Search

Your search keyword '"Tran, Tram T."' showing total 50 results
Start Over Author "Tran, Tram T." Publication Year Range Last 10 years
50 results on '"Tran, Tram T."'

4. Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection

Author

Lau, Daryl T-Y., Chung, Raymond T., Roberts, Lewis R., Hassan, Mohamed A., Lisker-Melman, Mauricio, Wong, David K., Juan, Joshua, Yim, Colina, Patel, Keyur, Murakami, Carol S., Do, Son, Han, Steven-Huy B., Tran, Tram T., Khalili, Mandana, Cooper, Stewart L., Fontana, Robert J., Tsai, Naoky, Younoszai, Barak, Muir, Andrew, Evon, Donna, Darling, Jama M., Carithers, Robert C., Shuhart, Margaret, Kowdley, Kris V., Wang, Chia C., Sterling, Richard K., Ghany, Marc G., Liang, T. Jake, Hoofnagle, Jay H., Doo, Edward, Chang, Kyong-Mi, Park, Jang-June, Wahed, Abdus, Cloonan, Yona, Kleiner, David, Brahmania, Mayur, Lombardero, Manuel, Hansen, Bettina E., Terrault, Norah A., Lok, Anna S., Perrillo, Robert P., Belle, Steven H., Di Bisceglie, Adrian M., Feld, Jordan J., Lee, William M., Fried, Michael W., and Janssen, Harry L.A.

Published
2019
Full Text
View/download PDF

6. Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Author

Ghany, Marc G, Perrillo, Robert, Li, Ruosha, Belle, Steven H, Janssen, Harry LA, Terrault, Norah A, Shuhart, Margaret C, Lau, Daryl T-Y, Kim, W Ray, Fried, Michael W, Sterling, Richard K, Di Bisceglie, Adrian M, Han, Steven-Huy B, Ganova-Raeva, Lilia Milkova, Chang, Kyong-Mi, Lok, Anna Suk-Fong, Network, Hepatitis B Research, Chung, Raymond T, Roberts, Lewis R, Smith, Coleman I, Lisker-Melman, Mauricio, Wong, David K, Juan, Joshua, Feld, Jordan, Yim, Colina, Heathcoate, Jenny, Lee, William M, Do, Son, Tran, Tram T, Khalili, Mandana, Cooper, Stewart L, Fontana, Robert J, Tsai, Naoky, Patel, Keyur, Evon, Donna, Carithers, Robert C, Kowdley, Kris V, Wang, Chia C, Liang, T Jake, Park, Jang-June, Wahed, Abdus, Kleiner, David, Afdhal, Nezam, Javaid, Asad, Niu, Jianghe, Han, Johanna, Nasser, Imad, Stahler, Alisha C, Stadheim, Linda, Hassan, Mohamed, King, Debra L, Nagy, Rosemary A, La, Danie, Liu, Lucie, Minshall, Stacey, Bass, Sheila, French, Samuel, Peacock, Velma, Ungermann, Ashley, Ayala, Claudia, Olson, Emma, Lau, Ivy, Podolskaya, Veronika, DeVole, Nata, McKenna, Barbara, Oberhelman, Kelly, Kaza, Sravanthi, Rodd, Cassandra, Huddleston, Leslie, Poerzgen, Peter, Darling, Jama M, Barritt, A Sidney, Marsh, Tiffany, Metheny, Vikki, Cardona, Danielle, Luketic, Velimir A, Smith, Paula G, Hofmann, Charlotte, Mathisen, Terri, Strom, Susan, Mooney, Jody, Cardona-Gonzalez, Lupita, Fryzek, Nancy, Rivera, Elenita, Morris, Nevitt, Haynes-Williams, Vanessa, Valiga, Mary E, Torrey, Keith, Levine, Danielle, Keith, James, Betts, Michael, Montaner, Luis J, Teo, Chong-Gee, Khudyakov, Yury, Punkova, Lili T, Cloonan, Yona, Danielson, Michelle, Haller, Tamara, Johnson, Geoffrey, and Kelley, Stephanie

Subjects
Liver Disease, Infectious Diseases, Hepatitis, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Hepatitis - B, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Canada, Emigrants and Immigrants, Female, Genotype, Hepatitis B virus, Hepatitis B, Chronic, Humans, Male, Middle Aged, United States, Young Adult, HBeAg, Chronic Hepatitis B Virus Infection, USA, ALT, Hepatitis B Research Network, Clinical Sciences, Gastroenterology & Hepatology
Abstract

Background & aimsChronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.MethodsThe HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America.ResultsHalf of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range.ConclusionsThe HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America.

Published
2015

7. Deferred treatment with sofosbuvir–velpatasvir–voxilaprevir for patients with chronic hepatitis C virus who were previously treated with an NS5A inhibitor: an open-label substudy of POLARIS-1

Author

Bourlière, Marc, Gordon, Stuart C, Schiff, Eugene R, Tran, Tram T, Ravendhran, Natarajan, Landis, Charles S, Hyland, Robert H, Stamm, Luisa M, Zhang, Jie, Dvory-Sobol, Hadas, Subramanian, G Mani, Brainard, Diana M, McHutchison, John G, Serfaty, Lawrence, Thompson, Alex J, Sepe, Thomas E, Curry, Michael P, Reddy, K Rajender, and Manns, Michael P

Published
2018
Full Text
View/download PDF

13. Contributors

Author

Allampati, Sanath, primary, Ayles, Helen M., additional, Bacon, Bruce R., additional, Bailey, Sarah Lou, additional, Balistreri, William F., additional, Bang, Ji Young, additional, Benias, Petros C., additional, Berenguer, Marina, additional, Bethea, Emily D., additional, Bhamidimarri, Kalyan Ram, additional, Bowlus, Christopher L., additional, Cardenas, Andres, additional, Carrion, Andres F., additional, Choi, Steve S., additional, Chopra, Sanjiv, additional, Chung, Raymond T., additional, Cobbold, Jeremy F.L., additional, Curry, Michael P., additional, Czaja, Albert J., additional, de Castro, Teresita Gomez, additional, deLemos, Andrew S., additional, Di Bisceglie, Adrian M., additional, Diehl, Anna Mae, additional, Fontana, Robert J., additional, Friedman, Lawrence S., additional, Ginès, Pere, additional, Grace, Norman D., additional, Han, Steven-Huy B., additional, Hirschfield, Gideon M., additional, House, Michael G., additional, Waasdorp Hurtado, Christine E., additional, Jacobson, Ira M., additional, Kowdley, Kris V., additional, Lai, Michelle, additional, Lefkowitch, Jay H., additional, Lertudomphonwanit, Chatmanee, additional, Lewis, James H., additional, Lillemoe, Keith D., additional, Lo Re, Vincent, additional, Manickavasagan, Hanisha, additional, Martin, Paul, additional, Mayo, Marlyn J., additional, Mitchell, Mack C., additional, Mullen, Kevin D., additional, Muñoz, Santiago J., additional, Neuschwander-Tetri, Brent A., additional, Nguyen, Kelvin T., additional, Patidar, Kavish R., additional, Pringle, Patricia, additional, Procaccini, Nicholas J., additional, Puleo, James, additional, Reddy, K. Rajender, additional, Rosen, Hugo R., additional, Sanyal, Arun J., additional, Schilsky, Michael L., additional, Sherman, Stuart, additional, Sokol, Ronald J., additional, Spengler, Erin, additional, Stoffel, Elena M., additional, Summerfield, John A., additional, Tapper, Elliot B., additional, Tran, Tram T., additional, Vinaixa, Carmen, additional, Webb, Gwilym J., additional, Weine, Douglas M., additional, Wolf, Jacqueline L., additional, Wong, Florence S., additional, and Zhang, Wei, additional

Published
2018
Full Text
View/download PDF

15. Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Author

Chung, Raymond T., Roberts, Lewis R., Smith, Coleman I., Lisker-Melman, Mauricio, Wong, David K., Juan, Joshua, Feld, Jordan, Yim, Colina, Heathcoate, Jenny, Lee, William M., Do, Son, Tran, Tram T., Khalili, Mandana, Cooper, Stewart L., Fontana, Robert J., Tsai, Naoky, Patel, Keyur, Evon, Donna, Carithers, Robert C., Kowdley, Kris V., Wang, Chia C., Liang, T. Jake, Park, Jang-June, Wahed, Abdus, Kleiner, David, Afdhal, Nezam, Javaid, Asad, Niu, Jianghe, Han, Johanna, Nasser, Imad, Stahler, Alisha C., Stadheim, Linda, Hassan, Mohamed, King, Debra L., Nagy, Rosemary A., La, Danie, Liu, Lucie, Minshall, Stacey, Bass, Sheila, French, Samuel, Peacock, Velma, Ungermann, Ashley, Ayala, Claudia, Olson, Emma, Lau, Ivy, Podolskaya, Veronika, DeVole, Nata, McKenna, Barbara, Oberhelman, Kelly, Kaza, Sravanthi, Rodd, Cassandra, Huddleston, Leslie, Poerzgen, Peter, Darling, Jama M., Barritt, A. Sidney, Marsh, Tiffany, Metheny, Vikki, Cardona, Danielle, Luketic, Velimir A., Smith, Paula G., Hofmann, Charlotte, Mathisen, Terri, Strom, Susan, Mooney, Jody, Cardona-Gonzalez, Lupita, Fryzek, Nancy, Rivera, Elenita, Morris, Nevitt, Haynes-Williams, Vanessa, Valiga, Mary E., Torrey, Keith, Levine, Danielle, Keith, James, Betts, Michael, Montaner, Luis J., Teo, Chong-Gee, Khudyakov, Yury, Punkova, Lili T., Cloonan, Yona, Danielson, Michelle, Haller, Tamara, Johnson, Geoffrey, Kelley, Stephanie, Lawlor, Sharon, Li, Ruosha, Lombardero, Manuel, MacGregor, Joan M., Pelesko, Andrew, Stoliker, Donna, Walters, Barbara, Zadorozny, Ella, Ghany, Marc G., Perrillo, Robert, Belle, Steven H., Janssen, Harry L.A., Terrault, Norah A., Shuhart, Margaret C., Lau, Daryl T.-Y., Kim, W. Ray, Fried, Michael W., Sterling, Richard K., Di Bisceglie, Adrian M., Han, Steven-Huy B., Ganova-Raeva, Lilia Milkova, Chang, Kyong-Mi, and Lok, Anna Suk-Fong

Published
2015
Full Text
View/download PDF

18. Prevalence of hepatitis B antiviral drug resistance variants in North American patients with chronic hepatitis B not receiving antiviral treatment

Author

Lok, A. S., Ganova‐Raeva, L., Cloonan, Y., Punkova, L., Lin, H.‐H. S., Lee, W. M., Ghany, M. G., Lau, Daryl T‐Y, Chung, Raymond T., Roberts, Lewis R., Smith, Coleman I., Di Bisceglie, Adrian M., ‐Melman, Mauricio, Janssen, L. A., Wong, David K., Juan, Joshua, Feld, Jordan, Yim, Colina, Heathcote, Jenny, Perrillo, Robert, Do, Son, Han, Steven‐Huy B., Tran, Tram T., Terrault, Norah A., Khalili, Mandana, Cooper, Stewart L., Fontana, Robert J., Tsai, Naoky, Fried, Michael W., Patel, Keyur, Evon, Donna, Carithers, Robert C., Shuhart, Margaret, Kowdley, Kris V., Wang, Chia C., Sterling, Richard K., Jake Liang, T., Hoofnagle, Jay H., Doo, Edward, Chang, Kyong‐Mi, Park, Jang‐June, Belle, Steven H., Wahed, Abdus, and Kleiner, David

Published
2017
Full Text
View/download PDF

23. Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection

Author

Feld, Jordan J., Jacobson, Ira M., Hézode, Christophe, Asselah, Tarik, Ruane, Peter J., Gruener, Norbert, Abergel, Armand, Mangia, Alessandra, Lai, Ching-Lung, Chan, Henry L.Y., Mazzotta, Francesco, Moreno, Christophe, Yoshida, Eric, Shafran, Stephen D., Towner, William J., Tran, Tram T., McNally, John, Osinusi, Anu, Svarovskaia, Evguenia, Zhu, Yanni, Brainard, Diana M., McHutchison, John G., Agarwal, Kosh, and Zeuzem, Stefan

Published
2015
Full Text
View/download PDF

24. Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

Author

Foster, Graham R., Afdhal, Nezam, Roberts, Stuart K., Bräu, Norbert, Gane, Edward J., Pianko, Stephen, Lawitz, Eric, Thompson, Alex, Shiffman, Mitchell L., Cooper, Curtis, Towner, William J., Conway, Brian, Ruane, Peter, Bourlière, Marc, Asselah, Tarik, Berg, Thomas, Zeuzem, Stefan, Rosenberg, William, Agarwal, Kosh, Stedman, Catherine A.M., Mo, Hongmei, Dvory-Sobol, Hadas, Han, Lingling, Wang, Jing, McNally, John, Osinusi, Anu, Brainard, Diana M., McHutchison, John G., Mazzotta, Francesco, Tran, Tram T., Gordon, Stuart C., Patel, Keyur, Reau, Nancy, Mangia, Alessandra, and Sulkowski, Mark

Published
2015
Full Text
View/download PDF

30. Investigation of factors in improving Agrobacterium-mediated gene transfer in Ruellia tuberosa L. and evaluation of α-glucosidase inhibitory activity in established hairy roots.

Author

CAO, Dai M., TRAN, Tram T. M., and QUACH, Phuong N. D.

Subjects
*GENETIC transformation, *ASIAN medicine, *BIOMASS production, *GLUCOSIDASES, *DRUG dosage, *ACANTHACEAE, *ALPHA-glucosidases
Abstract

Ruellia tuberosa (family Acanthaceae) is widely known in traditional medicine in Asian countries for the treatment of diabetes and other diseases. Its roots were demonstrated to possess a hypoglycemic ability in diabetic animal models. In this study, an original induced procedure was investigated to establish hairy root (HR) from R. tuberosa. With the aim of increasing the transformation rate, some induced factors (acetosyringone (AS) dosage, type of explant, age, infection time, bacterial density, co-cultivation duration) were individually examined. As a result, an improved procedure was implemented: ten-day-old in vitro cotyledon explants were injured and then immersed in the bacterial suspension (OD600 nm = 0.4) added 200 μM AS during 10 min. The infected explants were co-cultivated for 4 days in the Murashige & Skoog (MS) medium before transferring to the medium containing cefotaxime for bacterial elimination. After thirty days of culture, the improved procedure revealed a synergistic effect by enhancing the rooting rate and number of secondary roots per explant up to 4.4- and 8.0-fold, respectively, in comparison with the original procedure. The R. tuberosa HR was then cultured in liquid MS medium and achieved the highest biomass production at the late exponential growth phase (3rd week). Its ethanol extract was also higher 2.0-fold in 6-glucosidase inhibitory activity than that of the natural root. In conclusion, the 6-glucosidase inhibitory activity of HR inducing by the improved procedure may offer an effective and reliable substitute for the utilization of this herbal plant. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

31. Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection

Author

Brahmania, Mayur, primary, Lombardero, Manuel, additional, Hansen, Bettina E., additional, Terrault, Norah A., additional, Lok, Anna S., additional, Perrillo, Robert P., additional, Belle, Steven H., additional, Di Bisceglie, Adrian M., additional, Feld, Jordan J., additional, Lee, William M., additional, Fried, Michael W., additional, Janssen, Harry L.A., additional, Lau, Daryl T-Y., additional, Chung, Raymond T., additional, Roberts, Lewis R., additional, Hassan, Mohamed A., additional, Lisker-Melman, Mauricio, additional, Wong, David K., additional, Juan, Joshua, additional, Yim, Colina, additional, Patel, Keyur, additional, Murakami, Carol S., additional, Do, Son, additional, Han, Steven-Huy B., additional, Tran, Tram T., additional, Khalili, Mandana, additional, Cooper, Stewart L., additional, Fontana, Robert J., additional, Tsai, Naoky, additional, Younoszai, Barak, additional, Muir, Andrew, additional, Evon, Donna, additional, Darling, Jama M., additional, Carithers, Robert C., additional, Shuhart, Margaret, additional, Kowdley, Kris V., additional, Wang, Chia C., additional, Sterling, Richard K., additional, Ghany, Marc G., additional, Liang, T. Jake, additional, Hoofnagle, Jay H., additional, Doo, Edward, additional, Chang, Kyong-Mi, additional, Park, Jang-June, additional, Wahed, Abdus, additional, Cloonan, Yona, additional, and Kleiner, David, additional

Published
2019
Full Text
View/download PDF

33. Deferred treatment with a fixed‐dose combination of sofosbuvir‐velpatasvir for chronic hepatitis C virus genotype 1, 2, 4 and 6 infection

Author

Asselah, Tarik, primary, Shafran, Stephen D., additional, Bourgeois, Stefan, additional, Lai, Ching‐Lung, additional, Mathurin, Philippe, additional, Willems, Bernard, additional, Nguyen, Mindie H., additional, Davis, Mitchell N., additional, Huang, K. C., additional, Svarovskaia, Evguenia, additional, Osinusi, Anu, additional, McNally, John, additional, Brainard, Diana M., additional, Shaikh, Obaid S., additional, and Tran, Tram T., additional

Published
2019
Full Text
View/download PDF

35. Glecaprevir/Pibrentasvir Treatment in Liver or Kidney Transplant Patients With Hepatitis C Virus Infection

Author

Reau, Nancy, primary, Kwo, Paul Y., additional, Rhee, Susan, additional, Brown, Robert S., additional, Agarwal, Kosh, additional, Angus, Peter, additional, Gane, Edward, additional, Kao, Jia‐Horng, additional, Mantry, Parvez S., additional, Mutimer, David, additional, Reddy, K. Rajender, additional, Tran, Tram T., additional, Hu, Yiran B., additional, Gulati, Abhishek, additional, Krishnan, Preethi, additional, Dumas, Emily O., additional, Porcalla, Ariel, additional, Shulman, Nancy S., additional, Liu, Wei, additional, Samanta, Suvajit, additional, Trinh, Roger, additional, and Forns, Xavier, additional

Published
2018
Full Text
View/download PDF

36. Mo1389 - Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients with HCV Genotype 5 or 6 Infection: The Endurance-5,6 Study

Author

Asselah, Tarik, primary, Tran, Tram T., additional, Alves, Katia, additional, Nguyen, Tuan T., additional, Wong, Florence, additional, Mahomed, Adam, additional, Lim, Seng Gee, additional, Lee, Sam, additional, Abergel, Armando, additional, Sasadeusz, Joe, additional, Krishnan, Preethi, additional, Zhang, Zhenzhen, additional, Porcalla, Ariel R., additional, Trinh, Roger N., additional, and Gane, Edward, additional

Published
2018
Full Text
View/download PDF

39. Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection

Author

Bourlière, Marc, primary, Gordon, Stuart C., additional, Flamm, Steven L., additional, Cooper, Curtis L., additional, Ramji, Alnoor, additional, Tong, Myron, additional, Ravendhran, Natarajan, additional, Vierling, John M., additional, Tran, Tram T., additional, Pianko, Stephen, additional, Bansal, Meena B., additional, de Lédinghen, Victor, additional, Hyland, Robert H., additional, Stamm, Luisa M., additional, Dvory-Sobol, Hadas, additional, Svarovskaia, Evguenia, additional, Zhang, Jie, additional, Huang, K.C., additional, Subramanian, G. Mani, additional, Brainard, Diana M., additional, McHutchison, John G., additional, Verna, Elizabeth C., additional, Buggisch, Peter, additional, Landis, Charles S., additional, Younes, Ziad H., additional, Curry, Michael P., additional, Strasser, Simone I., additional, Schiff, Eugene R., additional, Reddy, K. Rajender, additional, Manns, Michael P., additional, Kowdley, Kris V., additional, and Zeuzem, Stefan, additional

Published
2017
Full Text
View/download PDF

42. Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Author

Hassan, Mohamed, MacGregor, Joan M., Luketic, Velimir A., Cooper, Stewart L., DeVole, Nata, Betts, Michael, Niu, Jianghe, Fontana, Robert J., Wong, David K., Khudyakov, Yury, Walters, Barbara, Chang, Kyong Mi, Punkova, Lili T., Cardona, Danielle, Lawlor, Sharon, Morris, Nevitt, Belle, Steven H., Zadorozny, Ella, Di Bisceglie, Adrian M., Mathisen, Terri, Minshall, Stacey, King, Debra L., Kleiner, David, Wahed, Abdus, Nagy, Rosemary A., Hofmann, Charlotte, Poerzgen, Peter, Haynes-Williams, Vanessa, Cardona-Gonzalez, Lupita, Haller, Tamara, Tran, Tram T., Cloonan, Yona, Chung, Raymond T., French, Samuel, Lisker-Melman, Mauricio, Peacock, Velma, Feld, Jordan, Danielson, Michelle, Stadheim, Linda, Barritt, A. Sidney, Olson, Emma, Do, Son, Terrault, Norah A., McKenna, Barbara, Juan, Joshua, Torrey, Keith, Smith, Paula G., Keith, James, Liu, Lucie, Perrillo, Robert, Park, Jang June, Kelley, Stephanie, Shuhart, Margaret C., Sterling, Richard K., Kowdley, Kris V., Yim, Colina, Montaner, Luis J., Carithers, Robert C., Kaza, Sravanthi, Oberhelman, Kelly, Tsai, Naoky, Pelesko, Andrew, Levine, Danielle, La, Danie, Javaid, Asad, Rodd, Cassandra, Lau, Daryl T.Y., Mooney, Jody, Janssen, Harry L.A., Lombardero, Manuel, Valiga, Mary E., Lok, Anna Suk Fong, Stoliker, Donna, Teo, Chong Gee, Heathcoate, Jenny, Li, Ruosha, Fried, Michael W., Roberts, Lewis R., Ungermann, Ashley, Lee, William M., Johnson, Geoffrey, Huddleston, Leslie, Strom, Susan, Metheny, Vikki, Lau, Ivy, Darling, Jama M., Han, Johanna, Ganova-Raeva, Lilia Milkova, Kim, W. Ray, Han, Steven Huy B., Nasser, Imad, Stahler, Alisha C., Smith, Coleman I., Afdhal, Nezam, Wang, Chia C., Khalili, Mandana, Patel, Keyur, Bass, Sheila, Ayala, Claudia, Marsh, Tiffany, Rivera, Elenita, Liang, T. Jake, Fryzek, Nancy, Ghany, Marc G., Podolskaya, Veronika, and Evon, Donna

Abstract

Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.

Published
2015
Full Text
View/download PDF

43. Su1414 On Treatment HCV RNA as a Predictor of SVR12 in Patients with Genotype 1-6 HCV Infection Treated With Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks: An Analysis of the ASTRAL-1, ASTRAL-2, and ASTRAL-3 Studies

Author

Tran, Tram T., primary, Alqahtani, Saleh, additional, Zeuzem, Stefan, additional, Bourgeois, Stefan, additional, Mathurin, Philippe, additional, Rojter, Sergio E., additional, Liu, Lin, additional, Ding, Xiao, additional, McNally, John, additional, Osinusi, Anu, additional, Lee, Jina, additional, Wolf, John, additional, Brainard, Diana, additional, McHutchison, John, additional, Everson, Gregory T., additional, Abergel, Armand, additional, de Ledinghen, Victor, additional, Mangia, Alessandra, additional, and Sulkowski, Mark, additional

Published
2016
Full Text
View/download PDF

44. Hepatitis B Virus–Specific and Global T-Cell Dysfunction in Chronic Hepatitis B

Author

Park, Jang-June, primary, Wong, David K., additional, Wahed, Abdus S., additional, Lee, William M., additional, Feld, Jordan J., additional, Terrault, Norah, additional, Khalili, Mandana, additional, Sterling, Richard K., additional, Kowdley, Kris V., additional, Bzowej, Natalie, additional, Lau, Daryl T., additional, Kim, W. Ray, additional, Smith, Coleman, additional, Carithers, Robert L., additional, Torrey, Keith W., additional, Keith, James W., additional, Levine, Danielle L., additional, Traum, Daniel, additional, Ho, Suzanne, additional, Valiga, Mary E., additional, Johnson, Geoffrey S., additional, Doo, Edward, additional, Lok, Anna S.F., additional, Chang, Kyong-Mi, additional, Chung, Raymond T., additional, Roberts, Lewis R., additional, Di Bisceglie, Adrian M., additional, Lisker-Melman, Mauricio, additional, Janssen, Harry L.A., additional, Juan, Joshua, additional, Yim, Colina, additional, Heathcote, Jenny, additional, Perrillo, Robert, additional, Do, Son, additional, Han, Steven-Huy B., additional, Tran, Tram T., additional, Cooper, Stewart L., additional, Fontana, Robert J., additional, Tsai, Naoky, additional, Fried, Michael W., additional, Patel, Keyur, additional, Evon, Donna, additional, Shuhart, Margaret, additional, Wang, Chia C., additional, Ghany, Marc G., additional, Liang, T. Jake, additional, Belle, Steven, additional, Cloonan, Yona, additional, and Kleiner, David, additional

Published
2016
Full Text
View/download PDF

49. Total Alanine Aminotransferase (ALT) Flares in Pregnant North American Women With Chronic Hepatitis B Infection: Results From a Prospective Observational Study.

Author

Bzowej NH, Tran TT, Li R, Belle SH, Smith CI, Khalili M, Chung R, Tsai N, and Terrault N

Subjects
Antiviral Agents therapeutic use, Asian People, Black People, Deprescriptions, Disease Progression, Female, Hepatitis B e Antigens immunology, Hepatitis B, Chronic drug therapy, Hepatitis B, Chronic immunology, Humans, Lamivudine therapeutic use, North America, Postpartum Period, Pregnancy, Pregnancy Complications, Infectious drug therapy, Pregnancy Complications, Infectious immunology, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prospective Studies, Tenofovir therapeutic use, Viral Load, Alanine Transaminase blood, DNA, Viral blood, Hepatitis B, Chronic blood, Pregnancy Complications, Infectious blood
Abstract

Introduction: Alterations in the immune system can result in alanine aminotransferase (ALT) flares either during pregnancy or after delivery in women with chronic hepatitis B virus (HBV) infection. The aim of this study was to prospectively assess changes in serum biochemical and virological markers of HBV infection during and after pregnancy in a large North American cohort of pregnant women with chronic HBV., Methods: Adult pregnant women enrolled in the Hepatitis B Research Network between 2011 and 2016 were included. Serum ALT values and HBV DNA viral levels were obtained at <28 weeks and >28 weeks of gestation and <16 weeks, 16-31 weeks, and 32-48 weeks postpartum. Outcomes of ALT flares included severity, duration, and initiation of antiviral therapy., Results: Among the 158 pregnant women with chronic HBV, the median age was 33 years, 73% were Asian, and 63% were hepatitis B e antigen (HBeAg) negative. The median HBV DNA level was substantially higher in the HBeAg-positive vs HBeAg-negative women (1.3 × 10 vs 343 IU/mL), but serum ALT levels at their first study visit were similar. Among untreated pregnant women, there was a very mild increase in serum ALT postpartum among both HBeAg-positive and HBeAg-negative women (P < 0.001). Serum ALT flares (range 107-513 U/L) developed in 3.4% (5/149) during pregnancy and in 4.3% (4/92) after delivery. Twenty-two percent were initiated on antiviral therapy. After withdrawal of prophylactic anti-HBV therapy, 17.2% (5/29) developed serum ALT flares (range 107-208 U/L) within 14 weeks of drug discontinuation, and 3 additional women had flares despite continuous anti-HBV therapy during pregnancy or postpartum. Many ALT flares were not associated with significant changes in HBV DNA levels. No flares were severe with elevations of bilirubin or clinical decompensation., Discussion: Spontaneous ALT flares in untreated pregnant women with chronic HBV are infrequent, mild, and self-limited both prepartum and postpartum. Although flares after the withdrawal of antiviral therapy postpartum are more common, they were also mild and self-limited. Further studies of the immunopathogenesis of pregnancy-related flares are needed, as well as effects on long-term outcome of the mother and infant.

Published
2019
Full Text
View/download PDF

50. A Case of mild idiopathic adulthood ductopenia and brief review of literature.

Author

Kaung A, Sundaram V, Dhall D, and Tran TT

Abstract

Mild idiopathic adulthood ductopenia (IAD) is a rare cholestatic disease of unknown cause and characterized by interlobular bile duct loss in less than 50% of the portal tracts. We describe the case of a middLe-aged male who presented with persistent elevation of transaminases and alkaline phosphatase. He had a normal biliary tree on endoscopic retrograde cholangiopathy and negative anti-mitochondrial antibody. His liver biopsy specimen showed chronic biliary disease, duct loss in 4 out of 15 portal tracts and prominent cholestasis. Based on the work-up, he likely had mild IAD. Liver transplantation would be necessary if his disease becomes progressive., (© The Author(s) 2014. Published by Oxford University Press and the Digestive Science Publishing Co. Limited.)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results