1. Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors
- Author
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Guiquan Zhu, Chuanshi He, Linlin Wang, and Ling Li
- Subjects
GAS6, growth retardant specific protein 6 ,Cancer Research ,ER, estrogen receptor ,SACC, salivary adenoid cystic carcinoma ,TNFR1, tumor necrosis factor receptor 1 ,HPLF, human periodontal ligament fibroblast ,MSC, mesenchymal stem cell ,Review ,FGF5, fibroblast growth factor 5 ,HNSCC, head and neck squamous cell carcinoma ,NID1, Nidogen 1 ,Signal transduction ,Metastasis ,lncRNA, long non-coding RNA ,Extracellular matrix ,EZH2, enhancer of zeste homolog 2 ,HUVEC, human umbilical vein endothelial cell ,GDF15, growth differentiation factor 15 ,RC254-282 ,Treg, cell regulatory T cell ,ncRNA, non-coding RNA ,VASH1, vasohibin 1 ,CAV1, caveolin 1 ,LIF, leukemia inhibitory factor ,PDGFRS, platelet-derived growth factor receptor ,TME, tumor microenvironment ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,FAP, fibroblast activating protein ,Extracellular vesicle ,VEGF, vascular endothelial growth factor ,ECM, extracellular matrix ,MCC, Merkel cell carcinogenic ,Oncology ,Tumor microenvironment ,CRC, colorectal cancer ,MVB, multivesicular body ,TP53InP1, TP53-induced nucleoprotein 1 ,CSCC, cervical squamous cell carcinoma ,EMT, epithelial-mesenchymal transition ,JAK, Janus kinase ,Stromal cell ,NGF, nerve growth factor ,PRSC, prostatic stromal cell ,Biology ,TNBC, triple-negative breast cancer ,CTGF, connective tissue growth factor ,α-SMA, α-smooth muscle actin ,CM, conditioned medium ,EV, extracellular vesicle ,medicine ,OSCC, oral squamous cell carcinoma ,FN, fibronectin ,tTG, tissue transglutaminase ,Cancer-associated fibroblasts ,CAF, cancer-associated fibroblast ,ILV, intracavinal vesicle ,CCAL, colorectal cancer-associated lncRNA ,HL, Hodgkin's lymphoma ,medicine.disease ,SRF, serum response factor ,YAP1, YES-associated protein 1 ,CYR61, cysteine-rich angiogenesis inducer 61 ,PAF, paracancerous fibroblast ,SNARE, soluble NSF-attachment protein receptor ,Tumor progression ,Cancer cell ,Cancer research ,Cancer-Associated Fibroblasts ,CSD, CAV1 scaffolding domain ,HGF, hepatocyte growth factor ,HCC, hepatocellular carcinoma - Abstract
Highlights • EVs mediate the interaction between tumor and stromal cells in the TME. • Tumors mediate CAF-like activation of stromal cells through EVs. • CAF-derived EVs promote tumor proliferation, metastasis and therapeutic resistance., Communication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communication medium between tumors and CAFs. Tumors regulate the activation of CAFs by secreting EVs. Conversely, CAFs can also affect tumor proliferation, metastasis, and therapeutic resistance through EVs. Here, we will classify EV cargoes and discuss the role of EV-mediated interactions between CAFs and tumors, reviewing current knowledge in combination with our confirmed results.
- Published
- 2021