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15 results on '"Tong YanPing"'

7. Association of Pain with Plasma C5a in Patients with Neuromyelitis Optica Spectrum Disorders During Remission

Author

Tong,Yanping, Liu,Jie, Yang,Tao, Wang,Jingwen, Zhao,Tianyou, Kang,Yuezhi, Fan,Yongping, Tong,Yanping, Liu,Jie, Yang,Tao, Wang,Jingwen, Zhao,Tianyou, Kang,Yuezhi, and Fan,Yongping

Abstract

Yanping Tong,1,2 Jie Liu,3 Tao Yang,1,2 Jingwen Wang,4 Tianyou Zhao,4 Yuezhi Kang,1,2 Yongping Fan1,2 1Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Beijing Integrative Medicine on Encephalopathy Research Institution, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 3Department of Respiratory Medicine, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing, 100026, People’s Republic of China; 4Department of Neurology, Beijing Miyun District Hospital of Traditional Chinese Medicine, Beijing, 101599, People’s Republic of ChinaCorrespondence: Yongping Fan, Email yongpingf@hotmail.comObjective: To investigate the association of pain with plasma C5a levels and other related inflammatory cytokines in neuromyelitis optica spectrum disorders (NMOSD) patients during remission.Participants and Methods: NMOSD patients (n = 87) and healthy controls (HC; n = 44) were consecutively recruited between January 2017 and April 2018. Plasma complement 5 (C5), C5a, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β levels were detected. Visual Analogue Scale (VAS), ID pain scale, 24-item Hamilton Depression Scale (HAMD), Multiple Sclerosis Impact Scale (MSIS-29), and Kurtzke Expanded Disability Status Scale (EDSS) were used to evaluate the degree and types of pain, the existence of depression and anxiety, and the life quality and disability status of patients. Binary logistic regression equation was used to assess the association of pain with plasma C5a levels.Results: Among the 87 NMOSD patients, 40 complained of pain that in 67.5% (27/40) of cases had a neuropathic component (ID pain ≥ 2). Plasma C5a, IL-6, TNF-α, and IL-1β levels were significantly elevated in NMOSD patients than in HC. Plasma C5 levels were negatively correlated with the time from sampling to the last relapse or disease onset.

Published
2022

9. Association between symbol digit modalities test and regional cortex thickness in young adults with relapsing-remitting multiple sclerosis

Author

Kang YueZhi, Wang Lei, Yang Xiao, Zhao Xuesong, Fan Yong-ping, Yang Tao, Tong YanPing, and Wang Xin

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Audiology, Neuropsychological Tests, Verbal learning, Young Adult, Multiple Sclerosis, Relapsing-Remitting, Cortex (anatomy), medicine, Humans, Cognitive Dysfunction, Young adult, Recognition memory, Cerebral Cortex, medicine.diagnostic_test, business.industry, Multiple sclerosis, Magnetic resonance imaging, Cognition, General Medicine, medicine.disease, medicine.anatomical_structure, Cerebellar cortex, Surgery, Female, Neurology (clinical), Atrophy, business
Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, predominating within young adults. Cognitive disorders are common in MS and have are associated with several Magnetic Resonance Imaging (MRI) markers, especially brain atrophy. Many have found the symbol digit modalities test (SDMT) to be the most sensitive individual cognitive measure relevant to MS. However, the relationship between SDMT and regional brain cortex thickness in young adults with relapsing-remitting multiple sclerosis (YA-RRMS) has been little explored. The purpose of this study was to investigate the association between the SDMT and regional cortex thickness in YA-RRMS by FreeSurfer, which is an automatic brain structure segmentation method.Twenty-eight YA-RRMS patients (18-35 years old) were enrolled in the present study. Informed consent and information including gender, age, disease duration, number of relapses, annual relapse rate was collected from all patients. Clinical cognitive evaluations (SDMT and auditory verbal learning test (AVLT)) and daily performance: activities of daily living (ADL) were assessed in the present study. MRI scans were performed at the Institute of Neurosurgery of Tiantan Hospital. Twenty-eight matched healthy controls (HC) MRI data were obtained from Tiantan Hospital database. Data on thirty-four points of bilateral cortical structure thickness using statistically defined brain regions-of-interest from FreeSurfer were obtained from all participants.Patients with RRMS exhibited extensively thinner cerebellar cortex compared with HC. SDMT scores were significantly correlated with AVLT subentries (IM, immediate memory; DRM, delayed recall memory; LTRM, long-term recognition memory) in YA-RRMS patients (P 0.05). SDMT was strongly correlated with regional cortex thickness differences of the right temporal pole (r = 0.68) and bilateral parahippocampal areas (right r = 0.62; left r = 0.60), and moderately correlated with regional cortex thickness differences including the left superior temporal and right insula (r = 0.57 and 0.56, respectively) in YA-RRMS patients.The present study has shown the SDMT is strongly correlated with selected cortex regions including the bilateral parahippocampal area and the right temporal pole which are involved in geometric structures processing.

Published
2021

15. Gastrodin improves the neurological score in MCAO rats by inhibiting inflammation and apoptosis, promoting revascularization.

Author

Wang S, Nan Y, Zhu W, Yang T, Tong Y, and Fan Y

Abstract

Gastrodin (GAS) is an active constituent of Chinese herbal medicine tianma ( Gastrodia elata ), which is commonly used to extinguish wind (TCM term). Tianma is also widely used to treat various neurological diseases such as stroke, dizziness, epilepsy, etc. Its clinical effect is quite satisfactory. However, the underlying mechanism has not been fully explored. In the present study, we choose a permanent cerebral occlusion model, MCAO, and used multiple methods to investigate the medicine. Our results show a significant improvement in neurological score after 3 days of GAS treatment. In addition, neurons in the hippocampus were rescued within after 7 days GAS treatment. Then we explore the drug's mechanism in the acute phase of stroke. CRP and IL-1β are common inflammatory factors. Elisa showed GAS can reduce these inflammatory factors in serum in the acute phase of stroke. What's more, GAS can up-regulate the expression of Bcl-2 and down-regulate the expression of BAX in the ischemic hemisphere, and the same result is observed in the protein level. The expression of Caspase-3 is also suppressed, indicating GAS has ability to inhibit apoptosis during the acute phase of stroke. On the other hand, GAS can up-regulate the expression of VEGF, thusly promoting micro-vacsular regeneration. In conclusion, our results demonstrate that GAS can alleviate the symptoms of stroke through various mechanisms. GAS might also serve as a potential candidate to treat acute cerebral infarction., Competing Interests: None., (IJCEP Copyright © 2018.)

Published
2018

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