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1,013 results on '"Tang, W.H. Wilson"'

3. Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease From the PVDOMICS Study

Author

Mukherjee, Monica, Mathai, Stephen C., Jellis, Christine, Freed, Benjamin H., Yanek, Lisa R., Agoglia, Hannah, Chiu, Caitlin, Jani, Vivek P., Simpson, Catherine E., Brittain, Evan L., Tang, W.H. Wilson, Park, Margaret M., Hemnes, Anna R., Rosenzweig, Erika B., Rischard, Franz P., Frantz, Robert P., Hassoun, Paul M., Beck, Gerald, Hill, Nicholas S., Erzurum, Serpil, Thomas, James D., Kwon, Deborah, Leopold, Jane A., Horn, Evelyn M., and Kim, Jiwon

Published
2024
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4. The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline

Author

Wang, Meng, Tang, W.H. Wilson, Li, Xinmin S., de Oliveira Otto, Marcia C., Lee, Yujin, Lemaitre, Rozenn N., Fretts, Amanda, Nemet, Ina, Sotoodehnia, Nona, Sitlani, Colleen M., Budoff, Matthew, DiDonato, Joseph A., Wang, Zeneng, Bansal, Nisha, Shlipak, Michael G., Psaty, Bruce M., Siscovick, David S., Sarnak, Mark J., Mozaffarian, Dariush, and Hazen, Stanley L.

Published
2024
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23. 2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure

Author

Chung, Mina K., Patton, Kristen K., Lau, Chu-Pak, Dal Forno, Alexander R.J., Al-Khatib, Sana M., Arora, Vanita, Birgersdotter-Green, Ulrika Maria, Cha, Yong-Mei, Chung, Eugene H., Cronin, Edmond M., Curtis, Anne B., Cygankiewicz, Iwona, Dandamudi, Gopi, Dubin, Anne M., Ensch, Douglas P., Glotzer, Taya V., Gold, Michael R., Goldberger, Zachary D., Gopinathannair, Rakesh, Gorodeski, Eiran Z., Gutierrez, Alejandra, Guzman, Juan C., Huang, Weijian, Imrey, Peter B., Indik, Julia H., Karim, Saima, Karpawich, Peter P., Khaykin, Yaariv, Kiehl, Erich L., Kron, Jordana, Kutyifa, Valentina, Link, Mark S., Marine, Joseph E., Mullens, Wilfried, Park, Seung-Jung, Parkash, Ratika, Patete, Manuel F., Pathak, Rajeev Kumar, Perona, Carlos A., Rickard, John, Schoenfeld, Mark H., Seow, Swee-Chong, Shen, Win-Kuang, Shoda, Morio, Singh, Jagmeet P., Slotwiner, David J., Sridhar, Arun Raghav M., Srivatsa, Uma N., Stecker, Eric C., Tanawuttiwat, Tanyanan, Tang, W.H. Wilson, Tapias, Carlos Andres, Tracy, Cynthia M., Upadhyay, Gaurav A., Varma, Niraj, Vernooy, Kevin, Vijayaraman, Pugazhendhi, Worsnick, Sarah Ann, Zareba, Wojciech, and Zeitler, Emily P.

Published
2023
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28. Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

Author

Alves, Renato, Amouyal, Chloe, Andersson Galijatovic, Ehm Astrid, Andreelli, Fabrizio, Barthelemy, Olivier, Bastard, Jean-Philippe, Batisse, Jean-Paul, Berland, Magalie, Bittar, Randa, Blüher, Matthias, Bork, Peer, Bourron, Olivier, Camus, Mickael, Cassuto, Dominique, Ciangura, Cecile, Coelho, Luis Pedro, Collet, Jean-Philippe, Dumas, Marc-Emmanuel, Ehrlich, S. Dusko, Engelbrechtsen, Line, Fezeu, Leopold, Forslund, Sofia, Fromentin, Sebastien, Galan, Pilar, Giral, Philippe, Gøtze, Jens Peter, Hansen, Torben, Hansen, Tue H., Hartemann, Agnes, Hartmann, Bolette, Hercberg, Serge, Holmes, Bridget, Holst, Jens Juul, Hornbak, Malene, Hoyles, Lesley, Hulot, Jean-Sebastien, Jaqueminet, Sophie, Kerneis, Mathieu, Khemis, Jean, Kozlowski, Ruby, Pedersen, Helle Krogh, Kuhn, Michael, Mannerås-Holm, Louise, Marko, Lajos, Martinez-Gili Robin Massey, Laura, Maziers, Nicolas, Medina-Stamminger, Jonathan, Moitinho-Silva, Lucas, Montalescot, Gilles, Moutel, Sandrine, Neves, Ana Luisa, Olanipekun, Michael, Oppert, Jean-Michel, Poitou, Christine, Pousset, Francoise, Pouzoulet, Laurence, Rouault, Christine, Silvain, Johanne, Vestergaard, Henrik, Molinaro, Antonio, Nemet, Ina, Bel Lassen, Pierre, Chakaroun, Rima, Nielsen, Trine, Aron-Wisnewsky, Judith, Bergh, Per-Olof, Li, Lin, Henricsson, Marcus, Køber, Lars, Isnard, Richard, Helft, Gerard, Stumvoll, Michael, Pedersen, Oluf, Smith, J. Gustav, Tang, W.H. Wilson, Clément, Karine, Hazen, Stanley L., and Bäckhed, Fredrik

Published
2023
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31. Rationale and design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy

Author

Januzzi, James L., Jr, Butler, Javed, Del Prato, Stefano, Ezekowitz, Justin A., Ibrahim, Nasrien E., Lam, Carolyn S.P., Lewis, Gregory D., Marwick, Thomas H., Rosenstock, Julio, Tang, W.H. Wilson, Zannad, Faiez, Lawson, Francesca, Perfetti, Riccardo, and Urbinati, Alessia

Published
2023
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34. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., Bernardo, Roberto J., Vanderpool, Rebecca R., Kwon, Deborah H., Acharya, Tushar, Park, Margaret M., Katrynuik, Austin, Insel, Michael, Kubba, Saad, Badagliacca, Roberto, Larive, A. Brett, Naeije, Robert, Garcia, Joe G.N., Beck, Gerald J., Erzurum, Serpil C., Frantz, Robert P., Hassoun, Paul M., Hemnes, Anna R., Hill, Nicholas S., Horn, Evelyn M., Leopold, Jane A., Rosenzweig, Erika B., Tang, W.H. Wilson, and Wilcox, Jennifer D.

Published
2023
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37. Pulmonary hypertension across the spectrum of left heart and lung disease

Author

Borlaug, Barry A., primary, Larive, Brett, additional, Frantz, Robert P., additional, Hassoun, Paul, additional, Hemnes, Anna, additional, Horn, Evelyn, additional, Leopold, Jane, additional, Rischard, Franz, additional, Berman‐Rosenzweig, Erika, additional, Beck, Gerald, additional, Erzurum, Serpil, additional, Farha, Samar, additional, Finet, J. Emanuel, additional, Highland, Kristin B., additional, Jacob, Miriam, additional, Jellis, Christine, additional, Mehra, Reena, additional, Renapurkar, Rahul, additional, Singh, Harsimran, additional, Tang, W.H. Wilson, additional, Vanderpool, Rebecca, additional, Wilcox, Jennifer, additional, Yu, Shilin, additional, and Hill, Nicholas, additional

Published
2024
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41. Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease

Author

Hemnes, Anna R., Leopold, Jane A., Radeva, Milena K., Beck, Gerald J., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Rosenzweig, Erika B., Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Desai, Ankit A., Dubrock, Hilary M., Erzurum, Serpil C., Finet, J. Emanuel, Frantz, Robert P., Garcia, Joe G.N., Geraci, Mark W., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Highland, Kristin B., Hill, Nicholas S., Hu, Bo, Kwon, Deborah H., Jacob, Miriam S., Jellis, Christine L., Larive, A. Brett, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., McCarthy, Kevin, Mehra, Reena, Nawabit, Rawan, Newman, John H., Olman, Mitchell A., Park, Margaret M., Ramos, Jose A., Renapurkar, Rahul D., Rischard, Franz P., Sherer, Susan G., Tang, W.H. Wilson, Thomas, James D., Vanderpool, Rebecca R., Waxman, Aaron B., Wilcox, Jennifer D., Yuan, Jason X.-J., and Horn, Evelyn M.

Published
2022
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45. Hemodynamic Response after Intra-aortic Balloon Counter-Pulsation in Cardiac Amyloidosis and Cardiogenic Shock.

Author

LONGINOW, JOSHUA, MARTENS, PIETER, IL'GIOVINE, ZACHARY J., HIGGINS, ANDREW, IVES, LAUREN, SOLTESZ, EDWARD G., TONG, MICHAEL Z., ESTEP, JERRY D., STARLING, RANDALL C., TANG, W.H. WILSON, HANNA, MAZEN, and LEE, RAN

Abstract

• In those with cardiac amyloidosis and heart failure-related cardiogenic shock, there was significant augmentation of cardiac index after intra-aortic balloon pump (IABP) and significant decreases in left ventricular and right ventricular filling pressures. • Predictors of lack of response to IABP by cardiac index were a smaller baseline left ventricular end-diastolic diameter size per centimeter and higher pre-IABP systemic vascular resistance. • Most patients with Society for Cardiovascular Angiography and Interventions stage C heart failure-related cardiogenic shock were stabilized successfully and bridged to advanced therapies with IABP alone. In those with heart failure-related cardiogenic shock (HF-CS), an intra-aortic balloon pump (IABP) may improve hemodynamics and be useful as a bridge to advanced therapies. We explore whether those with cardiac amyloidosis and HF-CS might experience hemodynamic improvement and describe the hemodynamic response after IABP. We retrospectively identified consecutive patients with a diagnosis of cardiac amyloid, either light chain or transthyretin, who were admitted to our intensive care unit with HF-CS. Patients were excluded if an IABP was placed during heart transplant or for shock related to acute myocardial infarction. Invasive hemodynamics before and after IABP placement were assessed. We identified 23 patients with cardiac amyloid who had an IABP placed for HF-CS. The 1-year survival rate was 74% and most (65%) were bridged to heart transplant, although 1 patient was bridged to destination left ventricular assist device. After IABP, the mean arterial pressure, cardiac index, and cardiac power index were significantly increased, whereas mean right atrial pressure, mean pulmonary artery pressure, and pulmonary capillary wedge pressure were all significantly decreased. A smaller left ventricular end-diastolic diameter (per cm) was associated with a higher likelihood of a cardiac index of <2.2 L/min/m2 after IABP (odds ratio 0.16, 95% confidence interval 0.01–0.93, P =.04). IABP significantly improved cardiac index while decreasing right atrial pressure, mean pulmonary artery pressure, and pulmonary capillary wedge pressure in cardiac amyloidosis patients with HF-CS. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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46. Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.

Author

Choucair, Ibrahim, Mallela, Deepthi P., Hilser, James R., Hartiala, Jaana A., Nemet, Ina, Gogonea, Valentin, Li, Lin, Lusis, Aldons J., Fischbach, Michael A., Tang, W.H. Wilson, Allayee, Hooman, and Hazen, Stanley L.

Subjects
LIQUID chromatography-mass spectrometry, DEOXYCHOLIC acid, BILE acids, DIABETES, HIGH performance liquid chromatography, GENOME-wide association studies
Abstract

Bile acids (BAs) are cholesterol-derived compounds that regulate glucose, lipid, and energy metabolism. Despite their significance in glucose homeostasis, the association between specific BA molecular species and their synthetic pathways with diabetes is unclear. Here, we used a recently validated, stable-isotope dilution, high-performance liquid chromatography with tandem mass spectrometry method to quantify a panel of BAs in fasting plasma from 2,145 study participants and explored structural and genetic determinants of BAs linked to diabetes, insulin resistance, and obesity. Multiple 12α-hydroxylated BAs were associated with diabetes (adjusted odds ratio [aOR] range, 1.3–1.9; P < 0.05 for all) and insulin resistance (aOR range, 1.3–2.2; P < 0.05 for all). Conversely, multiple 6α-hydroxylated BAs and isolithocholic acid (iso-LCA) were inversely associated with diabetes and obesity (aOR range, 0.3–0.9; P < 0.05 for all). Genome-wide association studies revealed multiple genome-wide significant loci linked with 9 of the 14 diabetes-associated BAs, including a locus for iso-LCA (rs11866815). Mendelian randomization analyses showed genetically elevated deoxycholic acid levels were causally associated with higher BMI, and iso-LCA levels were causally associated with reduced BMI and diabetes risk. In conclusion, comprehensive, large-scale, quantitative mass spectrometry and genetics analyses show circulating levels of multiple structurally specific BAs, especially DCA and iso-LCA, are clinically associated with and genetically linked to obesity and diabetes. Article Highlights: The association between specific circulating bile acid (BA) molecular species and diabetes in humans is not extensively studied. In the present study, we found that multiple 12α-hydroxylated BAs are positively associated with diabetes and insulin resistance, whereas multiple 6α-hydroxylated BAs are inversely associated with diabetes and obesity. Mendelian randomization analyses show isolithocholic acid levels are causally associated with reduced risk for diabetes and obesity, and deoxycholic acid levels are causally associated with obesity risk. The findings of this study provide new avenues for investigating the role of BAs in metabolic diseases and may have substantial therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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