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1. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J, Smeets, Xavier J N M, Kievit, Wietske, Verdonk, Robert C, Poen, Alexander C, Bhalla, Abha, Venneman, Niels G, Witteman, Ben J M, da Costa, David W, van Eijck, Brechje C, Schwartz, Matthijs P, Römkens, Tessa E H, Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M C J, Baak, Lubbertus C, Thijs, Willem J, van Wanrooij, Roy L, Tan, Adriaan C I T L, Seerden, Tom C J, Keulemans, Yolande C A, de Wijkerslooth, Thomas R, van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M, Hallensleben, Nora D L, Sperna Weiland, Ruud L, Timmerhuis, Hester C, Umans, Devica S, van Hooft, Jeanin E, van Goor, Harry, van Santvoort, Hjalmar C, Besselink, Marc G, Bruno, Marco J, Fockens, Paul, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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2. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, Dutch Pancreatitis Study Group, Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, and Dutch Pancreatitis Study Group

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and comp

Published
2023

3. Short- and long-term outcomes of a disruption and disconnection of the pancreatic duct in necrotizing pancreatitis: a multicenter cohort study in 896 patients : Disrupted pancreatic duct in acute pancreatitis

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, RS: FHML non-thematic output, MUMC+: MA Maag Darm Lever (9), and Interne Geneeskunde

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and complications. Central and subtotal pancreatic necrosis and high levels of serum C-reactive protein in the first 48 hours are independent predictors for DPD.

Published
2023

4. Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis.

Author

Timmerhuis, Hester C., den Berg, Fons F. van, Noorda, Paula C., van Dijk, Sven M., van Grinsven, Janneke, Weiland, Christina J. Sperna, Umans, Devica S., Mohamed, Yasmin A., Curvers, Wouter L., Bouwense, Stefan A. W., Hadithi, Muhammed, Inderson, Akin, Issa, Yama, Jansen, Jeroen M., de Jonge, Pieter Jan F., Quispel, Rutger, Schwartz, Matthijs P., Stommel, Martijn W. J., Tan, Adriaan C. I. T. L., and Venneman, Niels G.

Abstract

Objective: The use and impact of antibiotics and the impact of causative pathogens on clinical outcomes in a large real-world cohort covering the entire clinical spectrum of necrotizing pancreatitis remain unknown. Summary Background Data: International guidelines recommend broadspectrum antibiotics in patients with suspected infected necrotizing pancreatitis. This recommendation is not based on high-level evidence and clinical effects are unknown. Materials and Methods: This study is a post-hoc analysis of a nationwide prospective cohort of 401 patients with necrotizing pancreatitis in 15 Dutch centers (2010-2019). Across the patient population from the time of admission to 6 months postadmission, multivariable regression analyses were used to analyze (1) microbiological cultures and (2) antibiotic use. Results: Antibiotics were started in 321/401 patients (80%) administered at a median of 5 days (P25-P75: 1-13) after admission. The median duration of antibiotics was 27 days (P25-P75: 15-48). In 221/321 patients (69%) infection was not proven by cultures at the time of initiation of antibiotics. Empirical antibiotics for infected necrosis provided insuffi- cient coverage in 64/128 patients (50%) with a pancreatic culture. Prolonged antibiotic therapy was associated with Enterococcus infection (OR 1.08 [95% CI 1.03-1.16], P=0.01). Enterococcus infection was associated with new/persistent organ failure (OR 3.08 [95% CI 1.35-7.29], P< 0.01) and mortality (OR 5.78 [95% CI 1.46-38.73], P=0.03). Yeast was found in 30/147 cultures (20%). Discussion: In this nationwide study of patients with necrotizing pancreatitis, the vast majority received antibiotics, typically administered early in the disease course and without a proven infection. Empirical antibiotics were inappropriate based on pancreatic cultures in half the patients. Future clinical research and practice must consider antibiotic selective pressure due to prolonged therapy and coverage of Enterococcus and yeast. Improved guidelines on antimicrobial diagnostics and therapy could reduce inappropriate antibiotic use and improve clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study

Author

Hallensleben, Nora D, primary, Stassen, Pauline M C, additional, Schepers, Nicolien J, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bakker, Olaf J, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Brechje, additional, van Eijck, Casper H J, additional, Erkelens, Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin-Jan M, additional, van Grinsven, Janneke, additional, Hazen, Wouter L, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Poen, Alexander C, additional, Quispel, Rutger, additional, de Ridder, Rogier J, additional, Römkens, Tessa E H, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Seerden, Tom C J, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Umans, Devica S, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, van Wanrooij, Roy L J, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bouwense, Stefan A W, additional, and Bruno, Marco J, additional

Published
2023
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6. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Smeets, Xavier J. N. M., da Costa, David W., Fockens, Paul, Mulder, Chris J. J., Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J., Besselink, Marc G. H., Vleggaar, Frank P., van der Hulst, Rene W. M., Poen, Alexander C., Heine, Gerbrand D. N., Venneman, Niels G., Kolkman, Jeroen J., Baak, Lubbertus C., Römkens, Tessa E. H., van Dijk, Sven M., Hallensleben, Nora D. L., van de Vrie, Wim, Seerden, Tom C. J., Tan, Adriaan C. I. T. L., Voorburg, Annet M. C. J., Poley, Jan-Werner, Witteman, Ben J., Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J., Schwartz, Matthijs P., Vrolijk, Jan Maarten, Verdonk, Robert C., van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P. H., van Geenen, Erwin J. M., and for the Dutch Pancreatitis Study Group

Published
2018
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7. The additive value of CA19.9 monitoring in a pancreatic cyst surveillance program

Author

Levink, Iris J. M., Jaarsma, Sanne C., Koopmann, Brechtje D. M., Riet, Priscilla A., Overbeek, Kasper A., Meziani, Jihane, Sprij, Marloes L. J. A., Casadei, Riccardo, Ingaldi, Carlo, Polkowski, Marcin, Engels, Megan M. L., Waaij, Laurens A., Carrara, Silvia, Pando, Elizabeth, Vornhülz, Marlies, Honkoop, Pieter, Schoon, Erik J., Laukkarinen, Johanna, Bergmann, Jilling F., Rossi, Gemma, Vilsteren, Frederike G. I., Berkel, Anne‐Marie, Tabone, Trevor, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Hooft, Jeanin E., Quispel, Rutger, Soest, Ellert, Czacko, Laszlo, Bruno, Marco J., and Cahen, Djuna L.

Abstract

Surveillance of pancreatic cysts focuses on the detection of (mostly morphologic) features warranting surgery. European guidelines consider elevated CA19.9 as a relative indication for surgery. We aimed to evaluate the role of CA19.9 monitoring for early detection and management in a cyst surveillance population. The PACYFIC‐registry is a prospective collaboration that investigates the yield of pancreatic cyst surveillance performed at the discretion of the treating physician. We included participants for whom at least one serum CA19.9 value was determined by a minimum follow‐up of 12 months. Of 1865 PACYFIC participants, 685 met the inclusion criteria for this study (mean age 67 years, SD 10; 61% female). During a median follow‐up of 25 months (IQR 24, 1966 visits), 29 participants developed high‐grade dysplasia (HGD) or pancreatic cancer. At baseline, CA19.9 ranged from 1 to 591 kU/L (median 10 kU/L [IQR 14]), and was elevated (≥37 kU/L) in 64 participants (9%). During 191 of 1966 visits (10%), an elevated CA19.9 was detected, and these visits more often led to an intensified follow‐up (42%) than those without an elevated CA19.9 (27%; p< 0.001). An elevated CA19.9 was the sole reason for surgery in five participants with benign disease (10%). The baseline CA19.9 value was (as continuous or dichotomous variable at the 37 kU/L threshold) not independently associated with HGD or pancreatic cancer development, whilst a CA19.9 of ≥ 133 kU/L was (HR 3.8, 95% CI 1.1–13, p= 0.03). In this pancreatic cyst surveillance cohort, CA19.9 monitoring caused substantial harm by shortening surveillance intervals (and performance of unnecessary surgery). The current CA19.9 cutoff was not predictive of HGD and pancreatic cancer, whereas a higher cutoff may decrease false‐positive values. The role of CA19.9 monitoring should be critically appraised prior to implementation in surveillance programs and guidelines.

Published
2023
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8. Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial

Author

Walter, Daisy, van Boeckel, Petra G.A., Groenen, Marcel J.M., Weusten, Bas L.A.M., Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., van der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T.M., Scheffer, Robbert C.H., Steyerberg, Ewout W., May, Anne M., Leenders, Max, Hirdes, Meike M.C., Vleggaar, Frank P., and Siersema, Peter D.

Published
2017
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9. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients.

Author

Timmerhuis, Hester C., van Dijk, Sven M., Hollemans, Robbert A., Weiland, Christina J. Sperna, Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa E. H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Venneman, Niels G., and Vleggaar, Frank P.

Published
2023
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11. ID: 3520219 A RANDOMIZED TRIAL OF AGGRESSIVE FLUID HYDRATION TO PREVENT POST-ERCP PANCREATITIS (FLUYT)

Author

Sperna Weiland, Christa J., primary, Smeets, Xavier, additional, Kievit, Wietske, additional, Verdonk, Robert C., additional, Poen, A.C., additional, Bhalla, Abha, additional, Venneman, Niels G., additional, Witteman, Ben, additional, da Costa, David W., additional, van Eijck, Brechje, additional, Schwartz, Matthijs P., additional, Romkens, Tessa, additional, Vrolijk, Jan, additional, Hadithi, Muhammed, additional, Voorburg, Annet, additional, Baak, Lubbertus C., additional, Thijs, Willem, additional, Wanrooij, Roy V., additional, Tan, Adriaan C., additional, Seerden, Tom, additional, Keulemans, Yolande, additional, De Wijkerslooth, Thomas R., additional, Van De Vrie, W., additional, Van Der Schaar, Peter J., additional, Van Dijk, Sven M., additional, Hallensleben, Nora D., additional, Sperna Weiland, Ruud L., additional, Timmerhuis, Hester C., additional, Umans, Devica S., additional, van Hooft, Jeanin E., additional, van Goor, Harry, additional, Van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Bruno, Marco J., additional, Fockens, Paul, additional, Drenth, Joost, additional, and Van Geenen, Erwin-Jan M., additional

Published
2021
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12. Web-Based Educational Intervention for Patients With Uninvestigated Dyspepsia Referred for Upper Gastrointestinal Tract Endoscopy

Author

de Jong, Judith J., primary, Lantinga, Marten A., additional, Tan, Adriaan C. I. T. L., additional, Aquarius, Michel, additional, Scheffer, Robert C. H., additional, Uil, Jan J., additional, de Reuver, Philip R., additional, Keszthelyi, Daniel, additional, Westert, Gert P., additional, Masclee, Ad A. M., additional, and Drenth, Joost P. H., additional

Published
2021
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13. Additional file 2 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 2. List of parameters collected in the Case Record Form.

Published
2021
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14. Additional file 1 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 1. Definitions of Secondary Endpoints. *Severity of DB was defined according to the ASGE working party document for adverse events in colonoscopy [20].

Published
2021
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15. Additional file 3 of Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

Turan, Ayla S., Moons, Leon M. G., Ramon-Michel Schreuder, Schoon, Erik J., Jochim S. Terhaar Sive Droste, Schrauwen, Ruud W. M., Straathof, Jan Willem, Bastiaansen, Barbara A. J., Schwartz, Matthijs P., Hazen, Wouter L., Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, Spek, Bas W. Van Der, Heine, Dimitri G. D. N., Tan, Adriaan C. I. T. L., Graaf, Wilmar De, Boonstra, Jurjen J., Voogd, Fia J., Roomer, Robert, Ridder, Rogier J. J. De, Kievit, Wietske, Siersema, Peter D., Didden, Paul, and Geenen, Erwin J. M. Van

Abstract

Additional file 3. SPIRIT Checklist.

Published
2021
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16. Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial

Author

MS MDL 1, Cancer, Turan, Ayla S, Moons, Leon M G, Schreuder, Ramon-Michel, Schoon, Erik J, Terhaar Sive Droste, Jochim S, Schrauwen, Ruud W M, Straathof, Jan Willem, Bastiaansen, Barbara A J, Schwartz, Matthijs P, Hazen, Wouter L, Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, van der Spek, Bas W, Heine, Dimitri G D N, Tan, Adriaan C I T L, de Graaf, Wilmar, Boonstra, Jurjen J, Voogd, Fia J, Roomer, Robert, de Ridder, Rogier J J, Kievit, Wietske, Siersema, Peter D, Didden, Paul, van Geenen, Erwin J M, Dutch EMR Study Group, MS MDL 1, Cancer, Turan, Ayla S, Moons, Leon M G, Schreuder, Ramon-Michel, Schoon, Erik J, Terhaar Sive Droste, Jochim S, Schrauwen, Ruud W M, Straathof, Jan Willem, Bastiaansen, Barbara A J, Schwartz, Matthijs P, Hazen, Wouter L, Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, van der Spek, Bas W, Heine, Dimitri G D N, Tan, Adriaan C I T L, de Graaf, Wilmar, Boonstra, Jurjen J, Voogd, Fia J, Roomer, Robert, de Ridder, Rogier J J, Kievit, Wietske, Siersema, Peter D, Didden, Paul, van Geenen, Erwin J M, and Dutch EMR Study Group

Published
2021

17. Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease

Author

Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, Fidder, Herma H, Arts-assistenten Kinderen, MS MDL 1, Infection & Immunity, Cancer, Mahmmod, Shaden, Schultheiss, Johannes P D, van Bodegraven, Ad A, Dijkstra, Gerard, Gilissen, Lennard P L, Hoentjen, Frank, Lutgens, Maurice W M D, Mahmmod, Nofel, van der Meulen-de Jong, Andrea E, Smits, Lisa J T, Tan, Adriaan C I T L, Oldenburg, Bas, and Fidder, Herma H

Published
2021

19. Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients with Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial: The ESCAPE Randomized Clinical Trial

Author

Issa, Yama, Kempeneers, Marinus A., Bruno, Marco J., Fockens, Paul, Poley, Jan-Werner, Ahmed Ali, Usama, Bollen, Thomas L., Busch, Olivier R., Dejong, Cees H., van Duijvendijk, Peter, van Dullemen, Hendrik M., van Eijck, Casper H., van Goor, Harry, Hadithi, Muhammed, Haveman, Jan-Willem, Keulemans, Yolande, Nieuwenhuijs, Vincent B., Poen, Alexander C., Rauws, Erik A., Tan, Adriaan C., Thijs, Willem, Timmer, Robin, Witteman, Ben J., Besselink, Marc G., van Hooft, Jeanin E., van Santvoort, Hjalmar C., Dijkgraaf, Marcel G., Boermeester, Marja A., AII - Inflammatory diseases, AII - Infectious diseases, Graduate School, Gastroenterology and Hepatology, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, Surgery, AGEM - Endocrinology, metabolism and nutrition, Epidemiology and Data Science, APH - Methodology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
DUODENUM-PRESERVING RESECTION, SURGICAL DRAINAGE, MANAGEMENT, DUCT, HEAD, GUIDELINES, DIAGNOSIS, THERAPY
Abstract

Importance: For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could mitigate disease progression, providing better pain control and preserving pancreatic function. Objective: To determine whether early surgery is more effective than the endoscopy-first approach in terms of clinical outcomes. Design, Setting, and Participants: The ESCAPE trial was an unblinded, multicenter, randomized clinical superiority trial involving 30 Dutch hospitals participating in the Dutch Pancreatitis Study Group. From April 2011 until September 2016, a total of 88 patients with chronic pancreatitis, a dilated main pancreatic duct, and who only recently started using prescribed opioids for severe pain (strong opioids for ≤2 months or weak opioids for ≤6 months) were included. The 18-month follow-up period ended in March 2018. Interventions: There were 44 patients randomized to the early surgery group who underwent pancreatic drainage surgery within 6 weeks after randomization and 44 patients randomized to the endoscopy-first approach group who underwent medical treatment, endoscopy including lithotripsy if needed, and surgery if needed. Main Outcomes and Measures: The primary outcome was pain, measured on the Izbicki pain score and integrated over 18 months (range, 0-100 [increasing score indicates more pain severity]). Secondary outcomes were pain relief at the end of follow-up; number of interventions, complications, hospital admissions; pancreatic function; quality of life (measured on the 36-Item Short Form Health Survey [SF-36]); and mortality. Results: Among 88 patients who were randomized (mean age, 52 years; 21 (24%) women), 85 (97%) completed the trial. During 18 months of follow-up, patients in the early surgery group had a lower Izbicki pain score than patients in the group randomized to receive the endoscopy-first approach group (37 vs 49; between-group difference, -12 points [95% CI, -22 to -2]; P =.02). Complete or partial pain relief at end of follow-up was achieved in 23 of 40 patients (58%) in the early surgery vs 16 of 41 (39%)in the endoscopy-first approach group (P =.10). The total number of interventions was lower in the early surgery group (median, 1 vs 3; P

Published
2020

20. Outcome of Reverse Switching From CT-P13 to Originator Infliximab in Patients With Inflammatory Bowel Disease

Author

Mahmmod, Shaden, primary, Schultheiss, Johannes P D, additional, van Bodegraven, Ad A, additional, Dijkstra, Gerard, additional, Gilissen, Lennard P L, additional, Hoentjen, Frank, additional, Lutgens, Maurice W M D, additional, Mahmmod, Nofel, additional, van der Meulen–de Jong, Andrea E, additional, Smits, Lisa J T, additional, Tan, Adriaan C I T L, additional, Oldenburg, Bas, additional, and Fidder, Herma H, additional

Published
2021
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22. 607 DEVELOPMENT OF PANCREATIC DISEASES DURING LONG-TERM FOLLOW-UP OF PATIENTS WITH ACUTE PANCREATITIS IN A PROSPECTIVE NATIONWIDE MULTICENTER COHORT

Author

de Rijk, Florence E., Sissingh, Noor J., Boel, Thomas T., Timmerhuis, Hester C., de Jong, Mike J., Pauw, Hannah A., van Veldhuisen, Charlotte L., Hallensleben, Nora D., Anten, Marie-Paule, Brink, Menno A., Curvers, Wouter, van Duijvendijk, Peter, Hazen, Wouter L., Kuiken, Sjoerd D., Poen, A.C., Quispel, Rutger, Römkens, Tessa E., Spanier, B.W. Marcel, Tan, Adriaan C., Vleggaar, Frank P., Voorburg, Annet, Witteman, Ben, Ali, U Ahmed, Issa, Yama, Bouwense, Stefan A., Voermans, Rogier P., Van Geenen, Erwin-Jan M., Van Hooft, Jeanin E., De Jonge, P.J.F., van Goor, Harry, Boermeester, Marja A., Besselink, Marc G., Bruno, Marco J., Verdonk, Robert C., and Van Santvoort, Hjalmar C.

Published
2023
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23. Clinical Outcomes of Covid-19 in Patients With Inflammatory Bowel Disease: A Nationwide Cohort Study

Author

Derikx, Lauranne A A P, primary, Lantinga, Marten A, additional, de Jong, Dirk J, additional, van Dop, Willemijn A, additional, Creemers, Rob H, additional, Römkens, Tessa E H, additional, Jansen, Jeroen M, additional, Mahmmod, Nofel, additional, West, Rachel L, additional, Tan, Adriaan C I T L, additional, Bodelier, Alexander G L, additional, Gorter, Moniek H P, additional, Boekema, Paul J, additional, Halet, Eric R C, additional, Horjus, Carmen S, additional, van Dijk, Maarten A, additional, Hirdes, Meike M C, additional, Epping Stippel, Ludger S M, additional, Jharap, Bindia, additional, Lutgens, Maurice W M D, additional, Russel, Maurice G, additional, Gilissen, Lennard P L, additional, Nauta, Sjoukje, additional, van Bodegraven, Adriaan A, additional, and Hoentjen, Frank, additional

Published
2020
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24. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial

Author

Schepers, Nicolien J, primary, Hallensleben, Nora D L, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Delft, Foke, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Casper H J, additional, Erkelens, G Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin J M, additional, van Grinsven, Janneke, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, van der Hulst, Rene W M, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Laheij, Robert J F, additional, Quispel, Rutger, additional, de Ridder, Rogier J J, additional, Rijk, Marno C M, additional, Römkens, Tessa E H, additional, Ruigrok, Carola H M, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bakker, Olaf J, additional, and Bruno, Marco J, additional

Published
2020
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26. Impact of multidisciplinary tumor board discussion on palliation of patients with esophageal or gastro-esophageal junction cancer: a population-based study

Author

Vermeulen, Bram D., primary, Bruggeman, Lukas, additional, Bac, Dirk J., additional, Schrauwen, Ruud W. M., additional, Epping, Ludger S. M., additional, Scheffer, Robert C. H., additional, Tan, Adriaan C. I. T. L., additional, Groenen, Marcel J. M., additional, Verhoeven, Rob H. A., additional, and Siersema, Peter D., additional

Published
2020
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27. Correction : Electromagnetic-Guided Bedside Placement of Nasoenteral Feeding Tubes by Nurses Is Non-Inferior to Endoscopic Placement by Gastroenterologists: A Multicenter Randomized Controlled Trial. (American Journal of Gastroenterology 2019 (114) (1012) DOI: 10.1038/ajg.2016.224)

Author

Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, Willemien G., Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, Quintus I., Monkelbaan, Jan F., Mathus-Vliegen, Elisabeth M., and Besselink, Marc G.

Subjects
Hepatology, Gastroenterology
Abstract

In the August 2016 issue of The American Journal of Gastroenterology, in Electromagnetic-Guided Bedside Placement of Nasoenteral Feeding Tubes by Nurses Is Non-Inferior to Endoscopic Placement by Gastroenterologists: A Multicenter Randomized Controlled Trial the authors report a misspelling of an author's name in the author list. Author Elisabeth M. Mathus- Vliegent should have been written as Elisabeth M. Mathus-Vliegen.

Published
2019

28. Correction: Electromagnetic-Guided Bedside Placement of Nasoenteral Feeding Tubes by Nurses Is Non-Inferior to Endoscopic Placement by Gastroenterologists: A Multicenter Randomized Controlled Trial. (American Journal of Gastroenterology 2019 (114) (1012) DOI: 10.1038/ajg.2016.224)

Author

MS CGO, Cancer, MS MDL 1, Infection & Immunity, Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, Willemien G., Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, Quintus I., Monkelbaan, Jan F., Mathus-Vliegen, Elisabeth M., Besselink, Marc G., MS CGO, Cancer, MS MDL 1, Infection & Immunity, Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, Willemien G., Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, Quintus I., Monkelbaan, Jan F., Mathus-Vliegen, Elisabeth M., and Besselink, Marc G.

Published
2019

29. 570 – Early Endoscopic Retrograde Cholangiography with Biliary Sphincterotomy Or Conservative Treatment in Predicted Severe Acute Biliary Pancreatitis (APEC): A Multicenter Randomized Controlled Trial

Author

Schepers, Nicolien J., primary, Hallensleben, Nora D., additional, Besselink, Marc, additional, Anten, Marie-Paule, additional, Bollen, Thomas, additional, van Delft, Foke, additional, van Dullemen, Hendrik M., additional, Dijkgraaf, Marcel, additional, van Eijck, Casper H., additional, Erkelens, G. Willemien, additional, Erler, Nicole S., additional, Fockens, Paul, additional, van Geenen, Erwin-Jan M., additional, Gooszen, Hein G., additional, van Grinsven, Janneke, additional, van Hooft, Jeanin E., additional, van der Hulst, René W., additional, Jansen, Jeroen, additional, Kubben, Frank J.G.M., additional, Kuiken, Sjoerd D., additional, Laheij, Robert, additional, Quispel, Rutger, additional, de Ridder, Rogier, additional, Rijk, Marno C.M., additional, Romkens, Tessa, additional, Ruigrok, Carola H.M., additional, Schoon, Erik. J., additional, Schwartz, Matthijs P., additional, Spanier, Marcel, additional, Tan, Adriaan C., additional, Thijs, W., additional, Timmer, Robin, additional, Venneman, Niels, additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, van de Vrie, W, additional, Witteman, Ben, additional, van Santvoort, Hjalmar C., additional, Bakker, Olaf, additional, and Bruno, Marco J., additional

Published
2019
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30. Clinical Outcomes of Covid-19 in Patients With Inflammatory Bowel Disease: A Nationwide Cohort Study.

Author

Derikx, Lauranne A A P, Lantinga, Marten A, Jong, Dirk J de, Dop, Willemijn A van, Creemers, Rob H, Römkens, Tessa E H, Jansen, Jeroen M, Mahmmod, Nofel, West, Rachel L, Tan, Adriaan C I T L, Bodelier, Alexander G L, Gorter, Moniek H P, Boekema, Paul J, Halet, Eric R C, Horjus, Carmen S, Dijk, Maarten A van, Hirdes, Meike M C, Stippel, Ludger S M Epping, Jharap, Bindia, and Lutgens, Maurice W M D

Abstract

Background and Aims The COVID-19 risk and disease course in inflammatory bowel disease [IBD] patients remains uncertain. Therefore, we aimed to assess the clinical presentation, disease course, and outcomes of COVID-19 in IBD patients. Second, we determined COVID-19 incidences in IBD patients and compared this with the general population. Methods We conducted a multicentre, nationwide IBD cohort study in The Netherlands and identified patients with COVID-19. First, we assessed the COVID-19 disease course and outcomes. Second, we compared COVID-19 incidences between our IBD study cohort and the general Dutch population. Results We established an IBD cohort of 34 763 patients. COVID-19 was diagnosed in 100/34 763 patients [0.29%]; 20/100 of these patients [20%] had severe COVID-19 defined as admission to the intensive care unit, mechanical ventilation, and/or death. Hospitalisation occurred in 59/100 [59.0%] patients and 13/100 [13.0%] died. All patients who died had comorbidities and all but one were ≥65 years old. In line, we identified ≥1 comorbidity as an independent risk factor for hospitalisation (odds ratio [OR] 4.20, 95% confidence interval [CI] 1.58–11.17,; p = 0.004). Incidences of COVID-19 between the IBD study cohort and the general population were comparable (287.6 [95% CI 236.6–349.7] versus 333.0 [95% CI 329.3–336.7] per 100000 patients, respectively; p = 0.15). Conclusions Of 100 cases with IBD and COVID-19, 20% developed severe COVID-19, 59% were hospitalised and 13% died. A comparable COVID-19 risk was found between the IBD cohort [100/34 763 = 0.29%] and the general Dutch population. The presence of ≥1 comorbidities was an independent risk factor for hospitalisation due to COVID-19. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial) : study protocol for a randomized controlled trial

Author

Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, Dutch Pancreatitis Study Group, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, and Dutch Pancreatitis Study Group

Published
2018

32. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Arts-assistenten Radiologie, MS CGO, Cancer, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, Dutch Pancreatitis Study Group, Arts-assistenten Radiologie, MS CGO, Cancer, Smeets, Xavier J N M, da Costa, David W, Fockens, Paul, Mulder, Chris J J, Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J, Besselink, Marc G H, Vleggaar, Frank P, van der Hulst, Rene W M, Poen, Alexander C, Heine, Gerbrand D N, Venneman, Niels G, Kolkman, Jeroen J, Baak, Lubbertus C, Römkens, Tessa E H, van Dijk, Sven M, Hallensleben, Nora D L, van de Vrie, Wim, Seerden, Tom C J, Tan, Adriaan C I T L, Voorburg, Annet M C J, Poley, Jan-Werner, Witteman, Ben J, Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J, Schwartz, Matthijs P, Vrolijk, Jan Maarten, Verdonk, Robert C, van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P H, van Geenen, Erwin J M, and Dutch Pancreatitis Study Group

Published
2018

33. Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

Author

van den Brand, Floris F., primary, van Nieuwkerk, Carin M. J., additional, Verwer, Bart J., additional, de Boer, Ynto S., additional, de Boer, Nanne K. H., additional, Mulder, Chris J. J., additional, Bloemena, Elisabeth, additional, Bakker, Christine M., additional, Vrolijk, Jan M., additional, Drenth, Joost P. H., additional, Tan, Adriaan C. I. T. L., additional, ter Borg, Frank, additional, ter Borg, Martijn J., additional, van den Hazel, Sven J., additional, Inderson, Akin, additional, Tushuizen, Maarten E., additional, and Bouma, Gerd, additional

Published
2018
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34. Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: A randomized controlled trial

Author

MS MDL 1, Cancer, Unit Opleiding MDL, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, MS MDL Oncologie, Walter, Daisy, Van Boeckel, Petra G A, Groenen, Marcel J M, Weusten, Bas L A M, Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., Van Der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T M, Scheffer, Robbert C H, Steyerberg, Ewout W., May, Anne M., Leenders, Max, Hirdes, Meike M C, Vleggaar, Frank P., Siersema, Peter D., MS MDL 1, Cancer, Unit Opleiding MDL, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, MS MDL Oncologie, Walter, Daisy, Van Boeckel, Petra G A, Groenen, Marcel J M, Weusten, Bas L A M, Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., Van Der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T M, Scheffer, Robbert C H, Steyerberg, Ewout W., May, Anne M., Leenders, Max, Hirdes, Meike M C, Vleggaar, Frank P., and Siersema, Peter D.

Published
2017

35. Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial) : Study protocol for a randomized controlled trial

Author

Schepers, Nicolien J., Bakker, Olaf J., Besselink, Marc G H, Bollen, Thomas L., Dijkgraaf, Marcel G W, van Eijck, Casper H J, Fockens, Paul, van Geenen, Erwin J M, van Grinsven, Janneke, Hallensleben, Nora D L, Hansen, Bettina E., van Santvoort, Hjalmar C., Timmer, Robin, Anten, Marie Paule G F, Bolwerk, Clemens J M, van Delft, Foke, van Dullemen, Hendrik M., Erkelens, G. Willemien, van Hooft, Jeanin E., Laheij, Robert, van der Hulst, René W M, Jansen, Jeroen M., Kubben, Frank J G M, Kuiken, Sjoerd D., Perk, Lars E., de Ridder, Rogier J J, Rijk, Marno C M, Römkens, Tessa E H, Schoon, Erik J., Schwartz, Matthijs P., Spanier, B. W Marcel, Tan, Adriaan C I T L, Thijs, Willem J., Venneman, Niels G., Vleggaar, Frank P., van de Vrie, Wim, Witteman, Ben J., Gooszen, Hein G., Bruno, Marco J., Schepers, Nicolien J., Bakker, Olaf J., Besselink, Marc G H, Bollen, Thomas L., Dijkgraaf, Marcel G W, van Eijck, Casper H J, Fockens, Paul, van Geenen, Erwin J M, van Grinsven, Janneke, Hallensleben, Nora D L, Hansen, Bettina E., van Santvoort, Hjalmar C., Timmer, Robin, Anten, Marie Paule G F, Bolwerk, Clemens J M, van Delft, Foke, van Dullemen, Hendrik M., Erkelens, G. Willemien, van Hooft, Jeanin E., Laheij, Robert, van der Hulst, René W M, Jansen, Jeroen M., Kubben, Frank J G M, Kuiken, Sjoerd D., Perk, Lars E., de Ridder, Rogier J J, Rijk, Marno C M, Römkens, Tessa E H, Schoon, Erik J., Schwartz, Matthijs P., Spanier, B. W Marcel, Tan, Adriaan C I T L, Thijs, Willem J., Venneman, Niels G., Vleggaar, Frank P., van de Vrie, Wim, Witteman, Ben J., Gooszen, Hein G., and Bruno, Marco J.

Published
2016

36. Electromagnetic-guided bedside placement of nasoenteral feeding tubes by nurses is non-inferior to endoscopic placement by gastroenterologists : A multicenter randomized controlled trial

Author

Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, G. Willemien, Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, I. Quintus, Monkelbaan, Jan F., Mathus-Vliegent, Elisabeth M., Besselink, Marc G., Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, G. Willemien, Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, I. Quintus, Monkelbaan, Jan F., Mathus-Vliegent, Elisabeth M., and Besselink, Marc G.

Published
2016

37. Electromagnetic-guided bedside placement of nasoenteral feeding tubes by nurses is non-inferior to endoscopic placement by gastroenterologists: A multicenter randomized controlled trial

Author

Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, MS MDL 1, Infection & Immunity, Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, G. Willemien, Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, I. Quintus, Monkelbaan, Jan F., Mathus-Vliegent, Elisabeth M., Besselink, Marc G., Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, MS MDL 1, Infection & Immunity, Gerritsen, Arja, De Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., Van Duijvendijk, Peter, Erkelens, G. Willemien, Klos, Mariël, Kruyt, Philip M., Bac, Dirk Jan, Rosman, Camiel, Tan, Adriaan C., Molenaar, I. Quintus, Monkelbaan, Jan F., Mathus-Vliegent, Elisabeth M., and Besselink, Marc G.

Published
2016

38. Electromagnetic-Guided Bedside Placement of Nasoenteral Feeding Tubes by Nurses Is Non-Inferior to Endoscopic Placement by Gastroenterologists: A Multicenter Randomized Controlled Trial

Author

Gerritsen, Arja, primary, de Rooij, Thijs, additional, Dijkgraaf, Marcel G, additional, Busch, Olivier R, additional, Bergman, Jacques J, additional, Ubbink, Dirk T, additional, van Duijvendijk, Peter, additional, Erkelens, Willemien G, additional, Klos, Mariël, additional, Kruyt, Philip M, additional, Bac, Dirk Jan, additional, Rosman, Camiel, additional, Tan, Adriaan C, additional, Molenaar, Quintus I, additional, Monkelbaan, Jan F, additional, Mathus-Vliegent, Elisabeth M, additional, and Besselink, Marc G, additional

Published
2016
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39. Dutch Chronic Pancreatitis Registry (CARE) : Design and rationale of a nationwide prospective evaluation and follow-up

Author

Ali, U. Ahmed, Issa, Y., van Goor, H., van Eijck, Casper H., Nieuwenhuijs, Vincent B., Keulemans, Y., Fockens, P., Busch, O.R., Drenth, J.P., Dejong, Cornelis H., Dullemen, H.M., van Hooft, Jeanin E, Siersema, P. D., Spanier, B. W M, Poley, Jan W., Poen, Alexander C, Timmer, R., Seerden, T., Tan, Adriaan C., Thijs, Willem J., Witteman, Ben J. M., Romkens, T. E. H., Roeterdink, A. J., Gooszen, Hein G, Van Santvoort, H. C., Bruno, Marco J, Boermeester, Marja A, Ali, U. Ahmed, Issa, Y., van Goor, H., van Eijck, Casper H., Nieuwenhuijs, Vincent B., Keulemans, Y., Fockens, P., Busch, O.R., Drenth, J.P., Dejong, Cornelis H., Dullemen, H.M., van Hooft, Jeanin E, Siersema, P. D., Spanier, B. W M, Poley, Jan W., Poen, Alexander C, Timmer, R., Seerden, T., Tan, Adriaan C., Thijs, Willem J., Witteman, Ben J. M., Romkens, T. E. H., Roeterdink, A. J., Gooszen, Hein G, Van Santvoort, H. C., Bruno, Marco J, and Boermeester, Marja A

Published
2015

40. Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial

Author

Walter, Daisy, van Boeckel, Petra G A, Groenen, Marcel J, Weusten, Bas L A M, Witteman, Ben J, Tan, Gi, Brink, Menno A, Nicolai, Jan, Tan, Adriaan C, Alderliesten, Joyce, Venneman, Niels G, Laleman, Wim, Jansen, Jeroen M, Bodelier, Alexander, Wolters, Frank L, van der Waaij, Laurens A, Breumelhof, Ronald, Peters, Frank T M, Scheffer, Robbert C H, Leenders, Max, Hirdes, Meike M C, Steyerberg, Ewout W, Vleggaar, Frank P, Siersema, Peter D, Walter, Daisy, van Boeckel, Petra G A, Groenen, Marcel J, Weusten, Bas L A M, Witteman, Ben J, Tan, Gi, Brink, Menno A, Nicolai, Jan, Tan, Adriaan C, Alderliesten, Joyce, Venneman, Niels G, Laleman, Wim, Jansen, Jeroen M, Bodelier, Alexander, Wolters, Frank L, van der Waaij, Laurens A, Breumelhof, Ronald, Peters, Frank T M, Scheffer, Robbert C H, Leenders, Max, Hirdes, Meike M C, Steyerberg, Ewout W, Vleggaar, Frank P, and Siersema, Peter D

Published
2015

41. Electromagnetic guided bedside or endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE trial) : Study protocol for a randomized controlled trial

Author

Gerritsen, Arja, de Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., van Duijvendijk, Peter, Erkelens, G. Willemien, Molenaar, IQ, Monkelbaan, JF, Rosman, Camiel, Tan, Adriaan C., Kruyt, Philip M., Bac, Dirk Jan, Mathus-Vliegen, Elisabeth M., Besselink, Marc G., Gerritsen, Arja, de Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., van Duijvendijk, Peter, Erkelens, G. Willemien, Molenaar, IQ, Monkelbaan, JF, Rosman, Camiel, Tan, Adriaan C., Kruyt, Philip M., Bac, Dirk Jan, Mathus-Vliegen, Elisabeth M., and Besselink, Marc G.

Published
2015

42. Dutch Chronic Pancreatitis Registry (CARE): Design and rationale of a nationwide prospective evaluation and follow-up

Author

Heelkunde Opleiding, Cancer, MS MDL 1, MS MDL Oncologie, Ali, U. Ahmed, Issa, Y., van Goor, H., van Eijck, Casper H., Nieuwenhuijs, Vincent B., Keulemans, Y., Fockens, P., Busch, O.R., Drenth, J.P., Dejong, Cornelis H., Dullemen, H.M., van Hooft, Jeanin E, Siersema, P. D., Spanier, B. W M, Poley, Jan W., Poen, Alexander C, Timmer, R., Seerden, T., Tan, Adriaan C., Thijs, Willem J., Witteman, Ben J. M., Romkens, T. E. H., Roeterdink, A. J., Gooszen, Hein G, Van Santvoort, H. C., Bruno, Marco J, Boermeester, Marja A, Heelkunde Opleiding, Cancer, MS MDL 1, MS MDL Oncologie, Ali, U. Ahmed, Issa, Y., van Goor, H., van Eijck, Casper H., Nieuwenhuijs, Vincent B., Keulemans, Y., Fockens, P., Busch, O.R., Drenth, J.P., Dejong, Cornelis H., Dullemen, H.M., van Hooft, Jeanin E, Siersema, P. D., Spanier, B. W M, Poley, Jan W., Poen, Alexander C, Timmer, R., Seerden, T., Tan, Adriaan C., Thijs, Willem J., Witteman, Ben J. M., Romkens, T. E. H., Roeterdink, A. J., Gooszen, Hein G, Van Santvoort, H. C., Bruno, Marco J, and Boermeester, Marja A

Published
2015

43. Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial

Author

MS MDL 1, Unit Opleiding MDL, MS MDL Oncologie, Cancer, Walter, Daisy, van Boeckel, Petra G A, Groenen, Marcel J, Weusten, Bas L A M, Witteman, Ben J, Tan, Gi, Brink, Menno A, Nicolai, Jan, Tan, Adriaan C, Alderliesten, Joyce, Venneman, Niels G, Laleman, Wim, Jansen, Jeroen M, Bodelier, Alexander, Wolters, Frank L, van der Waaij, Laurens A, Breumelhof, Ronald, Peters, Frank T M, Scheffer, Robbert C H, Leenders, Max, Hirdes, Meike M C, Steyerberg, Ewout W, Vleggaar, Frank P, Siersema, Peter D, MS MDL 1, Unit Opleiding MDL, MS MDL Oncologie, Cancer, Walter, Daisy, van Boeckel, Petra G A, Groenen, Marcel J, Weusten, Bas L A M, Witteman, Ben J, Tan, Gi, Brink, Menno A, Nicolai, Jan, Tan, Adriaan C, Alderliesten, Joyce, Venneman, Niels G, Laleman, Wim, Jansen, Jeroen M, Bodelier, Alexander, Wolters, Frank L, van der Waaij, Laurens A, Breumelhof, Ronald, Peters, Frank T M, Scheffer, Robbert C H, Leenders, Max, Hirdes, Meike M C, Steyerberg, Ewout W, Vleggaar, Frank P, and Siersema, Peter D

Published
2015

44. Electromagnetic guided bedside or endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE trial): Study protocol for a randomized controlled trial

Author

MS CGO, Cancer, MS MDL 1, Gerritsen, Arja, de Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., van Duijvendijk, Peter, Erkelens, G. Willemien, Molenaar, IQ, Monkelbaan, JF, Rosman, Camiel, Tan, Adriaan C., Kruyt, Philip M., Bac, Dirk Jan, Mathus-Vliegen, Elisabeth M., Besselink, Marc G., MS CGO, Cancer, MS MDL 1, Gerritsen, Arja, de Rooij, Thijs, Dijkgraaf, Marcel G., Busch, Olivier R., Bergman, Jacques J., Ubbink, Dirk T., van Duijvendijk, Peter, Erkelens, G. Willemien, Molenaar, IQ, Monkelbaan, JF, Rosman, Camiel, Tan, Adriaan C., Kruyt, Philip M., Bac, Dirk Jan, Mathus-Vliegen, Elisabeth M., and Besselink, Marc G.

Published
2015

45. Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial

Author

Walter, Daisy, primary, van Boeckel, Petra G.A., additional, Groenen, Marcel J., additional, Weusten, Bas L.A.M., additional, Witteman, Ben J., additional, Tan, Gi, additional, Brink, Menno A., additional, Nicolai, Jan, additional, Tan, Adriaan C., additional, Alderliesten, Joyce, additional, Venneman, Niels G., additional, Laleman, Wim, additional, Jansen, Jeroen M., additional, Bodelier, Alexander, additional, Wolters, Frank L., additional, van der Waaij, Laurens A., additional, Breumelhof, Ronald, additional, Peters, Frank T.M., additional, Scheffer, Robbert C.H., additional, Leenders, Max, additional, Hirdes, Meike M.C., additional, Steyerberg, Ewout W., additional, Vleggaar, Frank P., additional, and Siersema, Peter D., additional

Published
2015
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46. Electromagnetic guided bedside or endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE trial): study protocol for a randomized controlled trial

Author

Gerritsen, Arja, primary, de Rooij, Thijs, additional, Dijkgraaf, Marcel G, additional, Busch, Olivier R, additional, Bergman, Jacques J, additional, Ubbink, Dirk T, additional, van Duijvendijk, Peter, additional, Erkelens, G Willemien, additional, Molenaar, I Quintus, additional, Monkelbaan, Jan F, additional, Rosman, Camiel, additional, Tan, Adriaan C, additional, Kruyt, Philip M, additional, Bac, Dirk Jan, additional, Mathus-Vliegen, Elisabeth M, additional, and Besselink, Marc G, additional

Published
2015
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48. Clip placement to prevent delayed bleeding after colonic endoscopic mucosal resection (CLIPPER): study protocol for a randomized controlled trial.

Author

Turan, Ayla S, Moons, Leon M G, Schreuder, Ramon-Michel, Schoon, Erik J, Terhaar Sive Droste, Jochim S, Schrauwen, Ruud W M, Straathof, Jan Willem, Bastiaansen, Barbara A J, Schwartz, Matthijs P, Hazen, Wouter L, Alkhalaf, Alaa, Allajar, Daud, Hadithi, Muhammed, van der Spek, Bas W, Heine, Dimitri G D N, Tan, Adriaan C I T L, de Graaf, Wilmar, Boonstra, Jurjen J, Voogd, Fia J, and Roomer, Robert

Subjects
HEMORRHAGE, ENDOSCOPIC surgery, RANDOMIZED controlled trials, HYPERTROPHIC scars, COLORECTAL cancer, COLON polyps
Abstract

Background: Endoscopic mucosal resection (EMR) for large colorectal polyps is in most cases the preferred treatment to prevent progression to colorectal carcinoma. The most common complication after EMR is delayed bleeding, occurring in 7% overall and in approximately 10% of polyps ≥ 2 cm in the proximal colon. Previous research has suggested that prophylactic clipping of the mucosal defect after EMR may reduce the incidence of delayed bleeding in polyps with a high bleeding risk.Methods: The CLIPPER trial is a multicenter, parallel-group, single blinded, randomized controlled superiority study. A total of 356 patients undergoing EMR for large (≥ 2 cm) non-pedunculated polyps in the proximal colon will be included and randomized to the clip group or the control group. Prophylactic clipping will be performed in the intervention group to close the resection defect after the EMR with a distance of < 1 cm between the clips. Primary outcome is delayed bleeding within 30 days after EMR. Secondary outcomes are recurrent or residual polyps and clip artifacts during surveillance colonoscopy after 6 months, as well as cost-effectiveness of prophylactic clipping and severity of delayed bleeding.Discussion: The CLIPPER trial is a pragmatic study performed in the Netherlands and is powered to determine the real-time efficacy and cost-effectiveness of prophylactic clipping after EMR of proximal colon polyps ≥ 2 cm in the Netherlands. This study will also generate new data on the achievability of complete closure and the effects of clip placement on scar surveillance after EMR, in order to further promote the debate on the role of prophylactic clipping in everyday clinical practice.Trial Registration: ClinicalTrials.gov NCT03309683 . Registered on 13 October 2017. Start recruitment: 05 March 2018. Planned completion of recruitment: 31 August 2021. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Validation and update of a prediction model for risk of relapse after cessation of anti-TNF treatment in Crohn's disease.

Author

Ten Bokkel Huinink S, de Jong DC, Nieboer D, Thomassen D, Steyerberg EW, Dijkgraaf MGW, Bodelier AGL, West RL, Römkens TEH, Hoentjen F, Mallant RC, van Tuyl BAC, Mares WGN, Wolfhagen FHJ, Dijkstra G, Reijnders JGP, de Boer NK, Tan ACITL, van Boeckel PGA, Tack GJ, van Asseldonk DP, D'Haens GRAM, van der Woude CJ, Duijvestein M, and de Vries AC

Subjects
Humans, Models, Statistical, Recurrence, Reproducibility of Results, Retrospective Studies, Risk Assessment, Crohn Disease drug therapy, Tumor Necrosis Factor Inhibitors therapeutic use, Withholding Treatment
Abstract

Background: Anti-tumor necrosis factor (TNF) therapy is effective for the treatment of Crohn's disease. Cessation may be considered in patients with a low risk of relapse. We aimed to externally validate and update our previously developed prediction model to estimate the risk of relapse after cessation of anti-TNF therapy., Methods: We performed a retrospective cohort study in 17 Dutch hospitals. Crohn's disease patients in clinical, biochemical or endoscopic remission were included after anti-TNF cessation. Primary outcome was a relapse necessitating treatment. Discrimination and calibration of the previously developed model were assessed. After external validation, the model was updated. The performance of the updated prediction model was assessed in internal-external validation and by using decision curve analysis., Results: 486 patients were included with a median follow-up of 1.7 years. Relapse rates were 35 and 54% after 1 and 2 years. At external validation, the discriminative ability of the prediction model was equal to that found at the development of the model [c-statistic 0.58 (95% confidence interval (CI) 0.54-0.62)], though the model was not well-calibrated on our cohort [calibration slope: 0.52 (0.28-0.76)]. After an update, a c-statistic of 0.60 (0.58-0.63) and calibration slope of 0.89 (0.69-1.09) were reported in internal-external validation., Conclusion: Our previously developed and updated prediction model for the risk of relapse after cessation of anti-TNF in Crohn's disease shows reasonable performance. The use of the model may support clinical decision-making to optimize patient selection in whom anti-TNF can be withdrawn. Clinical validation is ongoing in a prospective randomized trial., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2022
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50. Risk factors and clinical outcomes of endoscopic dilation in benign esophageal strictures: a long-term follow-up study.

Author

Vermeulen BD, de Zwart M, Sijben J, Soons E, van der Weerd L, Arese D, von den Hoff DW, Craviotto V, Tan ACITL, Groenen MJM, Bogte A, Repici A, Spaander MCW, and Siersema PD

Subjects
Dilatation, Follow-Up Studies, Humans, Netherlands, Retrospective Studies, Risk Factors, Treatment Outcome, Esophageal Stenosis etiology, Esophageal Stenosis therapy
Abstract

Background and Aims: Endoscopic dilation (ED) is still the mainstay of therapeutic management of benign esophageal strictures (BESs). This study aimed to establish risk factors for refractory BESs and assess long-term clinical outcomes of ED., Methods: We performed a retrospective study in 891 patients who underwent ED from 2003 to 2018 for BESs. We searched electronic medical records in 6 tertiary care centers in the Netherlands for data on clinical outcome of ED. Median follow-up was 39 months. The primary endpoint was risk factors for refractory BESs, defined as factors associated with an increased number of ED sessions during follow-up. Secondary endpoints were time from first to last ED session and adverse events., Results: Dilation up to 13 to 15 mm was associated with a higher number of ED sessions than dilation up to 16 to 18 mm (5.0 vs 4.1; hazard ratio [HR], 1.4; P = .001). Compared with peptic strictures, anastomotic (4.9 vs 3.6; HR, 2.1; P < .001), radiation (5.0 vs 3.6; HR, 3.0; P < .001), caustic (7.2 vs 3.6; HR, 2.7; P < .001), and postendotherapy (3.9 vs 3.6; HR, 1.8; P = .005) strictures were associated with a higher number of ED sessions. After 1 year of follow-up, the proportions of patients who remained free of ED was 75% in anastomotic, 71% in radiation, 70% in peptic, 83% in postendotherapy, and 62% in caustic strictures. Esophageal perforation occurred in 23 ED sessions (.4%) in 22 patients (2.4%)., Conclusions: More than 60% of patients with BESs remain free of ED after 1 year of follow-up. Because dilation up to 16 to 18 mm diameter was associated with fewer ED sessions during follow-up, we suggest that clinicians should consider dilation up to at least 16 mm to reduce the number of ED sessions in these patients., (Copyright © 2020 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)

Published
2020
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