210 results on '"Tjäderhane L"'
Search Results
2. The association between dental caries and physical activity, physical fitness, and background factors among Finnish male conscripts
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Huttunen, M. (Mika), Kämppi, A. (Antti), Soudunsaari, A. (Aapo), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), Laitala, M.-L. (Marja-Liisa), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Tanner, T. (Tarja), Huttunen, M. (Mika), Kämppi, A. (Antti), Soudunsaari, A. (Aapo), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), Laitala, M.-L. (Marja-Liisa), Anttonen, V. (Vuokko), Patinen, P. (Pertti), and Tanner, T. (Tarja)
- Abstract
Studies on measured physical fitness and oral health are sparse. The aim of this study was to investigate the associations between self-reported physical activity and measured physical fitness and oral health of young men. The study population consisted of 13,564 Finnish male conscripts who had mandatory clinical oral examinations and physical fitness tests at the beginning of military service in 2011. Finally, around 10,800 conscripts had physical fitness test outcomes available and a total of 8552 conscripts answered a computer-based questionnaire on background factors. Decayed Tooth (DT) and Decayed, Missing, or Filled Tooth (DMFT) indices, outcomes of surveys and fitness tests were used in analyses by cross-tabulation and multivariable logistic regression model (odds ratios [OR] with 95% confidence interval [CI]) were calculated. Regularly exercising conscripts had a reduced need for dental restorative treatment than those reporting no physical activity (p < 0.0001). The proportion of participants with sound dentition (DT = 0) increased steadily with increasing physical activity (39.0–59.4%). Good measured physical fitness was a protective factor against increased dental restorative treatment need. A low prevalence of smoking and low use of alcohol and energy drinks were associated with frequent exercise, whereas consumption of sport drinks and snuff use were common among those who exercised frequently. Good measured physical fitness and self-reported physical activity are associated with reduced caries burden. There is a need for information about the harms of tobacco products and the benefits of a healthy diet, even for the increased energy needs of the physically active.
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- 2023
3. ESE position statement on root resorption
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Patel, S. (Shanon), Krastl, G. (Gabriel), Weiger, R. (Roland), Lambrechts, P. (Paul), Tjäderhane, L. (Leo), Gambarini, G. (Gianluca), Teng, P.-H. (Peng-Hui), Patel, S. (Shanon), Krastl, G. (Gabriel), Weiger, R. (Roland), Lambrechts, P. (Paul), Tjäderhane, L. (Leo), Gambarini, G. (Gianluca), and Teng, P.-H. (Peng-Hui)
- Abstract
This Position Statement on root resorption represents the consensus of an expert committee convened by the European Society of Endodontology (ESE). The statement is based on current clinical and scientific evidence as well as the expertise of the committee. The aim is to provide clinicians with authoritative information on the aetiology, histopathology, clinical presentation and recommendations for the management of root resorption. It is the intention of the committee to update this position statement at appropriate intervals as further evidence emerges.
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- 2023
4. General- and oral-health-related predisposing factors for interrupting military service in the Finnish defence forces
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Patinen, P. (Pertti), Tanner, T. (Tarja), Honkanen, J. (Jesse), Tjäderhane, L. (Leo), Päkkilä, J. (Jari), Anttonen, V. (Vuokko), Kämppi, A. (Antti), Patinen, P. (Pertti), Tanner, T. (Tarja), Honkanen, J. (Jesse), Tjäderhane, L. (Leo), Päkkilä, J. (Jari), Anttonen, V. (Vuokko), and Kämppi, A. (Antti)
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Introduction: Finland’s security policy relies heavily on its own independent national defense, which is based on conscription. In 2011, 26,492 conscripts started their military service in Finland. Of these, 1,706 interrupted their military service and 191 changed to civilian service. Conscripts who interrupt their service seem to have an increased tendency to smoking, alcohol consumption, and taking snuff, which previous studies suggest to have strong associations with the need for restorative dental treatment and with lower socioeconomic status. The aim of this study was to compare the general and oral health habits between Finnish conscripts who interrupt their service and those who completed their military service and to find out what general- and oral-health-related factors could be used in predicting interruption of service. Methods: The study population consisted of 13,819 conscripts taking an oral examination during the service. Of these, 8,449 answered a computer-based anamnestic questionnaire and 264 interrupted their service. Predisposing factors on the anamnestic questionnaire for interrupting military service were evaluated by using a binary logistic regression model. The statistically significant factors were selected to form a sum variable which finally consisted of seven predisposing questions. Odds ratio (OR) values and 95% confidence intervals were calculated for each question and for the sum variable. Predictive accuracy was assessed by area under the receiver-operating curve. Results: The most obvious predisposing factor among those who interrupted their service compared to the reference group was lack of weekly physical exercise (OR = 5.80). The risk for interruption of military service was 68.6 times higher in cases where a subject exhibited six predisposing factors out of seven compared to those who had none. Conclusion: As a conclusion, a set of statistically chosen anamnestic questions could help identify conscripts who have an incr
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- 2023
5. Hammaspulpan biologiaa
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Tjäderhane, L. (Leo), Berggreen, E. (Ellen), Fristad, I. (Inge), Tjäderhane, L. (Leo), Berggreen, E. (Ellen), and Fristad, I. (Inge)
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Tiivistelmä Karieksen aiheuttamat komplikaatiot, hampaan voimakas kuluminen tai muu ulkoinen ärsytys voivat johtaa hammasytimen eli pulpan oireiseen tai oireettomaan inflammaatioon, jota seuraa pulpakudoksen osittainen tai etenevä hajoaminen ja kuolio. Sairaan pulpan asianmukaisella hoidolla pyritään säilyttämään hampaan vitaliteetti joko täydellisesti tai osittain, ja tällaista hoitoa voidaan siten pitää ”ehkäisevänä endodontiana”. Dentiini-pulpakompleksin fysiologian ja patologian ymmärtäminen on oikean diagnoosin ja näin ollen oikean hoidon edellytys. Tässä katsauksessa kuvataan terveen pulpan perusrakenne ja fysiologia. Lisäksi käydään läpi tulehdusreaktioiden käynnistymisen ja etenemisen periaatteita pulpakavumissa ja juurikanavissa, jotka ovat tulehdusprosessin kannalta joustamaton ympäristö. Tämän ohella käsitellään kivun ja hypersensitiivisyyden mekanismeja sekä keinoja, joilla dentiini-pulpakompleksi voi reagoida toistuvaan tai persistoivaan, kipua aiheuttavaan ärsytykseen. Pulpan tulehduksen hoitomuodot voivat vaihdella karieksen ekskavoinnista ja kaviteetin sulkemisesta sekä osittaisesta tai täydellisestä pulpotomiasta aina endodonttiseen hoitoon, ja niitä pohditaan tarkemmin tämän teeman muissa artikkeleissa, jotka käsittelevät diagnostiikkaa, vitaalin pulpan hoitoa ja kiireellistä hoitoa., Pulp Biology Pulpal complications of caries, extensive wear or other external irritations may result in symptomatic or asymptomatic inflammation, followed by partial or progressing pulp tissue degradation and necrosis. Appropriate treatment of diseased pulp may aim to preserve the vitality of the pulp, either completely or partially, and can thus be regarded as “preventive endodontics”. Understanding of the physiology and pathology of dentin-pulp complex is a prerequisite for the proper diagnosis and is thus the correct choice of treatment. This review describes the basic structure and physiology of a healthy dental pulp and the principles of the initiation and progression of inflammatory reactions in the low-compliance environment of the pulp chamber and root canals. The mechanisms of the pain and hypersensitivity, as well as the means that the dentin-pulp complex may react to a repeated or persistent pain-producing irritation, are also discussed. The chosen treatment modalities may vary from caries excavation and cavity sealing, partial or complete pulpotomy to an endodontic treatment, and will be discussed in detail in other articles in this issue dealing with the diagnostics, vital pulp therapies and emergency treatments.
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- 2023
6. Cytotoxicity of dimethyl sulfoxide (DMSO) in direct contact with odontoblast-like cells
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Hebling, J., Bianchi, L., Basso, F.G., Scheffel, D.L., Soares, D.G., Carrilho, M.R.O., Pashley, D.H., Tjäderhane, L., and de Souza Costa, C.A.
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- 2015
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7. Antibiotics in Endodontics: a review
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Segura‐Egea, J. J., Gould, K., Şen, B. Hakan, Jonasson, P., Cotti, E., Mazzoni, A., Sunay, H., Tjäderhane, L., and Dummer, P. M. H.
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- 2017
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8. Association of dental fear with caries status and self-reported dentition-related well-being in Finnish conscripts
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Kämppi, A. (Antti), Tanner, T. (Tarja), Viitanen, O. (Olavi), Pohjola, V. (Vesa), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Kämppi, A. (Antti), Tanner, T. (Tarja), Viitanen, O. (Olavi), Pohjola, V. (Vesa), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), Anttonen, V. (Vuokko), and Patinen, P. (Pertti)
- Abstract
The main aim of this cross-sectional study was to examine the prevalence of dental fear among Finnish conscripts. Other aims were to study the association between dental fear and cariological status as well as their self-reported, dentition-related well-being. The study material consisted of 13,564 men and 255 women conscripts who underwent oral examinations. Of those, 8713 responded to a computer-based questionnaire. The mean number of decayed teeth (DT) was used in analyses for cariological status. Self-reported dental fear, dentition-related well-being and regular check-ups were analysed. Data were analysed with cross tables, Pearson Chi-Square tests, Fisher’s exact test and binary logistic regressive analysis. High dental fear or finding dental visits very scary was associated with DT > 2 both among women (14.6%, when DT = 0; 33.3%, when DT > 2) and men conscripts (2.3% and 10.8%, respectively). In addition, those reporting that dental health had a negative impact on their well-being and had no regular check-ups were more likely to need cariological treatment than the rest. A high education level, both one’s own and parental, was a protective factor for restorative treatment need in male conscripts. The findings of this study support the concept of a vicious cycle of dental fear and dental caries. A preventive, interactive way of work by dental teams would most likely be beneficial for dental health, avoiding the development of dental fear, and dentition-related well-being.
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- 2022
9. European Society of Endodontology position statement : endodontic management of traumatized permanent teeth
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Krastl, G., Weiger, R., Filippi, A., Van Waes, H., Ebeleseder, K., Ree, M., Connert, T., Widbiller, M., Tjäderhane, L., Dummer, P. M. H., Galler, K., HUS Head and Neck Center, and Department of Oral and Maxillofacial Diseases
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RISK ,dental trauma ,PULP CANAL OBLITERATION ,DENTAL INJURIES ,diagnosis ,NECROSIS ,tooth injuries ,3126 Surgery, anesthesiology, intensive care, radiology ,endodontic management ,LUXATION ,313 Dentistry ,RESORPTION ,INTRAALVEOLAR ROOT FRACTURES ,tooth fracture ,avulsion ,INCISORS - Abstract
This position statement represents a consensus of an expert committee convened by the European Society of Endodontology (ESE) on the endodontic management of traumatized permanent teeth. A recent comprehensive review with detailed background information provides the basis for this position statement (Krastl et al. 2021, International Endodontic Journal, ). The statement is based on current scienti?c evidence as well as the expertise of the committee. Complementing the recently revised guidelines of the International Association of Dental Traumatology, this position statement aims to provide clinical guidance for the choice of the appropriate endodontic approach for traumatized permanent teeth. Given the dynamic nature of research in this area, this position statement will be updated at appropriate intervals.
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- 2021
10. Endodontic management of traumatized permanent teeth : a comprehensive review
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Krastl, G., Weiger, R., Filippi, A., Van Waes, H., Ebeleseder, K., Ree, M., Connert, T., Widbiller, M., Tjäderhane, L., Dummer, P. M. H., Galler, K., HUS Head and Neck Center, Department of Oral and Maxillofacial Diseases, and Doctoral Programme in Oral Sciences
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stomatognathic diseases ,dental trauma ,stomatognathic system ,diagnosis ,tooth fracture ,avulsion ,tooth injuries ,endodontic management ,313 Dentistry - Abstract
The pulp plays a key role in the treatment of traumatic dental injuries (TDIs) and is strongly associated with the outcome, particularly in severe cases. A correct pulp diagnosis is essential as it forms the basis for developing the appropriate management strategy. However, many TDIs are complex, and their treatment requires a profound knowledge of the physiological and pathological responses of the affected tissues. This comprehensive review will look at the dentine-pulp complex and its interaction with the surrounding tissues following TDIs. The literature up to 2020 was reviewed based on several searches on PubMed and the Cochrane Library using relevant terms. In addition to the recently revised guidelines of the International Association of Dental Traumatology, this article aims to provide background information with a focus on endodontic aspects and to gather evidence on which a clinician can make decisions on the choice of the appropriate endodontic approach for traumatized permanent teeth.
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- 2021
11. Enzymatic isolation of viable human odontoblasts
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Cuffaro, H. M., Pääkkönen, V., and Tjäderhane, L.
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- 2016
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12. Antimicrobial 2-hydroxyisocaproic acid and chlorhexidine resist inactivation by dentine
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Sakko, M., Tjäderhane, L., Sorsa, T., Hietala, P., and Rautemaa, R.
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- 2016
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13. MMP Inhibitors and Dentin Bonding : Systematic Review and Meta-Analysis
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Kiuru, O., Sinervo, J., Vähänikkilä, H., Anttonen, V., Tjäderhane, L., HUS Head and Neck Center, and Department of Oral and Maxillofacial Diseases
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BENZALKONIUM CHLORIDE ,Article Subject ,CHLORHEXIDINE-CONTAINING ACID ,DURABILITY ,STRENGTH ,RINSE ADHESIVE ,ARTIFICIAL SALIVA ,PRESERVATION ,DEGRADATION ,IN-VITRO EVALUATION ,INTERFACES ,313 Dentistry - Abstract
Objectives. Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix of the hybrid layer. Various MMP inhibitors with the ability to prevent enzymatic degradation have been identified. This study aimed to systematically review the literature for studies which evaluated the effect of MMP inhibitors on the immediate and aged dentin bond strengths. Study SelectionScreening and analysis were carried out by two reviewers. Two databases were searched, and from a total of 740 articles, 43 were accepted for full review. 21 articles with 0.2%–2% chlorhexidine (CHX) treatments were included for meta-analysis. A risk of bias assessment was performed on all studies chosen for meta-analysis. A variety of MMP inhibitors have been studied, CHX being the most widely used. Conclusions. A clear trend for a lower loss of dentin bond strength was observed with different MMP inhibitors. In meta-analysis, no significant difference was seen between the CHX and control in the immediate bond strengths. Bond strengths in the CHX group were significantly higher than the control group after aging (P
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- 2021
14. Endodontic infections and systemic health – where should we go?
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Tjäderhane, L.
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- 2015
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15. MMP Inhibitors and Dentin Bonding: Systematic Review and Meta-Analysis
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Kiuru, O., primary, Sinervo, J., additional, Vähänikkilä, H., additional, Anttonen, V., additional, and Tjäderhane, L., additional
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- 2021
- Full Text
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16. The pursuit of resin-dentin bond durability:simultaneous enhancement of collagen structure and polymer network formation in hybrid layers
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Stape, T. H. (Thiago Henrique Scarabello), Mutluay, M. M. (Mustafa Murat), Tjäderhane, L. (Leo), Uurasjärvi, E. (Emilia), Koistinen, A. (Arto), and Tezvergil-Mutluay, A. (Arzu)
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Bond strength ,Microtensile ,Degree of conversion ,Ethanol ,Wet bonding ,Micro Raman ,Dimethyl sulfoxide ,DMSO ,Adhesive systems ,Etch-and-rinse - Abstract
Objective: Imperfect polymer formation as well as collagen’s susceptibility to enzymatic degradation increase the vulnerability of hybrid layers over time. This study investigated the effect of new dimethyl sulfoxide (DMSO)-containing pretreatments on long-term bond strength, hybrid layer quality, monomer conversion and collagen structure. Methods: H₃PO₄-etched mid-coronal dentin surfaces from extracted human molars (n = 8) were randomly treated with aqueous and ethanolic DMSO solutions or following the ethanol-wet bonding technique. Dentin bonding was performed with a three-step etch-and-rinse adhesive. Resin-dentin beams (0.8 mm²) were stored in artificial saliva at 37 °C for 24 h and 2.5 years, submitted to microtensile bond strength testing at 0.5 mm/min and semi-quantitative SEM nanoleakage analysis (n = 8). Micro-Raman spectroscopy was used to determine the degree of conversion at different depths in the hybrid layer (n = 6). Changes in the apparent modulus of elasticity of demineralized collagen beams measuring 0.5 × 1.7 × 7 mm (n = 10) and loss of dry mass (n = 10) after 30 days were calculated via three-point bending and precision weighing, respectively. Results: DMSO-containing pretreatments produced higher bond strengths, which did not change significantly over time presenting lower incidence of water-filled zones. Higher uniformity in monomer conversion across the hybrid layer occurred for all pretreatments. DMSO-induced collagen stiffening was reversible in water, but with lower peptide solubilization. Significance: Improved polymer formation and higher stability of the collagen-structure can be attributed to DMSO’s unique ability to simultaneously modify both biological and resin components within the hybrid layer. Pretreatments composed of DMSO/ethanol may be a viable-effective alternative to extend the longevity of resin-dentin bonds.
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- 2021
17. Survival of primary molars with pulpotomy interventions:public oral health practice-based study in Helsinki
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Tseveenjav, B. (Battsetseg), Furuholm, J. (Jussi), Mulic, A. (Aida), Valen, H. (Håkon), Maisala, T. (Tuomo), Turunen, S. (Seppo), Varsio, S. (Sinikka), Auero, M. (Merja), and Tjäderhane, L. (Leo)
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restorative materials ,stomatognathic system ,pulpotomy ,primary molars ,survival ,caries - Abstract
Objectives: To assess long-term survival of pulpotomized primary molars and factors related to the survival of the teeth. Materials and methods: This retrospective longitudinal study was based on electronic dental health records of children who attended public health service. Eligible children were
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- 2021
18. Dry bonding to dentin:broadening the moisture spectrum and increasing wettability of etch-and-rinse adhesives
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Stape, T. H. (Thiago Henrique Scarabello), Uctasli, M. (Merve), Cibelik, H. S. (Hatice Sümeyye), Tjäderhane, L. (Leo), and Tezvergil-Mutluay, A. (Arzu)
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Bond strength ,stomatognathic system ,Ethanol ,Wet bonding ,HEMA ,Nanoleakage ,Collagen ,Dimethyl sulfoxide ,Contact angle ,DMSO - Abstract
Objectives: To determine whether the effect of dentin moisture on the etch-and-rinse bonding may be minimized by dry-bonding protocols utilizing aqueous or ethanolic dimethyl sulfoxide (DMSO) pretreatments. Methods: H₃PO₄-etched mid-coronal dentin surfaces from human molars were randomly blot- or air-dried for 30 s and pretreated with DMSO/H₂O or DMSO/EtOH solutions. Untreated samples served as control. Moisture control was performed by either blot- or air-drying. Samples were bonded with a multistep etch-and-rinse adhesive. Restored crown segments (n = 8/group) were stored in distilled water for 24 h and sectioned for microtensile bond strength testing. Resin-dentin beams (0.8 mm²) were tested under tension until fracture (0.5 mm/min) after 24 h and two years of storage in artificial saliva at 37 °C. SEM nanoleakage evaluation was performed on aged samples. Collagen wettability was also measured by sessile drops of the hydrophilic and hydrophobic bonding resins (n = 8/group). Data were examined by factorial ANOVA followed by the Tukey test (α = 0.05). Results: Dry bonding to untreated collagen produced inferior immediate and long-term bond strengths than wet bonding (p< 0.05). Regardless of initial hydration and moisture control, DMSO-dry bonding produced initially higher and stable bond strengths after aging (p
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- 2021
19. MMP inhibitors and dentin bonding:systematic review and meta-analysis
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Kiuru, O. (O.), Sinervo, J. (J.), Vähänikkilä, H. (H.), Anttonen, V. (V.), and Tjäderhane, L. (L.)
- Abstract
Objectives: Resin-dentin bond strength decreases over time. This reduction is related to the loss of hybrid layer integrity. Collagenolytic enzymes, especially matrix metalloproteinases (MMPs), are responsible for the degradation of the collagen matrix of the hybrid layer. Various MMP inhibitors with the ability to prevent enzymatic degradation have been identified. This study aimed to systematically review the literature for studies which evaluated the effect of MMP inhibitors on the immediate and aged dentin bond strengths. Study Selection: Screening and analysis were carried out by two reviewers. Two databases were searched, and from a total of 740 articles, 43 were accepted for full review. 21 articles with 0.2%–2% chlorhexidine (CHX) treatments were included for meta-analysis. A risk of bias assessment was performed on all studies chosen for meta-analysis. A variety of MMP inhibitors have been studied, CHX being the most widely used. Conclusions: A clear trend for a lower loss of dentin bond strength was observed with different MMP inhibitors. In meta-analysis, no significant difference was seen between the CHX and control in the immediate bond strengths. Bond strengths in the CHX group were significantly higher than the control group after aging (P < 0.001). The percentage of fractures occurring at the adhesive interface increased after aging. Five out of 21 studies included in the meta-analysis had high and the rest medium risk of bias. More long-term studies with lower risks of bias should be carried out to increase the reliability of results. Clinical Relevance: The use of MMP inhibition with chlorhexidine can be recommended to increase the longevity of resin-dentin bond strength.
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- 2021
20. European Society of Endodontology position statement:endodontic management of traumatized permanent teeth
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Krastl, G. (G.), Weiger, R. (R.), Filippi, A. (A.), Van Waes, H. (H.), Ebeleseder, K. (K.), Ree, M. (M.), Connert, T. (T.), Widbiller, M. (M.), Tjäderhane, L. (L.), Dummer, P. M. (P. M. H.), and Galler, K. (K.)
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dental trauma ,diagnosis ,tooth fracture ,avulsion ,tooth injuries ,endodontic management - Abstract
This position statement represents a consensus of an expert committee convened by the European Society of Endodontology (ESE) on the endodontic management of traumatized permanent teeth. A recent comprehensive review with detailed background information provides the basis for this position statement (Krastl et al. 2021, International Endodontic Journal, https://doi.org/10.1111/iej.13508). The statement is based on current scientific evidence as well as the expertise of the committee. Complementing the recently revised guidelines of the International Association of Dental Traumatology, this position statement aims to provide clinical guidance for the choice of the appropriate endodontic approach for traumatized permanent teeth. Given the dynamic nature of research in this area, this position statement will be updated at appropriate intervals.
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- 2021
21. Variability of salivary metabolite levels in patients with Sjögren’s syndrome
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Herrala, M. (Maria), Mikkonen, J. J. (Jopi J. W.), Pesonen, P. (Paula), Lappalainen, R. (Reijo), Tjäderhane, L. (Leo), Niemelä, R. K. (Raija K.), Seitsalo, H. (Hubertus), Salo, T. (Tuula), Myllymaa, S. (Sami), and Kullaa, A. M. (Arja M.)
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proton magnetic resonance spectroscopy ,hyposalivation ,metabolomics ,biological markers ,oral diagnosis - Abstract
Purpose: To investigate inter- and intra-individual variation in the levels and outputs (concentration multiplied by salivary flow rate) of salivary metabolites in patients with primary Sjögren’s syndrome (pSS). Methods: A total of 56 samples of stimulated saliva were collected from 14 female pSS patients during four laboratory visits within 20 weeks and analyzed using proton nuclear magnetic resonance spectroscopy. Single saliva samples from each of 15 controls were also analyzed. Results: Among 21 quantified metabolites, choline was significantly elevated in the pSS patients at each time point (P ≤ 0.015), taurine at the last three time points (P ≤ 0.013), alanine at the last two time points (P ≤ 0.007) and glycine at the last time point (P = 0.005). Inter-individual variation in metabolite concentrations was generally larger among the patients than among the controls, and significantly large variations were observed for glycine (P ≤ 0.007, all time points), choline (P ≤ 0.033, three last time points) and alanine (P = 0.028, baseline). Metabolite output analysis showed that choline had the lowest intra-patient variation. Conclusions: In spite of considerable intra- and inter-individual variation, levels and outputs of specific metabolites in patients with pSS differ from those in controls, and may be potentially applicable as new biological markers for monitoring of the response to treatment.
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- 2021
22. Hammasperäinen poskiontelotulehdus
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Tolvi, M. (Morag), Korpi, J. (Jarkko), Tjäderhane, L. (Leo), Grönroos, L. (Lisa), Blomgren, K. (Karin), Tolvi, M. (Morag), Korpi, J. (Jarkko), Tjäderhane, L. (Leo), Grönroos, L. (Lisa), and Blomgren, K. (Karin)
- Abstract
Tiivistelmä Hammasperäinen poskiontelotulehdus määritellään paikalliseksi poskiontelon limakalvon paksuuntumiseksi, joka liittyy tulehtuneeseen tai laajasti hoidettuun hampaaseen tai suukirurgiseen toimenpiteeseen. Hammasperäinen syy saattaa olla taustalla 15 %:ssa poskiontelotulehduksista, erityisryhmien osalta jopa 40 %:ssa. Hampaan tukikudos- ja juurikanavatulehdukset aiheuttavat yli puolet hammasperäisistä poskiontelotulehduksista. Hammasperäiset tulehdukset ovat yleensä anaerobivoittoisia ja polymikrobisia. Tyypillisimmät oireet ovat toispuolinen märkäinen erite sekä tukkoisuus, paha maku tai haju, toispuolinen poskikipu tai -arkuus, liman valuminen nenänielusta, epämukava tunne kasvoissa tai ikenissä ja hammassärky. Kuvantamisessa käytetään panoraamakuvausta, intraoraalikuvia ja kartiokeilatietokonetomografiaa, joihin liittyy kuitenkin virhelähteitä. Hoito onnistuu, jos suun tulehdus hoidetaan. Hammashoidon lisäksi tarvitaan yleensä mikrobilääkehoito, usein poskiontelopunktio ja joskus sivuontelokirurgiaa.
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- 2021
23. The effect of chlorhexidine and dimethyl sulfoxide on long-term sealing ability of two calcium silicate cements in root canal
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Lindblad, R. M. (R. M.), Lassila, L. V. (L. V. J.), Vallittu, P. K. (P. K.), Tjäderhane, L. (L.), Lindblad, R. M. (R. M.), Lassila, L. V. (L. V. J.), Vallittu, P. K. (P. K.), and Tjäderhane, L. (L.)
- Abstract
Objectives: To evaluate the long-term effect of chlorhexidine (CHX) and dimethyl sulfoxide (DMSO) on the sealing ability and biomineralization of two different calcium silicate cements (CSC) in root canal. Methods: Sixty human third molar root canals were obturated with ProRoot MTA or Biodentine. Before obturation the canals were irrigated with saline (control), 2% CHX or 5% DMSO. Microleakage was tested after three days and after six months. After additional six months (12 months after root filling) the roots were cut into 2 mm thick dentine discs. The discs were stored in artificial saliva for one year. The bond strength was measured with the push-out method, and the failure mode was evaluated with a stereomicroscope. The most apical disc of each tooth was used for Vickers hardness test. Results: No significant differences between the groups was found in initial microleakage. The leakage increased significantly during the 6-month storage in all groups except in Biodentine-CHX group and Biodentine-DMSO group. CHX and DMSO irrigation significantly increased the leakage with ProRoot MTA with time, but there was no statistically significant difference compared to the ProRoot MTA-control group at six months’ time point. CHX significantly reduced the push-out bond strength of ProRoot MTA. With Biodentine irrigation with CHX or DMSO resulted with significantly higher push-out strength compared to the Biodentine control group. Fracture analysis showed statistically significant difference in the distribution of the fractures between the groups, but neither CHX nor DMSO change the fracture pattern statistically significantly. With Vickers hardness test ProRoot MTA with and without DMSO as the final irrigant showed significantly higher dentin hardness than any Biodentine-group. Significance: Considering that aging increased the leakage in all groups except with Biodentine-DMSO and the differences in the push-out strength and surface microhardness data, it appears th
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- 2021
24. Association between dental factors and mortality
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Liljestrand, J. M. (J. M.), Salminen, A. (A.), Lahdentausta, L. (L.), Paju, S. (S.), P. Mäntylä, P. (P.), Buhlin, K. (K.), Tjäderhane, L. (L.), Sinisalo, J. (J.), Pussinen, J. (J.), Liljestrand, J. M. (J. M.), Salminen, A. (A.), Lahdentausta, L. (L.), Paju, S. (S.), P. Mäntylä, P. (P.), Buhlin, K. (K.), Tjäderhane, L. (L.), Sinisalo, J. (J.), and Pussinen, J. (J.)
- Abstract
Aim: To study whether oral parameters such as endodontic infections, root canal fillings, number of teeth or wearing removable dentures at baseline are associated with cardiovascular- and all-cause mortality in a follow-up of approximately 8 years. Methodology: The Finnish Parogene cohort consists of 508 Finnish adults (mean age 63.3 years, SD 9.1) with cardiac symptoms, all of whom had undergone coronary angiography for accurate baseline coronary status. Extensive clinical and radiographic oral examinations were performed, and additional data were acquired from medical records and questionnaires. Root canal fillings and endodontic lesions, as well as their co-occurrence, were determined from panoramic radiographs. The mortality data were assessed via record linkage with the Finnish Causes of Death register (mean follow-up time 7.81 years, SD 1.45 years). A total of n = 471 dentate patients were included in the statistical analyses. Results: A total of n = 69 deaths were recorded, of which n = 41 were due to cardiovascular diseases (CVDs, ICD-10 I00–I99). The deceased had fewer root canal fillings (mean 1.57; SD 1.64 vs. mean 2.30; SD 2.34, P = 0.03) than the survivors. The number of missing teeth was associated with smoking, occluded coronary arteries and diabetes. Cox regression with Firth’s penalized maximum-likelihood method using age as timescale revealed an inverse association (HR; 95%CI) between mortality and number of teeth (all-cause 0.91; 0.86–0.96, CVD mortality 0.89; 0.83–0.96), use of removable dentures (all-cause 0.24; 0.09–0.62, CVD mortality 0.20; 0.06–0.72), root canal fillings (all-cause 0.82; 0.70–0.94, CVD mortality 0.79; 0.63–0.96) and having root canal fillings in all teeth with apical rarefactions (all-cause 0.27; 0.06–0.79, CVD mortality 0.09; 0.01–0.63), when gender, smoking, occluded coronary arteries, periodontal inflammatory burden index and the number of teeth were adjusted for. Conclusions: The number of missing teeth appeared
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- 2021
25. Low-dose doxycycline treatment normalizes levels of some salivary metabolites associated with oral microbiota in patients with primary Sjögren’s syndrome
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Herrala, M. (Maria), Turunen, S. (Soile), Hanhineva, K. (Kati), Lehtonen, M. (Marko), Mikkonen, J. J. (Jopi J. W.), Seitsalo, H. (Hubertus), Lappalainen, R. (Reijo), Tjäderhane, L. (Leo), Niemelä, R. K. (Raija K.), Salo, T. (Tuula), Myllymaa, S. (Sami), Kullaa, A. M. (Arja M.), Kärkkäinen, O. (Olli), Herrala, M. (Maria), Turunen, S. (Soile), Hanhineva, K. (Kati), Lehtonen, M. (Marko), Mikkonen, J. J. (Jopi J. W.), Seitsalo, H. (Hubertus), Lappalainen, R. (Reijo), Tjäderhane, L. (Leo), Niemelä, R. K. (Raija K.), Salo, T. (Tuula), Myllymaa, S. (Sami), Kullaa, A. M. (Arja M.), and Kärkkäinen, O. (Olli)
- Abstract
Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjögren’s syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva samples (n = 15) of female patients with pSS in a group treated with low-dose doxycycline (LDD), saliva samples (n = 10) of non-treated female patients with pSS, and saliva samples (n = 14) of healthy age-matched females as controls. Saliva samples were analyzed with liquid chromatography mass spectrometry (LC-MS) based on the non-targeted metabolomics method. The saliva metabolite profile differed between pSS patients and the healthy control (HC). In the pSS patients, the LDD treatment normalized saliva levels of several metabolites, including tyrosine glutamine dipeptide, phenylalanine isoleucine dipeptide, valine leucine dipeptide, phenylalanine, pantothenic acid (vitamin B5), urocanic acid, and salivary lipid cholesteryl palmitic acid (CE 16:0), to levels seen in the saliva samples of the HC. In conclusion, the data showed that pSS is associated with an altered saliva metabolite profile compared to the HC and that the LLD treatment normalized levels of several metabolites associated with dysbiosis of oral microbiota in pSS patients. The role of the saliva metabolome in pSS pathology needs to be further studied to clarify if saliva metabolite levels can be used to predict or monitor the progress and treatment of pSS.
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- 2021
26. Regional variation in restorative treatment need among Finnish young people
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Karki, S. (Saujanya), Kämppi, A. (Antti), Tanner, T. (Tarja), Päkkilä, J. (Jari), Seppänen, M. (Marjo), Tjäderhane, L. (Leo), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Karki, S. (Saujanya), Kämppi, A. (Antti), Tanner, T. (Tarja), Päkkilä, J. (Jari), Seppänen, M. (Marjo), Tjäderhane, L. (Leo), Anttonen, V. (Vuokko), and Patinen, P. (Pertti)
- Abstract
Aim: To evaluate the regional variation in restorative treatment need among Finnish young people based on the socioeconomic factors. Materials and methods: This cross-sectional study was conducted in 20 garrisons of the Finnish Defence Forces in January and July 2011. The study population comprised 13,819 Finnish conscripts born in the beginning of 1990s, including females. A computer-based survey was done together with clinical oral examination to gather background information, e.g., educational status. Furthermore, average annual income of the conscript’s residence municipality was achieved from the Statistics of Finland. The zip code of the place of residence of each conscript was later extracted from the Mildoc® system. Georeferenced place of residence and income status were merged as information on provinces’ level in a dataset. The association between the outcome variable and explanatory variables was determined by using the generalized linear mixed model, and geomaps were constructed. Results: Mean D value was 1.41 ranging from 0.89 (Kymenlaakso) to 2.33 (Kainuu). Higher education and high-income level were protective factors for restorative treatment need. Restorative treatment need was also low in those areas with high (OR: 0.70, 95% CI: 0.56–0.87) and medium (OR: 0.79, 95% CI: 0.70–0.89) yearly income compared to low yearly income. The high odds for the need of restorative treatment were discovered in Northern Ostrobothnia (OR: 2.26, 95% CI: 1.53–3.33) followed by Central Ostrobothnia (OR: 2.08, 95% CI: 1.17–3.70), Uusimaa (OR: 1.55, 95% CI: 1.16–2.08), and Central Finland (OR: 1.54, 95% CI: 1.10–2.16) compared to Varsinais-Suomi. Conclusion: In conclusion, there is a significant regional variation in restorative treatment need among Finnish young people in their twenties based on the socioeconomic factors.
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- 2021
27. Endodontic management of traumatized permanent teeth:a comprehensive review
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Krastl, G. (G.), Weiger, R. (R.), Filippi, A. (A.), Van Waes, H. (H.), Ebeleseder, K. (K.), Ree, M. (M.), Connert, T. (T.), Widbiller, M. (M.), Tjäderhane, L. (L.), Dummer, P. M. (P. M. H.), Galler, K. (K.), Krastl, G. (G.), Weiger, R. (R.), Filippi, A. (A.), Van Waes, H. (H.), Ebeleseder, K. (K.), Ree, M. (M.), Connert, T. (T.), Widbiller, M. (M.), Tjäderhane, L. (L.), Dummer, P. M. (P. M. H.), and Galler, K. (K.)
- Abstract
The pulp plays a key role in the treatment of traumatic dental injuries (TDIs) and is strongly associated with the outcome, particularly in severe cases. A correct pulp diagnosis is essential as it forms the basis for developing the appropriate management strategy. However, many TDIs are complex, and their treatment requires a profound knowledge of the physiological and pathological responses of the affected tissues. This comprehensive review will look at the dentine–pulp complex and its interaction with the surrounding tissues following TDIs. The literature up to 2020 was reviewed based on several searches on PubMed and the Cochrane Library using relevant terms. In addition to the recently revised guidelines of the International Association of Dental Traumatology, this article aims to provide background information with a focus on endodontic aspects and to gather evidence on which a clinician can make decisions on the choice of the appropriate endodontic approach for traumatized permanent teeth.
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- 2021
28. Quality and findings of bitewing radiographs among twenty-year-old conscripts in Finland
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Hyvönen, M. (Miika), Jaakkola, A. (Arttu), Tanner, T. (Tarja), Päkkilä, J. (Jari), Kämppi, A. (Antti), Patinen, P. (Pertti), Tjäderhane, L. (Leo), Sipola, A. (Annina), Huumonen, S. (Sisko), Anttonen, V. (Vuokko), Hyvönen, M. (Miika), Jaakkola, A. (Arttu), Tanner, T. (Tarja), Päkkilä, J. (Jari), Kämppi, A. (Antti), Patinen, P. (Pertti), Tjäderhane, L. (Leo), Sipola, A. (Annina), Huumonen, S. (Sisko), and Anttonen, V. (Vuokko)
- Abstract
Objectives: Bitewing radiographs are mainly used to confirm clinical findings in caries diagnostics. The objective here was to investigate the quality of bitewing radiographs after short brush-up training and additional findings besides caries in a low-caries population. Methods: The material of this cross-sectional study comprised 377 pairs of bitewing radiographs of 19- to 20-year-olds taken by dentists. Radiography was considered indicated if one dentinal caries lesion was present on clinical examination. A senior oral radiologist evaluated quality and diagnosed the findings afterwards unaware of clinical status. The association between variables was analysed using cross tabulation and chi-squared testing. Results: Almost half of the images were of compromised quality (44.1%). Dentinal caries lesions were detected in 82.3% and enamel lesions in 73.5% of the subjects. On average, the subjects had 1.7 (SD 0.52) dentinal lesions. Fillings were found in 81.8%, fractures/cracks in 11.7%, and attrition in 7.4% of the subjects. Signs of excessive bite force were recorded in 19.4%, whereas marginal bone loss was detected in 6.4%. No significant correlation was detected between fractures, attrition, and excessive bite forces. Conclusions: Effort must be taken to ensure high quality of bitewing radiographs. In addition to caries detection, bitewing radiographs offer additional value, such as detecting excessive bite forces, tooth wear, and marginal bone loss among young adults.
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- 2021
29. Association of temporomandibular disorder symptoms with physical fitness among Finnish conscripts
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Miettinen, O. (Ossi), Kämppi, A. (Antti), Tanner, T. (Tarja), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), Sipilä, K. (Kirsi), Miettinen, O. (Ossi), Kämppi, A. (Antti), Tanner, T. (Tarja), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), and Sipilä, K. (Kirsi)
- Abstract
Studies on the role of physical fitness, physical activity and obesity as risk factors for temporomandibular disorders (TMD) are scarce. The aim of the present study was to evaluate the association of TMD symptoms with physical fitness, physical activity and body mass index (BMI) among Finnish conscripts. The study sample consisted of 8685 Finnish conscripts. Data on self-reported TMD symptoms were used as outcome variables. Physical activity (questionnaire), physical fitness (measured with physical tests: Cooper test, push-ups, sit-ups and standing long jump) and body mass index (BMI) were used as explanatory variables. The associations between TMD symptoms and explanatory variables were evaluated using Chi-squared test and logistic regression analysis. The prevalence of all TMD symptoms was significantly higher among those who exercised more rarely than weekly. Pain-related TMD symptoms were also significantly more frequent among those who were overweight (BMI ≥ 25). Poor push-up results and overweight (BMI ≥ 25) were significantly associated with jaw pain and TMJ pain at jaw rest. The present study showed that good physical fitness may be a protective factor against TMD pain. Dentists should also be prepared to motivate TMD patients to physical activity and regular exercise as part of the treatment.
- Published
- 2021
30. Mature human odontoblasts express virus-recognizing toll-like receptors
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Pääkkönen, V., Rusanen, P., Hagström, J., and Tjäderhane, L.
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- 2014
- Full Text
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31. Endodontic management of traumatized permanent teeth: a comprehensive review
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Krastl, G., primary, Weiger, R., additional, Filippi, A., additional, Van Waes, H., additional, Ebeleseder, K., additional, Ree, M., additional, Connert, T., additional, Widbiller, M., additional, Tjäderhane, L., additional, Dummer, P. M. H., additional, and Galler, K., additional
- Published
- 2021
- Full Text
- View/download PDF
32. The effect of chlorhexidine and dimethyl sulfoxide on long-term sealing ability of two calcium silicate cements in root canal
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Lindblad, R.M., primary, Lassila, L.V.J., additional, Vallittu, P.K., additional, and Tjäderhane, L., additional
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- 2021
- Full Text
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33. Consumption of snacks and dental caries among Finnish young men:a cross-sectional epidemiological study
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Tanner, T. (Tarja), Harju, L. (Laura), Päkkilä, J. (Jari), Patinen, P. (Pertti), Tjäderhane, L. (Leo), and Anttonen, V. (Vuokko)
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digestive, oral, and skin physiology ,Snacking ,Dental caries ,food and beverages ,Health behaviour ,Physical exercise ,Diet counselling - Abstract
The aim of this study was to investigate the frequency of consumption of snack products, as well as the association between snacking and restorative treatment need, and associated factors among a healthy Finnish male population. Approximately 8500 conscripts answered a computer-based questionnaire covering their snacking habits and other health behaviours. Restorative treatment need and history (DT, DMFT) were examined by trained and calibrated dentists. Cross-tabulations were used to investigate the associations between snacking habits and the other researched variables, and logistic regression analyses (odds ratio and 95% confidence interval) were used to investigate the variables influencing the restorative treatment need. In the present study, almost one-third of the study group consumed snack products daily, most often fizzy and energy drinks. Only 10% had received a diet counselling. The most common situations involving snacking were at the cinema and while playing computer games. According to Pearson’s Chi square test, snacking was associated with smoking and snuffing and infrequent tooth brushing (p
- Published
- 2020
34. Estimating molar-incisor-hypomineralization among 8-year-olds based on 15-year public oral health practice-based data
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Tseveenjav, B. (Battsetseg), Furuholm, J. (Jussi), Mulic, A. (Aida), Valen, H. (Håkon), Maisala, T. (Tuomo), Turunen, S. (Seppo), Varsio, S. (Sinikka), Auero, M. (Merja), Tjäderhane, L. (Leo), Tseveenjav, B. (Battsetseg), Furuholm, J. (Jussi), Mulic, A. (Aida), Valen, H. (Håkon), Maisala, T. (Tuomo), Turunen, S. (Seppo), Varsio, S. (Sinikka), Auero, M. (Merja), and Tjäderhane, L. (Leo)
- Abstract
Background: A wide range in the prevalence of molar-incisor-hypomineralization (MIH) has been reported. Population-based studies are recommended. However, such studies are expensive and time-consuming. Objectives: To estimate the magnitude of MIH condition among 8-year-olds based on routine oral health examinations and to associate first permanent molar (FPM) affection with that of other permanent teeth over time. Materials and methods: This retrospective study, with cross-sectional and longitudinal components, was based on electronic oral health records; all 8-year-olds examined between 2002 and 2016 were included. Results: The average estimated prevalence of MIH was 8.3%; yearly range was 4.8–15.9%. The mean number of affected teeth was 1.4; 62% had one affected tooth. One-surface defects were the most frequent (66%). Asymmetric distribution of affected teeth was observed. In follow-up, 10.7%, 8.4%, and 11.2% had at least one affected permanent canine, premolar, or second permanent molar, respectively. The proportion of children with other MIH-affected permanent teeth was higher in the group with ≥2 MIH-affected teeth than in group with one affected FPM at the age of 8. Conclusions: The average prevalence of MIH was comparable to that reported elsewhere. The number of MIH-affected teeth at early mixed dentition predicts the affection of other permanent teeth over time, mainly that of permanent canines. Further screening of children with MIH is recommended to improve individually tailored early preventive and restorative dental care.
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- 2020
35. Association between dental factors and mortality
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Liljestrand, J. M., primary, Salminen, A., additional, Lahdentausta, L., additional, Paju, S., additional, Mäntylä, P., additional, Buhlin, K., additional, Tjäderhane, L., additional, Sinisalo, J., additional, and Pussinen, P. J., additional
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- 2020
- Full Text
- View/download PDF
36. Effect of Remineralizing Agents on Initial Caries Lesions - Clinical Pilot Study on School-Children
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Anttonen, Vuokko, primary, Poikela, A., additional, Nikkinen, J., additional, Pasanen, K-M., additional, Tjäderhane, L., additional, Neva, M., additional, Pesonen, P., additional, and Anttonen, Vuokko, additional
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- 2020
- Full Text
- View/download PDF
37. Saliva and serum immune responses in apical periodontitis
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Pietiäinen, M. (Milla), Liljestrand, J. M. (John M.), Akhi, R. (Ramin), Buhlin, K. (Kåre), Johansson, A. (Anders), Paju, S. (Susanna), Salminen, A. (Aino), Mäntylä, P. (Päivi), Sinisalo, J. (Juha), Tjäderhane, L. (Leo), Hörkkö, S. (Sohvi), Pussinen, P. J. (Pirkko J.), Pietiäinen, M. (Milla), Liljestrand, J. M. (John M.), Akhi, R. (Ramin), Buhlin, K. (Kåre), Johansson, A. (Anders), Paju, S. (Susanna), Salminen, A. (Aino), Mäntylä, P. (Päivi), Sinisalo, J. (Juha), Tjäderhane, L. (Leo), Hörkkö, S. (Sohvi), and Pussinen, P. J. (Pirkko J.)
- Abstract
Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01–8.33) and 4.91 (2.48–9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48–2.97)), serum IgG to bacterial antigens (4.66 (1.22–10.1)), and Gram-negative subgingival species (1.98 (1.16–3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05–21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis—a putative risk factor for systemic diseases.
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- 2019
38. Association between dental factors and mortality.
- Author
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Liljestrand, J. M., Salminen, A., Lahdentausta, L., Paju, S., Mäntylä, P., Buhlin, K., Tjäderhane, L., Sinisalo, J., and Pussinen, P. J.
- Subjects
COMORBIDITY ,DEATH rate ,ENDODONTICS ,DENTURES ,ROOT canal treatment ,CORONARY angiography - Abstract
Aim: To study whether oral parameters such as endodontic infections, root canal fillings, number of teeth or wearing removable dentures at baseline are associated with cardiovascular‐ and all‐cause mortality in a follow‐up of approximately 8 years. Methodology: The Finnish Parogene cohort consists of 508 Finnish adults (mean age 63.3 years, SD 9.1) with cardiac symptoms, all of whom had undergone coronary angiography for accurate baseline coronary status. Extensive clinical and radiographic oral examinations were performed, and additional data were acquired from medical records and questionnaires. Root canal fillings and endodontic lesions, as well as their co‐occurrence, were determined from panoramic radiographs. The mortality data were assessed via record linkage with the Finnish Causes of Death register (mean follow‐up time 7.81 years, SD 1.45 years). A total of n = 471 dentate patients were included in the statistical analyses. Results: A total of n = 69 deaths were recorded, of which n = 41 were due to cardiovascular diseases (CVDs, ICD‐10 I00–I99). The deceased had fewer root canal fillings (mean 1.57; SD 1.64 vs. mean 2.30; SD 2.34, P = 0.03) than the survivors. The number of missing teeth was associated with smoking, occluded coronary arteries and diabetes. Cox regression with Firth's penalized maximum‐likelihood method using age as timescale revealed an inverse association (HR; 95%CI) between mortality and number of teeth (all‐cause 0.91; 0.86–0.96, CVD mortality 0.89; 0.83–0.96), use of removable dentures (all‐cause 0.24; 0.09–0.62, CVD mortality 0.20; 0.06–0.72), root canal fillings (all‐cause 0.82; 0.70–0.94, CVD mortality 0.79; 0.63–0.96) and having root canal fillings in all teeth with apical rarefactions (all‐cause 0.27; 0.06–0.79, CVD mortality 0.09; 0.01–0.63), when gender, smoking, occluded coronary arteries, periodontal inflammatory burden index and the number of teeth were adjusted for. Conclusions: The number of missing teeth appeared to be the strongest predictor of mortality in this study, whereas endodontic infections per se had no independent association. Nevertheless, signs of professional intervention in these problems, such as root canal fillings and removable dentures, appeared to be associated with improved survival, which might partly be explained by the utilization of healthcare services. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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39. A novel dry-bonding approach to reduce collagen degradation and optimize resin-dentin interfaces
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Stape, T. H. (Thiago Henrique Scarabello), Seseogullari-Dirihan, R. (Roda), Tjäderhane, L. (Leo), Abuna, G. (Gabriel), Martins, L. R. (Luís Roberto Marcondes), Tezvergil-Mutluay, A. (Arzu), Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, and HUS Head and Neck Center
- Subjects
Adolescent ,Hydrolases ,DURABILITY ,lcsh:Medicine ,Article ,Young Adult ,stomatognathic system ,Tensile Strength ,STRENGTH ,WATER ,Humans ,DMSO ,lcsh:Science ,SOLVENT ,ENZYMATIC BIODEGRADATION ,lcsh:R ,DIMETHYL-SULFOXIDE ,Dental Bonding ,Proteases ,313 Dentistry ,stomatognathic diseases ,Hydroxyproline ,Resins, Synthetic ,Dentin ,Proteolysis ,Gelatin ,lcsh:Q ,HYBRID LAYER ,Collagen ,MATRIX ,RINSE ADHESIVES - Abstract
In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and precipitate enzymes, the aim was to test whether the use of DMSO would permit adequate resin bonding to H3PO4-etched dehydrated dentin and assess its impact on collagen degradation by host-derived enzymes. Etched dentin surfaces from extracted sound human molars were randomly bonded in wet or dry conditions using aqueous or ethanolic DMSO solutions as pretreatments and bonding resins with or without DMSO. Bonded teeth were sectioned into resin-dentin slabs for confocal in situ zymography and beams for microtensile bond strength test. Demineralized powdered dentin was incubated in the tested DMSO -media and a hydroxyproline assay evaluated dissolution of collagen peptides. Zymography was performed on protein extracts obtained from dry and wet H3PO4-ecthed dentin powder treated with the DMSO- media. The correlative biochemical analysis demonstrated that reduction of water content during dentin hybridization by the innovative dry-bonding approaches with DMSO is effective to inactivate host-derived MMP-2 and MMP-9 and thus reduce collagen degradation while simultaneously optimizing resin-dentin bonding.
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- 2018
40. Microtensile bond strength to phosphoric acid-etched dentin treated with NaF, KF and CaF₂
- Author
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Altinci, P. (Pinar), Mutluay, M. (Murat), Tjäderhane, L. (Leo), and Tezvergil-Mutluay, A. (Arzu)
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Dentin ,Surface treatment ,Adhesion ,Durability - Abstract
Purpose: Fluoride compounds have been reported to play a protective role in the host-derived enzymatic degradation of demineralized dentin matrices. The objective of this study was to evaluate the effect of fluoride pretreatment on the immediate and long-term microtensile bond strength (µTBS) of resin-dentin interfaces. Materials and methods: Mid-coronal dentin surfaces of ninety-nine teeth were etched with 32%wt phosphoric acid and randomly assigned to pretreatment with NaF, KF or CaF2 solutions (6, 24 and 179 mM F content) for 30 s before the application of bonding agent (Scothbond Multi-Purpose, 3 M ESPE). No fluoride pretreatment and a commercially available bonding agent with KF (Excite F, Ivoclar Vivadent) were used as controls. After composite built-up, the specimens were sectioned into µTBS test beams, stored in artificial saliva at 37 °C for 24 h, 6 or 12 months and tested. Fracture types were evaluated under scanning electron microscope. The data were analyzed with ANOVA and Scheffe post-hoc tests (α = 0.05). Pearson Chi-Square test was used to compare the distribution of failure types. Results: Fluoride compound, fluoride concentration and storage time showed significant effect on µTBS (p < 0.05). NaF, KF and Excite F groups showed higher µTBS than the control (p < 0.05). After 24 h, µTBS ranged between 35.26(±10.25) MPa in control to 54.65(±14.60) MPa in NaF 24 mM group (p < 0.05), and the bond strength of 6 and 24 mM F groups were also found higher than the control (p < 0.05). After 12 months, all F groups showed stable bond strength (p > 0.05), except CaF2 179 mM (p < 0.05). According to Chi-square test, fracture types were also significantly influenced from the test factors (p < 0.05). Conclusions: NaF and KF treatment after acid-etching step of adhesive bonding procedures do not adversely influence the initial or long-term bond strength to dentin, and can improve the maintenance of bond strength durability.
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- 2018
41. A microCT study of three-dimensional patterns of biomineralization in pig molars
- Author
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Sova, S. S. (Susanna S.), Tjäderhane, L. (Leo), Heikkilä , P. A. (Pasi A.), and Jernvall, J. (Jukka)
- Subjects
3D-imaging ,microtomography ,stomatognathic diseases ,stomatognathic system ,beam hardening artifacts ,sus scrofa ,biomineralization ,tooth maturation ,teeth - Abstract
Domestic pig molars provide an interesting system to study the biomineralization process. The large size, thick enamel and complex crown morphology make pig molars relatively similar to human molars. However, compared to human molars, pig molars develop considerably faster. Here we use microCT to image the developing pig molars and to decipher spatial patterns of biomineralization. We used mineral grains to calibrate individual microCT-scans, which allowed an accurate measure of the electron density of the developing molars. The microCT results show that unerupted molars that are morphologically at the same stage of development, can be at markedly different stage of enamel biomineralization. Erupted molars show increased electron density, suggesting that mineralization continues in oral cavity. Yet, our comparisons show that human enamel has slightly higher electron density than pig enamel. These results support the relatively low hardness values and calcium level values that have been reported earlier in literature for pig teeth. The mineral calibration was an efficient method for the microCT-absorption models, allowing a relatively robust way to detect scanning artifacts. In conclusions, whereas thin sections remain the preferred way to analyze enamel features, such as incremental lines and crystal orientation, the microCT allows efficient and non-destructive comparisons between different teeth and species.
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- 2018
42. The types and management of dental trauma during military service in Finland
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Antikainen, A. (Atte), Patinen, P. (Pertti), Päkkilä, J. (Jari), Tjäderhane, L. (Leo), and Anttonen, V. (Vuokko)
- Subjects
stomatognathic diseases ,dental trauma ,stomatognathic system ,treatment ,conscript - Abstract
Background/Aims: All Finnish males must attend compulsory military service that lasts from 6 months to 1 year. About 25 000 males (approximately 80% of each age cohort) and 400 volunteer females complete the service annually. The aim of the study was to investigate the types of dental trauma occurring among Finnish conscripts during their military service. The article also focused on how dental trauma is treated in the Finnish Defence Forces. Material and Methods: All dental records in the Defence Forces’ patient register concerning dental trauma during the years 2011 and 2012 were analysed by tooth number, treatment procedures and number of visits. Results: According to the patient register, 361 conscripts suffered an oral trauma during their military service; thus, the average annual incidence was 7.2 trauma per 1000 conscripts. A total of 483 teeth were traumatized in the 2‐year period. The most frequently traumatized teeth were the maxillary central incisors (61%), and the most common findings were enamel or enamel‐dentin fractures (63% of all findings). Severe trauma was not common, and the most severe ones occurred during off‐duty hours. The most common treatment was direct filling (n = 189 patients). Only 53 patients had soft tissue injuries (bruises, wounds). Among patients with dental trauma, the mean number of visits to the Defence Forces’ dental clinic was 1.9. Great variation exists in recording findings concerning dental and oral trauma. Conclusion: Minor trauma is common. In all cases, recording trauma and treatments should be performed carefully.
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- 2018
43. Postradiation matrix metalloproteinase-20 expression and its impact on dental micromorphology and radiation-related caries
- Author
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Gomes-Silva, W. (Wagner), Prado-Ribeiro, . A. ( Ana Carolina), Brandão, T. B. (Thais Bianca), Morais-Faria, K. (Karina), de Castro Junior, G. (Gilberto), Perez Mak, M. (Milena), Ajudarte Lopes, M. (Marcio), Marques Rocha, M. (Marcelo), Salo, T. (Tuula), Tjäderhane, L. (Leo), and de Goes, M. F. (Mario Fernando)
- Subjects
stomatognathic diseases ,stomatognathic system ,Radiotherapy ,Caries ,Matrix metalloproteinase-20 ,Dentin-enamel junction ,Dental tissues ,Head-and-neck cancer - Abstract
Recent evidence suggests that head-and-neck radiotherapy (HNRT) increases active forms of matrix metalloproteinase-20 (MMP-20) in human tooth crowns, degrading the dentin-enamel junction (DEJ) and leading to enamel delamination, which is a pivotal step in the formation of radiation-related caries (RRC). Additional participation of enzymatic degradation of organic matrix components in caries progression was attributed to MMP-20 in dentin. Therefore, the current study tested the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes to the enamel and dentin. Thirty-six teeth were studied, including 19 post-HNRT specimens and 17 nonirradiated controls. Optical light microscopy was used to investigate the micromorphological components of the DEJ, dentin-pulp complex components, and carious dentin. The samples were divided into 2 subgroups: nondemineralized ground sections (n = 20) and demineralized histological sections (n = 16). In addition, immunohistochemical analysis using the immunoperoxidase technique was conducted to semiquantitatively assess MMP-20 expression in the DEJ, dentin-pulp complex components, and carious dentin. No apparent damage to the DEJ microstructure or other dentin-pulp complex components was observed and no statistically significant differences were detected in MMP-20 expression (p > 0.05) between the irradiated and control groups. This study rejected the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes. Hence, direct effects of radiation may not be regarded as an independent factor to explain aggressive clinical patterns of RRC.
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- 2017
44. Käypä hoito -suositus:hammasperäiset äkilliset infektiot ja mikrobilääkkeet
- Author
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Richardson, R. (Riina), Pöllänen, M. (Marja), Alapulli, H. (Heikki), Järvinen, A. (Asko), Parikka, M. (Mataleena), Pinnola, M. (Marianne), Soukka, T. (Tero), and Tjäderhane, L. (Leo)
- Abstract
In most cases, acute oral infections originate from the dentition. Dental procedures targeted at the infection source are the cornerstone of management. Antimicrobials are secondary to appropriate dental care and their use does not justify postponing elimination of the infection source. Medically compromised patients are more susceptible to odontogenic infection complications and antimicrobials have an important role in their treatment. Due to increasing antimicrobial resistance prophylaxis and treatment should be considered individually and used in patients likely to benefit most, taking into account both the patient and procedure-related risk factors. Tiivistelmä Hammasperäisten infektioiden hoidossa mikrobilääkehoito on toissijainen hoito, eikä se korvaa hammaslääketieteellistä hoitoa, koska infektiopesäkkeen hoidon viivästyminen tai puutteellinen hoito voi johtaa infektion kehittymiseen henkeä uhkaavaksi.
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- 2017
45. Dimethyl sulfoxide improves degree of conversion of hydrophobic bonding agents
- Author
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Zabeu, G.S., primary, Agulhari, M.A.S., additional, Giacomini, M.C., additional, Jacomine, J.C., additional, Scaffa, P.M.C., additional, Tjäderhane, L., additional, Soares, D.G., additional, Carvalho, R.M., additional, and Wang, L., additional
- Published
- 2018
- Full Text
- View/download PDF
46. Dry-bonding with dimethyl sulfoxide pretreatments to reduce collagen degradation
- Author
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Stape, T.H.S., primary, Seseogullari-Dirihan, R., additional, Tjäderhane, L., additional, Abuna, G., additional, Martins, L.R.M., additional, and Tezvergil-Mutluay, A., additional
- Published
- 2018
- Full Text
- View/download PDF
47. Role of Proteolytic Enzyme Inhibitors on Carious and Eroded Dentin Associated With a Universal Bonding System
- Author
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Giacomini, MC, primary, Scaffa, PMC, primary, Chaves, LP, primary, Vidal, CMP, primary, Machado, TN, primary, Honório, HM, primary, Tjäderhane, L, primary, and Wang, L, primary
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- 2017
- Full Text
- View/download PDF
48. Profiling of smokers and snuffers among young Finnish men:cross-sectional epidemiological study
- Author
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Päkkilä, J. (Jari), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Nyman, K. (Kai), Valkeapää, K. (Kirsi), Birkhed, D. (Dowen), Tjäderhane, L. (Leo), Tanner, T. (Tarja), Päkkilä, J. (Jari), Anttonen, V. (Vuokko), Patinen, P. (Pertti), Nyman, K. (Kai), Valkeapää, K. (Kirsi), Birkhed, D. (Dowen), Tjäderhane, L. (Leo), and Tanner, T. (Tarja)
- Abstract
Objective: The purpose of this study was to get new information from several sources about the background factors of Finnish smokers, snuffers, and dual users. Profiles of young smokers and snuffers were investigated in association with restorative treatment need, oral hygiene, eating habits, physical activity, body mass index (BMI), psychological and socioeconomic factors. Material and methods: The study group comprised 3420 conscripts. The data were collected from four different sources: a health examination including an oral health screening, a computer-based questionnaire for investigating individual background factors, a psychological test assessing cognitive skills, and the Cooper test. Statistical analyses comprised cross tabulation and binary logistic regression modelling. Results: The odds for smoking were the greatest among those who had DT (Decayed teeth) > 0, used energy drinks or alcohol regularly, or whose parents were divorced. A score of ≥2900 m in the Cooper test, a higher physical exercise level, a higher own education level, and using sports drinks decreased the odds for smoking. The odds for snuffing were higher among those who ran >2500 m in the Cooper test, had a BMI of ≥25, used sports/energy drinks, or exercised regularly, and lower among those who achieved good results in the cognitive test. Using energy/sports drinks or alcohol was positively and a higher education level was negatively associated with dual use. Conclusions: Along with increasing prevalence of snuffing, heterogeneity is likely among snuffers. Good cognitive skills may prevent from smoking and snuffing.
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- 2017
49. PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells
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Alvarez, M.M.P., primary, Moura, G.E., additional, Machado, M.F.M., additional, Viana, G.M., additional, de Souza Costa, C.A., additional, Tjäderhane, L., additional, Nader, H.B., additional, Tersariol, I.L.S., additional, and Nascimento, F.D., additional
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- 2017
- Full Text
- View/download PDF
50. European Society of Endodontology position statement: the use of antibiotics in endodontics
- Author
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Segura‐Egea, J. J., primary, Gould, K., additional, Hakan Şen, B., additional, Jonasson, P., additional, Cotti, E., additional, Mazzoni, A., additional, Sunay, H., additional, Tjäderhane, L., additional, and Dummer, P. M. H., additional
- Published
- 2017
- Full Text
- View/download PDF
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