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8. Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease

Author

Chida-Nagai, Ayako, primary, Masaki, Naoki, additional, Maeda, Kay, additional, Sasaki, Konosuke, additional, Sato, Hiroki, additional, Muneuchi, Jun, additional, Ochiai, Yoshie, additional, Murayama, Hiroomi, additional, Tahara, Masahiro, additional, Shiono, Atsuko, additional, Shinozuka, Atsushi, additional, Kono, Fumihiko, additional, Machida, Daisuke, additional, Toyooka, Shinichi, additional, Sugimoto, Seiichiro, additional, Nakamura, Kazufumi, additional, Akagi, Satoshi, additional, Kondo, Maiko, additional, Kasahara, Shingo, additional, Kotani, Yasuhiro, additional, Koizumi, Junichi, additional, Oda, Katsuhiko, additional, Harada, Masako, additional, Nakajima, Daisuke, additional, Murata, Akira, additional, Nagata, Hazumu, additional, Yatsunami, Koichi, additional, Kobayashi, Tomio, additional, Matsunaga, Yoshikiyo, additional, Inoue, Takahiro, additional, Yamagishi, Hiroyuki, additional, Nakagawa, Naomi, additional, Ohtani, Katsuki, additional, Yamamoto, Masaki, additional, Ito, Yushi, additional, Hokosaki, Tatsunori, additional, Kuwahara, Yuta, additional, Masutani, Satoshi, additional, Nomura, Koji, additional, Wada, Tsutomu, additional, Sawada, Hirofumi, additional, Abiko, Masayuki, additional, Takahashi, Tatsunori, additional, Ishikawa, Yuichi, additional, Okada, Seigo, additional, Naitoh, Atsushi, additional, Toda, Takako, additional, Ando, Tatsuya, additional, Masuzawa, Akihiro, additional, Hoshino, Shinsuke, additional, Kawada, Masaaki, additional, Nomura, Yuichi, additional, Ueno, Kentaro, additional, Ohashi, Naoki, additional, Tachibana, Tsuyoshi, additional, Cao, Yuchen, additional, Ueda, Hideaki, additional, Yanagi, Sadamitsu, additional, Koide, Masaaki, additional, Mitsushita, Norie, additional, Higashi, Kouji, additional, Minosaki, Yoshihiro, additional, Hayashi, Tomohiro, additional, Okamoto, Takashi, additional, Kuraishi, Kenji, additional, Ehara, Eiji, additional, Ishida, Hidekazu, additional, Horigome, Hitoshi, additional, Murakami, Takashi, additional, Takei, Kohta, additional, Ishii, Taku, additional, Harada, Gen, additional, Hirata, Yasutaka, additional, Maeda, Jun, additional, Tatebe, Shunsuke, additional, Ota, Chiharu, additional, Hayabuchi, Yasunobu, additional, Sakazaki, Hisanori, additional, Sasaki, Takashi, additional, Hirono, Keiichi, additional, Suzuki, Sayo, additional, Yasuda, Masahiro, additional, Takeda, Atsuhito, additional, Sawai, Madoka, additional, Miyaji, Kagami, additional, Kitagawa, Atsushi, additional, Nakai, Yosuke, additional, Kakimoto, Nobuyuki, additional, Agematsu, Kouta, additional, Manabe, Atsushi, additional, and Saiki, Yoshikatsu, additional

Published
2023
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11. Control of Heart Rate in Infant and Child Tachyarrhythmia With Reduced Cardiac Function Using Landiolol (HEARTFUL) ― Results of a Prospective, Multicenter, Uncontrolled Clinical Study ―

Author

Sagawa, Koichi, primary, Suzuki, Tsugutoshi, additional, Takei, Kohta, additional, Miura, Masaru, additional, Ueda, Hideaki, additional, Horigome, Hitoshi, additional, Ono, Hiroshi, additional, Ohashi, Naoki, additional, Sato, Seiichi, additional, Fukunaga, Hideo, additional, Aoki, Hisaaki, additional, Miyazaki, Aya, additional, Sakaguchi, Heima, additional, Morishima, Eiichiro, additional, Oki, Kaori, additional, and Sumitomo, Naokata, additional

Published
2022
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13. Survey results: status report on problems caused by sexual mismatch between sonographer and patient during echocardiography—a 2020 report of the Japanese Society of Echocardiography

Author

Iwataki, Mai, primary, Murata, Mitsushige, additional, Fujita, Masashi, additional, Toide, Hiroyuki, additional, Akasaka, Kazumi, additional, Iino, Takako, additional, Goda, Akiko, additional, Takei, Kohta, additional, Toh, Norihisa, additional, Miyasaka, Yoko, additional, Yamano, Michiyo, additional, Ishizu, Tomoko, additional, Nakatani, Satoshi, additional, and Yamamoto, Kazuhiro, additional

Published
2022
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16. Predictors of long-term mortality among perioperative survivors of Fontan operation

Author

Inai, Kei, primary, Inuzuka, Ryo, additional, Ono, Hiroshi, additional, Nii, Masaki, additional, Ohtsuki, Shinichi, additional, Kurita, Yoshihiko, additional, Takeda, Atsuhito, additional, Hirono, Keiichi, additional, Takei, Kohta, additional, Yasukouchi, Satoshi, additional, Yoshikawa, Tadahiro, additional, Furutani, Yoshiyuki, additional, Shimada, Eriko, additional, Shinohara, Tokuko, additional, Shinozaki, Tomohiro, additional, Matsuyama, Yutaka, additional, Senzaki, Hideaki, additional, and Nakanishi, Toshio, additional

Published
2021
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21. Predictors of long-term mortality among perioperative survivors of Fontan operation.

Author

Inai, Kei, Inuzuka, Ryo, Ono, Hiroshi, Nii, Masaki, Ohtsuki, Shinichi, Kurita, Yoshihiko, Takeda, Atsuhito, Hirono, Keiichi, Takei, Kohta, Yasukouchi, Satoshi, Yoshikawa, Tadahiro, Furutani, Yoshiyuki, Shimada, Eriko, Shinohara, Tokuko, Shinozaki, Tomohiro, Matsuyama, Yutaka, Senzaki, Hideaki, and Nakanishi, Toshio

Subjects
CARDIAC surgery, CENTRAL venous pressure, MORTALITY risk factors, OXYGEN saturation, HEMODYNAMICS, CARDIAC catheterization
Abstract

Aims The criteria for 'good' Fontan haemodynamics have been poorly defined in relation to long-term outcomes. The aim of this study was to identify the risk factors for mortality among haemodynamic parameters obtained early after the Fontan operation. Methods and results Clinical data of all perioperative survivors of the Fontan operation performed before 2011, from nine institutions, were collected through a retrospective chart review. In total, 1260 patients were included. The median age at the time of Fontan operation was 3.6 years. Post-operative cardiac catheterization was conducted in 1117 patients at a median period of 1.0 years after the operation. During the median follow-up period of 10.2 years, 107 patients died. The mortality rates at 10, 20, and 25 years after the operation were 5%, 12%, and 22%, respectively. On multivariable analysis, older age at the time of the operation {≥15 years, hazard ratio (HR) [95% confidence interval (CI)]: 3.2 (1.7–5.9)} and haemodynamic parameters obtained at post-operative catheterization, such as low ejection fraction [<30%, HR (95% CI): 7.5 (3.2–18)], low systemic oxygen saturation [<80%, HR (95% CI): 3.8 (1.6–9.1)], high central venous pressure [≥16 mmHg, HR (95% CI): 2.3 (1.3–3.9)], and low mean systemic arterial pressure [<60 mmHg, HR (95% CI): 3.0 (1.4–6.2)] were identified as independent predictors of mortality. The predictive model based on these parameters had a c-index of 0.75 at 10 years. Conclusions Haemodynamic parameters obtained at a median period of 1.0 years, post-operatively, can accurately identify patients with a high mortality risk, who may need intensive management to improve long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Frequency of malformed infants in a tertiary center over a period of ten years in Hokkaido, Japan

Author

Hayasaka, Itaru, Cho, Kazutoshi, Uzuki, Yutaka, Morioka, Keita, Akimoto, Takuma, Ishikawa, Satoshi, Takei, Kohta, Yamada, Takahiro, Morikawa, Mamoru, Yamada, Takashi, Ariga, Tadashi, and Minakami, Hisanori

Subjects
prenatal diagnosis, congenital malformation, fetal echocardiography, congenital heart disease, tertiary center
Abstract

Aim: This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated. Methods: An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005-2009 (first) and 2010-2014 (second), respectively. Cases including minor anomalies (accessory auricle, nevus and fistula auris congenita) were not included. Results: In total, 274 and 569 malformations were identified in 191 and 337 newborn infants in the first and second study periods, respectively. The number of malformed infants increased significantly over time (13% [191/1509] vs 19% [337/1743], respectively; P < 0.001), mainly as a result of an increase in cases of congenital heart disease (CHD), from 59 to 141 (31% [59/191] vs 42% [141/337] of all malformed infants in the first and second periods, respectively). The overall accurate prenatal diagnosis rate improved over time from 47% (128/274) to 58% (329/569) because of significant improvements in accurate prenatal diagnosis of CHD subtypes (23% [16/70] vs 65% [151/232] in the first and second periods, respectively, P < 0.0001). Conclusions: The frequency of malformed newborns was higher in the tertiary center than in the general population. The increased number of cases with prenatal suspicion and diagnosis of CHD contributed to the increased frequency of malformed infants during the study period.

Published
2017

26. Establishment of a Healthcare System for Patients With Adult Congenital Heart Disease in Collaboration With Children’s Hospital ― The Nagano Model ―

Author

Motoki, Hirohiko, primary, Yasukochi, Satoshi, additional, Takigiku, Kiyohiro, additional, Takei, Kohta, additional, Okamura, Toru, additional, Kimura, Kazuhiro, additional, Minamisawa, Masatoshi, additional, Okada, Ayako, additional, Saigusa, Tatsuya, additional, Ebisawa, Soichiro, additional, Seto, Tatsuichiro, additional, Shoda, Morio, additional, Okada, Kenji, additional, and Kuwahara, Koichiro, additional

Published
2019
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29. Abstract 14440: Normal Fetal Ventricular Strain by 2-Dimensional Speckle Tracking Echocardiography With Novel Imaging Modality With Higher Frame Rate and Spatial Resolution

Author

Takei, Kohta, Yasukochi, Satoshi, Takigiku, Kiyohiro, Tanaka, Noboru, Yonehara, Kosuke, Obinata, Haruka, Numata, Ryusuke, Koyama, Satoshi, Masamoto, Masato, and Yamada, Yuriko

Abstract

Introduction:Quantitative assessment of fetal cardiac systolic function is not fully established. Only a shortening fraction using 2D or M-mode images is mentioned in a scientific statement from AHA, because the previous studies using 2D speckle tracking echocardiography (2D-STE) derived strain imaging in fetus was limited by their low frame rate and image quality. In this study, we investigate to evaluate quantitative analysis of fetal myocardial strain using new 2D-STE with high frame rate imaging.Methods:89 fetuses between 18 and 37 weeks in gestational age with normal cardiac structure between May 2018 and June 2019 were enrolled in this study. 2D images with high frame rates (135 ? 36 frames/sec) of 4 chamber view (4CV) and short axis view (SAX) of fetal heart were obtained by Aprio i900 with i8CX1 probe (Canon Medical Systems). The acquired images were analyzed by offline software to calculate peak systolic global longitudinal strain (GLS), circumferential strain (GCS) and radial strain (GRS) of left ventricle (LV) and GLS of right ventricle (RV), and time to peak systolic strain (TPS).Results:Speckle tracking analyses of 4CV were feasible in all cases with good agreement of high inter- and intra-observer reliability. LV-GLS, GCS, GRS and RV-GLS were -22.9 ? 4.2%, -23.7 ? 6.1%, 28.6 ? 10.0%, -19.3 ? 2.9%, respectively. LV-GLS and LV-GRS were stable over gestation examined, meanwhile LV-GCS and RV-GLS showed weak negative correlation with gestational age (r = 0.23 p = 0.03, r = 0.28 p=0.03, respectively). TPS of all strains were stable over gestation examined. LV-GLS showed moderate correlation with LV single plane ejection fraction r = 0.57 p < 0.001). The averaged strain curves of LV-GLS and RV-GLS are showing in tables.Conclusions:Fetal strain by new 2D-STE system is feasible and consistent quantitatively. The LV-GLS is higher than RV-GLS along gestation, whose implication needs to be further investigated.

Published
2019
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30. Corrigendum: Use of the index of pulmonary vascular disease for predicting longterm outcome of pulmonary arterial hypertension associated with congenital heart disease.

Author

Chida-Nagai A, Masaki N, Maeda K, Sasaki K, Sato H, Muneuchi J, Ochiai Y, Murayama H, Tahara M, Shiono A, Shinozuka A, Kono F, Machida D, Toyooka S, Sugimoto S, Nakamura K, Akagi S, Kondo M, Kasahara S, Kotani Y, Koizumi J, Oda K, Harada M, Nakajima D, Murata A, Nagata H, Yatsunami K, Kobayashi T, Matsunaga Y, Inoue T, Yamagishi H, Nakagawa N, Ohtani K, Yamamoto M, Ito Y, Hokosaki T, Kuwahara Y, Masutani S, Nomura K, Wada T, Sawada H, Abiko M, Takahashi T, Ishikawa Y, Okada S, Naitoh A, Toda T, Ando T, Masuzawa A, Hoshino S, Kawada M, Nomura Y, Ueno K, Ohashi N, Tachibana T, Cao Y, Ueda H, Yanagi S, Koide M, Mitsushita N, Higashi K, Minosaki Y, Hayashi T, Okamoto T, Kuraishi K, Ehara E, Ishida H, Horigome H, Murakami T, Takei K, Ishii T, Harada G, Hirata Y, Maeda J, Tatebe S, Ota C, Hayabuchi Y, Sakazaki H, Sasaki T, Hirono K, Suzuki S, Yasuda M, Takeda A, Sawada M, Miyaji K, Kitagawa A, Nakai Y, Kakimoto N, Agematsu K, Manabe A, and Saiki Y

Abstract

[This corrects the article DOI: 10.3389/fcvm.2023.1212882.]., (© 2024 Chida-Nagai, Masaki, Maeda, Sasaki, Sato, Muneuchi, Ochiai, Murayama, Tahara, Shiono, Shinozuka, Kono, Machida, Toyooka, Sugimoto, Nakamura, Akagi, Kondo, Kasahara, Kotani, Koizumi, Oda, Harada, Nakajima, Murata, Nagata, Yatsunami, Kobayashi, Matsunaga, Inoue, Yamagishi, Nakagawa, Ohtani, Yamamoto, Ito, Hokosaki, Kuwahara, Masutani, Nomura, Wada, Sawada, Abiko, Takahashi, Ishikawa, Okada, Naitoh, Toda, Ando, Masuzawa, Hoshino, Kawada, Nomura, Ueno, Ohashi, Tachibana, Cao, Ueda, Yanagi, Koide, Mitsushita, Higashi, Minosaki, Hayashi, Okamoto, Kuraishi, Ehara, Ishida, Horigome, Murakami, Takei, Ishii, Harada, Hirata, Maeda, Tatebe, Ota, Hayabuchi, Sakazaki, Sasaki, Hirono, Suzuki, Yasuda, Takeda, Sawada, Miyaji, Kitagawa, Nakai, Kakimoto, Agematsu, Manabe and Saiki.)

Published
2024
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31. Pulmonary veno-occlusive disease after respiratory syncytial virus infection in a post hematopoietic stem cell transplantation patient.

Author

Watanabe T, Komori K, Saito S, Uchida E, Kurata T, Kitamura M, Matsui H, Takei K, Ogiso Y, Ohta-Ogo K, Nakazawa Y, and Sakashita K

Abstract

Background: Pulmonary veno-occlusive disease (PVOD) is a rare but fatal complication of hematopoietic stem cell transplantation (HSCT). Although literature on PVOD post-HSCT is scarce, a recent study has indicated that this condition may be underestimated. Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes common cold in healthy individuals but may lead to severe lower respiratory infection accompanied by respiratory distress in infants and immunocompromised individuals, such as post-HSCT patients. However, little is known about the relationship between PVOD and RSV infections., Case Report: A 4-year-old boy was diagnosed with metastatic neuroblastoma and underwent intensive chemotherapy, autologous HSCT, and allogeneic cord blood transplantation (CBT). He experienced PVOD on day 194 following CBT after displaying upper respiratory symptoms and positive RSV antigen test results approximately one month prior. Pathological examination of a lung biopsy specimen revealed lung injury suspected to be associated with viral infection in addition to PVOD-related findings, suggesting that RSV infection might have contributed to the onset of PVOD., Conclusions: The patient's clinical history and histological findings indicated that RSV could have triggered the development of PVOD under potential endothelial damage caused by HSCT and other prior treatments. Common respiratory viral infections, such as RSV infection, may evoke the development of PVOD., Competing Interests: The authors declare no conflict of interest. Disclosure forms provided by the authors are available on the website., (Copyright Ⓒ2023 Asia-Pacific Blood and Marrow Transplantation Group (APBMT).)

Published
2023
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32. Identification of metabolomic profile related to adult Fontan pathophysiology.

Author

Motoki N, Motoki H, Utsumi M, Yamazaki S, Obinata H, Takei K, and Yasukochi S

Abstract

Background: Metabolic disorders are important pathophysiologies that can cause multiple organ dysfunction and worsen prognosis in Fontan patients. This study aimed to comprehensively evaluate the metabolomic profile of adult Fontan patients and characterize its pathophysiology in relation to 2 control groups., Methods and Results: We performed metabolomic analysis of 31 plasma samples using capillary electrophoresis time-of-flight mass spectrometry. This observational cross-sectional study compared plasma metabolites of 14 heterogeneous adult Fontan patients with those of control groups, including 9 patients with congenital heart disease after biventricular repair and 8 normal healthy controls. Fontan patients exhibited significant differences in intermediate metabolite concentrations related to glycolysis, the tricarboxylic acid (TCA) cycle, and the urea cycle. The plasma concentrations of lactic acid, 2-oxoglutarate, isocitric acid, malic acid, cis -aconitic acid, arginine, citrulline, and the ratio of ornithine/citrulline showed significantly differences among the groups. Multiple logistic regression analysis with a stepwise selection-elimination method identified 2-oxoglutaric acid (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.76) and cis -aconitic acid (OR 2.69, 95% CI 1.04-6.99) as independently associated with Fontan patients. After adjustment for the covariates of age and gender, 2-oxoglutaric acid (OR 1.97, 95% CI 0.98-3.93) and cis -aconitic acid (OR 3.88, 95% CI 0.99-15.2) showed remarkable relationships with Fontan patients., Conclusions: The present findings suggest that abnormalities in the TCA cycle and amino acid metabolism are distinguishing features in the pathophysiology of Fontan patients. Future metabolomic studies will assist in developing biomarkers for the early prediction of "silent" Fontan pathophysiologies., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors.)

Published
2021
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33. A case report: Twin sisters with restrictive cardiomyopathy associated with rare mutations in the cardiac troponin I gene.

Author

Ueno M, Takeda A, Yamazawa H, Takei K, Furukawa T, Suzuki Y, Chida-Nagai A, and Kimura A

Abstract

Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy in children, and its prognosis until now, has been poor. Recently some sarcomeric mutations have been reported as disease-causing genes of RCM. However, the genotype-phenotype correlation is not fully understood. Additionally, prognostic factors including sudden death in patients with RCM have not been elucidated. We report our experience in treating twin sisters with RCM or hypertrophic cardiomyopathy with RCM phenotype, both carriers of the same mutation in TNNI3 , which encodes one of the major sarcomeric proteins in myofibrils. They were both diagnosed with RCM by cardiac catheterization at the age of 11 years. Despite appropriate follow-up and medical treatment, one died suddenly at the age of 11 years and the other also died at the age of 15 years due to heart failure while awaiting heart transplantation. In addition to our cases, other reports of younger fatal cases with RCM carrying TNNI3 mutations may suggest it as one of the prognostic factors. Genetic diagnosis is important in the clinical diagnosis, management, and treatment of cardiomyopathy. < Learning objective : Our cases involved twin sisters diagnosed with restrictive cardiomyopathy (RCM) with rare mutations in the cardiac troponin I. Based on their clinical course, this mutation appears to have a poor prognosis. It was reported that RCM was caused by sarcomere gene mutations, however, the relationship between genotype and phenotype is not clearly defined. To elucidate the prognosis of this rare disease not only the genetic mutations but the accumulation of various clinical outcomes is important.>., (© 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)

Published
2020
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