Search

Your search keyword '"Turner, James M.A."' showing total 21 results
Start Over Author "Turner, James M.A." Publication Year Range Last 10 years
21 results on '"Turner, James M.A."'

2. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Author

Aitken, Jim, Allen, Zoe, Ambler, Rachel, Ambrose, Karen, Ashton, Emma, Avola, Alida, Balakrishnan, Samutheswari, Barns-Jenkins, Caitlin, Barr, Genevieve, Barrell, Sam, Basu, Souradeep, Beale, Rupert, Beesley, Clare, Bhardwaj, Nisha, Bibi, Shahnaz, Bineva-Todd, Ganka, Biswas, Dhruva, Blackman, Michael J., Bonnet, Dominique, Bowker, Faye, Broncel, Malgorzata, Brooks, Claire, Buck, Michael D., Buckton, Andrew, Budd, Timothy, Burrell, Alana, Busby, Louise, Bussi, Claudio, Butterworth, Simon, Byott, Matthew, Byrne, Fiona, Byrne, Richard, Caidan, Simon, Campbell, Joanna, Canton, Johnathan, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Carzaniga, Raffaella, Chandler, Natalie, Chen, Qu, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Clayton, Bobbi, Cobolli Gigli, Clementina, Collins, Zena, Cottrell, Sally, Crawford, Margaret, Cubitt, Laura, Cullup, Tom, Davies, Heledd, Davis, Patrick, Davison, Dara, Dearing, Vicky, Debaisieux, Solene, Diaz-Romero, Monica, Dibbs, Alison, Diring, Jessica, Driscoll, Paul C., D'Avola, Annalisa, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Evangelopoulos, Dimitrios, Faraway, Rupert, Fearns, Antony, Ferron, Aaron, Fidanis, Efthymios, Fitz, Dan, Fleming, James, Frampton, Daniel, Frederico, Bruno, Gaiba, Alessandra, Gait, Anthony, Gamblin, Steve, Gärtner, Kathleen, Gaul, Liam, Golding, Helen M., Goldman, Jacki, Goldstone, Robert, Gomez Dominguez, Belen, Gong, Hui, Grant, Paul R., Greco, Maria, Grobler, Mariana, Guedan, Anabel, Gutierrez, Maximiliano G., Hackett, Fiona, Hall, Ross, Halldorsson, Steinar, Harris, Suzanne, Hashim, Sugera, Hatipoglu, Emine, Healy, Lyn, Heaney, Judith, Herbst, Susanne, Hewitt, Graeme, Higgins, Theresa, Hindmarsh, Steve, Hirani, Rajnika, Hope, Joshua, Horton, Elizabeth, Hoskins, Beth, Howell, Michael, Howitt, Louise, Hoyle, Jacqueline, Htun, Mint R., Hubank, Michael, Huerga Encabo, Hector, Hughes, Deborah, Hughes, Jane, Huseynova, Almaz, Hwang, Ming-Shih, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jenkins, Lucy, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kelly, Gavin, Kiely, Louise, Teixeira, Anastacio King Spert, Kirk, Stuart, Kjaer, Svend, Knuepfer, Ellen, Komarov, Nikita, Kotzampaltiris, Paul, Kousis, Konstantinos, Krylova, Tammy, Kucharska, Ania, Labrum, Robyn, Lambe, Catherine, Lappin, Michelle, Lee, Stacey-Ann, Levett, Andrew, Levett, Lisa, Levi, Marcel, Liu, Hon Wing, Loughlin, Sam, Lu, Wei-Ting, MacRae, James I., Madoo, Akshay, Marczak, Julie A., Martensson, Mimmi, Martinez, Thomas, Marzook, Bishara, Matthews, John, Matz, Joachim M., McCall, Samuel, McCoy, Laura E., McKay, Fiona, McNamara, Edel C., Minutti, Carlos M., Mistry, Gita, Molina-Arcas, Miriam, Montaner, Beatriz, Montgomery, Kylie, Moore, Catherine, Moore, David, Moraiti, Anastasia, Moreira-Teixeira, Lucia, Mukherjee, Joyita, Naceur-Lombardelli, Cristina, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, Nurse, Paul, Nutan, Savita, Oedekoven, Caroline, O'Garra, Anne, O'Leary, Jean D., Olsen, Jessica, O'Neill, Olga, O'Reilly, Nicola, Suarez, Paula Ordonez, Osborne, Neil, Pabari, Amar, Pajak, Aleksandra, Papayannopoulos, Venizelos, Paraskevopoulou, Stavroula M, Patel, Namita, Patel, Yogen, Paun, Oana, Peat, Nigel, Peces-Barba Castano, Laura, Caballero, Ana Perez, Perez-Lloret, Jimena, Perrault, Magali S., Perrin, Abigail, Poh, Roy, Poirier, Enzo Z., Polke, James M., Pollitt, Marc, Prieto-Godino, Lucia, Proust, Alize, Puvirajasinghe, Clinda, Queval, Christophe, Ramachandran, Vijaya, Ramaprasad, Abhinay, Ratcliffe, Peter, Reed, Laura, Reis e Sousa, Caetano, Richardson, Kayleigh, Ridewood, Sophie, Roberts, Fiona, Roberts, Rowenna, Rodgers, Angela, Romero Clavijo, Pablo, Rosa, Annachiara, Rossi, Alice, Roustan, Chloe, Rowan, Andrew, Sahai, Erik, Sait, Aaron, Sala, Katarzyna, Sanchez, Emilie, Sanderson, Theo, Santucci, Pierre, Sardar, Fatima, Sateriale, Adam, Saunders, Jill A., Sawyer, Chelsea, Schlott, Anja, Schweighoffer, Edina, Segura-Bayona, Sandra, Shah Punatar, Rajvee, Shahmanesh, Maryam, Shaw, Joe, Silva Dos Santos, Mariana, Silvestre, Margaux, Singer, Matthew, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Steel, Louisa, Strange, Amy, Sullivan, Adrienne E., Tan, Michele S.Y., Tautz-Davis, Zoe H., Taylor, Effie, Taylor, Gunes, Taylor, Harriet B., Taylor-Beadling, Alison, Teixeira Subtil, Fernanda, Terré Torras, Berta, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Treeck, Moritz, Trojer, Hadija, Tsai, Ming-Han C., Turner, James M.A., Turner, Melanie, Ule, Jernej, Ulferts, Rachel, Vanloo, Sharon P., Veeriah, Selvaraju, Venkatesan, Subramanian, Vousden, Karen, Wack, Andreas, Walder, Claire, Walker, Philip A., Wang, Yiran, Ward, Sophia, Wenman, Catharina, Williams, Luke, Williams, Matthew J., Keong Wong, Wai, Wright, Joshua, Wu, Mary, Wynne, Lauren, Xiang, Zheng, Yap, Melvyn, Zagalak, Julian A., Zecchin, Davide, Zillwood, Rachel, Carthiyaniamma, Santhakumari, DeTisi, Jane, Dick, Julie, Hill, Andrea, Kipper, Karin, Kullar, Birinder, Norris, Sarah, Rugg-Gunn, Fergus, Salvatierra, Rebecca, Shaya, Gabriel, Sloan, Astrid, Singh, Priyanka, Varley, James, Whatley, Ben, Balestrini, Simona, Koepp, Matthias J., Gandhi, Sonia, Rickman, Hannah M., Shin, Gee Yen, Houlihan, Catherine F., Anders-Cannon, Jonny, Silvennoinen, Katri, Xiao, Fenglai, Zagaglia, Sara, Hudgell, Kirsty, Ziomek, Mariusz, Haimes, Paul, Sampson, Adam, Parker, Annie, Helen Cross, J., Pardington, Rosemarie, Nastouli, Eleni, Swanton, Charles, Sander, Josemir W., and Sisodiya, Sanjay M.

Published
2021
Full Text
View/download PDF

3. A conserved transcriptional program for MAIT cells across mammalian evolution

Author

Bugaut, Hélène, primary, El Morr, Yara, additional, Mestdagh, Martin, additional, Darbois, Aurélie, additional, Paiva, Rafael A., additional, Salou, Marion, additional, Perrin, Laetitia, additional, Fürstenheim, Mariela, additional, du Halgouet, Anastasia, additional, Bilonda-Mutala, Linda, additional, Le Gac, Anne-Laure, additional, Arnaud, Manon, additional, El Marjou, Ahmed, additional, Guerin, Coralie, additional, Chaiyasitdhi, Atitheb, additional, Piquet, Julie, additional, Smadja, David M., additional, Cieslak, Agata, additional, Ryffel, Bernhard, additional, Maciulyte, Valdone, additional, Turner, James M.A., additional, Bernardeau, Karine, additional, Montagutelli, Xavier, additional, Lantz, Olivier, additional, and Legoux, François, additional

Published
2023
Full Text
View/download PDF

5. Contributors

Author

Albakri, Aref, primary, AlMahameed, Soufian T., additional, Andršová, Irena, additional, Asirvatham, Samuel J., additional, Avari Silva, Jennifer N., additional, Bacharova, Ljuba, additional, Bagliani, Giuseppe, additional, Barakat, Rody, additional, Barakat, Michel M., additional, Barletta, Valentina, additional, Barthel, Petra, additional, Bébarová, Markéta, additional, Beck, Hiroko, additional, Belhassen, Bernard, additional, Bende, Girish, additional, Berkefeld, Anna, additional, Birgersdotter-Green, Ulrika, additional, Blinova, Ksenia, additional, Blomström-Lundqvist, Carina, additional, Bongiorni, Maria Grazia, additional, Brand, Thomas, additional, Bugiardini, Raffaele, additional, Bunch, T. Jared, additional, Castiglione, Alessandro, additional, Cenko, Edina, additional, Chatzidou, Sofia, additional, Chee, Jennifer, additional, Chelu, Mihail G., additional, Chen, Shih Ann, additional, Ciconte, Giuseppe, additional, Curtis, Anne B., additional, Curtis, Stephanie, additional, Cygankiewicz, Iwona, additional, Dalal, Aarti S., additional, Day, John D., additional, Della Tommasina, Veronica, additional, Deshmukh, Abhishek J., additional, Dilaveris, Polychronis, additional, Di Summa, Roberto, additional, Dogan, Mehmet, additional, Dong, Jun, additional, du Fay de Lavallaz, Jeanne, additional, Eckhardt, Lee L., additional, Efimova, Elena, additional, Ernst, Sabine, additional, Fawzy, Ameenathul M., additional, Gaita, Fiorenzo, additional, Garber, Libet, additional, Garnett, Christine, additional, Georgiopoulos, Georgios, additional, Gillis, Anne M., additional, Giustetto, Carla, additional, Gonzalez Corcia, M. Cecilia, additional, Haim, Moti, additional, Halliday, Brian P., additional, Hamdan, Mohamed H., additional, Hammersley, Daniel J., additional, Hartikainen, Juha E.K., additional, Haugaa, Kristina H., additional, Haukilahti, M. Anette E., additional, Hautala, Arto J., additional, Helánová, Kateřina, additional, Hnatkova, Katerina, additional, Hu, Yu-Feng, additional, Hu, Xiao, additional, Hurley, David, additional, Iwai, Sei, additional, Jacobs, Victoria, additional, Jacobson, Jason T., additional, James, Cynthia A., additional, Jiang, Hongying, additional, Jones, Camelle, additional, Jones, Richard E., additional, Junttila, M. Juhani, additional, Kadish, Alan H., additional, Karavirta, Laura, additional, Karim, Saima, additional, Karnad, Dilip, additional, Karunatilleke, Anne, additional, Kaufman, Elizabeth S., additional, Kenttä, Tuomas V., additional, Kezerle, Louise, additional, Khalil, Fouad M., additional, Klingenheben, Thomas, additional, Kloosterman, M., additional, Kontogiannis, Christos, additional, Kowlgi, Gurukripa N., additional, Kroman, Anne M., additional, Kutyifa, Valentina, additional, Lampert, Rachel, additional, Laukkanen, Jari, additional, Lee, Hyon Jae, additional, Leinveber, Pavel, additional, Leren, Ida S., additional, Lima, Fabio V., additional, Linde, Cecilia, additional, Locati, Emanuela T., additional, Macfarlane, Peter W., additional, Maclachlan, Hamish, additional, Mäkikallio, Timo H., additional, Malik, Marek, additional, Manfrini, Olivia, additional, Marashly, Qussay, additional, Margioula, Eleni, additional, McCaffrey, James A., additional, Mehra, Nandini S., additional, Milman, Anat, additional, Moharem-Elgamal, Sarah, additional, Mujović, Nebojša, additional, Nagarajan, Darbhamulla V., additional, Nemec, Petr, additional, Novotný, Tomáš, additional, O'Neill, Louisa, additional, Odening, Katja E., additional, Panicker, Gopi Krishna, additional, Pappone, Carlo, additional, Patton, Kristen K., additional, Pelter, Michele M., additional, Peyracchia, Mattia, additional, Potpara, Tratjana, additional, Powell, Benjamin E., additional, Preben, Bjerregaard, additional, Sarkozy, Andrea, additional, Schneider, Birke, additional, Segreti, Luca, additional, Selzman, Kimberly A., additional, Sharma, Sanjay, additional, Šišáková, Martina, additional, Spears, D.A., additional, Spera, Francesco Raffaele, additional, Špinarová, Lenka, additional, Stein, Phyllis K., additional, Stergiopoulos, Kathleen, additional, Sticherling, Christian, additional, Stuart, Graham, additional, Sugrue, Alan M., additional, Svennberg, Emma, additional, Tada, Hiroshi, additional, Tampakis, Konstantinos, additional, Tereshchenko, Larisa G., additional, Terho, Henri, additional, te Riele, Anneline S.J.M., additional, Tikkanen, Jani T., additional, Toman, Ondřej, additional, Toso, Elisabetta, additional, Tracy, Cynthia M., additional, Trifunovic, Danijela, additional, Turner, James M.A., additional, Vaidya, Vaibhav R., additional, Van Gelder, Isabelle C., additional, Vasavan, Tharni, additional, Verrier, Richard L., additional, Veseli, Granit, additional, Vicente, Jose, additional, Williamson, Catherine, additional, Wu, Wendy W., additional, YH. Lip, Gregory, additional, Younis, Arwa, additional, Zabel, Markus, additional, Zathar, Zafraan, additional, Zegre-Hemsey, Jessica K., additional, Zheng, Nan, additional, and Zucchelli, Giulio, additional

Published
2020
Full Text
View/download PDF

7. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

Author

Douglas, Charlotte, Maciulyte, Valdone, Zohren, Jasmin, Snell, Daniel M., Mahadevaiah, Shantha K., Ojarikre, Obah A., Ellis, Peter J.I., Turner, James M.A., Douglas, Charlotte, Maciulyte, Valdone, Zohren, Jasmin, Snell, Daniel M., Mahadevaiah, Shantha K., Ojarikre, Obah A., Ellis, Peter J.I., and Turner, James M.A.

Abstract

Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is considerable. Using the mouse as a model, we develop a synthetic lethal, bicomponent CRISPR-Cas9 strategy that produces male-or female-only litters with one hundred percent efficiency. Strikingly, we observe a degree of litter size compensation relative to control matings, indicating that our system has the potential to increase the yield of the desired sex in comparison to standard breeding designs. The bicomponent system can also be repurposed to generate postnatal sex-specific phenotypes. Our approach, harnessing the technological applications of CRISPR-Cas9, may be applicable to other vertebrate species, and provides strides towards ethical improvements for laboratory research and agriculture.

Published
2021

9. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Author

Balestrini, Simona, primary, Koepp, Matthias J., additional, Gandhi, Sonia, additional, Rickman, Hannah M., additional, Shin, Gee Yen, additional, Houlihan, Catherine F., additional, Anders-Cannon, Jonny, additional, Silvennoinen, Katri, additional, Xiao, Fenglai, additional, Zagaglia, Sara, additional, Hudgell, Kirsty, additional, Ziomek, Mariusz, additional, Haimes, Paul, additional, Sampson, Adam, additional, Parker, Annie, additional, Helen Cross, J., additional, Pardington, Rosemarie, additional, Nastouli, Eleni, additional, Swanton, Charles, additional, Sander, Josemir W., additional, Sisodiya, Sanjay M., additional, Aitken, Jim, additional, Allen, Zoe, additional, Ambler, Rachel, additional, Ambrose, Karen, additional, Ashton, Emma, additional, Avola, Alida, additional, Balakrishnan, Samutheswari, additional, Barns-Jenkins, Caitlin, additional, Barr, Genevieve, additional, Barrell, Sam, additional, Basu, Souradeep, additional, Beale, Rupert, additional, Beesley, Clare, additional, Bhardwaj, Nisha, additional, Bibi, Shahnaz, additional, Bineva-Todd, Ganka, additional, Biswas, Dhruva, additional, Blackman, Michael J., additional, Bonnet, Dominique, additional, Bowker, Faye, additional, Broncel, Malgorzata, additional, Brooks, Claire, additional, Buck, Michael D., additional, Buckton, Andrew, additional, Budd, Timothy, additional, Burrell, Alana, additional, Busby, Louise, additional, Bussi, Claudio, additional, Butterworth, Simon, additional, Byott, Matthew, additional, Byrne, Fiona, additional, Byrne, Richard, additional, Caidan, Simon, additional, Campbell, Joanna, additional, Canton, Johnathan, additional, Cardoso, Ana, additional, Carter, Nick, additional, Carvalho, Luiz, additional, Carzaniga, Raffaella, additional, Chandler, Natalie, additional, Chen, Qu, additional, Cherepanov, Peter, additional, Churchward, Laura, additional, Clark, Graham, additional, Clayton, Bobbi, additional, Cobolli Gigli, Clementina, additional, Collins, Zena, additional, Cottrell, Sally, additional, Crawford, Margaret, additional, Cubitt, Laura, additional, Cullup, Tom, additional, Davies, Heledd, additional, Davis, Patrick, additional, Davison, Dara, additional, Dearing, Vicky, additional, Debaisieux, Solene, additional, Diaz-Romero, Monica, additional, Dibbs, Alison, additional, Diring, Jessica, additional, Driscoll, Paul C., additional, D'Avola, Annalisa, additional, Earl, Christopher, additional, Edwards, Amelia, additional, Ekin, Chris, additional, Evangelopoulos, Dimitrios, additional, Faraway, Rupert, additional, Fearns, Antony, additional, Ferron, Aaron, additional, Fidanis, Efthymios, additional, Fitz, Dan, additional, Fleming, James, additional, Frampton, Daniel, additional, Frederico, Bruno, additional, Gaiba, Alessandra, additional, Gait, Anthony, additional, Gamblin, Steve, additional, Gärtner, Kathleen, additional, Gaul, Liam, additional, Golding, Helen M., additional, Goldman, Jacki, additional, Goldstone, Robert, additional, Gomez Dominguez, Belen, additional, Gong, Hui, additional, Grant, Paul R., additional, Greco, Maria, additional, Grobler, Mariana, additional, Guedan, Anabel, additional, Gutierrez, Maximiliano G., additional, Hackett, Fiona, additional, Hall, Ross, additional, Halldorsson, Steinar, additional, Harris, Suzanne, additional, Hashim, Sugera, additional, Hatipoglu, Emine, additional, Healy, Lyn, additional, Heaney, Judith, additional, Herbst, Susanne, additional, Hewitt, Graeme, additional, Higgins, Theresa, additional, Hindmarsh, Steve, additional, Hirani, Rajnika, additional, Hope, Joshua, additional, Horton, Elizabeth, additional, Hoskins, Beth, additional, Howell, Michael, additional, Howitt, Louise, additional, Hoyle, Jacqueline, additional, Htun, Mint R., additional, Hubank, Michael, additional, Huerga Encabo, Hector, additional, Hughes, Deborah, additional, Hughes, Jane, additional, Huseynova, Almaz, additional, Hwang, Ming-Shih, additional, Instrell, Rachael, additional, Jackson, Deborah, additional, Jamal-Hanjani, Mariam, additional, Jenkins, Lucy, additional, Jiang, Ming, additional, Johnson, Mark, additional, Jones, Leigh, additional, Kanu, Nnennaya, additional, Kassiotis, George, additional, Kelly, Gavin, additional, Kiely, Louise, additional, Teixeira, Anastacio King Spert, additional, Kirk, Stuart, additional, Kjaer, Svend, additional, Knuepfer, Ellen, additional, Komarov, Nikita, additional, Kotzampaltiris, Paul, additional, Kousis, Konstantinos, additional, Krylova, Tammy, additional, Kucharska, Ania, additional, Labrum, Robyn, additional, Lambe, Catherine, additional, Lappin, Michelle, additional, Lee, Stacey-Ann, additional, Levett, Andrew, additional, Levett, Lisa, additional, Levi, Marcel, additional, Liu, Hon Wing, additional, Loughlin, Sam, additional, Lu, Wei-Ting, additional, MacRae, James I., additional, Madoo, Akshay, additional, Marczak, Julie A., additional, Martensson, Mimmi, additional, Martinez, Thomas, additional, Marzook, Bishara, additional, Matthews, John, additional, Matz, Joachim M., additional, McCall, Samuel, additional, McCoy, Laura E., additional, McKay, Fiona, additional, McNamara, Edel C., additional, Minutti, Carlos M., additional, Mistry, Gita, additional, Molina-Arcas, Miriam, additional, Montaner, Beatriz, additional, Montgomery, Kylie, additional, Moore, Catherine, additional, Moore, David, additional, Moraiti, Anastasia, additional, Moreira-Teixeira, Lucia, additional, Mukherjee, Joyita, additional, Naceur-Lombardelli, Cristina, additional, Nelson, Aileen, additional, Nicod, Jerome, additional, Nightingale, Luke, additional, Nofal, Stephanie, additional, Nurse, Paul, additional, Nutan, Savita, additional, Oedekoven, Caroline, additional, O'Garra, Anne, additional, O'Leary, Jean D., additional, Olsen, Jessica, additional, O'Neill, Olga, additional, O'Reilly, Nicola, additional, Suarez, Paula Ordonez, additional, Osborne, Neil, additional, Pabari, Amar, additional, Pajak, Aleksandra, additional, Papayannopoulos, Venizelos, additional, Paraskevopoulou, Stavroula M, additional, Patel, Namita, additional, Patel, Yogen, additional, Paun, Oana, additional, Peat, Nigel, additional, Peces-Barba Castano, Laura, additional, Caballero, Ana Perez, additional, Perez-Lloret, Jimena, additional, Perrault, Magali S., additional, Perrin, Abigail, additional, Poh, Roy, additional, Poirier, Enzo Z., additional, Polke, James M., additional, Pollitt, Marc, additional, Prieto-Godino, Lucia, additional, Proust, Alize, additional, Puvirajasinghe, Clinda, additional, Queval, Christophe, additional, Ramachandran, Vijaya, additional, Ramaprasad, Abhinay, additional, Ratcliffe, Peter, additional, Reed, Laura, additional, Reis e Sousa, Caetano, additional, Richardson, Kayleigh, additional, Ridewood, Sophie, additional, Roberts, Fiona, additional, Roberts, Rowenna, additional, Rodgers, Angela, additional, Romero Clavijo, Pablo, additional, Rosa, Annachiara, additional, Rossi, Alice, additional, Roustan, Chloe, additional, Rowan, Andrew, additional, Sahai, Erik, additional, Sait, Aaron, additional, Sala, Katarzyna, additional, Sanchez, Emilie, additional, Sanderson, Theo, additional, Santucci, Pierre, additional, Sardar, Fatima, additional, Sateriale, Adam, additional, Saunders, Jill A., additional, Sawyer, Chelsea, additional, Schlott, Anja, additional, Schweighoffer, Edina, additional, Segura-Bayona, Sandra, additional, Shah Punatar, Rajvee, additional, Shahmanesh, Maryam, additional, Shaw, Joe, additional, Silva Dos Santos, Mariana, additional, Silvestre, Margaux, additional, Singer, Matthew, additional, Snell, Daniel M., additional, Song, Ok-Ryul, additional, Spyer, Moira J., additional, Steel, Louisa, additional, Strange, Amy, additional, Sullivan, Adrienne E., additional, Tan, Michele S.Y., additional, Tautz-Davis, Zoe H., additional, Taylor, Effie, additional, Taylor, Gunes, additional, Taylor, Harriet B., additional, Taylor-Beadling, Alison, additional, Teixeira Subtil, Fernanda, additional, Terré Torras, Berta, additional, Toolan-Kerr, Patrick, additional, Torelli, Francesca, additional, Toteva, Tea, additional, Treeck, Moritz, additional, Trojer, Hadija, additional, Tsai, Ming-Han C., additional, Turner, James M.A., additional, Turner, Melanie, additional, Ule, Jernej, additional, Ulferts, Rachel, additional, Vanloo, Sharon P., additional, Veeriah, Selvaraju, additional, Venkatesan, Subramanian, additional, Vousden, Karen, additional, Wack, Andreas, additional, Walder, Claire, additional, Walker, Philip A., additional, Wang, Yiran, additional, Ward, Sophia, additional, Wenman, Catharina, additional, Williams, Luke, additional, Williams, Matthew J., additional, Keong Wong, Wai, additional, Wright, Joshua, additional, Wu, Mary, additional, Wynne, Lauren, additional, Xiang, Zheng, additional, Yap, Melvyn, additional, Zagalak, Julian A., additional, Zecchin, Davide, additional, Zillwood, Rachel, additional, Carthiyaniamma, Santhakumari, additional, DeTisi, Jane, additional, Dick, Julie, additional, Hill, Andrea, additional, Kipper, Karin, additional, Kullar, Birinder, additional, Norris, Sarah, additional, Rugg-Gunn, Fergus, additional, Salvatierra, Rebecca, additional, Shaya, Gabriel, additional, Sloan, Astrid, additional, Singh, Priyanka, additional, Varley, James, additional, and Whatley, Ben, additional

Published
2021
Full Text
View/download PDF

13. DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Author

ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., Turner, James M.A., Developmental Biology, Sub Developmental Biology, Developmental Biology, Sub Developmental Biology, Obstetrics and Gynaecology, Center for Reproductive Medicine, and ARD - Amsterdam Reproduction and Development

Subjects
Male, 0301 basic medicine, Ataxia Telangiectasia Mutated Proteins, Histones, Mice, 03 medical and health sciences, Spermatocytes, X Chromosome Inactivation, Homologous chromosome, medicine, Animals, Gene silencing, DNA Breaks, Double-Stranded, Spermatogenesis, General, X chromosome, Mice, Knockout, Genetics, Sex Chromosomes, Multidisciplinary, biology, BRCA1 Protein, Tumor Suppressor Proteins, Synapsis, Biological Sciences, Spermatids, Spermatozoa, Meiotic silencing, Spermatogonia, Chromosome Pairing, Meiosis, 030104 developmental biology, Histone, medicine.anatomical_structure, H2AFX, Premature chromosome condensation, biology.protein, DNA damage, TOPBP1, Carrier Proteins, Germ cell
Abstract

Meiotic synapsis and recombination between homologs permits the formation of cross-overs that are essential for generating chromosomally balanced sperm and eggs. In mammals, surveillance mechanisms eliminate meiotic cells with defective synapsis, thereby minimizing transmission of aneuploidy. One such surveillance mechanism is meiotic silencing, the inactivation of genes located on asynapsed chromosomes, via ATR-dependent serine-139 phosphorylation of histone H2AFX (gamma H2AFX). Stimulation of ATR activity requires direct interaction with an ATR activation domain (AAD)-containing partner. However, which partner facilitates the meiotic silencing properties of ATR is unknown. Focusing on the best-characterized example of meiotic silencing, meiotic sex chromosome inactivation, we reveal this AAD-containing partner to be the DNA damage and checkpoint protein TOPBP1. Conditional TOPBP1 deletion during pachynema causes germ cell elimination associated with defective X chromosome gene silencing and sex chromosome condensation. TOPBP1 is essential for localization to the X chromosome of silencing "sensors," including BRCA1, and effectors, including ATR, gamma H2AFX, and canonical repressive histone marks. We present evidence that persistent DNA double-strand breaks act as silencing initiation sites. Our study identifies TOPBP1 as a critical factor in meiotic sex chromosome silencing

Published
2017

16. A conserved transcriptional program for MAIT cells across mammalian evolution

Author

Bugaut, Hélène, El Morr, Yara, Mestdagh, Martin, Darbois, Aurélie, Paiva, Rafael A., Salou, Marion, Perrin, Laetitia, Fürstenheim, Mariela, du Halgouet, Anastasia, Bilonda-Mutala, Linda, Le Gac, Anne-Laure, Arnaud, Manon, El Marjou, Ahmed, Guerin, Coralie, Chaiyasitdhi, Atitheb, Piquet, Julie, Smadja, David M., Cieslak, Agata, Ryffel, Bernhard, Maciulyte, Valdone, Turner, James M.A., Bernardeau, Karine, Montagutelli, Xavier, Lantz, Olivier, and Legoux, François

Abstract

Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features remain unidentified. Using species-specific tetramers coupled to single-cell RNA sequencing, we characterized MAIT cell development in six species spanning 110 million years of evolution. Cross-species analyses revealed conserved transcriptional events underlying MAIT cell maturation, marked by ZBTB16 induction in all species. MAIT cells in human, sheep, cattle, and opossum acquired a shared type-1/17 transcriptional program, reflecting ancestral features. This program was also acquired by human iNKT cells, indicating common differentiation for innate-like T cells. Distinct type-1 and type-17 MAIT subsets developed in rodents, including pet mice and genetically diverse mouse strains. However, MAIT cells further matured in mouse intestines to acquire a remarkably conserved program characterized by concomitant expression of type-1, type-17, cytotoxicity, and tissue-repair genes. Altogether, the study provides a unifying view of the transcriptional features of innate-like T cells across evolution.

Published
2024
Full Text
View/download PDF

17. ATR is a multifunctional regulator of male mouse meiosis

Author

Widger, Alexander, primary, Mahadevaiah, Shantha K., additional, Lange, Julian, additional, ElInati, Elias, additional, Zohren, Jasmin, additional, Hirota, Takayuki, additional, Pacheco, Sarai, additional, Maldonado-Linares, Andros, additional, Stanzione, Marcello, additional, Ojarikre, Obah, additional, Maciulyte, Valdone, additional, de Rooij, Dirk G., additional, Tóth, Attila, additional, Roig, Ignasi, additional, Keeney, Scott, additional, and Turner, James M.A., additional

Published
2018
Full Text
View/download PDF

18. DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Author

Developmental Biology, Sub Developmental Biology, ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., Turner, James M.A., Developmental Biology, Sub Developmental Biology, ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., and Turner, James M.A.

Published
2017

21. Enhancer Evolution across 20 Mammalian Species

Author

Villar, Diego, primary, Berthelot, Camille, additional, Aldridge, Sarah, additional, Rayner, Tim F., additional, Lukk, Margus, additional, Pignatelli, Miguel, additional, Park, Thomas J., additional, Deaville, Robert, additional, Erichsen, Jonathan T., additional, Jasinska, Anna J., additional, Turner, James M.A., additional, Bertelsen, Mads F., additional, Murchison, Elizabeth P., additional, Flicek, Paul, additional, and Odom, Duncan T., additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results