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Your search keyword '"Umlauf Scott"' showing total 6 results
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6 results on '"Umlauf Scott"'

1. Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

Author

Cao, Mingyan, primary, Hussmann, G. Patrick, additional, Tao, Yeqing, additional, O’Connor, Ellen, additional, Parthemore, Conner, additional, Zhang-Hulsey, Diana, additional, Liu, Dengfeng, additional, Jiao, Yang, additional, Mel, Niluka de, additional, Prophet, Meagan, additional, Korman, Samuel, additional, Sonawane, Jaytee, additional, Grigoriadou, Christina, additional, Huang, Yue, additional, Umlauf, Scott, additional, and Chen, Xiaoyu, additional

Published
2023
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2. ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

Author

Baker, Alexander T., primary, Boyd, Ryan J., additional, Sarkar, Daipayan, additional, Teijeira-Crespo, Alicia, additional, Chan, Chun Kit, additional, Bates, Emily, additional, Waraich, Kasim, additional, Vant, John, additional, Wilson, Eric, additional, Truong, Chloe D., additional, Lipka-Lloyd, Magdalena, additional, Fromme, Petra, additional, Vermaas, Josh, additional, Williams, Dewight, additional, Machiesky, LeeAnn, additional, Heurich, Meike, additional, Nagalo, Bolni M., additional, Coughlan, Lynda, additional, Umlauf, Scott, additional, Chiu, Po-Lin, additional, Rizkallah, Pierre J., additional, Cohen, Taylor S., additional, Parker, Alan L., additional, Singharoy, Abhishek, additional, and Borad, Mitesh J., additional

Published
2021
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4. Potency Assay Variability Estimation in Practice.

Author

Li, Hang, Witkos, Tomasz M., Umlauf, Scott, and Thompson, Christopher

Subjects
*BIOLOGICAL assay, *DRUG development
Abstract

During the drug development process, testing potency plays an important role in the quality assessment required for the manufacturing and marketing of biologics. Due to multiple operational and biological factors, higher variability is usually observed in bioassays compared with physicochemical methods. In this paper, we discuss different sources of bioassay variability and how this variability can be statistically estimated. In addition, we propose an algorithm to estimate the variability of reportable results associated with different numbers of runs and their corresponding OOS rates under a given specification. Numerical experiments are conducted on multiple assay formats to elucidate the empirical distribution of bioassay variability. [ABSTRACT FROM AUTHOR]

Published
2024
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