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This study integrates various remote sensing datasets to analyze environmental changes and their impacts on ecosystems across Pakhtunkhwa Province in Pakistan. Precipitation data from the Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS) dataset, along with vegetation health assessments using Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) data from the Landsat dataset, were used to comprehensively analyze the impact of vegetation dynamics on environmental footprints (i.e., temperature, precipitation, and LST). Land use maps, generated through supervised classification of Landsat images from 1985 to 2023, highlight significant changes in different land use classes, including vegetation and forest cover. Bayesian Network Modelling (BNM) and Dummy Variable Regression (DVR) methods were employed to assess the impact of vegetation (using NDVI time series) on environmental footprint and forest cover in particular. The results suggest that the NDVI generally increase the cooling effect across most of the study area, indicating that higher vegetation density is linked to a decrease in temperatures. This inverse relationship is also apparent in the connection between the NDVI and the LST, depicting a negative trend in surface temperature over most of the pixels/districts. The regression coefficients for the NDVI and the LST vary across different pixels, ranging from −5.3839 °C to 5.2697 °C, with standard deviations from 2.057 °C to 5.138 °C, reflecting a variability in the strength of this cooling effect. Similarly, for the relationship between the NDVI and the LST, coefficients range from −7.1513 °C to 6.6322 °C, with standard deviations between 1.612 °C and 4.155 °C. In contrast, NDVI and precipitation show a positive relationship, with regression coefficients ranging from 4.1686 °C to 44.3932 °C and standard deviations between 2.242 °C and 8.224 °C, suggesting greater variability in precipitation corresponding to vegetation dynamics. Additionally, forest cover generally correlates positively with precipitation in most pixels, but the variability across pixels emphasizes the complex nature of these relationships. The study identified substantial fluctuations in land use categories over the decades, indicating environmental shifts driven by both natural and human factors. BNM demonstrated a positive impact of vegetation dynamics on precipitation and a negative impact on both temperature and LST. On the other hand, the increase in forest cover, particularly due to the Billion Tree Tsunami Project, has a significant impact on the environmental footprint identified through DVR. By combining high-resolution datasets with advanced statistical techniques, this study offers key insights into the dynamic interactions between land cover, vegetation, and climate in the study region, providing valuable information for sustainable environmental management. [ABSTRACT FROM AUTHOR]

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Sea conch peptide hydrolysate (CPH) was produced by enzymatic digestion of fresh conch meat with trypsin enzyme. To analyze the molecular composition, functional groups, and structural morphology of the hydrolysate, we employed liquid chromatography–mass spectrometry (LC–MS), Fourier‐transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Results confirmed that crude protein could be effectively digested by enzymes to generate peptides. In this study, we evaluated the bioactivities of CPH on dextran sulfate solution (DSS)‐induced colitis in mice. The findings demonstrated that CPH supplementation improved body weight, food and water intake, and colon length. The therapeutic efficacy and immunoregulatory effect of CPH were further determined. Our results exhibited that CPH treatment significantly ameliorated pathological symptoms by enhancing intestinal integrity, mucin production, and goblet cell count. Moreover, the immunoregulatory effect of CPH on mRNA expression levels of different pro‐ and anti‐inflammatory cytokines was determined. Results exhibited a decrease in the expression of pro‐inflammatory cytokines and an increase in anti‐inflammatory cytokines in the colon. Additionally, the CPH administration modulates the nuclear factor kappa B (NF‐κB) pathway, preventing DNA damage and cell death. Assays for apoptosis and DNA damage revealed that CPH reduced oxidative DNA damage and apoptosis. These findings highlight the immunomodulatory and treatment amelioration effect of CPH in reducing the severity of colitis. [ABSTRACT FROM AUTHOR]

The pyrolysis process of coconut residue and the activated carbon was investigated using thermogravimetric analysis in the range of 25 to 900 °C, with three altered heating rates: 3, 5, and 10 °C/min. The results of the thermal decomposition showed that it occurred in three distinct phases: dehydration, active pyrolysis, and passive pyrolysis. The derivative thermogravimetric analysis indicated that increasing the heating rate led to a shift in the maximum weight loss rate towards higher temperatures. To better understand the kinetics constraints, the Coats–Redfern method was applied to determine the activation energy (Ea) and the frequency factor (A). The activation energies for the pyrolysis process varied between 159.57 and 177.45 kJ/mol for RCR and from 132.62 to 147.1 kJ/mol for ACCR at different heating rates. Additionally, the physical properties of the samples were investigated using techniques like scanning electron microscopy and the Brunauer–Emmett–Teller surface analysis. The findings of the study demonstrated that the activation energies of the activated carbon were lower than those of the original biomass. Furthermore, the activation energy values achieved from the D1–D4 models were considered reliable, indicating that the D model was more suitable compared to other models for describing the pyrolysis process and predicting its kinetics. [ABSTRACT FROM AUTHOR]

Introduction: Vascular malignancies are categorized into benign hemangiomas, malignant angiosarcomas, and tumors of intermediate malignancy. Retiform hemangioendothelioma (RH) is one of the rare diagnoses belonging to the class of intermediate malignancies that was initially diagnosed. Case Presentation: In this case report, we have reported a rare case of RH, a locally aggressive, vascular tumor of malignant potential presenting at an unusual site. The most observed locations of this soft tissue tumor are skin and subcutaneous tissues of extremities; however, this case of RH was observed in an unusual site called pleura, which is a rare occurrence related to this tumor. The presence of cell surface markers like CD31 and ERG of vascular and endothelial origin and the presence of hobnail appearance of endothelial channels on the biopsy profile supported the vascular origin of the tumor; the clinical features and imaging studies further confirmed the diagnosis of RH. Conclusion: In this case report, a rare case of RH with an unusual site of origin was highlighted. RH is a vascular neoplasm; commonly observed sites of this vascular tumor were skin and subcutaneous tissue of the extremities; however, in this case, the site was unusually different, which was the pleura of the left lung. [ABSTRACT FROM AUTHOR]

In Northwestern Pakistan's rice-based cropping systems, the prevalent reliance on inorganic nitrogen fertilizers (INF) has led to insufficient nitrogen (N) contributions from soil organic manures (OM). This study aims to evaluate the impact of organic sources (OS), including animal manures (AM) and crop residues (CR), on crop growth rates (CGR) in a rice-wheat rotation. A two-year field experiment involving hybrid rice (Oryza sativa L., Pukhraj) was conducted in Batkhela, Khyber Pakhtunkhwa. Various OS and inorganic-N (urea) combinations were applied, emphasizing their influence on CGR. The findings highlight poultry manure (PM) application as the most impactful on CGR, while wheat straw (WS) application resulted in the lowest CGR among the six OS investigated. Additionally, the use of AM showcased superior CGR compared to CR. In the initial year, the highest CGR occurred, with 75% of N sourced from urea and 25% from OS. In the second year, a balanced 50% N application from each source yielded the highest CGR. Urea and PM demonstrated the most robust CGR among OS combinations, while urea and WS yielded the lowest. Notably, onion leaves, a cost-effective option, delivered promising results comparable to berseem residues, indicating their potential as organic manure, especially in sulfur-deficient soils. These findings underscore the viability of onion residue management as a cost-effective alternative to ammonium sulfate fertilizers with global applicability. The abstract recommends promoting organic sources, particularly poultry manure and onion leaves, alongside inorganic-N fertilizers to enhance CGR and reduce dependence on costly alternatives. However, further research and field trials are necessary to explore the long-term impacts of these organic sources on soil health, nutrient cycling, and the sustainability of rice-based cropping systems in Northwestern Pakistan and beyond. In conclusion, this study investigates the influence of organic sources on CGR in rice-wheat rotations, emphasizing the superiority of poultry manure and onion leaves. The findings highlight cost-effective alternatives to conventional fertilizers, emphasizing the need for further research to validate long-term sustainability and applicability beyond the study area. [ABSTRACT FROM AUTHOR]