were extracted from medical and dental records according to the World Health Organization International Classification of Diseases (ICD-10) for systemic or remote infections. Different groups were formed using modified Skapinakis classification for socioeconomic status (SES), from I (high) to V (low). Underlying medical conditions were retrieved according to McCabe classi- fication: healthy, nonfatal, ultimately fatal, and rapidly fatal diseases. The data were analyzed using the statistical software package SPSS (IBM). Results: Patients were referred most often from the Departments of Infectious Diseases and Internal Medicine. Because of infection, 12 patients needed aortic or mitral valve operations. Many of the patients were intravenous drug users. However, the majority of patients presented McCabe class I, indicating no systemic disease. The main SES was intermediate III. Tooth extraction was the principal mode of treatment. No demographic background variables were identified to explain increase of the risk for bacteremia except that most patients were men with untreated dental problems. Conclusions: Contrary to the authors' expectation, poor SES and underlying diseases did not seem to link to the outcome. However, untreated dental infections present an evident risk for life-threatening septic complications also in generally healthy individuals. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)—Three-Month Interim Results

Author

Pakarinen, Saila, primary, Saarela, Riitta K. T., additional, Välimaa, Hannamari, additional, Heikkinen, Anna Maria, additional, Kankuri, Esko, additional, Noponen, Marja, additional, Alapulli, Heikki, additional, Tervahartiala, Taina, additional, Räisänen, Ismo T., additional, Sorsa, Timo, additional, and Pätilä, Tommi, additional

Published
2022
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10. HERQ-9 Is a New Multiplex PCR for Differentiation and Quantification of All Nine Human Herpesviruses

Author

Pyöriä, Lari, primary, Jokinen, Maija, additional, Toppinen, Mari, additional, Salminen, Henri, additional, Vuorinen, Tytti, additional, Hukkanen, Veijo, additional, Schmotz, Constanze, additional, Elbasani, Endrit, additional, Ojala, Päivi M., additional, Hedman, Klaus, additional, Välimaa, Hannamari, additional, and Perdomo, Maria F., additional

Published
2020
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14. Seksitaudit

Author

Hiltunen-Back, Eija, Alanen, Anna, Puolakkainen, Mirja, Suomalainen, Pekka, Valtonen, Kirsi, Vuento, Risto, Välimaa, Hannamari, Vuorela, Piia, Komulainen, Jorma, Ihotautien, allergologian ja sukupuolitautien osasto, Mirja Puolakkainen / Vastuullinen tutkija, Virologian osasto, HUS Naistentaudit ja synnykset, Naistenklinikka, HUS Tulehduskeskus, and HUSLAB

Subjects
3111 Biolääketieteet
Abstract

Käypä hoito -suositus. Päivitystiivistelmä. English summary

Published
2018

21. Interactions between the Aggregatibacter actinomycetemcomitans secretin HofQ and host cytokines indicate a link between natural competence and interleukin-8 uptake

Author

Ahlstrand, Tuuli, Torittu, Annamari, Elovaara, Heli, Välimaa, Hannamari, Pöllänen, Marja T., Kasvandik, Sergo, Högbom, Martin, Ihalin, Riikka, Ahlstrand, Tuuli, Torittu, Annamari, Elovaara, Heli, Välimaa, Hannamari, Pöllänen, Marja T., Kasvandik, Sergo, Högbom, Martin, and Ihalin, Riikka

Abstract

Naturally competent bacteria acquire DNA from their surroundings to survive in nutrient-poor environments and incorporate DNA into their genomes as new genes for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter actinomycetemcomitans has been associated with DNA uptake. Cytokine sequestering is a potential virulence mechanism in various bacteria and may modulate both host defense and bacterial physiology. The objective of this study was to elucidate a possible connection between natural competence and cytokine uptake in A. actinomycetemcomitans. The extramembranous domain of HofQ (emHofQ) was shown to interact with various cytokines, of which IL-8 exhibited the strongest interaction. The dissociation constant between emHofQ and IL-8 was 43nM in static settings and 2.4M in dynamic settings. The moderate binding affinity is consistent with the hypothesis that emHofQ recognizes cytokines before transporting them into the cells. The interaction site was identified via crosslinking and mutational analysis. By structural comparison, relateda type I KH domain with a similar interaction site was detected in the Neisseria meningitidis secretin PilQ, which has been shown to participate in IL-8 uptake. Deletion of hofQ from the A. actinomycetemcomitans genome decreased the overall biofilm formation of this organism, abolished the response to cytokines, i.e., decreased eDNA levels in the presence of cytokines, and increased the susceptibility of the biofilm to tested -lactams. Moreover, we showed that recombinant IL-8 interacted with DNA. These results can be used in further studies on the specific role of cytokine uptake in bacterial virulence without interfering with natural-competence-related DNA uptake.

Published
2018
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25. Treatment of acute dental infections.

Author

PARIKKA, MATALEENA, NORPPA, ANNA, VÄLIMAA, HANNAMARI, HUTTUNEN, REETTA, JÄRVINEN, ASKO, and RICHARDSON, RIINA

Subjects
ANTI-infective agents, PUBLIC health, ANTIBIOTICS, PERIODONTAL disease treatment, MEDICAL care
Abstract

Copyright of Tandlaegebladet is the property of Tandlaegeforeningen and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

26. Interactions between the Aggregatibacter actinomycetemcomitanssecretin HofQ and host cytokines indicate a link between natural competence and interleukin-8 uptake

Author

Ahlstrand, Tuuli, Torittu, Annamari, Elovaara, Heli, Välimaa, Hannamari, Pöllänen, Marja T., Kasvandik, Sergo, Högbom, Martin, and Ihalin, Riikka

Abstract

ABSTRACTNaturally competent bacteria acquire DNA from their surroundings to survive in nutrient-poor environments and incorporate DNA into their genomes as new genes for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter actinomycetemcomitanshas been associated with DNA uptake. Cytokine sequestering is a potential virulence mechanism in various bacteria and may modulate both host defense and bacterial physiology. The objective of this study was to elucidate a possible connection between natural competence and cytokine uptake in A. actinomycetemcomitans. The extramembranous domain of HofQ (emHofQ) was shown to interact with various cytokines, of which IL-8 exhibited the strongest interaction. The dissociation constant between emHofQ and IL-8 was 43 nM in static settings and 2.4 μM in dynamic settings. The moderate binding affinity is consistent with the hypothesis that emHofQ recognizes cytokines before transporting them into the cells. The interaction site was identified via crosslinking and mutational analysis. By structural comparison, relateda type I KH domain with a similar interaction site was detected in the Neisseria meningitidissecretin PilQ, which has been shown to participate in IL-8 uptake. Deletion of hofQfrom the A. actinomycetemcomitansgenome decreased the overall biofilm formation of this organism, abolished the response to cytokines, i.e., decreased eDNA levels in the presence of cytokines, and increased the susceptibility of the biofilm to tested β-lactams. Moreover, we showed that recombinant IL-8 interacted with DNA. These results can be used in further studies on the specific role of cytokine uptake in bacterial virulence without interfering with natural-competence-related DNA uptake.

Published
2018
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