10 results on '"Toshihide Sato"'
Search Results
2. Effect of Antimicrobial Prophylaxis Duration on Health Care-Associated Infections After Clean Orthopedic Surgery: A Cluster Randomized Trial
- Author
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Kosei, Nagata, Koji, Yamada, Tomohiro, Shinozaki, Tsuyoshi, Miyazaki, Fumiaki, Tokimura, Yasuhito, Tajiri, Takuya, Matsumoto, Kiyofumi, Yamakawa, Hiroyuki, Oka, Akiro, Higashikawa, Toshihide, Sato, Kenichi, Kawano, Tatsuro, Karita, Takuya, Koyama, Takahiro, Hozumi, Hiroaki, Abe, Makoto, Hodohara, Kazuhiro, Kohata, Masato, Toyonaga, Yasushi, Oshima, Sakae, Tanaka, Hiroshi, Okazaki, and Yuko, Nagai
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Adult ,Male ,Cross Infection ,Anti-Infective Agents ,Humans ,Surgical Wound Infection ,Female ,Orthopedic Procedures ,General Medicine ,Delivery of Health Care ,Aged ,Anti-Bacterial Agents - Abstract
Postoperative health care-associated infections are associated with a greater deterioration in patients' general health status and social and economic burden, with at least 1 occurring in approximately 4% of acute care hospital patients. Antimicrobial prophylaxis prevents surgical site infections in various orthopedic procedures; however, its relationship with health care-associated infections remains unknown.To examine whether a shorter antimicrobial prophylaxis duration of less than 24 hours after surgery is not inferior to a longer duration in preventing health care-associated infections after clean orthopedic surgery.This open-label, multicenter, cluster randomized, noninferiority clinical trial was conducted in 5 tertiary referral hospitals in greater Tokyo metropolitan area, Japan, from May to December 2018. Adult patients undergoing clean orthopedic surgery were recruited until the planned number of participants was achieved (500 participants per group). Statistical analysis was conducted from July to December 2019.Antimicrobial prophylaxis was discontinued within 24 hours after surgery in group 24 and 24 to 48 hours after surgery in group 48. Group allocation was switched every 2 or 4 months according to the facility-based cluster rule. Study-group assignments were masked from participants.The primary outcome was the incidence of health care-associated infections requiring antibiotic therapies within 30 days after surgery. The noninferiority margin was 4%.Of the 1211 participants who underwent cluster allocation, 633 participants were in group 24 (median [IQR] age, 73 [61-80] years; 250 men [39.5%] and 383 women [60.5%]), 578 participants were in group 48 (median [IQR] age, 74 [62-81] years; 204 men [35.3%] and 374 women [64.7%]), and all were eligible for the intention-to-treat analyses. Health care-associated infections occurred in 29 patients (4.6%) in group 24 and 38 patients (6.6%) in group 48. Intention-to-treat analyses showed a risk difference of -1.99 percentage points (95% CI, -5.05 to 1.06 percentage points; P .001 for noninferiority) between groups, indicating noninferiority. Results of adjusted intention-to-treat, per-protocol, and per designated procedure population analyses supported this result, without a risk of antibiotic resistance and prolonged hospitalization.This cluster randomized trial found noninferiority of a shorter antimicrobial prophylaxis duration in preventing health care-associated infections without an increase in antibiotic resistance risk. These findings lend support to the global movement against antimicrobial resistance and provide additional information on adequate antimicrobial prophylaxis for clean orthopedic surgery.Identifier: UMIN000030929.
- Published
- 2022
3. Influence of body and head posture on the deviation of the condylar point during dental treatment
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Keishi Ohta, Toshihide Sato, Mami Ishii, and Kaoru Koide
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Orthodontics ,Head posture ,business.industry ,Medicine ,Point (geometry) ,General Medicine ,business ,Condyle - Published
- 2020
4. Ionic Mechanisms of the Resting Potential and Quinine-Induced Receptor Potential in Frog Taste Cells
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Toshihide Sato, Takenori Miyamoto, and Yukio Okada
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Taste ,Quinine ,Chemistry ,Receptor potential ,Biophysics ,medicine ,Ionic bonding ,Resting potential ,medicine.drug - Published
- 2021
5. Highly producible method for determination of occlusal vertical dimension: relationship between measurement of lip contact position with the closed mouth and area of upper prolabium
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Toshihide Sato, Kaoru Koide, Yuko Watarai, and Fumi Mizuhashi
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Adult ,Male ,Rest ,Rest position ,Mandible ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Position (vector) ,mental disorders ,Maxilla ,Humans ,Dentistry (miscellaneous) ,Conventional technique ,Mathematics ,Orthodontics ,Mouth ,Vertical dimension of occlusion ,Upper lip ,Reproducibility of Results ,Vertical Dimension ,030206 dentistry ,Closed mouth ,Lip ,stomatognathic diseases ,Contact position ,Female ,Oral Surgery ,psychological phenomena and processes ,030217 neurology & neurosurgery - Abstract
Purpose A new method inducing the physiologic rest position of the mandible using the lip contact position with the closed mouth have compared with those obtained using conventional methods of placing the mandible in the physiologic rest position. Methods The lip contact position with the closed mouth as a method was investigated whether the technique was useful for determining the occlusal vertical dimension. The relationship between the space between the maxillary and mandibular front teeth in the lip contact position with the closed mouth and the areas of the prolabia was also investigated. Results Median space between the maxillary and mandibular front teeth in the lip contact position with the closed mouth was 1.53 mm, a value intermediate between the value of 2.16 mm in the resting mandibular position obtained by the conventional technique and that of 1.33 mm in the swallowing position. The coefficient of variation of the space in the lip contact position with the closed mouth was significantly lower than those in the resting mandibular position and in the swallowing position. A significant positive correlation was recognized between the space in the lip contact position with the closed mouth and the area of the prolabium of the upper lip. Conclusions These results clarified that the lip contact position with the closed mouth obtained the excellent reproducibility comparing to the conventional methods. These findings suggested that the area of the prolabium of the upper lip might offer an effective index for individual determination of the correct free-way space.
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- 2018
6. Enhancement of Gustatory Neural Responses by Parasympathetic Nerve in the Frog
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Toshihide Sato and Yukio Okada
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0301 basic medicine ,Taste ,Action Potentials ,Stimulation ,Sodium Chloride ,Autonomic Nervous System ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Parasympathetic nervous system ,0302 clinical medicine ,Parasympathetic Nervous System ,medicine ,Animals ,Acetylcholine receptor ,Rana catesbeiana ,Cell Biology ,General Medicine ,Electric Stimulation ,Autonomic nervous system ,030104 developmental biology ,medicine.anatomical_structure ,Nicotinic agonist ,chemistry ,Glossopharyngeal nerve ,Hexamethonium ,Neuroscience ,030217 neurology & neurosurgery - Abstract
The autonomic nervous system affects the gustatory responses in animals. Frog glossopharyngeal nerve (GPN) contains the parasympathetic nerve. We checked the effects of electrical stimulation (ES) of the parasympathetic nerves on the gustatory neural responses. The gustatory neural impulses of the GPNs were recorded using bipolar AgCl wires under normal blood circulation and integrated with a time constant of 1 s. Electrical stimuli were applied to the proximal side of the GPN with a pair of AgCl wires. The parasympathetic nerves of the GPN were strongly stimulated for 10 s with 6 V at 30 Hz before taste stimulation. The integrated neural responses to 0.5 M NaCl, 2.5 mM CaCl2, water, and 1 M sucrose were enhanced to 130-140% of the controls. On the other hand, the responses for 1 mM Q-HCl and 0.3 mM acetic acid were not changed by the preceding applied ES. After hexamethonium (a blocker of nicotinic ACh receptor) was intravenously injected, ES of the parasympathetic nerve did not modulate the responses for all six taste stimuli. The mechanism for enhancement of the gustatory neural responses is discussed.
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- 2017
7. Relationships between the upper central incisor crown forms and degree of labial inclination, overbite, and overjet in Japanese young adults
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Kaoru Koide, Fumi Mizuhashi, Takeshi Kurita, and Toshihide Sato
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Overjet ,medicine.medical_treatment ,0206 medical engineering ,Crown forms ,02 engineering and technology ,Overbite ,Crown (dentistry) ,Labial inclination ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Dentistry (miscellaneous) ,Maxillary central incisor ,Upper central incisor ,Mathematics ,Orthodontics ,Incisal Edge ,030206 dentistry ,medicine.disease ,020601 biomedical engineering ,Tooth Cervix ,Ovoid ,Original Article ,Oral Surgery - Abstract
PURPOSE The present study aimed to investigate the relationships between the crown form of the upper central incisor and their labial inclination, overbite, and overjet. MATERIALS AND METHODS Maxillary and mandibular casts of 169 healthy dentitions were subjected to 3D dental scanning, and analyzed using CAD software. The crown forms were divided into tapered, square, and ovoid based on the mesiodistal dimensions at 20% of the crown height to that at 40%. The degree of labial inclination of the upper central incisor was defined as the angle between the occlusal plane and the line connecting the incisal edge and tooth cervix. The incisal edges of the right upper and lower central incisor that in contact with lines parallel to the occlusal plane were used to determine the overbite and overjet. One-way ANOVA was performed to compare the labial inclination, overbite, and overjet among the crown forms. RESULTS The crown forms were classified into three types; crown forms with a 20%/40% dimension ratio of 1.00±0.01 were defined as square, >1.01 as tapered, and
- Published
- 2020
8. Investigation of vacuum forming techniques for reduction of loss in mouthguard thickness: part 2-effects of sheet grooving and thermal shrinkage
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Mutsumi Takahashi, Fumi Mizuhashi, Toshihide Sato, and Kaoru Koide
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Engineering drawing ,Materials science ,business.product_category ,Vacuum ,Incisal Edge ,Temperature ,Molding (process) ,Vacuum forming ,Buccal Surface ,Humans ,Mouth Protectors ,Polyvinyls ,Extrusion ,Mouthguard ,Oral Surgery ,Composite material ,business ,Thermoforming ,Software ,Groove (music) - Abstract
The aim of this study was to investigate vacuum forming techniques for reduction of loss in mouthguard thickness effects of sheet grooving and thermal shrinkage of extruded sheets on molded mouthguard thickness. Mouthguards were fabricated with ethylene vinyl acetate (EVA) sheets (4.0 mm thick) using a vacuum forming machine. Sheet form was a convexing v-shaped groove toward the back, 10-40 mm from the anterior end. The sheets were placed in the forming machine with the sheet extrusion direction either vertical or parallel to the model's centerline of right and left. Molding was performed by crimping the sheet using suction when the most descending portion of the sheet sagged downwards from the clamp, 15 mm below the basal surface. Postmolding thickness was determined using a measuring device. Measurement points were the incisal portion (incisal edge and labial surface) and molar portion (cusp and buccal surface). Differences in molded mouthguard thickness with the sheet orientation of extruded EVA sheets were analyzed by student's t-test. The sheet in parallel axis orientation with the model's centerline yielded higher thickness than vertical orientation at the labial surface and the buccal surface. The present results suggested that addition of a groove to the sheet in conjunction with placement of the sheet with its axis of orientation parallel the centerline of the working model can effectively reduce thickness loss in the molded mouthguard with the equipment and materials used in this study.
- Published
- 2015
9. Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study
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Toshihide Sato, Takushi Yoshida, Tomoyuki Kanemitsu, Hideto Yoshida, Takeshi Yamasaki, Osamu Urushibata, Yasunobu Masuda, Wataru Odanaka, Wakako Sakamoto, and Chinatsu Kawada
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medicine.medical_specialty ,Nutrition and Dietetics ,integumentary system ,business.industry ,Clinical Biochemistry ,Dietary supplement ,skin moisture content ,Placebo-controlled study ,Medicine (miscellaneous) ,molecular weight ,Placebo ,Placebo group ,Surgery ,Double blind ,hyaluronan ,Animal science ,Dry skin ,medicine ,ingestion ,Ingestion ,Original Article ,medicine.symptom ,dry skin ,Adverse effect ,business - Abstract
Hyaluronan (HA) has been increasingly used as a dietary supplement to improve the skin. However, the effect of ingested HA may depend on its molecular weight (MW) because its physiological activities in the body vary with its MW. In this study, we examined the effects of ingested HA with varying MW on the skin. In this randomized, double blind, placebo controlled study, 61 subjects with dry skin received oral HA (120 mg/day), of MWs 800 k and 300 k or placebo, for 6 weeks. The skin moisture contents of the first two groups increased more than those of the placebo group during the ingestion period. In addition, group HA 300 k exhibited significant improvements in skin moisture content 2 weeks after ingestion ended compared with the placebo group. A questionnaire survey about subjective facial aging symptoms showed that the HA treated groups exhibited significantly improved the skin condition compared with the placebo treated group. Furthermore, dermatologists objectively evaluated the clinical symptoms of the facial and whole body skin, showing that no adverse events were related to daily ingestion of HA. This study shows that both of ingesting HAs (MWs 800 k and 300 k) improved the skin condition by increasing the moisture content.
- Published
- 2014
10. Relationships between the upper central incisor crown forms and degree of labial inclination, overbite, and overjet in Japanese young adults.
- Author
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Takeshi Kurita, Fumi Mizuhashi, Toshihide Sato, and Kaoru Koide
- Subjects
YOUNG adults ,INCISORS ,TOOTH cervix ,COMPUTER-aided design software ,CROWNS - Abstract
PURPOSE. The present study aimed to investigate the relationships between the crown form of the upper central incisor and their labial inclination, overbite, and overjet. MATERIALS AND METHODS. Maxillary and mandibular casts of 169 healthy dentitions were subjected to 3D dental scanning, and analyzed using CAD software. The crown forms were divided into tapered, square, and ovoid based on the mesiodistal dimensions at 20% of the crown height to that at 40%. The degree of labial inclination of the upper central incisor was defined as the angle between the occlusal plane and the line connecting the incisal edge and tooth cervix. The incisal edges of the right upper and lower central incisor that in contact with lines parallel to the occlusal plane were used to determine the overbite and overjet. One-way ANOVA was performed to compare the labial inclination, overbite, and overjet among the crown forms. RESULTS. The crown forms were classified into three types; crown forms with a 20%/40% dimension ratio of 1.00±0.01 were defined as square, >1.01 as tapered, and <0.99 as ovoid. The labial inclination degree was the greatest in tapered and the least in square. Both overbite and overjet in tapered and ovoid were higher than those in square. CONCLUSION. Upper central incisor crown forms were related to their labial inclination, overbite, and overjet. It was suggested that the labial inclination, overbite, and overjet should be taken into consideration for the prosthetic treatment or restoring the front teeth crowns. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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